Page last updated: 2024-10-31

metoclopramide and HIV Coinfection

metoclopramide has been researched along with HIV Coinfection in 9 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research Excerpts

ExcerptRelevanceReference
" Although past attempts to reverse anorexia-cachexia have generally been disappointing, several promising new pharmacologic approaches are currently being evaluated, including megestrol acetate, hydrazine sulfate, metoclopramide, and dronabinol."4.78Management of anorexia-cachexia associated with cancer and HIV infection. ( Gorter, R, 1991)
" Using a Delphi study method, physicians were asked to rank preferences of drug and dosing schedule for first-line opioid, antiemetic, and laxative for the treatment of adults with chronic pain due to cancer and other life-threatening conditions."1.38Strategic pain management: the identification and development of the IAHPC opioid essential prescription package. ( Bennett, MI; Bruera, E; De Lima, L; Nekolaichuk, C; Ripamonti, CI; Vignaroli, E; Wenk, R, 2012)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's6 (66.67)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ogunlesi, TA1
Adekanmbi, FA1
Fetuga, BM1
Ogundeyi, MM1
Vignaroli, E1
Bennett, MI1
Nekolaichuk, C1
De Lima, L1
Wenk, R1
Ripamonti, CI1
Bruera, E1
Leaños-Miranda, A1
Contreras-Hernández, I1
Parra, A3
Ramírez-Peredo, J3
Coutiño, B2
Lagunes, B1
Marín, A1
Ponce de Leon, S1
Ruiz-Argüelles, GJ1
Oudesluys-Murphy, AM1
Snowden, H1
Woolridge, M1
Renfrew, M1
Larrea, F2
Pérez-Romano, B2
Cabrera, V2
Torres, I2
Reyes-Núñez, V1
Ruiz-Argüelles, G2
Ruiz-Argüelles, A2
Angeles, A1
Gorter, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161]Phase 3293 participants (Actual)Interventional2007-04-30Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All-cause 28-day Mortality Rate.

(NCT00395161)
Timeframe: 28 days after admission to the PICU

Interventionparticipants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide15
Enteral Whey Protein, IV Saline8

Antibiotic-free Days

(NCT00395161)
Timeframe: 48 hours after admission until PICU discharge

InterventionDays (Median)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide1
Enteral Whey Protein, IV Saline2

Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days)

What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU

Interventionparticipants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide5
Enteral Whey Protein, IV Saline12

Rate of Nosocomial Infection or Clinical Sepsis Per 100 Study Days

(NCT00395161)
Timeframe: 48 hours after PICU admission till discharge from PICU

InterventionMean number of events per 100 study days (Mean)
Daily Nutriceutical Supplementation4.99
Whey Protein4.83

The Primary Endpoint of This Study is the Median Time Between Admission to the PICU and Occurrence of Nosocomial Infection or Clinical Sepsis in PICU Patients Who Have Endotracheal Tubes, Central Venous Catheters, or Urinary Catheters.

(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU

InterventionDays (Median)
Daily Nutriceutical Supplementation12.1
Whey Protein13.2

Reviews

2 reviews available for metoclopramide and HIV Coinfection

ArticleYear
Non-puerperal induced lactation: an infant feeding option in paediatric HIV/AIDS in tropical Africa.
    Journal of child health care : for professionals working with children in the hospital and community, 2008, Volume: 12, Issue:3

    Topics: Africa; Attitude to Health; Breast Feeding; Chlorpromazine; Communication; Family; Female; Health Ed

2008
Management of anorexia-cachexia associated with cancer and HIV infection.
    Oncology (Williston Park, N.Y.), 1991, Volume: 5, Issue:9 Suppl

    Topics: Anorexia; Antineoplastic Agents; Cachexia; Dronabinol; HIV Infections; Humans; Hydrazines; Megestrol

1991

Other Studies

7 other studies available for metoclopramide and HIV Coinfection

ArticleYear
Strategic pain management: the identification and development of the IAHPC opioid essential prescription package.
    Journal of palliative medicine, 2012, Volume: 15, Issue:2

    Topics: Analgesics, Opioid; Antiemetics; Clinical Protocols; Constipation; Delphi Technique; Dioctyl Sulfosu

2012
Antiprolactin autoantibodies are associated with hyperprolactinemic status in men infected with human immunodeficiency virus.
    Endocrine, 2002, Volume: 19, Issue:2

    Topics: Adult; Aged; Autoantibodies; HIV Infections; Humans; Hyperprolactinemia; Male; Metoclopramide; Middl

2002
Impaired metoclopramide-induced pituitary prolactin release in men with human immunodeficiency virus infection.
    The Journal of laboratory and clinical medicine, 1999, Volume: 133, Issue:1

    Topics: Adult; Area Under Curve; CD4 Lymphocyte Count; Dopamine Antagonists; HIV Infections; HIV Seronegativ

1999
Galactorrhoea, hyperprolactinaemia, and protease inhibitors.
    Lancet (London, England), 2001, Feb-10, Volume: 357, Issue:9254

    Topics: Drug Therapy, Combination; Female; Galactorrhea; HIV Infections; HIV Protease Inhibitors; Humans; La

2001
Galactorrhoea, hyperprolactinaemia, and protease inhibitors.
    Lancet (London, England), 2001, Feb-10, Volume: 357, Issue:9254

    Topics: Drug Therapy, Combination; Female; Fluoxetine; Galactorrhea; HIV Infections; HIV Protease Inhibitors

2001
Serum prolactin is associated with apoptosis in men with human immunodeficiency virus infection.
    Immunology and cell biology, 2001, Volume: 79, Issue:3

    Topics: Adult; Animals; Apoptosis; Area Under Curve; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cell

2001
Decreased dopaminergic tone and increased basal bioactive prolactin in men with human immunodeficiency virus infection.
    Clinical endocrinology, 2001, Volume: 54, Issue:6

    Topics: Adult; Area Under Curve; Case-Control Studies; CD4 Lymphocyte Count; Cross-Sectional Studies; Dopami

2001