Page last updated: 2024-10-31

metoclopramide and Gastric Stasis

metoclopramide has been researched along with Gastric Stasis in 58 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research Excerpts

ExcerptRelevanceReference
"We identified 28 studies assessing AEs experienced by patients treated for gastroparesis with domperidone and metoclopramide; 22 studies contributed data to the meta-analyses."9.41Risk of Adverse Events Associated with Domperidone and Metoclopramide in Gastroparesis: Systematic Review and Meta-analysis. ( Bennett, D; Betts, M; Fahrbach, K; Huh, SY; Junqueira, DR; Neupane, B, 2023)
"Metoclopramide nasal spray reduces symptoms of gastroparesis in women, but not in men, with diabetes."9.20Metoclopramide Nasal Spray Reduces Symptoms of Gastroparesis in Women, but not Men, With Diabetes: Results of a Phase 2B Randomized Study. ( Carlson, MR; Gonyer, D; Parkman, HP, 2015)
"To observe the clinical effects of acupoint injection of metoclopramide for postsurgical gastroparesis syndrome (PGS)."9.19[Observation on therapeutic effects of acupoint injection of metoclopramide for postsurgical gastroparesis syndrome]. ( Huang, XK; Jiang, J; Luo, Y; Wan, L; Wang, L; Zhang, CN, 2014)
"Metoclopramide nasal spray offers better symptom control than metoclopramide oral tablet in diabetic patients with symptoms of gastroparesis."9.19Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet. ( Carlson, MR; Gonyer, D; Parkman, HP, 2014)
"Domperidone and metoclopramide effectively reduce the symptoms of diabetic gastroparesis; CNS side effects are more pronounced with metoclopramide."9.09A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis. ( Abell, T; Barnett, J; Koch, K; Patterson, D; Rothstein, R, 1999)
"The risk of tardive dyskinesia due to metoclopramide is far below approximated numbers in treatment guidelines."9.01Gastroparesis, metoclopramide, and tardive dyskinesia: Risk revisited. ( Al-Saffar, A; Hellström, PM; Lennernäs, H, 2019)
"To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis."8.82Chronic metoclopramide therapy for diabetic gastroparesis. ( Lata, PF; Pigarelli, DL, 2003)
"The risks of weight gain that accompany the administration of metoclopramide are discussed, as well as the postulated etiology and psychological implications for the patient."7.72Metoclopramide and unintended weight gain. ( Sansone, LA; Sansone, RA, 2003)
" Erythromycin is associated with adverse reactions, including corrected QT interval prolongation and cytochrome P450 3A4 isoenzyme inhibition."5.72Safe Use of Erythromycin For Refractory Gastroparesis After Small Bowel Transplantation. ( Cruz, RJ; Humar, A; Poloyac, K; Roberts, M; Stein, W, 2022)
"We identified 28 studies assessing AEs experienced by patients treated for gastroparesis with domperidone and metoclopramide; 22 studies contributed data to the meta-analyses."5.41Risk of Adverse Events Associated with Domperidone and Metoclopramide in Gastroparesis: Systematic Review and Meta-analysis. ( Bennett, D; Betts, M; Fahrbach, K; Huh, SY; Junqueira, DR; Neupane, B, 2023)
"Metoclopramide nasal spray reduces symptoms of gastroparesis in women, but not in men, with diabetes."5.20Metoclopramide Nasal Spray Reduces Symptoms of Gastroparesis in Women, but not Men, With Diabetes: Results of a Phase 2B Randomized Study. ( Carlson, MR; Gonyer, D; Parkman, HP, 2015)
