metoclopramide and Cross Infection studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Cross Infection: Any infection which a patient contracts in a health-care institution.

Research Excerpts

Excerpt	Relevance	Reference
"The pediatric Critical Illness Stress-induced Immune Suppression (CRISIS) trial compared the effectiveness of 2 nutraceutical supplementation strategies and found no difference in the development of nosocomial infection and sepsis in the overall population."	2.84	Interaction Between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial. ( Anand, KJS; Bell, MJ; Berg, RA; Berger, J; Burr, J; Carcillo, JA; Dalton, H; Dean, JM; Doctor, A; Harrison, R; Heidemann, SM; Holubkov, R; Jenkins, TL; Meert, KL; Newth, CJL; Nicholson, C; Shanley, TP; Tamburro, RF; Webster, A; Willson, DF; Zimmerman, JJ, 2017)
"The National Institutes of Health-appointed CRISIS Data and Safety Monitoring Board was charged with monitoring sample size adequacy and feasibility, safety with respect to adverse events and 28-day mortality, and efficacy with respect to the primary nosocomial infection/sepsis outcome."	1.39	The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study. ( Anand, KJ; Berger, J; Casper, TC; Dean, JM; Harrison, R; Holubkov, R; Meert, KL; Newth, CJ; Nicholson, C; Willson, DF; Zimmerman, J, 2013)

Research

Studies (6)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

All-cause 28-day Mortality Rate.

Antibiotic-free Days

Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	5 (83.33)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Carcillo, JA	2
Dean, JM	3
Holubkov, R	3
Berger, J	3
Meert, KL	3
Anand, KJS	1
Zimmerman, JJ	1
Newth, CJL	1
Harrison, R	3
Burr, J	2
Willson, DF	3
Nicholson, C	3
Bell, MJ	1
Berg, RA	1
Shanley, TP	1
Heidemann, SM	1
Dalton, H	1
Jenkins, TL	1
Doctor, A	1
Webster, A	1
Tamburro, RF	1
Martins, IS	1
Pellegrino, FL	1
Freitas, Ad	1
Santos, Mda S	1
Ferraiuoli, GI	1
Vasques, MR	1
Amorim, EL	1
Oliveira, S	1
Nouér, SA	1
Cardoso, FL	1
Mascarenhas, LA	1
Magalhães, AC	1
Cleinman, IB	1
Figueiredo, AM	1
Moreira, BM	1
Nassaji, M	1
Ghorbani, R	1
Frozeshfard, M	1
Mesbahian, F	1
Anand, KJ	2
Zimmerman, J	2
Newth, CJ	2
Casper, TC	1
Yavagal, DR	1
Karnad, DR	1
Oak, JL	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161]	Phase 3	293 participants (Actual)	Interventional	2007-04-30	Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	15
Enteral Whey Protein, IV Saline	8

Intervention	Days (Median)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	1
Enteral Whey Protein, IV Saline	2

What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU

Rate of Nosocomial Infection or Clinical Sepsis Per 100 Study Days

The Primary Endpoint of This Study is the Median Time Between Admission to the PICU and Occurrence of Nosocomial Infection or Clinical Sepsis in PICU Patients Who Have Endotracheal Tubes, Central Venous Catheters, or Urinary Catheters.

Intervention	participants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	5
Enteral Whey Protein, IV Saline	12

Intervention	Mean number of events per 100 study days (Mean)
Daily Nutriceutical Supplementation	4.99
Whey Protein	4.83

(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU

Article	Year
Interaction Between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial. JPEN. Journal of parenteral and enteral nutrition, 2017, Volume: 41, Issue:8 Topics: Adolescent; Child; Child, Preschool; Critical Illness; Cross Infection; Dietary Supplements; Female;	2017
Effect of metoclopramide on nosocomial pneumonia in patients with nasogastric feeding in the intensive care unit. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 2010, Volume: 16, Issue:4 Topics: Administration, Oral; Adult; Antiemetics; Chi-Square Distribution; Critical Care; Cross Infection; D	2010
The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:2 Topics: Adolescent; Child; Child, Preschool; Critical Illness; Cross Infection; Dietary Supplements; Double-	2012
Metoclopramide for preventing pneumonia in critically ill patients receiving enteral tube feeding: a randomized controlled trial. Critical care medicine, 2000, Volume: 28, Issue:5 Topics: Antiemetics; Critical Care; Cross Infection; Dose-Response Relationship, Drug; Drug Administration S	2000

Article	Year
Case-crossover study of Burkholderia cepacia complex bloodstream infection associated with contaminated intravenous bromopride. Infection control and hospital epidemiology, 2010, Volume: 31, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Bacteremia; Brazil; Burkholderia cepacia complex; Burkholderia Infec	2010
The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013, Volume: 14, Issue:4 Topics: Adolescent; Biomedical Research; Child; Child, Preschool; Clinical Trials Data Monitoring Committees	2013

metoclopramide and Cross Infection