metoclopramide has been researched along with Acathisia, Drug-Induced in 42 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effects of metoclopramide infusion in emergency department (ED) patients complaining of nausea to determine the changes in its therapeutic effect and prevention of side effects such as akathisia and sedation." | 9.16 | Slow infusion metoclopramide does not affect the improvement rate of nausea while reducing akathisia and sedation incidence. ( Aydin, B; Erdur, B; Parlak, I; Tura, P; Turkcuer, I, 2012) |
| " Patients who presented to our emergency department with a primary or secondary chief complaint of nausea were randomized to one of the following 4 groups: (1) metoclopramide 10 mg+diphenhydramine 25 mg; (2) metoclopramide 10 mg+placebo; (3) metoclopramide 20 mg+diphenhydramine 25 mg; (4) metoclopramide 20 mg+placebo." | 9.14 | A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients. ( Bender, B; Bijur, P; Davitt, M; Esses, D; Friedman, BW; Gallagher, EJ; Paternoster, J; Solorzano, C, 2009) |
| "In a randomized, double-blind study, we compared the efficacy of metoclopramide hydrochloride with that of low-dose droperidol for prevention of nausea and vomiting during and after elective cesarean section with epidural anesthesia." | 9.06 | Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section. ( Bates, JN; Chestnut, DH; Choi, WW; Geiger, M; Ostman, PL; Owen, CL, 1989) |
| "Metoclopramide was ineffective." | 6.68 | The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. ( Clark, K; Cronin, MK; Darvish, AH; Desilva, PH; McDonald, SM, 1995) |
| " The case presented is an aged male who developed impotence and akathisia after long-term use of metoclopramide." | 5.29 | Metoclopramide-induced impotence and akathisia: a case report. ( Tsai, SJ, 1996) |
| "To compare the effects of metoclopramide infusion in emergency department (ED) patients complaining of nausea to determine the changes in its therapeutic effect and prevention of side effects such as akathisia and sedation." | 5.16 | Slow infusion metoclopramide does not affect the improvement rate of nausea while reducing akathisia and sedation incidence. ( Aydin, B; Erdur, B; Parlak, I; Tura, P; Turkcuer, I, 2012) |
| " Patients who presented to our emergency department with a primary or secondary chief complaint of nausea were randomized to one of the following 4 groups: (1) metoclopramide 10 mg+diphenhydramine 25 mg; (2) metoclopramide 10 mg+placebo; (3) metoclopramide 20 mg+diphenhydramine 25 mg; (4) metoclopramide 20 mg+placebo." | 5.14 | A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients. ( Bender, B; Bijur, P; Davitt, M; Esses, D; Friedman, BW; Gallagher, EJ; Paternoster, J; Solorzano, C, 2009) |
| "Ondansetron, a new 5-HT3 receptor antagonist, has been compared with high-dose metoclopramide in the control of acute emesis (24 h) induced by cisplatin (greater than or equal to 100 mg/m2)." | 5.07 | Progress in the control of acute and delayed emesis induced by cisplatin. ( Gandara, DR, 1991) |
| "In a randomized, double-blind study, we compared the efficacy of metoclopramide hydrochloride with that of low-dose droperidol for prevention of nausea and vomiting during and after elective cesarean section with epidural anesthesia." | 5.06 | Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section. ( Bates, JN; Chestnut, DH; Choi, WW; Geiger, M; Ostman, PL; Owen, CL, 1989) |
| "A case of severe metoclopramide-induced akathisia in a breast cancer patient being treated with chemotherapy is presented, eventually culminating in hospital admission." | 3.76 | Severe akathisia as a side effect of metoclopramide. ( Doorduijn, JK; Seynaeve, C; Van Gool, AR, 2010) |
| " Metoclopramide-treated patients had significantly greater severity of tardive dyskinesia, drug-induced parkinsonism, and subjective akathisia than controls." | 3.68 | The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders. ( Casey, DE; Ganzini, L; Hoffman, WF; McCall, AL, 1993) |
| "Metoclopramide was administered as a 2-minute bolus infusion." | 2.77 | A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. ( Aydin, B; Erdur, B; Ergin, A; Kabay, B; Ozen, M; Parlak, I; Tura, P, 2012) |
| "34) and no adverse reactions in the study period." | 2.73 | Intravenous administration of metoclopramide by 2 min bolus vs 15 min infusion: does it affect the improvement of headache while reducing the side effects? ( Ayrik, C; Erdur, B; Ergin, A; Ergin, N; Parlak, I; Parlak, M; Tomruk, O; Turkcuer, I, 2007) |
| "When compared at 2 and 24 hours, aggressive (20 mg dosed up to four times) IV metoclopramide and 6 mg of subcutaneous sumatriptan relieved migraine headache pain comparably." | 2.71 | A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. ( Bijur, PE; Corbo, J; Esses, D; Friedman, BW; Gallagher, EJ; Lipton, RB; Solorzano, C, 2005) |