"Metoclopramide nasal spray offers better symptom control than metoclopramide oral tablet in diabetic patients with symptoms of gastroparesis."5.19Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet. ( Carlson, MR; Gonyer, D; Parkman, HP, 2014)
"To observe the clinical effects of acupoint injection of metoclopramide for postsurgical gastroparesis syndrome (PGS)."5.19[Observation on therapeutic effects of acupoint injection of metoclopramide for postsurgical gastroparesis syndrome]. ( Huang, XK; Jiang, J; Luo, Y; Wan, L; Wang, L; Zhang, CN, 2014)
"Domperidone and metoclopramide effectively reduce the symptoms of diabetic gastroparesis; CNS side effects are more pronounced with metoclopramide."5.09A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis. ( Abell, T; Barnett, J; Koch, K; Patterson, D; Rothstein, R, 1999)
" the proportional cumulative area under the curve of paracetamol) was utilized in diabetic patients in order to detect both gastroparesis and the influence of metoclopramide, a known prokinetic drug, on this condition."5.08The proportional cumulative area under the curve of paracetamol used as an index of gastric emptying in diabetic patients with symptoms of gastroparesis. ( Moncrieff, J; Snyman, JR; Sommers, DK; van Wyk, M, 1995)
"The risk of tardive dyskinesia due to metoclopramide is far below approximated numbers in treatment guidelines."5.01Gastroparesis, metoclopramide, and tardive dyskinesia: Risk revisited. ( Al-Saffar, A; Hellström, PM; Lennernäs, H, 2019)
"A PubMed search was performed using search terms including gastroparesis, gastric retention, gastric emptying, accommodation, manometry, prokinetics, antiemetics, metoclopramide, domperidone, erythromycin, botulinum toxin, gastric pacing."4.84Review article: The diagnosis and management of gastroparesis. ( Haans, JJ; Masclee, AA, 2007)
"Metoclopramide, the only drug approved by the FDA for treatment of diabetic gastroparesis, but used off-label for a variety of other gastrointestinal indications, has many potentially troublesome adverse neurologic effects, particularly movement disorders."4.83Drug Insight: from disturbed motility to disordered movement--a review of the clinical benefits and medicolegal risks of metoclopramide. ( Jankovic, J; Pasricha, PJ; Pehlivanov, N; Sugumar, A, 2006)
"To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis."4.82Chronic metoclopramide therapy for diabetic gastroparesis. ( Lata, PF; Pigarelli, DL, 2003)
"For the drug treatment of gastroparesis, domperidone, metoclopramide and cisapride may be prescribed as prokinetics."4.80[Treatment of severely delayed gastric emptying]. ( Gooszen, HG; Samsom, M, 2000)
" Metoclopramide was administered for the treatment of gastroparesis."4.79Sinus arrest after administration of intravenous metoclopramide. ( Cruz-Flores, S; Gomez, CR; Malkoff, MD; Myles, GL; Ponzillo, JJ, 1995)
"This case report describes a patient, who presented with extrapyramidal side effects to the treatment with metoclopramide, which is used as an antiemetic, for gastroparesis and reflux."3.91[Metoclopramide-induced respiratory dyskinesia]. ( Lange, P; Vorre, MM, 2019)
" Submissions related to metoclopramide by far exceeded reports about other agents and mostly described tardive dyskinesia or other neurological concerns."3.85From Harmful Treatment to Secondary Gain: Adverse Event Reporting in Dyspepsia and Gastroparesis. ( Bielefeldt, K, 2017)
