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metoclopramide and Adverse Drug Event

metoclopramide has been researched along with Adverse Drug Event in 19 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research Excerpts

ExcerptRelevanceReference
" Food and Drug Administration (FDA) placed a black box warning on metoclopramide (MCP) due to the increased risks and prevalence of tardive dyskinesia (TD)."7.85MSBIS: A Multi-Step Biomedical Informatics Screening Approach for Identifying Medications that Mitigate the Risks of Metoclopramide-Induced Tardive Dyskinesia. ( Caylor, ML; Culbertson, VL; Dang, HK; Economen, PJ; Flynn, ST; Ham, AG; Johnson, RW; Tao, A; Tivis, RD; Xu, D, 2017)
" Food and Drug Administration (FDA) placed a black box warning on metoclopramide (MCP) due to the increased risks and prevalence of tardive dyskinesia (TD)."3.85MSBIS: A Multi-Step Biomedical Informatics Screening Approach for Identifying Medications that Mitigate the Risks of Metoclopramide-Induced Tardive Dyskinesia. ( Caylor, ML; Culbertson, VL; Dang, HK; Economen, PJ; Flynn, ST; Ham, AG; Johnson, RW; Tao, A; Tivis, RD; Xu, D, 2017)
"Drug-induced symptoms of functional dyspepsia are rare and do not contribute to the use of cisapride."3.70Drug-induced symptoms of functional dyspepsia and nausea. A symmetry analysis of one million prescriptions. ( Bytzer, P; Hallas, J, 2000)
"As metoclopramide is a dopamine receptor antagonist, it has the potential to cause drug-induced movement disorders, including akathisia, which is characterised by an inner restlessness resulting in a need for constant movement."1.62[Tardive akathisia after long-term metoclopramide treatment]. ( Andersen, CU; Hjelholt, AJ; Steffensen, C, 2021)
"We conducted a cross-sectional study using the Korea Adverse Event Reporting System database between July 1, 2010, and June 30, 2015."1.51Current Status of Parkinsonism-Related Adverse Events and Associated Drugs in Korea. ( Kim, S; Suh, HS, 2019)
"5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects."1.32Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004)
" At the same time about 1/3 of these serious adverse drug reactions (ADR) was found to have been reported to the ADR-register."1.27Drug utilization and morbidity statistics for the evaluation of drug safety in Sweden. ( Westerholm, B; Wiholm, BE, 1984)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.79)18.7374
1990's1 (5.26)18.2507
2000's5 (26.32)29.6817
2010's8 (42.11)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Matthews, EJ1
Kruhlak, NL1
Weaver, JL1
Benz, RD1
Contrera, JF1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W1
Morgan, RE1
van Staden, CJ1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Afshari, CA1
Hamadeh, HK1
Kirkpatrick, L1
Sogawa, Y1
Cleves, C1
Hjelholt, AJ1
Andersen, CU1
Steffensen, C1
Kim, S1
Suh, HS1
Xu, D1
Ham, AG1
Tivis, RD1
Caylor, ML1
Tao, A1
Flynn, ST1
Economen, PJ1
Dang, HK1
Johnson, RW1
Culbertson, VL1
Svendsen, K1
Wood, M1
Olsson, E1
Nordeng, H1
Pessoa, TL1
Clemente Junior, WS1
Costa, TXD1
Bezerra, PKDV1
Martins, RR1
Kass, JS1
Rose, RV1
Donatelli, NS1
Somes, J1
Hennessy, S1
Leonard, CE1
Palumbo, CM1
Bilker, WB1
Newcomb, C1
Kimmel, SE1
Schwarzberg, MN1
Wiholm, BE1
Westerholm, B1
Rochon, PA1
Gurwitz, JH1
Bytzer, P1
Hallas, J1
Cunha, UV1
Ricci, DA1
McCallum, RW1

Reviews

4 reviews available for metoclopramide and Adverse Drug Event

ArticleYear
Liability and Failure to Warn a Patient.
    Continuum (Minneapolis, Minn.), 2019, Volume: 25, Issue:4

