metoclopramide and Hematochezia studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Hematochezia: The passage of bright red blood from the rectum. The blood may or may not be mixed with formed stool in the form of blood, blood clots, bloody stool or diarrhea.

Research Excerpts

Excerpt	Relevance	Reference
"In nineteen patients with portal hypertension and oesophageal varices, transmural variceal blood pressure was determined endoscopically by direct puncture of the varices before and after intravenous administration of 20 mg metoclopramide or placebo."	5.07	Reduction of transmural oesophageal variceal pressure by metoclopramide. ( Fischer, G; Geigenberger, G; Kleber, G; Paumgartner, G; Sauerbruch, T, 1991)
"Erythromycin acts as a motilin receptor agonist in the upper gastrointestinal (GI) tract and increases gastric emptying, which may lead to better quality of visualisation and improved treatment effectiveness."	3.01	Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage. ( Adão, D; Gois, AF; Pacheco, RL; Pimentel, CF; Riera, R, 2023)
"The pharmacologic treatment of portal hypertension should be able to stop as well as to prevent variceal hemorrhage."	2.38	Pharmacologic treatment of portal hypertension. ( Groszmann, RJ; Rodríguez-Pérez, F, 1992)
"A sliding hiatus hernia is a common radiological finding and is not always relevant to the patient's symptoms."	1.25	Common gastroenterological problems. II.--Sliding hiatus hernia. ( Salter, RH, 1975)

Research

Studies (20)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Number of Subjects Experiencing Adverse Effects in the Periprocedural Period

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (25.00)	18.7374
1990's	11 (55.00)	18.2507
2000's	1 (5.00)	29.6817
2010's	2 (10.00)	24.3611
2020's	1 (5.00)	2.80

Authors	Studies
Adão, D	1
Gois, AF	1
Pacheco, RL	1
Pimentel, CF	1
Riera, R	1
Barkun, AN	1
Bardou, M	1
Martel, M	1
Gralnek, IM	1
Sung, JJ	1
Daram, SR	1
Garretson, R	1
Schwarzberg, MN	1
Groĭsman, SD	1
Karevina, TG	1
Khokholia, VP	1
Stanciu, C	1
Cijevschi, C	1
Stan, M	1
Sandulescu, E	1
Harrington, ML	1
Moore, MP	1
Talcott, PA	1
Bagley, RS	1
Sandmeier, P	1
Patch, D	1
Burroughs, AK	2
Salter, RH	1
Rodríguez-Pérez, F	1
Groszmann, RJ	1
Kleber, G	1
Sauerbruch, T	1
Fischer, G	1
Geigenberger, G	1
Paumgartner, G	1
Walker, S	1
Gupta, IP	2
Sharma, MP	2
Arora, A	1
Nijhawan, S	1
Hosking, SW	1
Doss, W	1
el-Zeiny, H	1
Robinson, P	1
Barsoum, MS	1
Johnson, AG	1
Shih, WJ	1
DeLand, FH	1
Stadler, H	1
Giebler, A	1
Tscheliessnigg, KH	1
Berger, A	1
Mischinger, HJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized Controlled Trial of Metoclopramide Versus Placebo During Gastrojejunostomy Tube Placement for Facilitating Guidewire Advancement Through the Pylorus[NCT03331965]	Phase 2	110 participants (Actual)	Interventional	2018-04-09	Completed
Premedication With Metoclopramide in Upper Gastrointestinal Bleeds a Prospective Double Blinded Single Center Randomized Control Trial in a Small Community Hospital[NCT05746377]	Phase 4	60 participants (Anticipated)	Interventional	2023-05-20	Recruiting
A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population[NCT01592708]		233 participants (Actual)	Interventional	2012-06-30	Completed
Erythromycin Versus Gastric Lavage to Improve Quality of Endoscopic Examination in Patients With Upper Gastrointestinal Bleeding. A Prospective Randomized Trial.[NCT01716572]	Phase 3	122 participants (Anticipated)	Interventional	2012-02-29	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To assess the safety of a single dose of promotility agent prior to GJ tube placement by assessing rates of adverse events in the periprocedural period in patients receiving IV metoclopramide versus placebo. (NCT03331965)
Timeframe: Up to 30 days after procedure.

Time to Duodenal Intubation

Intervention	Participants (Count of Participants)
Metoclopramide	0
Saline	0

The fluoroscopy time required to advance a guidewire through the pylorus. (NCT03331965)
Timeframe: Up to 45 minutes.

Total Procedure Air Kerma

Intervention	Minutes (Mean)
Metoclopramide	1.6
Saline	4.1

The total procedure Air Kerma (energy released in a unit mass of air) measured in milligray (mGy). (NCT03331965)
Timeframe: Up to 1 hour.