"8% of patients received metoclopramide for gastroparesis, compared with 23."3.79The metoclopramide black box warning for tardive dyskinesia: effect on clinical practice, adverse event reporting, and prescription drug lawsuits. ( Deepak, P; Devi, R; Du, H; Ehrenpreis, ED; Leikin, JB; Sifuentes, H, 2013)
"To determine associations of clinical and pharmacogenetic parameters with response and side effects to metoclopramide in patients with upper gastrointestinal symptoms suggestive of gastroparesis."3.78Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. ( Gaughan, J; Jacobs, M; Krynetskiy, E; Mishra, A; Parkman, HP; Pathikonda, M; Sachdeva, P, 2012)
"The risks of weight gain that accompany the administration of metoclopramide are discussed, as well as the postulated etiology and psychological implications for the patient."3.72Metoclopramide and unintended weight gain. ( Sansone, LA; Sansone, RA, 2003)
"Gastroparesis is a functional gastrointestinal disorder that more commonly affects women, with most cases being diagnosed during childbearing age."3.01Gastroparesis in pregnancy. ( Min, YW; Moosavi, S; Rezaie, A; Wong, M, 2023)
"Gastroparesis is a neuromuscular disorder of the upper gastrointestinal tract."3.01Pharmacologic treatment of gastroparesis: What is (still) on the horizon? ( Pohl, D; Schweckendiek, D, 2023)
"Diabetic gastroparesis is defined as delayed gastric emptying without mechanical obstruction in the setting of diabetes."2.72Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists. ( Baker, C; Petri, M; Rasouli, N; Singh, I; Underkofler, C, 2021)
"Gastroparesis is a chronic motility disorder that leads to delayed gastric emptying and negatively impacts morbidity, mortality, and quality of life."2.49Gastroparesis: what is the current state-of-the-art for evaluation and medical management? What are the results? ( Lee, A, 2013)
"During childhood, gastroparesis is quite rare, and is mostly seen in preterm infants, with either immaturity of the gastrointestinal tract, or when allergic to cow's milk protein."2.42Current pharmacological treatment of gastroparesis. ( Hauser, B; Salvatore, S; Vandenplas, Y, 2004)
" The appropriate use of prokinetic agents in these groups requires an understanding of the unique dosage considerations that may be necessary to ensure safe, effective therapy."2.39Use of prokinetic agents in special populations. ( Horn, JR, 1996)
" Erythromycin is associated with adverse reactions, including corrected QT interval prolongation and cytochrome P450 3A4 isoenzyme inhibition."1.72Safe Use of Erythromycin For Refractory Gastroparesis After Small Bowel Transplantation. ( Cruz, RJ; Humar, A; Poloyac, K; Roberts, M; Stein, W, 2022)
"Biopsy revealed a pulmonary squamous cell carcinoma, which was inoperable."1.62Gastrointestinal dysmotility in a patient with advanced lung cancer: paraneoplastic or drug-induced? ( Dias, RF; Diniz, MML; Nobre, VA; Santos, BC, 2021)
"Fatigue was reported by 93 % of patients."1.38Fatigue: a prevalent symptom in gastroparesis. ( Cherian, D; Paladugu, S; Parkman, HP; Pathikonda, M, 2012)
"Metoclopramide has the greatest evidence for efficacy followed by phenothiazines and tropisetron."1.36Nausea and vomiting in advanced cancer. ( Ang, SK; Davis, MP; Shoemaker, LK, 2010)
"Gastroparesis is a recognized cause of these symptoms in non-transplant patients but less is known about patients who undergo BMT."1.31Gastroparesis following bone marrow transplantation. ( Eagle, DA; Gian, V; Lauwers, GY; Manivel, JC; Mastin, S; Moreb, JS; Wingard, JR, 2001)

