Compounds > metoclopramide
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metoclopramide and Blood Poisoning

metoclopramide has been researched along with Blood Poisoning in 10 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research Excerpts

ExcerptRelevanceReference
"Metoclopramide is often used in the treatment of postoperative nausea and vomiting, but a literature review failed to find reports on the influence of this drug on the healing of bowel anastomoses in the setting of abdominal sepsis."7.79Effects of metoclopramide on healing of colonic anastomoses in a rat model of abdominal sepsis. ( Carneiro, FP; Ferreira, VM; Marques e Silva, S; Oliveira, PG; Sousa, JB, 2013)
"To evaluate the effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis."7.78Effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis. ( Carneiro, FP; Morais, PH; Oliveira, PG; Silva, NG; Silva, SM; Sousa, JB, 2012)
"To evaluate the effects of metoclopramide on abdominal wall healing in rats in the presence of sepsis."7.77Influence of metoclopramide on abdominal wall healing in rats subjected to colonic anastomosis in the presence of peritoneal sepsis induced. ( Brandão, AM; Carneiro, FP; Marques e Silva, S; Morais, PH; Oliveira, MV; Silva, NG; Sousa, JB, 2011)
"Evaluate the effects of bromopride on abdominal wall healing of rats with induced peritoneal sepsis after segmental colectomy and colonic anastomosis."7.77Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats. ( Brandão, AM; Carneiro, FP; Morais, PH; Oliveira, MV; Silva, NG; Silva, SM; Sousa, JB, 2011)
"Eighty rats were divided into two groups for euthanasia on the 3rd or 7th postoperative day (POD), then into two subgroups for sepsis induction or not, and then into subgroups to receive either metoclopramide or saline solution."3.81Effects of metoclopramide on the expression of metalloproteinases and interleukins in left colonic anastomoses. An experimental study. ( Bocca, AL; Jerônimo, MS; Marques e Silva, S; Silva-Pereira, Id; Sousa, JB; Tavares, AH, 2015)
" To evaluate the effects of bromopride on MMP and cytokine gene expression in left colonic anastomoses in rats with or without induced abdominal sepsis, 80 rats were divided into two groups for euthanasia on the third or seventh postoperative day (POD)."3.80Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study. ( Bocca, AL; Jerônimo, MS; Silva, SM; Silva-Pereira, I; Sousa, JB, 2014)
"Metoclopramide is often used in the treatment of postoperative nausea and vomiting, but a literature review failed to find reports on the influence of this drug on the healing of bowel anastomoses in the setting of abdominal sepsis."3.79Effects of metoclopramide on healing of colonic anastomoses in a rat model of abdominal sepsis. ( Carneiro, FP; Ferreira, VM; Marques e Silva, S; Oliveira, PG; Sousa, JB, 2013)
"To evaluate the effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis."3.78Effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis. ( Carneiro, FP; Morais, PH; Oliveira, PG; Silva, NG; Silva, SM; Sousa, JB, 2012)
"To evaluate the effects of metoclopramide on abdominal wall healing in rats in the presence of sepsis."3.77Influence of metoclopramide on abdominal wall healing in rats subjected to colonic anastomosis in the presence of peritoneal sepsis induced. ( Brandão, AM; Carneiro, FP; Marques e Silva, S; Morais, PH; Oliveira, MV; Silva, NG; Sousa, JB, 2011)
"Evaluate the effects of bromopride on abdominal wall healing of rats with induced peritoneal sepsis after segmental colectomy and colonic anastomosis."3.77Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats. ( Brandão, AM; Carneiro, FP; Morais, PH; Oliveira, MV; Silva, NG; Silva, SM; Sousa, JB, 2011)
"The pediatric Critical Illness Stress-induced Immune Suppression (CRISIS) trial compared the effectiveness of 2 nutraceutical supplementation strategies and found no difference in the development of nosocomial infection and sepsis in the overall population."2.84Interaction Between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial. ( Anand, KJS; Bell, MJ; Berg, RA; Berger, J; Burr, J; Carcillo, JA; Dalton, H; Dean, JM; Doctor, A; Harrison, R; Heidemann, SM; Holubkov, R; Jenkins, TL; Meert, KL; Newth, CJL; Nicholson, C; Shanley, TP; Tamburro, RF; Webster, A; Willson, DF; Zimmerman, JJ, 2017)
"The National Institutes of Health-appointed CRISIS Data and Safety Monitoring Board was charged with monitoring sample size adequacy and feasibility, safety with respect to adverse events and 28-day mortality, and efficacy with respect to the primary nosocomial infection/sepsis outcome."1.39The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study. ( Anand, KJ; Berger, J; Casper, TC; Dean, JM; Harrison, R; Holubkov, R; Meert, KL; Newth, CJ; Nicholson, C; Willson, DF; Zimmerman, J, 2013)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's0 (0.00)29.6817
2010's9 (90.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Marques e Silva, S3
Carneiro, FP4
Ferreira, VM1
Oliveira, PG2
Sousa, JB6
Silva, SM3
Jerônimo, MS2
Silva-Pereira, I1
Bocca, AL2
Silva-Pereira, Id1
Tavares, AH1
Carcillo, JA2
Dean, JM3
Holubkov, R3
Berger, J3
Meert, KL3
Anand, KJS1
Zimmerman, JJ1
Newth, CJL1
Harrison, R3
Burr, J2
Willson, DF3
Nicholson, C3
Bell, MJ1
Berg, RA1
Shanley, TP1
Heidemann, SM1
Dalton, H1
Jenkins, TL1
Doctor, A1
Webster, A1
Tamburro, RF1
Silva, NG3
Brandão, AM2
Oliveira, MV2
Morais, PH3
Anand, KJ2
Zimmerman, J2
Newth, CJ2
Casper, TC1
Zhu, XH1
Zellweger, R1
Wichmann, MW1
Ayala, A1
Chaudry, IH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161]Phase 3293 participants (Actual)Interventional2007-04-30Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All-cause 28-day Mortality Rate.

