Page last updated: 2024-10-31

metoclopramide and Aging

metoclopramide has been researched along with Aging in 13 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Pain on injection is still a major problem with propofol; metoclopramide effectively decreases this pain."9.12Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006)
"Aging is known to reduce arginine vasopressin (AVP) response to volumetric stimulations and to increase AVP responses to osmotic stimuli and to administration of metoclopramide (MCP)."7.68Abnormal arginine vasopressin response to cigarette smoking and metoclopramide (but not to insulin-induced hypoglycemia) in elderly subjects. ( Bianconi, L; Caiazza, A; Capretti, L; Cavazzini, U; Chiodera, P; Coiro, V; Marchesi, C; Marchesi, M; Volpi, R, 1991)
"Pain on injection is still a major problem with propofol; metoclopramide effectively decreases this pain."5.12Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006)
"To investigate the influence of aging on dopaminergic modulation of pulsatile thyrotropin (TSH) secretion, we examined changes in circulating TSH levels during the day and night, with and without a dopamine antagonist metoclopramide, in healthy young (20-35 yr old) and old (69-83 yr old) subjects, with the use of cluster analysis."3.68Age-related alterations in pulsatile secretion of TSH: role of dopaminergic regulation. ( Elahi, D; Greenspan, SL; Klibanski, A; Rowe, JW, 1991)
"Aging is known to reduce arginine vasopressin (AVP) response to volumetric stimulations and to increase AVP responses to osmotic stimuli and to administration of metoclopramide (MCP)."3.68Abnormal arginine vasopressin response to cigarette smoking and metoclopramide (but not to insulin-induced hypoglycemia) in elderly subjects. ( Bianconi, L; Caiazza, A; Capretti, L; Cavazzini, U; Chiodera, P; Coiro, V; Marchesi, C; Marchesi, M; Volpi, R, 1991)
" Blood and urine were collected for measurement of pharmacokinetic parameters."2.67The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide. ( Bateman, DN; Boddy, A; Cope, LH; Woodhouse, KW; Wynne, HA; Yelland, C, 1993)
"Out-of-hospital sudden cardiac death was assessed by linkage with Hospital Episode Statistics and death certificates."1.42Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study. ( Arana, A; Fife, D; Johannes, CB; McQuay, LJ; Rothman, KJ; Varas-Lorenzo, C, 2015)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19904 (30.77)18.7374
1990's6 (46.15)18.2507
2000's2 (15.38)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arana, A1
Johannes, CB1
McQuay, LJ1
Varas-Lorenzo, C1
Fife, D1
Rothman, KJ1
Madan, R1
Bhatia, A1
Chakithandy, S1
Subramaniam, R1
Rammohan, G1
Deshpande, S1
Singh, M1
Kaul, HL1
Fujii, Y1
Shiga, Y1
Van Arsdalen, KN1
Wein, AJ1
Scanlon, MF1
Chan, V1
Heath, M1
Pourmand, M1
Rodriguez-Arnao, MD1
Weightman, DR1
Lewis, M1
Hall, R1
Wynne, HA1
Yelland, C1
Cope, LH1
Boddy, A1
Woodhouse, KW1
Bateman, DN1
Ramírez, A2
Espinosa de los Monteros, A2
Coria, I1
Hortencia Valencia, Q1
Parra, A2
Alarcón, J1
Gaviño, F1
Greenspan, SL2
Klibanski, A2
Rowe, JW2
Elahi, D2
Chiodera, P1
Capretti, L1
Marchesi, M1
Caiazza, A1
Bianconi, L1
Cavazzini, U1
Marchesi, C1
Volpi, R1
Coiro, V1
Holt, PR1
Mori, M1
Hoshino, Y1
Obara, H1
Iwai, S1

Trials

3 trials available for metoclopramide and Aging

ArticleYear
Prophylactic dexamethasone for postoperative nausea and vomiting in pediatric strabismus surgery: a dose ranging and safety evaluation study.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:6

    Topics: Adolescent; Aging; Anesthesia, General; Antiemetics; Blood Glucose; Child; Child, Preschool; Dexamet

2005
Age-related differences in metoclopramide requirement for pain on injection of propofol.
    Clinical drug investigation, 2006, Volume: 26, Issue:11

    Topics: Adult; Aged; Aging; Double-Blind Method; Female; Humans; Injections; Male; Metoclopramide; Middle Ag

2006
The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide.
    Age and ageing, 1993, Volume: 22, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aging; Female; Frail Elderly; Humans; Infusions, Intravenous; Mal

1993

Other Studies

10 other studies available for metoclopramide and Aging

ArticleYear
Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study.
    Drug safety, 2015, Volume: 38, Issue:12

    Topics: Aging; Antiemetics; Case-Control Studies; Death, Sudden, Cardiac; Domperidone; Dose-Response Relatio

2015
Drug-induced sexual dysfunction in older men.
    Geriatrics, 1984, Volume: 39, Issue:10

    Topics: Aged; Aging; Antihypertensive Agents; Cimetidine; Clofibrate; Estrogens; Female; Humans; Male; Metoc

1984
Dopaminergic control of thyrotropin, alpha-subunit, thyrotropin beta-subunit, and prolactin in euthyroidism and hypothyroidism: dissociated responses to dopamine receptor blockade with metoclopramide in hypothyroid subjects.
    The Journal of clinical endocrinology and metabolism, 1981, Volume: 53, Issue:2

    Topics: Adult; Aged; Aging; Dopamine; Female; Humans; Hypothyroidism; Kinetics; Male; Metoclopramide; Middle

1981
[Serum prolactin during oral metoclopramide in normal nulliparous women].
    Ginecologia y obstetricia de Mexico, 1993, Volume: 61

    Topics: Administration, Oral; Adolescent; Adult; Aging; Analysis of Variance; Female; Humans; Menstrual Cycl

1993
Age-related changes in the metoclopramide-induced prolactin release in nulliparous women.
    Fertility and sterility, 1993, Volume: 60, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Aging; Female; Humans; Metoclopramide; Middle Aged; Parity;

1993
Age-related alterations in pulsatile secretion of TSH: role of dopaminergic regulation.
    The American journal of physiology, 1991, Volume: 260, Issue:3 Pt 1

    Topics: Adult; Aged; Aging; Circadian Rhythm; Cluster Analysis; Dopamine; Humans; Kinetics; Male; Metoclopra

1991
Abnormal arginine vasopressin response to cigarette smoking and metoclopramide (but not to insulin-induced hypoglycemia) in elderly subjects.
    Journal of gerontology, 1991, Volume: 46, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine Vasopressin; Blood Glucose; Humans; Hydrocortisone;

1991
Age alters pulsatile prolactin release: influence of dopaminergic inhibition.
    The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 1

    Topics: Adult; Aged; Aging; Circadian Rhythm; Humans; Male; Metoclopramide; Prolactin; Reference Values

1990
Gastrointestinal drugs in the elderly.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:6

    Topics: Aged; Aging; Aluminum; Antacids; Antidiarrheals; Biological Availability; Digestive System; Drug Int

1986
Maturation-related changes in dopamine-induced relaxation of isolated rabbit pulmonary artery.
    Pediatric research, 1988, Volume: 24, Issue:2

    Topics: Aging; Animals; Dopamine; Dose-Response Relationship, Drug; Female; Flupenthixol; Male; Metocloprami

1988