metoclopramide has been researched along with Complications of Diabetes Mellitus in 43 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metoclopramide nasal spray reduces symptoms of gastroparesis in women, but not in men, with diabetes." | 9.20 | Metoclopramide Nasal Spray Reduces Symptoms of Gastroparesis in Women, but not Men, With Diabetes: Results of a Phase 2B Randomized Study. ( Carlson, MR; Gonyer, D; Parkman, HP, 2015) |
| " Intranasal metoclopramide is being developed as an alternative to oral metoclopramide for patients with diabetic gastroparesis." | 9.19 | Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet. ( Carlson, MR; Gonyer, D; Parkman, HP, 2014) |
| "To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis." | 8.82 | Chronic metoclopramide therapy for diabetic gastroparesis. ( Lata, PF; Pigarelli, DL, 2003) |
| "Gonadotropin responses to GnRH and PRL responses to TRH and metoclopramide (MTC) were investigated in nine consecutive women with amenorrhea and insulin-treated diabetes mellitus." | 7.66 | Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus. ( Andersen, AN; Carstensen, L; Djursing, H; Hagen, C; Nyholm, HC, 1983) |
| "Metoclopramide nasal spray reduces symptoms of gastroparesis in women, but not in men, with diabetes." | 5.20 | Metoclopramide Nasal Spray Reduces Symptoms of Gastroparesis in Women, but not Men, With Diabetes: Results of a Phase 2B Randomized Study. ( Carlson, MR; Gonyer, D; Parkman, HP, 2015) |
| " Intranasal metoclopramide is being developed as an alternative to oral metoclopramide for patients with diabetic gastroparesis." | 5.19 | Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet. ( Carlson, MR; Gonyer, D; Parkman, HP, 2014) |
| "Fifty-five patients with delayed gastric emptying and the symptoms of nausea, vomiting, postprandial bloating and early satiety were treated with metoclopramide." | 5.05 | Metoclopramide therapy in fifty-five patients with delayed gastric emptying. ( Davidson, ED; Hersh, T; Moore, C; Perkel, MS, 1980) |
| "To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis." | 4.82 | Chronic metoclopramide therapy for diabetic gastroparesis. ( Lata, PF; Pigarelli, DL, 2003) |
| " Metoclopramide-treated patients had significantly greater severity of tardive dyskinesia, drug-induced parkinsonism, and subjective akathisia than controls." | 3.68 | The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders. ( Casey, DE; Ganzini, L; Hoffman, WF; McCall, AL, 1993) |
| "Gonadotropin responses to GnRH and PRL responses to TRH and metoclopramide (MTC) were investigated in nine consecutive women with amenorrhea and insulin-treated diabetes mellitus." | 3.66 | Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus. ( Andersen, AN; Carstensen, L; Djursing, H; Hagen, C; Nyholm, HC, 1983) |
| "Domperidone, which has also been shown to stimulate gastric motility and to possess antiemetic properties, improves symptoms in patients suffering from diabetic gastroparesis." | 2.38 | Use of metoclopramide, domperidone, and cisapride in the management of diabetic gastroparesis. ( Brown, CK; Khanderia, U, 1990) |
| "Metoclopramide appears to be an effective drug in stimulating the mobility of the upper gastrointestinal tract without increasing gastric secretions." | 2.36 | Review of a new gastrointestinal drug--metoclopramide. ( Nappi, JM; Ponte, CD, 1981) |