(NCT00395161)
Timeframe: 28 days after admission to the PICU

Interventionparticipants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide15
Enteral Whey Protein, IV Saline8

Antibiotic-free Days

(NCT00395161)
Timeframe: 48 hours after admission until PICU discharge

InterventionDays (Median)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide1
Enteral Whey Protein, IV Saline2

Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days)

What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU

Interventionparticipants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide5
Enteral Whey Protein, IV Saline12

Rate of Nosocomial Infection or Clinical Sepsis Per 100 Study Days

(NCT00395161)
Timeframe: 48 hours after PICU admission till discharge from PICU

InterventionMean number of events per 100 study days (Mean)
Daily Nutriceutical Supplementation4.99
Whey Protein4.83

The Primary Endpoint of This Study is the Median Time Between Admission to the PICU and Occurrence of Nosocomial Infection or Clinical Sepsis in PICU Patients Who Have Endotracheal Tubes, Central Venous Catheters, or Urinary Catheters.

(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU

InterventionDays (Median)
Daily Nutriceutical Supplementation12.1
Whey Protein13.2

Trials

2 trials available for metoclopramide and Blood Poisoning

ArticleYear
Interaction Between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial.
    JPEN. Journal of parenteral and enteral nutrition, 2017, Volume: 41, Issue:8

    Topics: Adolescent; Child; Child, Preschool; Critical Illness; Cross Infection; Dietary Supplements; Female;

2017
The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Critical Illness; Cross Infection; Dietary Supplements; Double-

2012

Other Studies

8 other studies available for metoclopramide and Blood Poisoning

ArticleYear
Effects of metoclopramide on healing of colonic anastomoses in a rat model of abdominal sepsis.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2013, Volume: 26, Issue:5

    Topics: Abdominal Wall; Anastomosis, Surgical; Animals; Cecum; Colon; Disease Models, Animal; Hydroxyproline

2013
Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2014, Volume: 47, Issue:10

    Topics: Anastomosis, Surgical; Animals; Antiemetics; Cecum; Colon, Descending; Gene Expression; Interferon-g

2014
Effects of metoclopramide on the expression of metalloproteinases and interleukins in left colonic anastomoses. An experimental study.
    Acta cirurgica brasileira, 2015, Volume: 30, Issue:11

    Topics: Anastomosis, Surgical; Animals; Antiemetics; Colon; Disease Models, Animal; Gene Expression; Interle

2015
Influence of metoclopramide on abdominal wall healing in rats subjected to colonic anastomosis in the presence of peritoneal sepsis induced.
    Acta cirurgica brasileira, 2011, Volume: 26 Suppl 2

    Topics: Abdominal Wall; Anastomosis, Surgical; Animals; Colon; Disease Models, Animal; Dopamine Antagonists;

2011
Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats.
    Acta cirurgica brasileira, 2011, Volume: 26, Issue:6

    Topics: Abdominal Wall; Anastomosis, Surgical; Animals; Antiemetics; Colectomy; Male; Metoclopramide; Perito

2011
Effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis.
    Acta cirurgica brasileira, 2012, Volume: 27, Issue:6

    Topics: Anastomosis, Surgical; Animals; Antiemetics; Collagen; Colon; Drug Evaluation, Preclinical; Hydroxyp

2012
The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013, Volume: 14, Issue:4

    Topics: Adolescent; Biomedical Research; Child; Child, Preschool; Clinical Trials Data Monitoring Committees

2013
Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsis.
    Cytokine, 1997, Volume: 9, Issue:6

    Topics: Animals; Cytokines; Dopamine Antagonists; Gene Expression; Immunity, Cellular; Interleukin-1; Interl

1997