metoclopramide has been researched along with Acute Pain in 7 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the clinical efficacy of prophylactic metoclopramide in reducing the incidence of nausea and vomiting in emergency department (ED) patients with acute pain who were treated with intravenous tramadol." | 9.69 | The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial. ( Lokeskrawee, T; Patumanond, J; Phinyo, P; Sriwiset, H; Wongyikul, P, 2023) |
| "To examine the clinical efficacy of prophylactic metoclopramide in reducing the incidence of nausea and vomiting in emergency department (ED) patients with acute pain who were treated with intravenous tramadol." | 5.69 | The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial. ( Lokeskrawee, T; Patumanond, J; Phinyo, P; Sriwiset, H; Wongyikul, P, 2023) |
| "The data suggest that the combination of metoclopramide and ketamine synergistically controls acute pain in mice." | 3.78 | Antinociception by metoclopramide, ketamine and their combinations in mice. ( Al-Baggou, BKh; Mohammad, FK; Naser, AS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 5 (71.43) | 2.80 |
| Authors | Studies |
|---|---|
| Chowdhury, SS | 1 |
| Shaw, M | 1 |
| Berezowski, I | 1 |
| Abdelmonem, A | 1 |
| Patel, J | 1 |
| Atif, H | 1 |
| McGhee, J | 1 |
| Sriwiset, H | 1 |
| Lokeskrawee, T | 1 |
| Patumanond, J | 1 |
| Wongyikul, P | 1 |
| Phinyo, P | 1 |
| Rowland, KD | 1 |
| Fuehrer, J | 1 |
| Motov, SM | 1 |
| Vilke, G | 1 |
| Rosenbaum, SB | 1 |
| Quenzer, F | 1 |
| Friedman, BW | 2 |
| Irizarry, E | 2 |
| Cain, D | 1 |
| Caradonna, A | 1 |
| Minen, MT | 1 |
| Solorzano, C | 1 |
| Zias, E | 1 |
| Zybert, D | 1 |
| McGregor, M | 1 |
| Bijur, PE | 1 |
| Gallagher, EJ | 1 |
| Babbush, K | 1 |
| White, D | 1 |
| John Gallagher, E | 1 |
| Mohammad, FK | 1 |
| Al-Baggou, BKh | 1 |
| Naser, AS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Placebo Controlled Trial of IV Metoclopramide for Acute Post-traumatic Headache[NCT03220958] | Phase 3 | 160 participants (Actual) | Interventional | 2017-08-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Improvement in this 0 to 10 verbal rating scale (NCT03220958)
Timeframe: 1 hour after medication administration
| Intervention | units on a scale (Mean) |
|---|---|
| Metoclopramide | 5.2 |
| Placebo | 3.8 |
"Number of days with any headache. Participants report the actual number of days they experienced headache. A day begins when they awake for the beginning of daily activities and ends when they go to sleep after completion of daily activities" (NCT03220958)
Timeframe: 7 days after ED visit
| Intervention | days (Mean) |
|---|---|
| Metoclopramide | 3.3 |
| Placebo | 3.3 |
Achieving a headache intensity of mild or none in the ED without use of rescue medication and maintaining a level of mild or none. Participants rate their headache as none, mild, moderate, or severe (NCT03220958)
Timeframe: 48 hours after medication administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Metoclopramide | 24 |
| Placebo | 18 |
1 review available for metoclopramide and Acute Pain
| Article | Year |
|---|---|
Should Antiemetics be Given Prophylactically with Intravenous Opioids While Treating Acute Pain in the Emergency Department?: Clinical Practice Paper Approved by American Academy of Emergency Medicine Clinical Guidelines Committee.
Topics: Acute Pain; Analgesics, Opioid; Antiemetics; Emergency Medicine; Emergency Service, Hospital; Humans | 2020 |
4 trials available for metoclopramide and Acute Pain
| Article | Year |
|---|---|
IV metoclopramide Vs IV ketorolac in the treatment of acute primary headaches: A randomized clinical trial.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Headache; Humans; Ketorola | 2022 |
The efficacy of prophylactic metoclopramide in preventing nausea and vomiting in patients with acute pain treated with intravenous tramadol: a randomized double-blinded, placebo-controlled trial.
Topics: Acute Pain; Analgesics, Opioid; Antiemetics; Double-Blind Method; Humans; Metoclopramide; Nausea; Tr | 2023 |
Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache.
Topics: Acute Pain; Administration, Intravenous; Adult; Diphenhydramine; Dopamine D2 Receptor Antagonists; D | 2021 |
An exploratory study of IV metoclopramide+diphenhydramine for acute post-traumatic headache.
Topics: Acute Pain; Diphenhydramine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Dou | 2018 |
2 other studies available for metoclopramide and Acute Pain
| Article | Year |
|---|---|
Randomized IV metoclopramide vs IV ketorolac in treatment of acute primary headache.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Headache; Humans; Ketorola | 2022 |
Antinociception by metoclopramide, ketamine and their combinations in mice.
Topics: Acute Pain; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Syne | 2012 |