| " Eighteen patients received a total of 20 courses of therapy with dosage schedules ranging from 5 mg tid to 10 mg qid." | 1.27 | Prescribing of oral metoclopramide for nonapproved indications. ( Schwinghammer, TL, 1984) |
| " The initial bioavailability was 67." | 1.27 | Bioavailability and disposition of metoclopramide after single- and multiple-dose administration in diabetic patients with gastroparesis. ( Awni, WM; Cass, O; Goodman, M; Matzke, GR; Melikian, AP; O'Connell, ME; Wright, GJ, 1987) |
| "Two patients with orthostatic hypotension, complicating diabetes mellitus, were treated with dopaminergic antagonist metoclopramide alone or combined with the nonsteroidal anti-inflammatory agent flurbiprofen." | 1.26 | Metoclopramide alone or combined with flurbiprofen in the treatment of orthostatic hypotension associated with diabetes mellitus. ( Beretta-Piccoli, C; Weidmann, P, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (46.51) | 18.7374 |
| 1990's | 8 (18.60) | 18.2507 |
| 2000's | 8 (18.60) | 29.6817 |
| 2010's | 6 (13.95) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Asha, MZ | 1 |
| Khalil, SFH | 1 |
| Lacy, BE | 1 |
| Cangemi, DJ | 1 |
| Shakhatreh, M | 1 |
| Jehangir, A | 1 |
| Malik, Z | 1 |
| Parkman, HP | 3 |
| Carlson, MR | 2 |
| Gonyer, D | 3 |
| Lankarani, K | 1 |
| Parkman, H | 1 |
| Carlson, M | 1 |
| Shakil, A | 1 |
| Church, RJ | 1 |
| Rao, SS | 1 |
| Bernstein, R | 1 |
| Lata, PF | 1 |
| Pigarelli, DL | 1 |
| Tsuji, S | 1 |
| Hayashi, N | 1 |
| Kong, MF | 1 |
| Horowitz, M | 1 |
| Tarsy, D | 1 |
| Bessa, AM | 1 |
| Zanella, MT | 1 |
| Saragoça, MA | 1 |
| Mulinari, RA | 1 |
| Czepielewski, M | 1 |
| Ribeiro, AB | 1 |
| Ramos, OL | 1 |
| Feldman, M | 1 |
| Schiller, LR | 1 |
| Djursing, H | 1 |
| Hagen, C | 1 |
| Nyholm, HC | 1 |
| Carstensen, L | 1 |
| Andersen, AN | 1 |
| Schwinghammer, TL | 1 |
| Beretta-Piccoli, C | 1 |
| Weidmann, P | 1 |
| Medina, LA | 1 |
| Ponte, CD | 1 |
| Nappi, JM | 1 |
| Snape, WJ | 1 |
| Battle, WM | 1 |
| Schwartz, SS | 1 |
| Braunstein, SN | 1 |
| Goldstein, HA | 1 |
| Alavi, A | 1 |
| Domstad, PA | 2 |
| Deland, FH | 2 |
| Malagelada, JR | 1 |
| Rees, WD | 1 |
| Mazzotta, LJ | 1 |
| Go, VL | 1 |
| Kim, EE | 1 |
| Coupal, JJ | 1 |
| Beihn, R | 1 |
| Yonts, S | 1 |
| Choy, YC | 1 |
| Mandelstam, P | 1 |
| Stahl, E | 1 |
| Bischof, G | 1 |
| Rösner, K | 1 |
| List, A | 1 |
| Bretzke, G | 1 |
| Perkel, MS | 1 |
| Hersh, T | 1 |
| Moore, C | 1 |
| Davidson, ED | 1 |
| Ganzini, L | 2 |
| Casey, DE | 2 |
| Hoffman, WF | 2 |
| McCall, AL | 1 |
| Czambor-Ksiazek, E | 1 |
| Pokrzywnicki, W | 1 |
| Grzeszczak, W | 1 |
| Duda, G | 1 |
| Dumitrascu, DL | 1 |
| Weinbeck, M | 1 |
| Drenth, JP | 1 |
| Engels, LG | 1 |
| Heintz, RT | 1 |
| Jian, R | 1 |
| Gora, ML | 1 |
| Visconti, JA | 1 |
| Seth, S | 1 |
| Shields, B | 1 |
| Bay, W | 1 |
| Hongo, M | 1 |
| Toyota, T | 1 |
| Brown, CK | 1 |
| Khanderia, U | 1 |
| Ricci, DA | 1 |
| McCallum, RW | 1 |
| Braverman, DZ | 1 |
| O'Connell, ME | 1 |
| Awni, WM | 1 |
| Goodman, M | 1 |
| Cass, O | 1 |
| Melikian, AP | 1 |
| Wright, GJ | 1 |
| Matzke, GR | 1 |
| Chaussade, S | 1 |
| Grandjouan, S | 1 |
| Couturier, D | 1 |
| Bernstein, G | 1 |
| Rifkin, H | 1 |
| Robillard, J | 1 |
| Brownlee, M | 1 |
