Page last updated: 2024-10-31

metoclopramide and Bradycardia

metoclopramide has been researched along with Bradycardia in 12 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.

Research Excerpts

ExcerptRelevanceReference
" We diagnosed an esophageal hamartoma in an infant girl who had first presented when she was 8 days old with symptoms of apnea and cyanosis."7.76Esophageal hamartoma as an unusual cause of neonatal apnea and bradycardia. ( Coury, J; Steinfeld, J; Zwillenberg, D; Zwillenberg, S, 2010)
"A central dopaminergic origin has been demonstrated for the bromocriptine-induced tachycardia in conscious, normotensive rats."7.71Central bromocriptine-induced tachycardia is reversed to bradycardia in conscious, deoxycorticosterone acetate-salt hypertensive rats. ( Lahlou, S, 2001)
"Crizotinib is an orally active multi-target tyrosine kinase inhibitor which is the standard of care in patients with anaplastic lymphoma kinase translocated non-small-cell lung cancer."5.42When crizotinib-induced bradycardia becomes symptomatic: role of concomitant drugs. ( Aieta, M; Gallucci, G; Lombardi, L; Tartarone, A, 2015)
" Theophylline was administered due to postoperative bradycardia."3.80Seizures after heart transplantation--two cases of non-immunosuppressant drug interactions in young patients. ( Baszyńska-Wachowiak, H; Buczkowski, P; Jemielity, M; Pawłowska, M; Perek, B; Straburzyńska-Migaj, E; Urbanowicz, T, 2014)
" We diagnosed an esophageal hamartoma in an infant girl who had first presented when she was 8 days old with symptoms of apnea and cyanosis."3.76Esophageal hamartoma as an unusual cause of neonatal apnea and bradycardia. ( Coury, J; Steinfeld, J; Zwillenberg, D; Zwillenberg, S, 2010)
"A central dopaminergic origin has been demonstrated for the bromocriptine-induced tachycardia in conscious, normotensive rats."3.71Central bromocriptine-induced tachycardia is reversed to bradycardia in conscious, deoxycorticosterone acetate-salt hypertensive rats. ( Lahlou, S, 2001)
"Crizotinib is an orally active multi-target tyrosine kinase inhibitor which is the standard of care in patients with anaplastic lymphoma kinase translocated non-small-cell lung cancer."1.42When crizotinib-induced bradycardia becomes symptomatic: role of concomitant drugs. ( Aieta, M; Gallucci, G; Lombardi, L; Tartarone, A, 2015)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's2 (16.67)18.2507
2000's4 (33.33)29.6817
2010's5 (41.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ritchie, HE1
Huss, IB1
Webster, WS1
Urbanowicz, T1
Pawłowska, M1
Buczkowski, P1
Perek, B1
Baszyńska-Wachowiak, H1
Straburzyńska-Migaj, E1
Jemielity, M1
Gallucci, G1
Tartarone, A1
Lombardi, L1
Aieta, M1
Wheatley, E1
Kennedy, KA1
Clark, RH1
Spitzer, AR1
Coury, J1
Steinfeld, J1
Zwillenberg, D1
Zwillenberg, S1
Schwartz, BG1
Midttun, M1
Oberg, B1
Lahlou, S2
Misis Del Campo, M1
Garro Martínez, P1
Mesalles Sanjuán, E1
Gener Reixac, J1
Withington, DE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Cross-over Trial of Medical Treatment for GERD in Preterm Infants[NCT00131248]Phase 318 participants (Actual)Interventional2004-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Bradycardia Episodes/Day

(NCT00131248)
Timeframe: 7 days

Interventionepisodes per day (Mean)
Medications4.6
Placebo3.6

Trials

1 trial available for metoclopramide and Bradycardia

ArticleYear
Cross-over trial of treatment for bradycardia attributed to gastroesophageal reflux in preterm infants.
    The Journal of pediatrics, 2009, Volume: 155, Issue:4

    Topics: Anti-Ulcer Agents; Bradycardia; Cross-Over Studies; Female; Gastroesophageal Reflux; Humans; Infant,

2009

Other Studies

11 other studies available for metoclopramide and Bradycardia

ArticleYear
The effect of anti-emetic drugs on rat embryonic heart activity.
    Reproductive toxicology (Elmsford, N.Y.), 2019, Volume: 87

    Topics: Animals; Antiemetics; Bradycardia; Domperidone; Droperidol; Embryo, Mammalian; Granisetron; Heart; H

2019
Seizures after heart transplantation--two cases of non-immunosuppressant drug interactions in young patients.
    Annals of transplantation, 2014, Aug-22, Volume: 19

    Topics: Adult; Antiemetics; Bradycardia; Brain; Dopamine D2 Receptor Antagonists; Drug Interactions; Epileps

2014
When crizotinib-induced bradycardia becomes symptomatic: role of concomitant drugs.
    Expert review of anticancer therapy, 2015, Volume: 15, Issue:7

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Combined Chemotherapy Protocols; Bradycardia;

2015
Patience is a virtue in the management of gastroesophageal reflux.
    The Journal of pediatrics, 2009, Volume: 155, Issue:4

    Topics: Bradycardia; Dopamine Antagonists; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans; Infant

2009
Esophageal hamartoma as an unusual cause of neonatal apnea and bradycardia.
    Ear, nose, & throat journal, 2010, Volume: 89, Issue:3

    Topics: Anti-Ulcer Agents; Apnea; Bradycardia; Esophageal Diseases; Female; Gastroesophageal Reflux; Hamarto

2010
Metoclopramide and digoxin cause 22 episodes of bradyarrhythmias.
    The American journal of medicine, 2010, Volume: 123, Issue:6

    Topics: Atrial Fibrillation; Bradycardia; Burns; Digoxin; Electrocardiography; Follow-Up Studies; Heart Rate

2010
Total heart block after intravenous metoclopramide.
    Lancet (London, England), 1994, Jan-15, Volume: 343, Issue:8890

    Topics: Aged; Bradycardia; Heart Block; Humans; Male; Metoclopramide; Middle Aged

1994
Involvement of spinal dopamine receptors in mediation of the hypotensive and bradycardic effects of systemic quinpirole in anaesthetised rats.
    European journal of pharmacology, 1998, Jul-24, Volume: 353, Issue:2-3

    Topics: Animals; Bradycardia; Domperidone; Dopamine Agonists; Dose-Response Relationship, Drug; Hypotension;

1998
Central bromocriptine-induced tachycardia is reversed to bradycardia in conscious, deoxycorticosterone acetate-salt hypertensive rats.
    Pharmacology & toxicology, 2001, Volume: 88, Issue:5

    Topics: Animals; Aorta, Abdominal; Blood Pressure; Bradycardia; Bromocriptine; Desoxycorticosterone; Domperi

2001
[Sinus arrest after the administration of intravenous metoclopramide].
    Medicina clinica, 2001, Jul-14, Volume: 117, Issue:6

    Topics: Adult; Bradycardia; Dopamine Antagonists; Humans; Male; Metoclopramide

2001
Dysrhythmias following intravenous metoclopramide.
    Intensive care medicine, 1986, Volume: 12, Issue:5

    Topics: Bradycardia; Critical Care; Heart Block; Humans; Male; Metoclopramide; Middle Aged

1986