metoclopramide has been researched along with Diabetes Mellitus in 20 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effect of metoclopramide (MCP), a dopaminergic antagonist, on orthostatic hypotension associated with diabetes mellitus, was investigated to prove its plausible role of renin-angiotensin-aldosterone and catecholamine activation by comparative study in 6 diabetics with orthostatic hypotension (OH) and 9 diabetics without OH." | 7.67 | Effect of metoclopramide on orthostatic hypotension in diabetes mellitus: failure to demonstrate the role of vasoconstrictive hormones. ( Ikeda, M; Koshida, H; Miyamori, I; Morise, T; Nagai, K; Takeda, R; Takeda, Y; Yasuhara, S, 1988) |
| "Gonadotropin responses to GnRH and PRL responses to TRH and metoclopramide (MTC) were investigated in nine consecutive women with amenorrhea and insulin-treated diabetes mellitus." | 7.66 | Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus. ( Andersen, AN; Carstensen, L; Djursing, H; Hagen, C; Nyholm, HC, 1983) |
| "Metoclopramide is associated with variable efficacy and side effects when used in the treatment of gastroparesis." | 3.78 | Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. ( Gaughan, J; Jacobs, M; Krynetskiy, E; Mishra, A; Parkman, HP; Pathikonda, M; Sachdeva, P, 2012) |
| "Effect of metoclopramide (MCP), a dopaminergic antagonist, on orthostatic hypotension associated with diabetes mellitus, was investigated to prove its plausible role of renin-angiotensin-aldosterone and catecholamine activation by comparative study in 6 diabetics with orthostatic hypotension (OH) and 9 diabetics without OH." | 3.67 | Effect of metoclopramide on orthostatic hypotension in diabetes mellitus: failure to demonstrate the role of vasoconstrictive hormones. ( Ikeda, M; Koshida, H; Miyamori, I; Morise, T; Nagai, K; Takeda, R; Takeda, Y; Yasuhara, S, 1988) |
| "Gonadotropin responses to GnRH and PRL responses to TRH and metoclopramide (MTC) were investigated in nine consecutive women with amenorrhea and insulin-treated diabetes mellitus." | 3.66 | Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus. ( Andersen, AN; Carstensen, L; Djursing, H; Hagen, C; Nyholm, HC, 1983) |
| "Diabetic gastroparesis is defined as delayed gastric emptying without mechanical obstruction in the setting of diabetes." | 2.72 | Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists. ( Baker, C; Petri, M; Rasouli, N; Singh, I; Underkofler, C, 2021) |
| "Cisapride is a prokinetic agent believed to facilitate acetylcholine release from the myenteric plexus of the gut." | 2.66 | Effect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorum. A comparison with metoclopramide and placebo. ( Feldman, M; Smith, HJ, 1987) |
| " The initial bioavailability was 67." | 1.27 | Bioavailability and disposition of metoclopramide after single- and multiple-dose administration in diabetic patients with gastroparesis. ( Awni, WM; Cass, O; Goodman, M; Matzke, GR; Melikian, AP; O'Connell, ME; Wright, GJ, 1987) |
| "In patients with untreated hyperthyroidism, aldosterone response was similar to that in normal subjects." | 1.26 | [Dopaminergic control of aldosterone secretion in man (author's transl)]. ( Ieiri, T; Kasai, K; Naitoh, T; Nakamura, T; Shimoda, S; Shina, H; Suzuki, H; Takemura, Y, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (70.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petri, M | 1 |
| Singh, I | 1 |
| Baker, C | 1 |
| Underkofler, C | 1 |
| Rasouli, N | 1 |
| Gajendran, M | 1 |
| Sarosiek, I | 1 |
| McCallum, R | 1 |
| Parkman, HP | 1 |
| Mishra, A | 1 |
| Jacobs, M | 1 |
| Pathikonda, M | 1 |
| Sachdeva, P | 1 |
| Gaughan, J | 1 |
| Krynetskiy, E | 1 |
| Jellish, WS | 1 |
| Kartha, V | 1 |
| Fluder, E | 1 |
| Slogoff, S | 1 |
| Keeble, EJ | 1 |
| Albibi, R | 1 |
| McCallum, RW | 2 |
| Djursing, H | 1 |
| Hagen, C | 1 |
| Nyholm, HC | 1 |
| Carstensen, L | 1 |
| Andersen, AN | 1 |
| Barnett, AH | 1 |
| Chapman, C | 1 |
| Gailer, K | 1 |
| Hayter, CJ | 1 |
| Suzuki, H | 1 |
| Kasai, K | 1 |
| Naitoh, T | 1 |
| Nakamura, T | 1 |
| Shina, H | 1 |
| Ieiri, T | 1 |
| Takemura, Y | 1 |
| Shimoda, S | 1 |
| Krassowski, J | 1 |
| Jeske, W | 1 |
| Kim, EE | 2 |
| Choy, YC | 2 |
| Domstad, PA | 2 |
| Beihn, R | 2 |
| Coupal, J | 1 |
| Yonts, S | 2 |
| DeLand, FH | 2 |
| Muls, EE | 1 |
| Lamberigts, GF | 1 |
| Coupal, JJ | 1 |
| Mandelstam, P | 1 |
| Battle, WM | 1 |
| Snape, WJ | 1 |
| Alavi, A | 1 |
| Cohen, S | 1 |
| Braunstein, S | 1 |
| Takeda, R | 1 |
| Takeda, Y | 1 |
| Koshida, H | 1 |
| Ikeda, M | 1 |
| Yasuhara, S | 1 |
| Nagai, K | 1 |
| Morise, T | 1 |
| Miyamori, I | 1 |
| O'Connell, ME | 1 |
| Awni, WM | 1 |
| Goodman, M | 1 |
| Cass, O | 1 |
| Melikian, AP | 1 |
| Wright, GJ | 1 |
| Matzke, GR | 1 |
| Chaussade, S | 1 |
| Grandjouan, S | 1 |
| Couturier, D | 1 |
| Feldman, M | 1 |
| Smith, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ultrasound Evaluation of Gastric Content in Diabetic and Non-Diabetic Term Pregnant Women: An Observational Study[NCT05959135] | 80 participants (Actual) | Observational | 2023-07-26 | Completed | |||
| A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622] | Phase 2 | 3 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Lack of recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for metoclopramide and Diabetes Mellitus
| Article | Year |
|---|---|
Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists.