| Kroopf, SS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel Group, Dose-Ranging Clinical Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray Solution in Diabetic Subjects With Gastroparesis[NCT00845858] | Phase 2 | 287 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622] | Phase 2 | 3 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Lack of recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change from Baseline to Week 4 of the treatment period in the mGCSI-DD total score in Female subjects receiving metoclopramide nasal spray versus Female subjects receiving placebo.~The mGCSI-DD is a patient reported outcome measure of gastroparesis symptom severity composed of 4 individual symptoms (listed below) with each symptom graded on a scale from 0 (none) to 5 (very severe).~Nausea (feeling sick to your stomach as if you were going to vomit or throw up)~Early satiety (not able to finish a normal sized meal)~Bloating (feeling like you need to loosen clothes)~Upper abdominal pain (above the navel) The mGCSI-DD daily score is a mean of the 4 individual symptom scores. The total score is a mean of the daily scores for the observation period.~A mean change (improvement) of >1 category (for example, moderate to mild or severe to moderate) is considered to be clinically meaningful." (NCT00845858)
Timeframe: 4 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Female-Metoclopramide Nasal Spray 10 mg | -1.2 |
| Female-Metoclopramide Nasal Spray 14 mg | -1.3 |
| Female-Placebo Nasal Spray | -0.8 |
"Change from Baseline to Week 4 of the treatment period in the mGCSI-DD total score in male and female subjects receiving metoclopramide nasal spray versus subjects receiving placebo.~The mGCSI-DD is a patient reported outcome measure of gastroparesis symptom severity composed of 4 individual symptoms (listed below) with each symptom graded on a scale from 0 (none) to 5 (very severe).~Nausea (feeling sick to your stomach as if you were going to vomit or throw up)~Early satiety (not able to finish a normal sized meal)~Bloating (feeling like you need to loosen clothes)~Upper abdominal pain (above the navel) The mGCSI-DD daily score is a mean of the 4 individual symptom scores. The total score is a mean of the daily scores for the observation period.~A mean change (improvement) of >1 category (for example, moderate to mild or severe to moderate) is considered to be clinically meaningful." (NCT00845858)
Timeframe: 4 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Metoclopramide Nasal Spray 10 mg | -1.2 |
| Metoclopramide Nasal Spray 14 mg | -1.2 |
| Placebo Nasal Spray | -1.0 |
14 reviews available for metoclopramide and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials.
Topics: Antiemetics; Cisapride; Diabetes Complications; Domperidone; Gastric Emptying; Gastrointestinal Agen | 2019 |
Metoclopramide for the treatment of diabetic gastroparesis.
Topics: Diabetes Complications; Dopamine D2 Receptor Antagonists; Gastric Emptying; Gastroparesis; Humans; M | 2019 |
Gastrointestinal complications of diabetes.
Topics: Algorithms; Antiemetics; Diabetes Complications; Fatty Liver; Gastric Emptying; Gastroparesis; Human | 2008 |
Chronic metoclopramide therapy for diabetic gastroparesis.
Topics: Antiemetics; Diabetes Complications; Drug Administration Schedule; Gastroparesis; Humans; Metoclopra | 2003 |
[Digestive disorders in diabetic patients].
Topics: Autonomic Nervous System; Diabetes Complications; Diagnostic Imaging; Gastrectomy; Gastric Acidity D | 2005 |
Disorders of gastrointestinal motility associated with diabetes mellitus.
