metoclopramide has been researched along with Anemia, Diamond-Blackfan in 4 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Anemia, Diamond-Blackfan: A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metoclopramide induces the release of prolactin from the pituitary and stimulates erythropoiesis." | 1.33 | Successful treatment of Diamond-Blackfan anemia with metoclopramide. ( Akiyama, M; Ariga, M; Eto, Y; Fujisawa, K; Hoshi, Y; Yanagisawa, T; Yokoi, K; Yuza, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abkowitz, JL | 1 |
| Schaison, G | 1 |
| Boulad, F | 1 |
| Brown, DL | 1 |
| Buchanan, GR | 1 |
| Johnson, CA | 1 |
| Murray, JC | 1 |
| Sabo, KM | 1 |
| Akiyama, M | 1 |
| Yanagisawa, T | 1 |
| Yuza, Y | 1 |
| Yokoi, K | 1 |
| Ariga, M | 1 |
| Fujisawa, K | 1 |
| Hoshi, Y | 1 |
| Eto, Y | 1 |
| Leblanc, TM | 1 |
| Da Costa, L | 1 |
| Marie, I | 1 |
| Demolis, P | 1 |
| Tchernia, G | 1 |
| Nawel, G | 1 |
| Fethi, M | 1 |
| Kouki, R | 1 |
| Mohamed, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/II, Open-Label Study to Determine Safety and Efficacy of Sotatercept (ACE-011) in Adults With Red Blood Cell Transfusion- Dependent Diamond Blackfan Anemia[NCT01464164] | Phase 1/Phase 2 | 19 participants (Actual) | Interventional | 2012-01-31 | Terminated (stopped due to Supporter terminated the study due to no active patients (secondary to travel restrictions due to COVID).) | ||
| The Use of Novel Therapies to Reconstitute Blood Cell Production and Promote Organ Performance Using Bone Marrow Failure as a Model: a Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackf[NCT01362595] | Phase 1/Phase 2 | 55 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Complete response is transfusion independence with hemoglobin >9 gm/dl; partial response is transfusion dependence with hemoglobin < 9gm/dl with an increase in reticulocyte count over baseline (NCT01464164)
Timeframe: 9 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Sotatercept Cohort 1 | 0 |
| Sotatercept Cohort 2 | 0 |
| Sotatercept Cohort 3 | 0 |
| Sotatercept With Prednisone Boost Cohort 4a | 0 |
| Sotatercept Cohort 4b | 0 |
| Sotatercept With Prednisone Boost Cohort 5a | 0 |
| Sotatercept Cohort 5b | 0 |
Assess severity of adverse events and relationship to sotatercept according to the currently active minor version of the NCI Common Terminology for Adverse Events version 4.0 (NCT01464164)
Timeframe: 9 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Sotatercept Cohort 1 | 0 |
| Sotatercept Cohort 2 | 0 |
| Sotatercept Cohort 3 | 0 |
| Sotatercept With Prednisone Boost Cohort 4a | 0 |
| Sotatercept Cohort 4b | 0 |
| Sotatercept With Prednisone Boost Cohort 5a | 0 |
| Sotatercept Cohort 5b | 0 |
"The primary outcome is the type of response observed at 9 months. Response to treatment can be one of the following:~Complete response (CR): Hb > 9 gm/dL and transfusion-independence as defined in DBA~Partial response (PR): Hb < 9 gm/dL and increased reticulocyte count to greater than baseline.~No response (NR): no change in transfusion requirements and no significant change reticulocyte count from baseline~Progression: worsening of disease as defined by the need for more frequent transfusions" (NCT01362595)
Timeframe: 9 Months
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Complete Hematologic Response | Partial hematologic response | No hematologic response | Progression | |
| Leucine | 2 | 5 | 36 | 0 |
2 trials available for metoclopramide and Anemia, Diamond-Blackfan
| Article | Year |
|---|---|
Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis.
Topics: Anemia, Diamond-Blackfan; Erythropoiesis; Female; Humans; Metoclopramide; Middle Aged; Pilot Project | 2002 |
Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis.
Topics: Anemia, Diamond-Blackfan; Erythropoiesis; Female; Humans; Metoclopramide; Middle Aged; Pilot Project | 2002 |
Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis.
Topics: Anemia, Diamond-Blackfan; Erythropoiesis; Female; Humans; Metoclopramide; Middle Aged; Pilot Project | 2002 |
Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis.
Topics: Anemia, Diamond-Blackfan; Erythropoiesis; Female; Humans; Metoclopramide; Middle Aged; Pilot Project | 2002 |
Metoclopramide treatment in DBA patients: no complete response in a French prospective study.
Topics: Adolescent; Adult; Anemia, Diamond-Blackfan; Child; Child, Preschool; Female; France; Humans; Male; | 2007 |
Metoclopramide treatment in DBA patients: no complete response in a French prospective study.
Topics: Adolescent; Adult; Anemia, Diamond-Blackfan; Child; Child, Preschool; Female; France; Humans; Male; | 2007 |
Metoclopramide treatment in DBA patients: no complete response in a French prospective study.
Topics: Adolescent; Adult; Anemia, Diamond-Blackfan; Child; Child, Preschool; Female; France; Humans; Male; | 2007 |
Metoclopramide treatment in DBA patients: no complete response in a French prospective study.
Topics: Adolescent; Adult; Anemia, Diamond-Blackfan; Child; Child, Preschool; Female; France; Humans; Male; | 2007 |
2 other studies available for metoclopramide and Anemia, Diamond-Blackfan
| Article | Year |
|---|---|
Successful treatment of Diamond-Blackfan anemia with metoclopramide.
Topics: Adult; Anemia, Diamond-Blackfan; Dopamine Antagonists; Hemoglobins; Humans; Male; Metoclopramide; Pr | 2005 |
Successful treatment of Diamond Blackfan anemia with metoclopramide.
Topics: Anemia, Diamond-Blackfan; Child; Dopamine Antagonists; Hemoglobins; Humans; Male; Metoclopramide; Re | 2007 |