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (10.34)18.2507
2000's19 (32.76)29.6817
2010's20 (34.48)24.3611
2020's13 (22.41)2.80

Authors

AuthorsStudies
Camilleri, M4
Moosavi, S1
Min, YW1
Wong, M1
Rezaie, A1
Junqueira, DR1
Bennett, D1
Huh, SY1
Fahrbach, K1
Neupane, B1
Betts, M1
Schweckendiek, D1
Pohl, D1
Asha, MZ1
Khalil, SFH1
Usai-Satta, P1
Bellini, M1
Morelli, O1
Geri, F1
Lai, M1
Bassotti, G1
Petri, M1
Singh, I1
Baker, C1
Underkofler, C1
Rasouli, N1
Dias, RF1
Diniz, MML1
Santos, BC1
Nobre, VA1
Gajendran, M1
Sarosiek, I1
McCallum, R1
Lacy, BE1
Cangemi, DJ1
Cruz, RJ1
Poloyac, K1
Roberts, M1
Stein, W1
Humar, A1
Kuo, B1
Mahadeva, S1
Bielefeldt, K1
Kim, GH1
Jung, KW1
Vorre, MM1
Lange, P1
Al-Saffar, A1
Lennernäs, H1
Hellström, PM1
Shakhatreh, M1
Jehangir, A1
Malik, Z1
Parkman, HP5
Ehrenpreis, ED1
Deepak, P1
Sifuentes, H1
Devi, R1
Du, H1
Leikin, JB1
Lee, A1
Janssen, P1
Harris, MS1
Jones, M1
Masaoka, T1
Farré, R1
Törnblom, H1
Van Oudenhove, L1
Simrén, M1
Tack, J1
Carlson, MR2
Gonyer, D3
Lankarani, K1
Parkman, H1
Carlson, M1
Zhang, CN1
Huang, XK1
Luo, Y1
Jiang, J1
Wan, L1
Wang, L1
Acosta, A1
Shakil, A1
Church, RJ1
Rao, SS1
Bernstein, R1
Ang, SK1
Shoemaker, LK1
Davis, MP1
Sun, BM1
Luo, M1
Wu, SB1
Chen, XX1
Wu, MC1
Cherian, D1
Paladugu, S1
Pathikonda, M2
Shin, A1
Mishra, A1
Jacobs, M1
Sachdeva, P1
Gaughan, J1
Krynetskiy, E1
Lyday, WD1
DiBaise, JK1
Lata, PF1
Pigarelli, DL1
Sansone, RA1
Sansone, LA1
Bouras, EP1
Scolapio, JS1
Vandenplas, Y1
Hauser, B1
Salvatore, S1
Tsuji, S1
Hayashi, N1
Kong, MF1
Horowitz, M1
Pasricha, PJ1
Pehlivanov, N1
Sugumar, A1
Jankovic, J1
Wollheim, FA1
Akesson, A1
Tarsy, D1
Nagula, S1
Schattner, M1
Haans, JJ1
Masclee, AA1
Malkoff, MD1
Ponzillo, JJ1
Myles, GL1
Gomez, CR1
Cruz-Flores, S1
Jia, B1
van Wyk, M1
Sommers, DK1
Snyman, JR1
Moncrieff, J1
Horn, JR1
Ross, EA1
Koo, LC1
Patterson, D1
Abell, T1
Rothstein, R1
Koch, K1
Barnett, J1
Dumitrascu, DL1
Weinbeck, M1
Zaloga, GP1
Marik, P1
Samsom, M1
Gooszen, HG1
Eagle, DA1
Gian, V1
Lauwers, GY1
Manivel, JC1
Moreb, JS1
Mastin, S1
Wingard, JR1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622]Phase 23 participants (Actual)Interventional2014-07-31Terminated (stopped due to Lack of recruitment)
A Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel Group, Dose-Ranging Clinical Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray Solution in Diabetic Subjects With Gastroparesis[NCT00845858]Phase 2287 participants (Actual)Interventional2009-04-30Completed
Impact of Prokinetic Use After Emergency Intestinal Anastomosis on Short and long_term Clinical Outcome[NCT05290753]15 participants (Anticipated)Interventional2022-01-01Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

The Pre-specified Endpoint is the Change From Baseline to Week 4 of the Treatment Period in the Modified Gastroparesis Cardinal Symptom Index-Daily Diary (mGCSI-DD) Total Score by Gender.

"Change from Baseline to Week 4 of the treatment period in the mGCSI-DD total score in Female subjects receiving metoclopramide nasal spray versus Female subjects receiving placebo.~The mGCSI-DD is a patient reported outcome measure of gastroparesis symptom severity composed of 4 individual symptoms (listed below) with each symptom graded on a scale from 0 (none) to 5 (very severe).~Nausea (feeling sick to your stomach as if you were going to vomit or throw up)~Early satiety (not able to finish a normal sized meal)~Bloating (feeling like you need to loosen clothes)~Upper abdominal pain (above the navel) The mGCSI-DD daily score is a mean of the 4 individual symptom scores. The total score is a mean of the daily scores for the observation period.~A mean change (improvement) of >1 category (for example, moderate to mild or severe to moderate) is considered to be clinically meaningful." (NCT00845858)
Timeframe: 4 weeks

Interventionunits on a scale (Mean)
Female-Metoclopramide Nasal Spray 10 mg-1.2
Female-Metoclopramide Nasal Spray 14 mg-1.3
Female-Placebo Nasal Spray-0.8

The Primary Efficacy Endpoint is the Change From Baseline to Week 4 of the Treatment Period in the Modified Gastroparesis Cardinal Symptom Index-Daily Diary (mGCSI-DD) Total Score.