Topics: Autonomic Nervous System Diseases; Bethanechol Compounds; Constipation; Diabetes Complications; Diab | 1983 |
[Gastric motility and emptying].
Topics: Adult; Diabetes Complications; Dyspepsia; Female; Gastric Emptying; Gastrointestinal Motility; Human | 1982 |
Review of a new gastrointestinal drug--metoclopramide.
Topics: Diabetes Complications; Gastric Emptying; Humans; Metoclopramide; Stomach Diseases; Vomiting | 1981 |
[Disorders of gastric emptying in diabetes. II. Treatment].
Topics: Cisapride; Diabetes Complications; Domperidone; Dopamine Agents; Erythromycin; Gastric Emptying; Hum | 1997 |
Diabetic gastroparesis. A critical reappraisal of new treatment strategies.
Topics: Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cisapride; Diabetes | 1992 |
[Disorders of gastric emptying].
Topics: Cisapride; Diabetes Complications; Domperidone; Dyspepsia; Gastric Emptying; Gastroesophageal Reflux | 1992 |
Use of metoclopramide, domperidone, and cisapride in the management of diabetic gastroparesis.
Topics: Cisapride; Diabetes Complications; Domperidone; Gastric Emptying; Gastrointestinal Diseases; Humans; | 1990 |
Diagnosis and treatment of delayed gastric emptying.
Topics: Anemia, Pernicious; Anorexia Nervosa; Cisapride; Connective Tissue Diseases; Diabetes Complications; | 1988 |
[Treatment of gastroparesis by primperan].
Topics: Diabetes Complications; Gastric Emptying; Gastrointestinal Motility; Humans; Metoclopramide; Stomach | 1985 |
7 trials available for metoclopramide and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet.
Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antiem | 2014 |
Metoclopramide Nasal Spray Reduces Symptoms of Gastroparesis in Women, but not Men, With Diabetes: Results of a Phase 2B Randomized Study.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Antiemetics; Diabetes Complications; Double-Bli | 2015 |
Metoclopramide to treat gastroparesis due to diabetes mellitus: a double-blind, controlled trial.
Topics: Adult; Diabetes Complications; Double-Blind Method; Drug Evaluation; Gastric Emptying; Humans; Metoc | 1982 |
Gastric motor abnormalities in diabetic and postvagotomy gastroparesis: effect of metoclopramide and bethanechol.
Topics: Adult; Bethanechol Compounds; Diabetes Complications; Female; Gastrectomy; Gastric Emptying; Gastroe | 1980 |
Metoclopramide therapy in fifty-five patients with delayed gastric emptying.
Topics: Adolescent; Adult; Aged; Diabetes Complications; Drainage; Female; Gastric Emptying; Humans; Male; M | 1980 |
Domperidone versus metoclopramide in the treatment of diabetic gastroparesis.
Topics: Adult; Aged; Diabetes Complications; Domperidone; Double-Blind Method; Female; Gastric Emptying; Gas | 2000 |
Diabetic gastroparesis. A critical reappraisal of new treatment strategies.
Topics: Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cisapride; Diabetes | 1992 |
23 other studies available for metoclopramide and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Controversies in Gastroparesis: Discussing the Sticky Points.
Topics: Abdominal Pain; Antiemetics; Chronic Disease; Diabetes Complications; Diagnosis, Differential; Diagn | 2021 |
Is metoclopramide nasal spray an acceptable alternative to its oral form?
Topics: Antiemetics; Diabetes Complications; Female; Gastroparesis; Humans; Male; Metoclopramide | 2014 |
Response to Dr. Lankarani.
Topics: Antiemetics; Diabetes Complications; Female; Gastroparesis; Humans; Male; Metoclopramide; Nasal Spra | 2014 |
Gastroparesis: what you should know.
Topics: Antiemetics; Diabetes Complications; Diet; Gastroparesis; Humans; Metoclopramide | 2008 |
Warnings on metoclopramide treatment.
