Page last updated: 2024-10-31

metoclopramide and Complications, Hematologic Pregnancy

metoclopramide has been researched along with Complications, Hematologic Pregnancy in 1 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abkowitz, JL1
Schaison, G1
Boulad, F1
Brown, DL1
Buchanan, GR1
Johnson, CA1
Murray, JC1
Sabo, KM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase I/II, Open-Label Study to Determine Safety and Efficacy of Sotatercept (ACE-011) in Adults With Red Blood Cell Transfusion- Dependent Diamond Blackfan Anemia[NCT01464164]Phase 1/Phase 219 participants (Actual)Interventional2012-01-31Terminated (stopped due to Supporter terminated the study due to no active patients (secondary to travel restrictions due to COVID).)
The Use of Novel Therapies to Reconstitute Blood Cell Production and Promote Organ Performance Using Bone Marrow Failure as a Model: a Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackf[NCT01362595]Phase 1/Phase 255 participants (Actual)Interventional2013-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Complete Response and Partial Response

Complete response is transfusion independence with hemoglobin >9 gm/dl; partial response is transfusion dependence with hemoglobin < 9gm/dl with an increase in reticulocyte count over baseline (NCT01464164)
Timeframe: 9 months

InterventionParticipants (Count of Participants)
Sotatercept Cohort 10
Sotatercept Cohort 20
Sotatercept Cohort 30
Sotatercept With Prednisone Boost Cohort 4a0
Sotatercept Cohort 4b0
Sotatercept With Prednisone Boost Cohort 5a0
Sotatercept Cohort 5b0

Severe Adverse Events Attributable to Study Drug

Assess severity of adverse events and relationship to sotatercept according to the currently active minor version of the NCI Common Terminology for Adverse Events version 4.0 (NCT01464164)
Timeframe: 9 months

InterventionParticipants (Count of Participants)
Sotatercept Cohort 10
Sotatercept Cohort 20
Sotatercept Cohort 30
Sotatercept With Prednisone Boost Cohort 4a0
Sotatercept Cohort 4b0
Sotatercept With Prednisone Boost Cohort 5a0
Sotatercept Cohort 5b0

Response to Leucine in Transfusion Dependent Patients With Diamond Blackfan Anemia

"The primary outcome is the type of response observed at 9 months. Response to treatment can be one of the following:~Complete response (CR): Hb > 9 gm/dL and transfusion-independence as defined in DBA~Partial response (PR): Hb < 9 gm/dL and increased reticulocyte count to greater than baseline.~No response (NR): no change in transfusion requirements and no significant change reticulocyte count from baseline~Progression: worsening of disease as defined by the need for more frequent transfusions" (NCT01362595)
Timeframe: 9 Months

InterventionParticipants (Count of Participants)
Complete Hematologic ResponsePartial hematologic responseNo hematologic responseProgression
Leucine25360

Trials

1 trial available for metoclopramide and Complications, Hematologic Pregnancy

ArticleYear
Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis.
    Blood, 2002, Oct-15, Volume: 100, Issue:8

    Topics: Anemia, Diamond-Blackfan; Erythropoiesis; Female; Humans; Metoclopramide; Middle Aged; Pilot Project

2002
Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis.
    Blood, 2002, Oct-15, Volume: 100, Issue:8

    Topics: Anemia, Diamond-Blackfan; Erythropoiesis; Female; Humans; Metoclopramide; Middle Aged; Pilot Project

2002
Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis.
    Blood, 2002, Oct-15, Volume: 100, Issue:8

    Topics: Anemia, Diamond-Blackfan; Erythropoiesis; Female; Humans; Metoclopramide; Middle Aged; Pilot Project

2002
Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis.
    Blood, 2002, Oct-15, Volume: 100, Issue:8

    Topics: Anemia, Diamond-Blackfan; Erythropoiesis; Female; Humans; Metoclopramide; Middle Aged; Pilot Project

2002