metoclopramide and Complication, Intraoperative studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research Excerpts

Excerpt	Relevance	Reference
"In a randomized, double-blind study, we compared the efficacy of metoclopramide hydrochloride with that of low-dose droperidol for prevention of nausea and vomiting during and after elective cesarean section with epidural anesthesia."	9.06	Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section. ( Bates, JN; Chestnut, DH; Choi, WW; Geiger, M; Ostman, PL; Owen, CL, 1989)
"Metoclopramide is a prokinetic agent reported to be safe in parturients."	6.48	Metoclopramide for nausea and vomiting prophylaxis during and after Caesarean delivery: a systematic review and meta-analysis. ( Habib, AS; Mishriky, BM, 2012)
"To estimate whether the addition of metoclopramide or its combination with ondansetron to a prophylactic phenylephrine infusion provides improved intraoperative nausea and vomiting prophylaxis compared with phenylephrine infusion alone."	5.17	Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. ( Allen, TK; George, RB; Habib, AS; Ituk, US; McKeen, DM; Megalla, SA; White, WD, 2013)
"In a randomized, double-blind study, we compared the efficacy of metoclopramide hydrochloride with that of low-dose droperidol for prevention of nausea and vomiting during and after elective cesarean section with epidural anesthesia."	5.06	Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section. ( Bates, JN; Chestnut, DH; Choi, WW; Geiger, M; Ostman, PL; Owen, CL, 1989)
"The effect of metoclopramide premedication on the incidence of gastric regurgitation and postoperative nausea and vomiting was studied in 101 women during gynaecological procedures performed under mask anaesthesia."	3.67	Silent regurgitation in day case gynaecological patients. ( Anderson, WG; Miller, CD, 1988)
"Metoclopramide is a prokinetic agent reported to be safe in parturients."	2.48	Metoclopramide for nausea and vomiting prophylaxis during and after Caesarean delivery: a systematic review and meta-analysis. ( Habib, AS; Mishriky, BM, 2012)

Research

Studies (13)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Discharge on Postoperative Day #2

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (46.15)	18.7374
1990's	2 (15.38)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (38.46)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Habib, AS	3
George, RB	1
McKeen, DM	1
White, WD	1
Ituk, US	1
Megalla, SA	1
Allen, TK	1
Voigt, M	1
Fröhlich, CW	1
Hüttel, C	1
Kranke, P	1
Mennen, J	1
Boessneck, O	1
Lenz, C	1
Erbes, T	1
Ernst, J	1
Kerger, H	1
Xeridat, F	1
Vidal, V	1
Puech, JB	1
Gariboldi, V	1
Kerbaul, F	1
Mishriky, BM	2
Spelina, KR	1
Gerber, HR	1
Pagels, IL	1
Hughes, RL	1
Kafle, SK	1
Stein, DJ	1
Birnbach, DJ	1
Danzer, BI	1
Kuroda, MM	1
Grunebaum, A	1
Thys, DM	1
Chestnut, DH	1
Owen, CL	1
Geiger, M	1
Bates, JN	1
Choi, WW	1
Ostman, PL	1
Miller, CD	1
Anderson, WG	1
Adelhøj, B	1
Petring, OU	1
Manchikanti, L	1
Grow, JB	1
Colliver, JA	1
Hadley, CH	1
Hohlbein, LJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Enhanced Recovery at Cesarean Birth to Improve Postoperative Outcomes and Reduce Postoperative Length of Stay[NCT02956616]	Phase 2	118 participants (Actual)	Interventional	2017-09-01	Completed
The Effect of Adding Metoclopramide and Ondansetron to a Prophylactic Phenylephrine Infusion for the Management of Nausea and Vomiting Associated With Spinal Anesthesia for Cesarean Section[NCT01216410]		306 participants (Actual)	Interventional	2008-12-31	Completed
The Effect of Antibiotic Prophylaxis Timing on Intraoperative Nausea and Vomiting in Patients Undergoing Cesarean Section Under Regional Anesthesia.[NCT04697277]	Phase 4	120 participants (Anticipated)	Interventional	2015-08-20	Recruiting
Comparison of Gastric Volumes by Gastric Ultrasound in Term Parturients Undergoing Scheduled Elective Cesarean Delivery With and Without Metoclopramide[NCT05033041]	Phase 4	72 participants (Anticipated)	Interventional	2021-10-20	Recruiting
Is Intra-operative Acupuncture Point P6 Stimulation as Effective as Traditional Pharmacotherapy in Reducing Nausea and Vomiting During Cesarean Section With Regional Anesthesia?[NCT02959840]	Phase 4	180 participants (Actual)	Interventional	2015-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of patients discharged on postoperative Day #2 (NCT02956616)
Timeframe: Until patient's day of hospital discharge or a maximum of one month from cesarean delivery

Postoperative Length of Hospital Stay

Intervention	Participants (Count of Participants)
Enhanced Recovery	5
Routine Perioperative Care	2

Postoperative Length of Hospital Stay in Hours from time of surgery (NCT02956616)
Timeframe: Until patient's day of hospital discharge or a maximum of one month from cesarean delivery

