metoclopramide has been researched along with Huntington Disease in 3 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because of vomiting, a 15 years old girl inserted one metoclopramide suppository." | 3.67 | [Effect of metoclopramide in a subject at risk for Huntington's chorea]. ( Escousse, A; Fabre, JL; Giroud, M; Nivelon-Chevallier, A; Putelat, R, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, S | 1 |
| Seeman, P | 1 |
| Liu, F | 1 |
| Giroud, M | 2 |
| Fabre, JL | 2 |
| Putelat, R | 2 |
| Caillot, X | 1 |
| Escousse, A | 2 |
| Nivelon-Chevalier, A | 1 |
| Dumas, R | 1 |
| Nivelon-Chevallier, A | 1 |
3 other studies available for metoclopramide and Huntington Disease
| Article | Year |
|---|---|
Antipsychotic drug binding in the substantia nigra: an examination of high metoclopramide binding in the brains of normal, Alzheimer's disease, Huntington's disease, and Multiple Sclerosis patients, and its relation to tardive dyskinesia.
Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Dopamine Antagonists; Dose-Response Relationship, | 2011 |
Can metoclopramide reveal Huntington's disease?
Topics: Adolescent; Female; Humans; Huntington Disease; Male; Metoclopramide; Pedigree; Suppositories; Vomit | 1982 |
[Effect of metoclopramide in a subject at risk for Huntington's chorea].
Topics: Adolescent; Female; Humans; Huntington Disease; Metoclopramide; Pedigree; Risk; Vomiting | 1985 |