"Change from Baseline to Week 4 of the treatment period in the mGCSI-DD total score in male and female subjects receiving metoclopramide nasal spray versus subjects receiving placebo.~The mGCSI-DD is a patient reported outcome measure of gastroparesis symptom severity composed of 4 individual symptoms (listed below) with each symptom graded on a scale from 0 (none) to 5 (very severe).~Nausea (feeling sick to your stomach as if you were going to vomit or throw up)~Early satiety (not able to finish a normal sized meal)~Bloating (feeling like you need to loosen clothes)~Upper abdominal pain (above the navel) The mGCSI-DD daily score is a mean of the 4 individual symptom scores. The total score is a mean of the daily scores for the observation period.~A mean change (improvement) of >1 category (for example, moderate to mild or severe to moderate) is considered to be clinically meaningful." (NCT00845858)
Timeframe: 4 weeks

Interventionunits on a scale (Mean)
Metoclopramide Nasal Spray 10 mg-1.2
Metoclopramide Nasal Spray 14 mg-1.2
Placebo Nasal Spray-1.0

Reviews

25 reviews available for metoclopramide and Gastric Stasis

ArticleYear
Gastroparesis in pregnancy.
    American journal of obstetrics and gynecology, 2023, Volume: 228, Issue:4

    Topics: Female; Gastrointestinal Agents; Gastroparesis; Humans; Metoclopramide; Pregnancy

2023
Risk of Adverse Events Associated with Domperidone and Metoclopramide in Gastroparesis: Systematic Review and Meta-analysis.
    Drugs in R&D, 2023, Volume: 23, Issue:1

    Topics: Adult; Child; Domperidone; Dopamine Antagonists; Gastroparesis; Humans; Metoclopramide

2023
Pharmacologic treatment of gastroparesis: What is (still) on the horizon?
    Current opinion in pharmacology, 2023, Volume: 72

    Topics: Gastroparesis; Humans; Metoclopramide

2023
Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials.
    Sultan Qaboos University medical journal, 2019, Volume: 19, Issue:4

    Topics: Antiemetics; Cisapride; Diabetes Complications; Domperidone; Gastric Emptying; Gastrointestinal Agen

2019
Gastroparesis: New insights into an old disease.
    World journal of gastroenterology, 2020, May-21, Volume: 26, Issue:19

    Topics: Antidepressive Agents, Tricyclic; Antiemetics; Cannabinoids; Capsule Endoscopy; Electric Stimulation

2020
Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists.
    Journal of diabetes and its complications, 2021, Volume: 35, Issue:2

    Topics: Diabetes Mellitus; Diabetic Neuropathies; Gastric Emptying; Gastroparesis; Humans; Metoclopramide; Q

2021
Metoclopramide nasal spray (Gimoti) for diabetic gastroparesis.
    The Medical letter on drugs and therapeutics, 2021, 01-11, Volume: 63, Issue:1615

    Topics: Clinical Trials as Topic; Diabetes Mellitus; Dopamine D2 Receptor Antagonists; Gastroparesis; Humans

2021
Metoclopramide nasal spray for management of symptoms of acute and recurrent diabetic gastroparesis in adults.
    Expert review of endocrinology & metabolism, 2021, Volume: 16, Issue:2

    Topics: Diabetes Mellitus; Diabetic Neuropathies; Gastroparesis; Humans; Metoclopramide; Nasal Sprays; Treat

2021
[Vomiting].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2017, 12-25, Volume: 70, Issue:6

    Topics: Antineoplastic Agents; Feeding Behavior; Gastric Emptying; Gastritis; Gastroparesis; Humans; Metoclo

2017
Gastroparesis, metoclopramide, and tardive dyskinesia: Risk revisited.
    Neurogastroenterology and motility, 2019, Volume: 31, Issue:11

    Topics: Antiemetics; Dopamine D2 Receptor Antagonists; Gastroparesis; Humans; Metoclopramide; Risk Factors;

2019
Metoclopramide for the treatment of diabetic gastroparesis.
    Expert review of gastroenterology & hepatology, 2019, Volume: 13, Issue:8

    Topics: Diabetes Complications; Dopamine D2 Receptor Antagonists; Gastric Emptying; Gastroparesis; Humans; M

2019
Gastroparesis: what is the current state-of-the-art for evaluation and medical management? What are the results?
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013, Volume: 17, Issue:9

    Topics: Botulinum Toxins; Combined Modality Therapy; Diet Therapy; Domperidone; Erythromycin; Gastrointestin