Postoperative Pain Medication Requirement

Intervention	Hours (Median)
Enhanced Recovery	73.58
Routine Perioperative Care	75.50

The amount of postoperative pain medication required for each patient in Morphine Milligram Equivalents (NCT02956616)
Timeframe: Until patient's day of hospital discharge or a maximum of one month from cesarean delivery

Breastfeeding Initiation

Intervention	Morphine Milligram Equivalents (Mean)
Enhanced Recovery	117.16
Routine Perioperative Care	119.38

All patients will be queried regarding whether breastfeeding was initiated after cesarean birth and how soon after birth (NCT02956616)
Timeframe: Until patient's day of hospital discharge or a maximum of one month from cesarean delivery

Intraoperative Nausea and Vomiting

Intervention	Participants (Count of Participants)
	Breastfeeding	Bottlefeeding	Both Breastfeeding and Bottlefeeding
Enhanced Recovery	39	4	15
Routine Perioperative Care	29	2	29

Comparison of intraoperative nausea and vomiting between the 3 groups. (NCT01216410)
Timeframe: Intraoperatively

Maternal Hemodynamics

Intervention	participants (Number)
Combination Group	23
Metoclopramide	31
Phenylephrine Infusion	49

The number of patients with systolic blood pressure decrease to less than 20 % of baseline intraoperatively (NCT01216410)
Timeframe: Intraoperatively

Pruritus

Satisfaction

Intervention	participants with SBP< 20 % baseline (Number)
Combination Group	16
Metoclopramide	19
Phenylephrine Infusion	16

Intervention	participants (Number)
Combination Group	95
Metoclopramide	93
Phenylephrine Infusion	97

1=very satisfied, 2=somewhat satisfied, 3= neither satisfied nor dissatisfied, 4=somewhat dissatisfied, 5= very dissatisfied. Number of very satisfied subjects posted. (NCT01216410)
Timeframe: 24 h

Postoperative Nausea and Vomiting (PONV)

Nausea

Intervention	participants (Number)
Combination Group	94
Metoclopramide	85
Phenylephrine Infusion	87

Intervention	participants (Number)
	0-2 hrs PONV	2-6 hrs PONV	6-24 hrs PONV
Combination Group	20	28	22
Metoclopramide	33	35	26
Phenylephrine Infusion	39	41	22

The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea at any point during the surgical procedure in each group. (NCT02959840)
Timeframe: During the surgical procedure

Nausea During Stage I (After the Administration of CSE and Until Eversion of the Uterus)

Intervention	Participants (Count of Participants)
Control	44
Metoclopramide, Ondansetron	14
Acupressure Point P6 Stimulator	22

Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) during stage I. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02959840)
Timeframe: During the surgical procedure

Nausea During Stage II (After Eversion of the Uterus and Until Replacement of the Uterus)

Intervention	Participants (Count of Participants)
Control	33
Metoclopramide, Ondansetron	7
Acupressure Point P6 Stimulator	14

Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) during stage II. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02959840)
Timeframe: During the surgical procedure

Nausea During Stage III (After Replacement of the Uterus and to the Next 15 Minutes)

Intervention	Participants (Count of Participants)
Control	12
Metoclopramide, Ondansetron	6
Acupressure Point P6 Stimulator	5

Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) during stage III. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02959840)
Timeframe: During the surgical procedure

Nausea During Stage IV (the Rest of the Time Until Arrival at PACU)

Intervention	Participants (Count of Participants)
Control	16
Metoclopramide, Ondansetron	8
Acupressure Point P6 Stimulator	14

Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) during stage IV. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02959840)
Timeframe: During the surgical procedure

Overall Anesthetic Care Satisfaction

Intervention	Participants (Count of Participants)
Control	3
Metoclopramide, Ondansetron	4
Acupressure Point P6 Stimulator	0

Patients are asked their overall anesthetic care satisfaction (0 = Not Satisfied, 10 = Extremely Satisfied). Data are expressed as number of parturients who gave a score of 8 or higher. (NCT02959840)
Timeframe: During the surgical procedure

Satisfaction of Anti-emetic Treatment

Intervention	Participants (Count of Participants)
Control	53
Metoclopramide, Ondansetron	58
Acupressure Point P6 Stimulator	56

Patients are asked their anti-emetic treatment satisfaction (0 = Not Satisfied, 10 = Extremely Satisfied). Data are expressed as number of parturients who gave a score of 8 or higher. (NCT02959840)
Timeframe: During the surgical procedure

Vomiting

Intervention	Participants (Count of Participants)
Control	49
Metoclopramide, Ondansetron	58
Acupressure Point P6 Stimulator	55

The investigators will perform objective assessments of whether or not the patients have vomited during the procedure. The investigators will then analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02959840)
Timeframe: During the surgical procedure

Vomiting During Stage I (After the Administration of CSE and Until Eversion of the Uterus)

Intervention	Participants (Count of Participants)
Control	27
Metoclopramide, Ondansetron	10
Acupressure Point P6 Stimulator	8

The investigators will perform objective assessments of whether or not the patients have vomited during stage I. The investigators will then analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02959840)
Timeframe: During the surgical procedure