Total Procedure Fluoroscopy Time

Total Procedure Time

Hospital Length of Stay

Intervention	mGy (Mean)
Metoclopramide	91
Saline	130

Intervention	Minutes (Mean)
Metoclopramide	5.8
Saline	8.8

Intervention	Minutes (Mean)
Metoclopramide	16.4
Saline	19.9

Anesthesia start time determined from anesthesia portion of the medical record. Time at which discharge order was placed will serve as time of discharge. (NCT01592708)
Timeframe: Anesthesia start time to placement of hospital discharge order - average 26 - 28 hours

Post-discharge Nausea

Intervention	hours (Median)
Intervention Cohort	26.4
Comparison Cohort	28.2

To be assessed based on patient diary completed daily for 1 week following discharge to home from the hospital (NCT01592708)
Timeframe: 1 week from discharge from hospital

Post-discharge Vomiting

Post-operative Nausea

Intervention	percentage of subjects with PDN (Number)
Intervention Cohort	72
Comparison Cohort	60

Intervention	percentage of subjects with PDV (Number)
Intervention Cohort	22
Comparison Cohort	29

End of surgery time determined by anesthesia portion of the medical record. PONV to be assessed by review of surgeons' and nurses' notes in the medical record as well as through review of patient diaries. Vomiting constitutes a safety issue and, as such, associated adverse events will be noted. (NCT01592708)
Timeframe: End of surgery to discharge from hospital

Article	Year
Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage. The Cochrane database of systematic reviews, 2023, 02-01, Volume: 2 Topics: Endoscopy; Erythromycin; Female; Gastrointestinal Hemorrhage; Humans; Male; Metoclopramide; Middle A	2023
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy, 2010, Volume: 72, Issue:6 Topics: Acute Disease; Blood Transfusion; Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esop	2010
Pharmacological treatment of portal hypertension. Progress in liver diseases, 1995, Volume: 13 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Catheterization; Clinical Trials as Topic; Diu	1995
Pharmacological treatment of acute variceal bleeding. Digestion, 1998, Volume: 59 Suppl 2 Topics: Domperidone; Esophageal and Gastric Varices; Gastrointestinal Agents; Gastrointestinal Hemorrhage; H	1998
Pharmacologic treatment of portal hypertension. Gastroenterology clinics of North America, 1992, Volume: 21, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Clonidine; Gastrointestinal Hemorrha	1992
Vasoconstrictor therapy in bleeding esophageal varices. Hepato-gastroenterology, 1990, Volume: 37, Issue:6 Topics: Clinical Trials as Topic; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Lypre	1990

Article	Year
Reduction of transmural oesophageal variceal pressure by metoclopramide. Journal of hepatology, 1991, Volume: 12, Issue:3 Topics: Aged; Blood Pressure; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; H	1991
Control of variceal bleed with metoclopramide. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 1991, Volume: 10, Issue:1 Topics: Adolescent; Adult; Blood Transfusion; Double-Blind Method; Esophageal and Gastric Varices; Female; G	1991
Control of variceal bleed by constricting esophageal sphincter with metoclopramide. The American journal of gastroenterology, 1990, Volume: 85, Issue:4 Topics: Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Metoclopramide; Randomized Cont	1990
Pharmacological constriction of the lower oesophageal sphincter: a simple method of arresting variceal haemorrhage. Gut, 1988, Volume: 29, Issue:8 Topics: Adult; Clinical Trials as Topic; Constriction; Esophageal and Gastric Varices; Esophagogastric Junct	1988
[Conservative therapy of upper gastrointestinal hemorrhage (prospective, randomized, controlled)]. Wiener medizinische Wochenschrift (1946), 1985, Nov-15, Volume: 135, Issue:21 Topics: Aluminum; Benzodiazepinones; Calcium; Cimetidine; Drug Therapy, Combination; Estrogens; Gastrointest	1985

Article	Year
Erythromycin is preferable to metoclopramide as a prokinetic in acute upper GI bleeding. Gastrointestinal endoscopy, 2011, Volume: 74, Issue:1 Topics: Duodenal Diseases; Endoscopy, Digestive System; Erythromycin; Esophageal Diseases; Gastrointestinal	2011
Pro-kinetic medications as aids in imaging the small bowel by video-capsule. Medical hypotheses, 2005, Volume: 64, Issue:3 Topics: Antiemetics; Capsules; Cisapride; Diagnostic Imaging; Diagnostic Uses of Chemicals; Drug-Related Sid	2005
[Role of dopamine receptors in the mechanism of formation of stress-induced stomach lesions]. Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 97, Issue:1 Topics: Animals; Apomorphine; Female; Gastrointestinal Hemorrhage; Humans; Levodopa; Male; Metoclopramide; R	1984
Endoscopic intravascular esophageal pressure measurements in cirrhotic patients: response to metoclopramide. Hepato-gastroenterology, 1993, Volume: 40, Issue:2 Topics: Blood Pressure; Esophageal and Gastric Varices; Esophagogastric Junction; Female; Gastrointestinal H	1993
Suspected herbicide toxicosis in a dog. Journal of the American Veterinary Medical Association, 1996, Dec-15, Volume: 209, Issue:12 Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Abdominal Pain; Animals; Anorexia; Antidotes; Antiemetics; Atax	1996
Common gastroenterological problems. II.--Sliding hiatus hernia. The Practitioner, 1975, Volume: 214, Issue:1280 Topics: Antacids; Diagnosis, Differential; Diet, Reducing; Dietary Fats; Gastroesophageal Reflux; Gastrointe	1975
Metoclopramide in variceal bleeding. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 1991, Volume: 10, Issue:2 Topics: Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Metoclopramide	1991
Non-surgical treatment of acute upper gastrointestinal haemorrhage. The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:8 Topics: Acute Disease; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Metoclopramide;	1990
Scintigraphy in disorders of the gastrointestinal tract. Comprehensive therapy, 1985, Volume: 11, Issue:12 Topics: Child; Child, Preschool; Diagnosis, Differential; Female; Gastric Emptying; Gastroesophageal Reflux;	1985

metoclopramide and Hematochezia