Topics: Antiemetics; Diabetes Complications; Dopamine Antagonists; Gastroparesis; Metoclopramide | 2009 |
Diabetic gastroparesis.
Topics: Adult; Antiemetics; Diabetes Complications; Diet; Domperidone; Dopamine Agonists; Erythromycin; Fema | 2005 |
Diabetic gastroparesis.
Topics: Diabetes Complications; Dopamine Antagonists; Dyskinesia, Drug-Induced; Gastroparesis; Humans; Metoc | 2007 |
Acute hemodynamic and humoral effects of metoclopramide on blood pressure control improvement in subjects with diabetic orthostatic hypotension.
Topics: Adult; Aged; Aldosterone; Blood Glucose; Blood Pressure; Cardiac Output; Diabetes Complications; Dia | 1984 |
Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus.
Topics: Adult; Amenorrhea; Diabetes Complications; Diabetes Mellitus; Female; Follicle Stimulating Hormone; | 1983 |
Prescribing of oral metoclopramide for nonapproved indications.
Topics: Diabetes Complications; Drug Prescriptions; Humans; Metoclopramide; Stomach Diseases; United States; | 1984 |
Metoclopramide alone or combined with flurbiprofen in the treatment of orthostatic hypotension associated with diabetes mellitus.
Topics: Catecholamines; Diabetes Complications; Female; Flurbiprofen; Humans; Hypotension, Orthostatic; Male | 1982 |
Management of gastric outlet obstruction.
Topics: Diabetes Complications; Gastric Emptying; Gastrointestinal Motility; Humans; Metoclopramide; Stomach | 1982 |
Biologic gastric emptying time in diabetic patients, using Tc-99m-labeled resin-oatmeal with and without metoclopramide.
Topics: Administration, Oral; Adult; Diabetes Complications; Diabetes Mellitus; Female; Gastric Emptying; Hu | 1980 |
[Diabetic gastroparesis].
Topics: Diabetes Complications; Fasting; Gastric Lavage; Humans; Male; Metoclopramide; Middle Aged; Paralysi | 1980 |
The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders.
Topics: Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Basal Ganglia Diseases; Diabetes Complicati | 1993 |
Tardive dyskinesia and diabetes mellitus.
Topics: Adult; Aged; Antipsychotic Agents; Diabetes Complications; Dyskinesia, Drug-Induced; Female; Humans; | 1992 |
Pharmacokinetics of intraperitoneal metoclopramide in a patient with renal failure.
Topics: Administration, Oral; Adult; Diabetes Complications; Humans; Infusions, Parenteral; Injections, Intr | 1992 |
[Diabetic gastropathy].
Topics: Diabetes Complications; Domperidone; Gastric Emptying; Gastrointestinal Motility; Humans; Insulin; M | 1991 |
The lack of effect of metoclopramide on gallbladder volume and contraction in diabetic cholecystoparesis.
Topics: Adult; Diabetes Complications; Female; Gallbladder; Gallbladder Diseases; Humans; Male; Metocloprami | 1986 |
Bioavailability and disposition of metoclopramide after single- and multiple-dose administration in diabetic patients with gastroparesis.
Topics: Adult; Biological Availability; Diabetes Complications; Diabetes Mellitus; Female; Gastric Emptying; | 1987 |
Motilin and diabetic gastroparesis: effect of MTC.
Topics: Diabetes Complications; Diabetes Mellitus; Gastrointestinal Motility; Humans; Metoclopramide; Motili | 1986 |
Diabetes mellitus: gastrointestinal complications.
Topics: Blood Glucose; Cholecystitis; Cholelithiasis; Diabetes Complications; Diabetic Neuropathies; Esophag | 1986 |
Letter: Metoclopramide for gastroparesis diabeticorum.
Topics: Adult; Diabetes Complications; Female; Gastrointestinal Motility; Humans; Metoclopramide; Stomach Di | 1974 |