metoclopramide has been researched along with Diabetic Neuropathies in 24 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| " the proportional cumulative area under the curve of paracetamol) was utilized in diabetic patients in order to detect both gastroparesis and the influence of metoclopramide, a known prokinetic drug, on this condition." | 5.08 | The proportional cumulative area under the curve of paracetamol used as an index of gastric emptying in diabetic patients with symptoms of gastroparesis. ( Moncrieff, J; Snyman, JR; Sommers, DK; van Wyk, M, 1995) |
| "Metoclopramide hydrochloride was administered to nine children for the treatment of gastric stasis (N=6) and unexplained vomiting (N=3)." | 3.66 | Enhanced gastroduodenal motility in children. ( Hitch, DC; Torres-Pinedo, RB; Vanhoutte, JJ, 1982) |
| "Diabetic gastroparesis is defined as delayed gastric emptying without mechanical obstruction in the setting of diabetes." | 2.72 | Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists. ( Baker, C; Petri, M; Rasouli, N; Singh, I; Underkofler, C, 2021) |
| " While both cisapride and metoclopramide normalized impaired solid emptying, cisapride at its highest dosage (10 mg) resulted in significantly faster gastric emptying (P = 0." | 2.67 | Cisapride vs metoclopramide. An acute study in diabetic gastroparesis. ( Diamant, NE; Lico, S; McHugh, S, 1992) |
| "Metoclopramide tablets have been approved for use in the acute and chronic management of diabetic gastroparesis." | 1.27 | Effect of metoclopramide on gastric liquid emptying in patients with diabetic gastroparesis. ( Dugas, MC; Gavaler, JS; Lhotsky, DM; Schade, RR; Van Thiel, DH, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (70.83) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Petri, M | 1 |
| Singh, I | 1 |
| Baker, C | 1 |
| Underkofler, C | 1 |
| Rasouli, N | 1 |
| Gajendran, M | 1 |
| Sarosiek, I | 1 |
| McCallum, R | 1 |
| Jellish, WS | 1 |
| Kartha, V | 1 |
| Fluder, E | 1 |
| Slogoff, S | 1 |
| Valenzuela, JE | 1 |
| Dooley, CP | 1 |
| Bessa, AM | 1 |
| Zanella, MT | 1 |
| Saragoça, MA | 1 |
| Mulinari, RA | 1 |
| Czepielewski, M | 1 |
| Ribeiro, AB | 1 |
| Ramos, OL | 1 |
| Feldman, M | 1 |
| Schiller, LR | 1 |
| Hitch, DC | 1 |
| Vanhoutte, JJ | 1 |
| Torres-Pinedo, RB | 1 |
| Fox, S | 1 |
| Behar, J | 1 |
| Erbas, T | 1 |
| Varoglu, E | 1 |
| Erbas, B | 1 |
| Tastekin, G | 1 |
| Akalin, S | 1 |
| Hüppe, D | 1 |
| Tromm, A | 1 |
| Tegenthoff, M | 1 |
| Faig, J | 1 |
| Brunke, F | 1 |
| Depka, S | 1 |
| May, B | 1 |
| van Wyk, M | 1 |
| Sommers, DK | 1 |
| Snyman, JR | 1 |
| Moncrieff, J | 1 |
| Longstreth, GF | 1 |
| Malagelada, JR | 1 |
| Kelly, KA | 1 |
| Hartong, WA | 1 |
| Moore, J | 1 |
| Booth, JP | 1 |
| Campbell, IW | 1 |
| Heading, RC | 2 |
| Tothill, P | 2 |
| Buist, TA | 1 |
| Ewing, DJ | 2 |
| Clarke, BF | 2 |
| Brady, PG | 1 |
| Richardson, R | 1 |
| McHugh, S | 1 |
| Lico, S | 1 |
| Diamant, NE | 1 |
| de Caestecker, JS | 1 |
| Champion, MC | 1 |
| Vogelberg, KH | 1 |
| Dalügge, A | 1 |
| Smout, AJ | 1 |
| Bernstein, G | 1 |
| Rifkin, H | 1 |
| Wright, RA | 1 |
| Clemente, R | 1 |
| Wathen, R | 1 |
| Schade, RR | 1 |
| Dugas, MC | 1 |
| Lhotsky, DM | 1 |
| Gavaler, JS | 1 |
| Van Thiel, DH | 1 |
| Adams, CD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ultrasound Evaluation of Gastric Content in Diabetic and Non-Diabetic Term Pregnant Women: An Observational Study[NCT05959135] | 80 participants (Actual) | Observational | 2023-07-26 | Completed | |||
| A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622] | Phase 2 | 3 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Lack of recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for metoclopramide and Diabetic Neuropathies
| Article | Year |
|---|---|
Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists.
Topics: Diabetes Mellitus; Diabetic Neuropathies; Gastric Emptying; Gastroparesis; Humans; Metoclopramide; Q | 2021 |
Metoclopramide nasal spray for management of symptoms of acute and recurrent diabetic gastroparesis in adults.