2013
The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis.
    The American journal of gastroenterology, 2013, Volume: 108, Issue:9

    Topics: Cisapride; Diabetes Mellitus, Type 2; Domperidone; Erythromycin; Gastric Emptying; Gastrointestinal

2013
Prokinetics in gastroparesis.
    Gastroenterology clinics of North America, 2015, Volume: 44, Issue:1

    Topics: Gastrointestinal Agents; Gastrointestinal Motility; Gastroparesis; Humans; Metoclopramide; Off-Label

2015
Gastrointestinal complications of diabetes.
    American family physician, 2008, Jun-15, Volume: 77, Issue:12

    Topics: Algorithms; Antiemetics; Diabetes Complications; Fatty Liver; Gastric Emptying; Gastroparesis; Human

2008
Chronic metoclopramide therapy for diabetic gastroparesis.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:1

    Topics: Antiemetics; Diabetes Complications; Drug Administration Schedule; Gastroparesis; Humans; Metoclopra

2003
Gastric motility disorders: management that optimizes nutritional status.
    Journal of clinical gastroenterology, 2004, Volume: 38, Issue:7

    Topics: Antiemetics; Diet; Dumping Syndrome; Gastrointestinal Agents; Gastrointestinal Motility; Gastropares

2004
Current pharmacological treatment of gastroparesis.
    Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:11

    Topics: Adult; Child; Cisapride; Domperidone; Erythromycin; Gastrointestinal Agents; Gastroparesis; Humans;

2004
[Digestive disorders in diabetic patients].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6

    Topics: Autonomic Nervous System; Diabetes Complications; Diagnostic Imaging; Gastrectomy; Gastric Acidity D

2005
Drug Insight: from disturbed motility to disordered movement--a review of the clinical benefits and medicolegal risks of metoclopramide.
    Nature clinical practice. Gastroenterology & hepatology, 2006, Volume: 3, Issue:3

    Topics: Dopamine Antagonists; Drug Utilization Review; Gastroparesis; Humans; Metoclopramide; Movement Disor

2006
Review article: The diagnosis and management of gastroparesis.
    Alimentary pharmacology & therapeutics, 2007, Volume: 26 Suppl 2

    Topics: Diet; Domperidone; Dopamine Antagonists; Erythromycin; Gastric Emptying; Gastrointestinal Agents; Ga

2007
Sinus arrest after administration of intravenous metoclopramide.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:4

    Topics: Arrhythmia, Sinus; Autonomic Nervous System Diseases; Female; Gastroparesis; Humans; Injections, Int

1995
Use of prokinetic agents in special populations.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1996, Nov-15, Volume: 53, Issue:22 Suppl 3

    Topics: Age Factors; Cisapride; Drug Interactions; Gastroesophageal Reflux; Gastrointestinal Agents; Gastroi

1996
Promotility agents in the intensive care unit.
    Critical care medicine, 2000, Volume: 28, Issue:7

    Topics: Cisapride; Enteral Nutrition; Erythromycin; Gastrointestinal Agents; Gastrointestinal Motility; Gast

2000
[Treatment of severely delayed gastric emptying].
    Nederlands tijdschrift voor geneeskunde, 2000, Oct-07, Volume: 144, Issue:41

    Topics: Cisapride; Diagnosis, Differential; Digestive System Surgical Procedures; Domperidone; Dyspepsia; El

2000

Trials

7 trials available for metoclopramide and Gastric Stasis

ArticleYear
Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet.
    Neurogastroenterology and motility, 2014, Volume: 26, Issue:4

    Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antiem

2014
[Observation on therapeutic effects of acupoint injection of metoclopramide for postsurgical gastroparesis syndrome].
    Zhen ci yan jiu = Acupuncture research, 2014, Volume: 39, Issue:5

    Topics: Acupuncture Points; Adult; Aged; Female; Gastroparesis; Humans; Male; Metoclopramide; Middle Aged; P

2014
Metoclopramide Nasal Spray Reduces Symptoms of Gastroparesis in Women, but not Men, With Diabetes: Results of a Phase 2B Randomized Study.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015, Volume: 13, Issue:7

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Antiemetics; Diabetes Complications; Double-Bli

