Page last updated: 2024-10-31

metoclopramide and Infant, Premature, Diseases

metoclopramide has been researched along with Infant, Premature, Diseases in 10 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.

Research Excerpts

ExcerptRelevanceReference
"Metoclopramide was introduced routinely in premature babies followed in ambulatory care by the Colombian Kangaroo Mother Care program (KMCP), based on a 2004 Cochrane review."7.01Randomized Clinical Trial of Metoclopramide as Prophylaxis of Gastroesophageal Reflux Disease in Preterm Infants. ( Charpak, N; Montealegre-Pomar, ADP, 2021)
"Metoclopramide was introduced routinely in premature babies followed in ambulatory care by the Colombian Kangaroo Mother Care program (KMCP), based on a 2004 Cochrane review."3.01Randomized Clinical Trial of Metoclopramide as Prophylaxis of Gastroesophageal Reflux Disease in Preterm Infants. ( Charpak, N; Montealegre-Pomar, ADP, 2021)
"During childhood, gastroparesis is quite rare, and is mostly seen in preterm infants, with either immaturity of the gastrointestinal tract, or when allergic to cow's milk protein."2.42Current pharmacological treatment of gastroparesis. ( Hauser, B; Salvatore, S; Vandenplas, Y, 2004)
"Metoclopramide was associated with increased risk of AEs compared with erythromycin."1.42Use and Safety of Erythromycin and Metoclopramide in Hospitalized Infants. ( Arnold, C; Benjamin, DK; Cheeseman, J; Cho, J; Chu, V; Clark, RH; Ericson, JE; Hornik, CP; Kaneko, S; Smith, PB; Wilson, E, 2015)
"Metoclopramide is a prokinetic drug used to treat GERD and it has been reported to be a most commonly prescribed medication in neonatal intensive care unit (NICU)."1.39Is metoclopramide safe for the premature infant? ( Dilmen, U; Eras, Z; Oğuz, SS, 2013)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's2 (20.00)18.2507
2000's3 (30.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Montealegre-Pomar, ADP1
Charpak, N1
Eras, Z1
Oğuz, SS1
Dilmen, U1
Ericson, JE1
Arnold, C1
Cheeseman, J1
Cho, J1
Kaneko, S1
Wilson, E1
Clark, RH2
Benjamin, DK1
Chu, V1
Smith, PB1
Hornik, CP1
Wheatley, E1
Kennedy, KA1
Spitzer, AR1
Vandenplas, Y1
Hauser, B1
Salvatore, S1
Sankaran, K1
Yeboah, E1
Bingham, WT1
Ninan, A1
Fanning, S1
Ishisaka, DY1
Merritt, TA1
Mukhopadhyay, K1
Narang, A1
Kumar, P1
Chakraborty, S1
Mittal, BR1
Sulyok, E1
Kovács, L1
Lichardus, B1
Bircak, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Use of Metoclopramide for the Prevention of Gastroesophageal Reflux in Premature Infants Followed in an Outpatient Kangaroo Mother Care Clinic Before 40 Weeks of Gestational Age: A Randomized Controlled Trial[NCT02907632]Phase 4490 participants (Actual)Interventional2017-04-26Completed
Cross-over Trial of Medical Treatment for GERD in Preterm Infants[NCT00131248]Phase 318 participants (Actual)Interventional2004-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Bradycardia Episodes/Day

(NCT00131248)
Timeframe: 7 days

Interventionepisodes per day (Mean)
Medications4.6
Placebo3.6

Reviews

1 review available for metoclopramide and Infant, Premature, Diseases

ArticleYear
Current pharmacological treatment of gastroparesis.
    Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:11

    Topics: Adult; Child; Cisapride; Domperidone; Erythromycin; Gastrointestinal Agents; Gastroparesis; Humans;

2004

Trials

2 trials available for metoclopramide and Infant, Premature, Diseases

ArticleYear
Randomized Clinical Trial of Metoclopramide as Prophylaxis of Gastroesophageal Reflux Disease in Preterm Infants.
    Paediatric drugs, 2021, Volume: 23, Issue:6

    Topics: Child; Gastroesophageal Reflux; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Prematur

2021
Cross-over trial of treatment for bradycardia attributed to gastroesophageal reflux in preterm infants.
    The Journal of pediatrics, 2009, Volume: 155, Issue:4

    Topics: Anti-Ulcer Agents; Bradycardia; Cross-Over Studies; Female; Gastroesophageal Reflux; Humans; Infant,

2009

Other Studies

7 other studies available for metoclopramide and Infant, Premature, Diseases

ArticleYear
Is metoclopramide safe for the premature infant?
    European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:12

    Topics: Antiemetics; Dystonia; Gastroesophageal Reflux; Humans; Infant, Newborn; Infant, Premature; Infant,

2013
Use and Safety of Erythromycin and Metoclopramide in Hospitalized Infants.
    Journal of pediatric gastroenterology and nutrition, 2015, Volume: 61, Issue:3

    Topics: Enteral Nutrition; Erythromycin; Female; Gastroesophageal Reflux; Gastrointestinal Agents; Humans; H

2015
Patience is a virtue in the management of gastroesophageal reflux.
    The Journal of pediatrics, 2009, Volume: 155, Issue:4

    Topics: Bradycardia; Dopamine Antagonists; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans; Infant

2009
Use of metoclopramide in preterm infants.
    Developmental pharmacology and therapeutics, 1982, Volume: 5, Issue:3-4

    Topics: Gastric Emptying; Gestational Age; Humans; Hyaline Membrane Disease; Infant; Infant, Newborn; Infant

1982
Possible metoclopramide-induced increase in serum aldosterone in a premature infant.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1995, Feb-01, Volume: 52, Issue:3

    Topics: Aldosterone; Gastroesophageal Reflux; Humans; Hyperaldosteronism; Infant; Infant, Newborn; Infant, P

1995
Gastroesophageal reflux and pulmonary complication in a neonate.
    Indian pediatrics, 1998, Volume: 35, Issue:7

    Topics: Antiemetics; Apnea; Cisapride; Follow-Up Studies; Gastroesophageal Reflux; Gastrointestinal Agents;

1998
Effect of metoclopramide therapy on arginine vasopressin excretion and renal water handling in premature infants.
    Biology of the neonate, 1987, Volume: 51, Issue:1

    Topics: Arginine Vasopressin; Diuresis; Dopamine; Gastrointestinal Diseases; Humans; Hyponatremia; Infant, N

1987