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metoclopramide and Arrhythmia

metoclopramide has been researched along with Arrhythmia in 15 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research Excerpts

ExcerptRelevanceReference
"The results of two large epidemiological studies on the association between domperidone and ventricular arrhythmia or sudden cardiac death were published in 2015; one study was conducted in Taiwan and the other in the United Kingdom."7.83Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia. ( , 2016)
"We aimed to examine the association between cisapride and ventricular arrhythmia, and examine the relationship to dose and CYP3A4 inhibitors."7.74Cisapride and ventricular arrhythmia. ( Bilker, WB; Hennessy, S; Kimmel, SE; Leonard, CE; Newcomb, C, 2008)
" From these publications, it cannot be concluded that domperidone exposure definitely increases the risk of "sudden cardiac death", "death associated with ventricular arrhythmia" or "ventricular arrhythmia" The most concrete result of these studies is that the risk is higher with metoclopramide exposure compared to domperidone exposure."5.01Critical review of European Medicines Agency (EMA) assessment report and related literature on domperidone. ( Tuğlular, I; Yüksel, K, 2019)
"The results of two large epidemiological studies on the association between domperidone and ventricular arrhythmia or sudden cardiac death were published in 2015; one study was conducted in Taiwan and the other in the United Kingdom."3.83Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia. ( , 2016)
"We aimed to examine the association between cisapride and ventricular arrhythmia, and examine the relationship to dose and CYP3A4 inhibitors."3.74Cisapride and ventricular arrhythmia. ( Bilker, WB; Hennessy, S; Kimmel, SE; Leonard, CE; Newcomb, C, 2008)
" In the dog arrhythmias were induced by epinephrine, ouabain and coronary artery ligation."3.65[Anti-arrhythmic effects of derivatives of metoclopramide]. ( Cheymol, G; Mouillé, P, 1975)
"Severe vomiting was present in 34 (89%) and proved to be a serious obstacle to the administration of enteral charcoal."1.28Management of theophylline overdose patients in the intensive care unit. ( Henderson, A; Pond, SM; Wright, DM, 1992)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19907 (46.67)18.7374
1990's2 (13.33)18.2507
2000's4 (26.67)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yüksel, K1
Tuğlular, I1
Hennessy, S2
Leonard, CE2
Palumbo, CM1
Bilker, WB2
Newcomb, C2
Kimmel, SE2
Ellidokuz, E1
Kaya, D1
Sood, JD1
Empson, M1
Fitzharris, P1
Stewart, J1
Hughes, RL1
Somberg, JC1
Bozzi, G1
Terranova, P1
Paolino, C1
Cialfi, A1
Gandini, R1
Bevilacqua, M1
Baguley, WA1
Hay, WT1
Mackie, KP1
Cheney, FW1
Cullen, BF1
Guckenbiehl, W1
Gilfrich, HJ1
Just, H1
Raineri, A1
Hoffmann, E1
Mercadante, G1
Sammartano, S1
Traina, M1
Cheymol, G1
Mouillé, P1
Henderson, A1
Wright, DM1
Pond, SM1
Shaklai, M1
Pinkhas, J1
de Vries, A1

Reviews

1 review available for metoclopramide and Arrhythmia

ArticleYear
Critical review of European Medicines Agency (EMA) assessment report and related literature on domperidone.
    International journal of clinical pharmacy, 2019, Volume: 41, Issue:2

    Topics: Antiemetics; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperidone; Humans; Metoclopramide; Risk

2019

Trials

1 trial available for metoclopramide and Arrhythmia

ArticleYear
The effect of metoclopramide on QT dynamicity: double-blind, placebo-controlled, cross-over study in healthy male volunteers.
    Alimentary pharmacology & therapeutics, 2003, Jul-01, Volume: 18, Issue:1

    Topics: Adult; Arrhythmias, Cardiac; Cross-Over Studies; Dopamine Antagonists; Electrocardiography; Heart Ra

2003

Other Studies

13 other studies available for metoclopramide and Arrhythmia

ArticleYear
Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia.
    Prescrire international, 2016, Volume: 25, Issue:175

    Topics: Antiemetics; Arrhythmias, Cardiac; Clinical Decision-Making; Death, Sudden, Cardiac; Domperidone; Do

2016
Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database.
    Pharmacoepidemiology and drug safety, 2008, Volume: 17, Issue:12

    Topics: Arrhythmias, Cardiac; Cisapride; Cohort Studies; Databases, Factual; Death, Sudden, Cardiac; Domperi

2008
Cisapride and ventricular arrhythmia.
    British journal of clinical pharmacology, 2008, Volume: 66, Issue:3

    Topics: Adult; Aged; Arrhythmias, Cardiac; Case-Control Studies; Cisapride; Cytochrome P-450 CYP3A; Death, S

2008
Too much of a good thing, is it bad? Adrenaline on trial.
    The New Zealand medical journal, 2007, Apr-13, Volume: 120, Issue:1252

    Topics: Acetaminophen; Adult; Angioedema; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Combi

2007
Hypotension and dysrhythmia following intravenous metoclopramide.
    Anaesthesia, 1984, Volume: 39, Issue:7

    Topics: Adult; Arrhythmias, Cardiac; Female; Humans; Hypotension; Intraoperative Complications; Metocloprami

1984
Localization of neurally mediated arrhythmogenic and coronary vasoconstrictor properties of digitalis.
    Federation proceedings, 1984, Volume: 43, Issue:15

    Topics: Animals; Arrhythmias, Cardiac; Biological Transport; Cations, Monovalent; Cats; Cerebral Ventricles;

1984
[Effects of acute administration of metoclopramide on atrial and AV conduction in man].
    Bollettino della Societa italiana di cardiologia, 1981, Volume: 26, Issue:11

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Humans; Male; Metoclopramide; Mid

1981
Cardiac dysrhythmias associated with the intravenous administration of ondansetron and metoclopramide.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:6

    Topics: Adult; Antiemetics; Arrhythmias, Cardiac; Female; Humans; Injections, Intravenous; Male; Metoclopram

1997
[Effect of laxatives and metoclopramide on plasma quinidine concentration during prolonged administration in patients with heart rhythm disorders].
    Die Medizinische Welt, 1976, Jun-25, Volume: 27, Issue:26

    Topics: Adult; Aged; Arrhythmias, Cardiac; Biological Availability; Cathartics; Drug Interactions; Heart; Hu

1976
[Cardiac rhythm disorders and esophageal hiatal hernias].
    Bollettino della Societa italiana di cardiologia, 1976, Volume: 21, Issue:12

    Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Female; Hernia, Diaphragmatic; Hernia, Hiatal; Humans

1976
[Anti-arrhythmic effects of derivatives of metoclopramide].
    Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 215, Issue:1

    Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Epinephrine; Female; Guin

1975
Management of theophylline overdose patients in the intensive care unit.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Absorption; Adolescent; Adult; Arrhythmias, Cardiac; Charcoal; Critical Care; Drug Overdose; Female;

1992
Metoclopramide and cardiac arrhythmia.
    British medical journal, 1974, May-18, Volume: 2, Issue:5915

    Topics: Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Injections, Intramuscular; Metoclopramide

1974