metoclopramide has been researched along with Astrocytoma in 2 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "3-Chloroprocainamide (3-CPA), an analog of metoclopramide (MCA), dose-dependently inhibited tumor growth in scid mice xenografted with a human brain astrocytoma (T24) when given intramuscularly to mice every third day for 14-20 days." | 3.69 | Toxicity, antitumor and chemosensitizing effects of 3-chloroprocainamide. ( Hua, J; Pero, RW, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hua, J | 2 |
| Olsson, AR | 1 |
| Pero, RW | 2 |
2 other studies available for metoclopramide and Astrocytoma
| Article | Year |
|---|---|
Neutral metoclopramide sensitizes cytotoxicity induced by ionizing radiation in SCID mice xenografted with a human brain astrocytoma.
Topics: Animals; Astrocytoma; Blood-Brain Barrier; Body Weight; Brain; Chromatography, High Pressure Liquid; | 1997 |
Toxicity, antitumor and chemosensitizing effects of 3-chloroprocainamide.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Cisplatin; Dose-Response Relationship, | 1997 |