2015
Acupuncture versus metoclopramide in treatment of postoperative gastroparesis syndrome in abdominal surgical patients: a randomized controlled trial.
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2010, Volume: 8, Issue:7

    Topics: Acupuncture Points; Acupuncture Therapy; Adult; Female; Gastroparesis; Humans; Male; Metoclopramide;

2010
The proportional cumulative area under the curve of paracetamol used as an index of gastric emptying in diabetic patients with symptoms of gastroparesis.
    Clinical and experimental pharmacology & physiology, 1995, Volume: 22, Issue:9

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Diabetes Mellitus, Type 1; Diabetic Neuropathi

1995
A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:5

    Topics: Adult; Aged; Antiemetics; Diabetes Mellitus, Type 1; Domperidone; Dopamine Antagonists; Double-Blind

1999
Domperidone versus metoclopramide in the treatment of diabetic gastroparesis.
    The American journal of gastroenterology, 2000, Volume: 95, Issue:1

    Topics: Adult; Aged; Diabetes Complications; Domperidone; Double-Blind Method; Female; Gastric Emptying; Gas

2000

Other Studies

26 other studies available for metoclopramide and Gastric Stasis

ArticleYear
Beyond Metoclopramide for Gastroparesis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022, Volume: 20, Issue:1

    Topics: Antiemetics; Gastric Emptying; Gastroparesis; Humans; Metoclopramide

2022
Gastrointestinal dysmotility in a patient with advanced lung cancer: paraneoplastic or drug-induced?
    BMJ case reports, 2021, Jan-26, Volume: 14, Issue:1

    Topics: Aged; Antiemetics; Carcinoma, Squamous Cell; Constipation; Gastrointestinal Agents; Gastrointestinal

2021
Controversies in Gastroparesis: Discussing the Sticky Points.
    The American journal of gastroenterology, 2021, 08-01, Volume: 116, Issue:8

    Topics: Abdominal Pain; Antiemetics; Chronic Disease; Diabetes Complications; Diagnosis, Differential; Diagn

2021
Safe Use of Erythromycin For Refractory Gastroparesis After Small Bowel Transplantation.
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2022, Volume: 20, Issue:2

    Topics: Cytochrome P-450 Enzyme System; Erythromycin; Female; Gastroparesis; Humans; Metoclopramide; Tacroli

2022
Editorial: finding the ideal prokinetic for gastroparesis-we are not there yet. Authors' reply.
    Alimentary pharmacology & therapeutics, 2021, Volume: 54, Issue:2

    Topics: Gastric Emptying; Gastroparesis; Humans; Metoclopramide

2021
Editorial: finding the ideal prokinetic for gastroparesis-we are not there yet.
    Alimentary pharmacology & therapeutics, 2021, Volume: 54, Issue:2

    Topics: Gastric Emptying; Gastroparesis; Humans; Metoclopramide

2021
From Harmful Treatment to Secondary Gain: Adverse Event Reporting in Dyspepsia and Gastroparesis.
    Digestive diseases and sciences, 2017, Volume: 62, Issue:11

    Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Antiemetics; Databases, Factual; Deglutition D

2017
[Metoclopramide-induced respiratory dyskinesia].
    Ugeskrift for laeger, 2019, Apr-22, Volume: 181, Issue:17

    Topics: Antiemetics; Dyskinesia, Drug-Induced; Gastroparesis; Humans; Metoclopramide

2019
The metoclopramide black box warning for tardive dyskinesia: effect on clinical practice, adverse event reporting, and prescription drug lawsuits.
    The American journal of gastroenterology, 2013, Volume: 108, Issue:6

    Topics: Adverse Drug Reaction Reporting Systems; Domperidone; Dopamine Antagonists; Drug Labeling; Gastropar

2013
Is metoclopramide nasal spray an acceptable alternative to its oral form?
    Neurogastroenterology and motility, 2014, Volume: 26, Issue:6

    Topics: Antiemetics; Diabetes Complications; Female; Gastroparesis; Humans; Male; Metoclopramide

2014
Response to Dr. Lankarani.
    Neurogastroenterology and motility, 2014, Volume: 26, Issue:6

    Topics: Antiemetics; Diabetes Complications; Female; Gastroparesis; Humans; Male; Metoclopramide; Nasal Spra