Topics: Diabetes Mellitus; Diabetic Neuropathies; Gastric Emptying; Gastroparesis; Humans; Metoclopramide; Q | 2021 |
Metoclopramide nasal spray (Gimoti) for diabetic gastroparesis.
Topics: Clinical Trials as Topic; Diabetes Mellitus; Dopamine D2 Receptor Antagonists; Gastroparesis; Humans | 2021 |
Metoclopramide nasal spray for management of symptoms of acute and recurrent diabetic gastroparesis in adults.
Topics: Diabetes Mellitus; Diabetic Neuropathies; Gastroparesis; Humans; Metoclopramide; Nasal Sprays; Treat | 2021 |
Metoclopramide: pharmacology and clinical application.
Topics: Anorexia Nervosa; Antiemetics; Diabetes Mellitus; Dopamine Antagonists; Endocrine Glands; Gastric Em | 1983 |
Pathophysiology of gastric emptying in humans.
Topics: Anemia, Pernicious; Anorexia Nervosa; Diabetes Mellitus; Food; Gastric Emptying; Gastrointestinal Di | 1984 |
3 trials available for metoclopramide and Diabetes Mellitus
| Article | Year |
|---|---|
Effect of metoclopramide on gastric fluid volumes in diabetic patients who have fasted before elective surgery.
Topics: Aged; Anesthesia, General; Body Fluids; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Melli | 2005 |
Effect of bromocriptine on maturity onset diabetes.
Topics: Blood Glucose; Bromocriptine; Diabetes Mellitus; Female; Glucose Tolerance Test; Growth Hormone; Hum | 1980 |
Effect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorum. A comparison with metoclopramide and placebo.
Topics: Adult; Cisapride; Diabetes Mellitus; Double-Blind Method; Female; Gastric Emptying; Humans; Male; Me | 1987 |
12 other studies available for metoclopramide and Diabetes Mellitus
| Article | Year |
|---|---|
Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters.
Topics: Adult; Age Factors; Body Mass Index; Diabetes Mellitus; Dopamine Antagonists; Dose-Response Relation | 2012 |
Clinical snapshot. Polyuria, polydipsia, and glycosuria in a white rabbit.
Topics: Animals; Diabetes Mellitus; Dietary Fiber; Hypoglycemic Agents; Metoclopramide; Rabbits; Weight Loss | 2007 |
Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus.
Topics: Adult; Amenorrhea; Diabetes Complications; Diabetes Mellitus; Female; Follicle Stimulating Hormone; | 1983 |
[Dopaminergic control of aldosterone secretion in man (author's transl)].
Topics: Adolescent; Adult; Aged; Aldosterone; Binding, Competitive; Bromocriptine; Diabetes Mellitus; Dopami | 1980 |
Exaggerated prolactin response to metoclopramide in non-insulin dependent diabetes mellitus.
Topics: Diabetes Mellitus; Female; Humans; Male; Metoclopramide; Prolactin | 1982 |
Biologic gastric emptying time using Tc-99m TETA polystyrene resin in various clinical conditions.
Topics: Adolescent; Adult; Aged; Diabetes Mellitus; Esophagitis, Peptic; Ethylenediamines; Female; Gastrecto | 1981 |
Uncontrolled diabetes mellitus due to gastroparesis diabeticorum: treatment with metoclopramide.
Topics: Aged; Diabetes Mellitus; Female; Gastric Emptying; Humans; Metoclopramide; Paralysis; Stomach Diseas | 1981 |
Biologic gastric emptying time in diabetic patients, using Tc-99m-labeled resin-oatmeal with and without metoclopramide.
Topics: Administration, Oral; Adult; Diabetes Complications; Diabetes Mellitus; Female; Gastric Emptying; Hu | 1980 |
Colonic dysfunction in diabetes mellitus.
Topics: Action Potentials; Adolescent; Adult; Colon; Constipation; Diabetes Mellitus; Diabetes Mellitus, Typ | 1980 |
Effect of metoclopramide on orthostatic hypotension in diabetes mellitus: failure to demonstrate the role of vasoconstrictive hormones.
Topics: Administration, Oral; Adult; Aldosterone; Angiotensin II; Diabetes Mellitus; Dose-Response Relations | 1988 |
Bioavailability and disposition of metoclopramide after single- and multiple-dose administration in diabetic patients with gastroparesis.
Topics: Adult; Biological Availability; Diabetes Complications; Diabetes Mellitus; Female; Gastric Emptying; | 1987 |
Motilin and diabetic gastroparesis: effect of MTC.
Topics: Diabetes Complications; Diabetes Mellitus; Gastrointestinal Motility; Humans; Metoclopramide; Motili | 1986 |