Vomiting During Stage II (After Eversion of the Uterus and Until Replacement of the Uterus)

Intervention	Participants (Count of Participants)
Control	20
Metoclopramide, Ondansetron	5
Acupressure Point P6 Stimulator	4

The investigators will perform objective assessments of whether or not the patients have vomited during stage II. The investigators will then analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02959840)
Timeframe: During the surgical procedure

Vomiting During Stage III (After Replacement of the Uterus and to the Next 15 Minutes)

Intervention	Participants (Count of Participants)
Control	10
Metoclopramide, Ondansetron	1
Acupressure Point P6 Stimulator	3

The investigators will perform objective assessments of whether or not the patients have vomited during stage III. The investigators will then analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02959840)
Timeframe: During the surgical procedure

Vomiting During Stage IV (the Rest of the Time Until Arrival at PACU)

Intervention	Participants (Count of Participants)
Control	9
Metoclopramide, Ondansetron	4
Acupressure Point P6 Stimulator	6

The investigators will perform objective assessments of whether or not the patients have vomited during stage IV. The investigators will then analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02959840)
Timeframe: During the surgical procedure

Article	Year
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstetrics and gynecology, 2013, Volume: 121, Issue:3 Topics: Adult; Anesthesia, Spinal; Antiemetics; Cardiotonic Agents; Cesarean Section; Drug Therapy, Combinat	2013
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstetrics and gynecology, 2013, Volume: 121, Issue:3 Topics: Adult; Anesthesia, Spinal; Antiemetics; Cardiotonic Agents; Cesarean Section; Drug Therapy, Combinat	2013
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstetrics and gynecology, 2013, Volume: 121, Issue:3 Topics: Adult; Anesthesia, Spinal; Antiemetics; Cardiotonic Agents; Cesarean Section; Drug Therapy, Combinat	2013
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstetrics and gynecology, 2013, Volume: 121, Issue:3 Topics: Adult; Anesthesia, Spinal; Antiemetics; Cardiotonic Agents; Cesarean Section; Drug Therapy, Combinat	2013
Prophylaxis of intra- and postoperative nausea and vomiting in patients during cesarean section in spinal anesthesia. Medical science monitor : international medical journal of experimental and clinical research, 2013, Nov-14, Volume: 19 Topics: Anesthesia, Spinal; Antiemetics; Cesarean Section; Dexamethasone; Dimenhydrinate; Female; Humans; In	2013
Nausea and vomiting during spinal anaesthesia. Effect of metoclopramide and domperidone: a double-blind trial. Anaesthesia, 1984, Volume: 39, Issue:2 Topics: Aged; Anesthesia, Spinal; Blood Pressure; Clinical Trials as Topic; Domperidone; Double-Blind Method	1984
Intrathecal meperidine for elective caesarean section: a comparison with lidocaine. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:8 Topics: Adult; Analgesia, Obstetrical; Anesthesia, Epidural; Apgar Score; Cesarean Section; Female; Humans;	1993
Acupressure versus intravenous metoclopramide to prevent nausea and vomiting during spinal anesthesia for cesarean section. Anesthesia and analgesia, 1997, Volume: 84, Issue:2 Topics: Acupressure; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Doub	1997
Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section. Southern medical journal, 1989, Volume: 82, Issue:10 Topics: Adult; Akathisia, Drug-Induced; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Dou	1989

Article	Year
[A rare cause of cardiogenic shock treated by extracorporeal life support: catecholamine secreting paraganglioma]. Annales francaises d'anesthesie et de reanimation, 2011, Volume: 30, Issue:4 Topics: Adolescent; Adrenal Gland Neoplasms; Assisted Circulation; Catecholamines; Dopamine Antagonists; Ele	2011
Impact of data by Fujii and colleagues on the meta-analysis of metoclopramide for antiemetic prophylaxis in women undergoing Caesarean delivery under neuraxial anaesthesia. British journal of anaesthesia, 2012, Volume: 109, Issue:5 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Female; Humans; Intraope	2012
Hypotension and dysrhythmia following intravenous metoclopramide. Anaesthesia, 1984, Volume: 39, Issue:7 Topics: Adult; Arrhythmias, Cardiac; Female; Humans; Hypotension; Intraoperative Complications; Metocloprami	1984
Silent regurgitation in day case gynaecological patients. Anaesthesia, 1988, Volume: 43, Issue:4 Topics: Adult; Ambulatory Surgical Procedures; Female; Gastroesophageal Reflux; Genital Diseases, Female; Hu	1988
[Anesthesia and metoclopramide]. Ugeskrift for laeger, 1986, Jul-28, Volume: 148, Issue:31 Topics: Anesthesia; Humans; Intraoperative Complications; Metoclopramide; Postoperative Complications; Preme	1986
Bicitra (sodium citrate) and metoclopramide in outpatient anesthesia for prophylaxis against aspiration pneumonitis. Anesthesiology, 1985, Volume: 63, Issue:4 Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Antacids; Cimetidine; Citrates; Citric Acid; Fema	1985

metoclopramide and Complication, Intraoperative