Page last updated: 2024-10-31

metoclopramide and Bacterial Pneumonia

metoclopramide has been researched along with Bacterial Pneumonia in 1 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Yavagal, DR	1
Karnad, DR	1
Oak, JL	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161]			Phase 3	293 participants (Actual)	Interventional	2007-04-30	Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All-cause 28-day Mortality Rate.

(NCT00395161)
Timeframe: 28 days after admission to the PICU

Intervention	participants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	15
Enteral Whey Protein, IV Saline	8

Antibiotic-free Days

(NCT00395161)
Timeframe: 48 hours after admission until PICU discharge

Intervention	Days (Median)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	1
Enteral Whey Protein, IV Saline	2

Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days)

What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU

Intervention	participants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	5
Enteral Whey Protein, IV Saline	12

Rate of Nosocomial Infection or Clinical Sepsis Per 100 Study Days

(NCT00395161)
Timeframe: 48 hours after PICU admission till discharge from PICU

Intervention	Mean number of events per 100 study days (Mean)
Daily Nutriceutical Supplementation	4.99
Whey Protein	4.83

The Primary Endpoint of This Study is the Median Time Between Admission to the PICU and Occurrence of Nosocomial Infection or Clinical Sepsis in PICU Patients Who Have Endotracheal Tubes, Central Venous Catheters, or Urinary Catheters.

(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU

Intervention	Days (Median)
Daily Nutriceutical Supplementation	12.1
Whey Protein	13.2

Trials

1 trial available for metoclopramide and Bacterial Pneumonia

Article	Year
Metoclopramide for preventing pneumonia in critically ill patients receiving enteral tube feeding: a randomized controlled trial. Critical care medicine, 2000, Volume: 28, Issue:5 Topics: Antiemetics; Critical Care; Cross Infection; Dose-Response Relationship, Drug; Drug Administration S	2000