    Topics: Dopamine D2 Receptor Antagonists; Drug-Related Side Effects and Adverse Reactions; Humans; Liability

2019
Beers list: what's NOT on "tap" for the older adult.
    Journal of emergency nursing, 2013, Volume: 39, Issue:5

    Topics: Aged, 80 and over; Antiemetics; Antihypertensive Agents; Arthritis; Chlorpropamide; Confusion; Diabe

2013
Optimising drug treatment for elderly people: the prescribing cascade.
    BMJ (Clinical research ed.), 1997, Oct-25, Volume: 315, Issue:7115

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Benzothiadiazines; Chronic D

1997
Diagnosis and treatment of delayed gastric emptying.
    Advances in internal medicine, 1988, Volume: 33

    Topics: Anemia, Pernicious; Anorexia Nervosa; Cisapride; Connective Tissue Diseases; Diabetes Complications;

1988

Other Studies

15 other studies available for metoclopramide and Adverse Drug Event

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru

2004
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Acute Dystonic Reactions in Children Treated for Headache With Prochlorperazine or Metoclopramide.
    Pediatric neurology, 2020, Volume: 106

    Topics: Adolescent; Child; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactions; Dystonia;

2020
[Tardive akathisia after long-term metoclopramide treatment].
    Ugeskrift for laeger, 2021, 05-24, Volume: 183, Issue:21

    Topics: Akathisia, Drug-Induced; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactions; Huma

2021
Current Status of Parkinsonism-Related Adverse Events and Associated Drugs in Korea.
    Journal of patient safety, 2019, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antiemetics; An

2019
MSBIS: A Multi-Step Biomedical Informatics Screening Approach for Identifying Medications that Mitigate the Risks of Metoclopramide-Induced Tardive Dyskinesia.
    EBioMedicine, 2017, Volume: 26

    Topics: Antipsychotic Agents; Databases, Factual; Drug Interactions; Drug-Related Side Effects and Adverse R

2017
Reported time to onset of neurological adverse drug reactions among different age and gender groups using metoclopramide: an analysis of the global database Vigibase®.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:5

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Antiemetics; Child; Child, Preschool; Da

2018
Drug interactions in maternal intensive care: prevalence, risk factors, and potential risk medications.
    Einstein (Sao Paulo, Brazil), 2019, May-30, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Brazil; Cross-Sectional Studies; Diazepam; Drug Interactions; Drug-Related Side E

2019
Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database.
    Pharmacoepidemiology and drug safety, 2008, Volume: 17, Issue:12

    Topics: Arrhythmias, Cardiac; Cisapride; Cohort Studies; Databases, Factual; Death, Sudden, Cardiac; Domperi

2008
Phaeochromocytoma unmasked by drug therapy.
    Prescrire international, 2003, Volume: 12, Issue:67

    Topics: Adrenal Gland Neoplasms; Adrenergic beta-Antagonists; Antidepressive Agents; Antipsychotic Agents; D

2003
Pro-kinetic medications as aids in imaging the small bowel by video-capsule.
    Medical hypotheses, 2005, Volume: 64, Issue:3

    Topics: Antiemetics; Capsules; Cisapride; Diagnostic Imaging; Diagnostic Uses of Chemicals; Drug-Related Sid

2005
Drug utilization and morbidity statistics for the evaluation of drug safety in Sweden.
    Acta medica Scandinavica. Supplementum, 1984, Volume: 683

    Topics: Acidosis; Aged; Anti-Infective Agents, Urinary; Biguanides; Congenital Abnormalities; Contraceptives

1984
Drug-induced symptoms of functional dyspepsia and nausea. A symmetry analysis of one million prescriptions.
    Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Antiemetics; Cisapride; Databases, Factual; Drug-

2000
Management of orthostatic hypotension in the elderly.
    Geriatrics, 1987, Volume: 42, Issue:9

    Topics: Aged; Cardiac Pacing, Artificial; Clothing; Cyclooxygenase Inhibitors; Dihydroergotamine; Drug-Relat

1987