2014
Gastroparesis: what you should know.
    American family physician, 2008, Jun-15, Volume: 77, Issue:12

    Topics: Antiemetics; Diabetes Complications; Diet; Gastroparesis; Humans; Metoclopramide

2008
Warnings on metoclopramide treatment.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009, Volume: 7, Issue:10

    Topics: Antiemetics; Diabetes Complications; Dopamine Antagonists; Gastroparesis; Metoclopramide

2009
Nausea and vomiting in advanced cancer.
    The American journal of hospice & palliative care, 2010, Volume: 27, Issue:3

    Topics: Algorithms; Antiemetics; Causality; Decision Trees; Drug Therapy, Combination; Evidence-Based Medici

2010
Fatigue: a prevalent symptom in gastroparesis.
    Digestive diseases and sciences, 2012, Volume: 57, Issue:8

    Topics: Adult; Diagnostic Self Evaluation; Domperidone; Dopamine Antagonists; Dyspepsia; Fatigue; Female; Ga

2012
Lessons from pharmacogenetics and metoclopramide: toward the right dose of the right drug for the right patient.
    Journal of clinical gastroenterology, 2012, Volume: 46, Issue:6

    Topics: Dopamine Antagonists; Female; Gastroparesis; Humans; Male; Metoclopramide; Polymorphism, Single Nucl

2012
Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters.
    Journal of clinical gastroenterology, 2012, Volume: 46, Issue:6

    Topics: Adult; Age Factors; Body Mass Index; Diabetes Mellitus; Dopamine Antagonists; Dose-Response Relation

2012
Metoclopramide-stimulated gastric emptying scintigraphy: does it predict symptom response to prokinetic therapy in chronic gastroparesis?
    The American journal of gastroenterology, 2002, Volume: 97, Issue:9

    Topics: Chronic Disease; Dopamine Antagonists; Dose-Response Relationship, Drug; Gastric Emptying; Gastroint

2002
Metoclopramide and unintended weight gain.
    The International journal of eating disorders, 2003, Volume: 34, Issue:2

    Topics: Adult; Anorexia Nervosa; Antiemetics; Body Constitution; Body Image; Dose-Response Relationship, Dru

2003
Diabetic gastroparesis.
    Diabetic medicine : a journal of the British Diabetic Association, 2005, Volume: 22 Suppl 4

    Topics: Adult; Antiemetics; Diabetes Complications; Diet; Domperidone; Dopamine Agonists; Erythromycin; Fema

2005
Management of intestinal involvement in systemic sclerosis.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2007, Volume: 13, Issue:3

    Topics: Domperidone; Dopamine Antagonists; Gastrointestinal Agents; Gastroparesis; Humans; Indoles; Metoclop

2007
Diabetic gastroparesis.
    The New England journal of medicine, 2007, Jul-26, Volume: 357, Issue:4

    Topics: Diabetes Complications; Dopamine Antagonists; Dyskinesia, Drug-Induced; Gastroparesis; Humans; Metoc

2007
Malignant gastroparesis: diagnostics and therapeutics.
    The journal of supportive oncology, 2007, Volume: 5, Issue:8

    Topics: Anti-Bacterial Agents; Antiemetics; Erythromycin; Gastroparesis; Humans; Metoclopramide; Neoplasms

2007
[Drug therapy of gastrointestinal motility disorders].
    Zhonghua nei ke za zhi, 1995, Volume: 34, Issue:3

    Topics: Cisapride; Domperidone; Dyspepsia; Gastroesophageal Reflux; Gastroparesis; Humans; Metoclopramide; P

1995
Improved nutrition after the detection and treatment of occult gastroparesis in nondiabetic dialysis patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1998, Volume: 31, Issue:1

    Topics: Erythromycin; Female; Gastric Emptying; Gastroparesis; Humans; Kidney Failure, Chronic; Male; Metocl

1998
Gastroparesis following bone marrow transplantation.
    Bone marrow transplantation, 2001, Volume: 28, Issue:1

    Topics: Adult; Antiemetics; Bone Marrow Transplantation; Case-Control Studies; Erythromycin; Female; Gastric

2001