Topics: Diabetes Mellitus; Diabetic Neuropathies; Gastroparesis; Humans; Metoclopramide; Nasal Sprays; Treat | 2021 |
Dopamine antagonists in the upper gastrointestinal tract.
Topics: Diabetic Neuropathies; Digestive System; Domperidone; Dopamine Antagonists; Duodenum; Dyspepsia; Eso | 1984 |
Disorders of gastrointestinal motility associated with diabetes mellitus.
Topics: Autonomic Nervous System Diseases; Bethanechol Compounds; Constipation; Diabetes Complications; Diab | 1983 |
Management of idiopathic, diabetic and miscellaneous gastroparesis with cisapride.
Topics: Cisapride; Clinical Trials as Topic; Diabetic Neuropathies; Domperidone; Gastric Emptying; Humans; M | 1989 |
6 trials available for metoclopramide and Diabetic Neuropathies
| Article | Year |
|---|---|
Effect of metoclopramide on gastric fluid volumes in diabetic patients who have fasted before elective surgery.
Topics: Aged; Anesthesia, General; Body Fluids; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Melli | 2005 |
Comparison of metoclopramide and erythromycin in the treatment of diabetic gastroparesis.
Topics: Administration, Oral; Adult; Aged; Diabetic Neuropathies; Dose-Response Relationship, Drug; Erythrom | 1993 |
The proportional cumulative area under the curve of paracetamol used as an index of gastric emptying in diabetic patients with symptoms of gastroparesis.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Diabetes Mellitus, Type 1; Diabetic Neuropathi | 1995 |
Cisapride vs metoclopramide. An acute study in diabetic gastroparesis.
Topics: Adult; Autonomic Nervous System Diseases; Cisapride; Diabetic Neuropathies; Dose-Response Relationsh | 1992 |
Evaluation of oral cisapride and metoclopramide in diabetic autonomic neuropathy: an eight-week double-blind crossover study.
Topics: Adult; Autonomic Nervous System Diseases; Blood Glucose; Cisapride; Diabetic Neuropathies; Double-Bl | 1989 |
Management of idiopathic, diabetic and miscellaneous gastroparesis with cisapride.
Topics: Cisapride; Clinical Trials as Topic; Diabetic Neuropathies; Domperidone; Gastric Emptying; Humans; M | 1989 |
14 other studies available for metoclopramide and Diabetic Neuropathies
| Article | Year |
|---|---|
Acute hemodynamic and humoral effects of metoclopramide on blood pressure control improvement in subjects with diabetic orthostatic hypotension.
Topics: Adult; Aged; Aldosterone; Blood Glucose; Blood Pressure; Cardiac Output; Diabetes Complications; Dia | 1984 |
Enhanced gastroduodenal motility in children.
Topics: Adolescent; Child; Child, Preschool; Diabetic Neuropathies; Gastrointestinal Motility; Humans; Infan | 1982 |
Pathogenesis of diabetic gastroparesis: a pharmacologic study.
Topics: Adult; Atropine; Bethanechol Compounds; Diabetic Neuropathies; Gastric Emptying; Gastrointestinal Mo | 1980 |
[Acute effect of metoclopramide on esophagus motility in diabetes mellitus].
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Esophagoga | 1993 |
Metoclopramide stimulation of gastric motility and emptying in diabetic gastroparesis.
Topics: Adult; Diabetic Neuropathies; Female; Gastrointestinal Motility; Humans; Metoclopramide; Stomach Dis | 1977 |
Metoclopramide in diabetic gastroparesis.
Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Gastrointestinal Motility; Humans; | 1977 |
Gastric emptying in diabetic autonomic neuropathy.
Topics: Adult; Autonomic Nervous System; Diabetic Neuropathies; Gastrointestinal Motility; Humans; Male; Met | 1977 |
Gastric bezoar formation secondary to gastroparesis diabeticorum.
Topics: Autonomic Nervous System; Bezoars; Diabetic Neuropathies; Gastric Emptying; Humans; Male; Metoclopra | 1977 |
[Sonographic studies during drug treatment of diabetic gastroparesis].
Topics: Adult; Cisapride; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Gastric Emptying; Gastro | 1988 |
[The significance of disordered gastric emptying].
Topics: Combined Modality Therapy; Diabetic Neuropathies; Duodenal Ulcer; Gastric Emptying; Humans; Metoclop | 1986 |
Diabetes mellitus: gastrointestinal complications.
Topics: Blood Glucose; Cholecystitis; Cholelithiasis; Diabetes Complications; Diabetic Neuropathies; Esophag | 1986 |
Diabetic gastroparesis: an abnormality of gastric emptying of solids.
Topics: Autonomic Nervous System Diseases; Beverages; Blood Glucose; Diabetic Neuropathies; Food; Gastric Em | 1985 |
Effect of metoclopramide on gastric liquid emptying in patients with diabetic gastroparesis.
Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Gastric Emptying; Humans; Kidney Failure, C | 1985 |
Metoclopramide and depression.
Topics: Adult; Depression; Diabetic Neuropathies; Drug Administration Schedule; Female; Humans; Male; Metocl | 1985 |