| "Metoclopramide was ineffective." | 2.68 | The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. ( Clark, K; Cronin, MK; Darvish, AH; Desilva, PH; McDonald, SM, 1995) |
| "As metoclopramide is a dopamine receptor antagonist, it has the potential to cause drug-induced movement disorders, including akathisia, which is characterised by an inner restlessness resulting in a need for constant movement." | 1.62 | [Tardive akathisia after long-term metoclopramide treatment]. ( Andersen, CU; Hjelholt, AJ; Steffensen, C, 2021) |
| "Chest pain is an alarming symptom; it justifies many visits to the emergency department (ED)." | 1.40 | Chest pain a manifestation of migraine. ( Roldan, CJ, 2014) |
| " Extrapyramidal side effects like tardive dyskinesia are known to develop with chronic use of metoclopramide, while acute akathisia is a lesser known side effect following IV administration." | 1.37 | Case of acute akathisia from intravenous metoclopramide. ( Lim, BL; Qiu, LM, 2011) |
| " The case presented is an aged male who developed impotence and akathisia after long-term use of metoclopramide." | 1.29 | Metoclopramide-induced impotence and akathisia: a case report. ( Tsai, SJ, 1996) |
| "The authors describe two cases of tardive akathisia following metoclopramide therapy, in which there were concomitant symptoms of agitated depression." | 1.27 | Tardive akathisia and agitated depression during metoclopramide therapy. ( Bownes, IT; Curran, P; Shearer, RM, 1984) |
| " Before studying the efficacy of MCP as an antiemetic in children, we first had to establish the safe dose range." | 1.27 | Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy. ( Allen, JC; Gralla, R; Kellick, M; Reilly, L; Young, C, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (26.19) | 18.7374 |
| 1990's | 15 (35.71) | 18.2507 |
| 2000's | 7 (16.67) | 29.6817 |
| 2010's | 8 (19.05) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Hjelholt, AJ | 1 |
| Andersen, CU | 1 |
| Steffensen, C | 1 |
| Egerton-Warburton, D | 1 |
| Povey, K | 1 |
| Roldan, CJ | 1 |
| Friedman, BW | 3 |
| Bender, B | 1 |
| Davitt, M | 1 |
| Solorzano, C | 3 |
| Paternoster, J | 2 |
| Esses, D | 3 |
| Bijur, P | 1 |
| Gallagher, EJ | 3 |
| Friedman, JH | 1 |
| Van Gool, AR | 1 |
| Doorduijn, JK | 1 |
| Seynaeve, C | 1 |
| Erdur, B | 5 |
| Tura, P | 2 |
| Aydin, B | 2 |
| Ozen, M | 1 |
| Ergin, A | 3 |
| Parlak, I | 5 |
| Kabay, B | 1 |
| Mulvey, L | 1 |
| Lipton, RB | 2 |
| Turkcuer, I | 3 |
| Qiu, LM | 1 |
| Lim, BL | 1 |
| Anfinson, TJ | 1 |
| Corbo, J | 1 |
| Bijur, PE | 1 |
| Atilla, R | 1 |
| Cicek, M | 1 |
| Parlak, M | 3 |
| Guryay, M | 1 |
| Sever, M | 1 |
| Karaduman, S | 1 |
| Ayrik, C | 2 |
| Tomruk, O | 2 |
| Ergin, N | 2 |
| Barnes, TR | 1 |
| Braude, WM | 1 |
| Hill, DJ | 1 |
| Jungmann, E | 1 |
| Schöffling, K | 1 |
| Shearer, RM | 1 |
| Bownes, IT | 1 |
| Curran, P | 1 |
| Desilva, PH | 1 |
| Darvish, AH | 1 |
| McDonald, SM | 1 |
| Cronin, MK | 1 |
| Clark, K | 1 |
| Robinson, D | 1 |
| Omar, SJ | 1 |
| Dangel, C | 1 |
| Fenn, H | 1 |
| Tinklenberg, J | 1 |
| Cory, DA | 1 |
| Fleishman, SB | 1 |
| Lavin, MR | 1 |
| Sattler, M | 1 |
| Szarka, H | 1 |
| Ganzini, L | 1 |
| Casey, DE | 1 |
| Hoffman, WF | 1 |
| McCall, AL | 1 |
| Masters, JC | 1 |
| O'Grady, M | 1 |
| Tsai, SJ | 1 |
| Gualthérie van Weezel, L | 1 |
| LaGorio, J | 1 |
| Thompson, VA | 1 |
| Sternberg, D | 1 |
| Dorje, P | 1 |
| Shuster, J | 1 |
| Akagi, H | 1 |
| Kumar, TM | 1 |
| Rodgers, C | 1 |
| Gandara, DR | 1 |
| Beightol, RW | 1 |
| Coupal, JJ | 1 |
| Shih, WJ | 1 |
| Sachdev, P | 1 |
| Chee, KY | 1 |
| Martínez Rodés, P | 1 |
| Tres Sánchez, A | 1 |
| Bateman, DN | 2 |
| Darling, WM | 1 |
| Boys, R | 1 |
| Rawlins, MD | 1 |
| Chestnut, DH | 1 |
| Owen, CL | 1 |
| Geiger, M | 1 |
| Bates, JN | 1 |
| Choi, WW | 1 |
| Ostman, PL | 1 |
| Isah, AO | 1 |
| Hamilton, FA | 1 |
| Caldwell, C | 1 |
| Rains, G | 1 |
| McKiterick, K | 1 |
| Weddington, WW | 1 |
| Banner, A | 1 |
| Allen, JC | 1 |
| Gralla, R | 1 |
| Reilly, L | 1 |
| Kellick, M | 1 |
| Young, C | 1 |
| Alavi, JB | 1 |
| Torri, S | 1 |
| Glover, D | 1 |
| Hurwitz, S | 1 |
| Glick, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oral v. Parenteral Medications for the Emergency Management of Acute Migraine: a Pilot Randomized Control Trial[NCT05983354] | 55 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | |||
| Acute Mountain Sickness Treatment: A Double-blind Comparison of Metoclopramide vs. Ibuprofen[NCT01522326] | 300 participants (Anticipated) | Interventional | 2012-03-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 trials available for metoclopramide and Acathisia, Drug-Induced
| Article | Year |
|---|---|
Administration of metoclopramide by infusion or bolus does not affect the incidence of drug-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Double-Blind Method; Female; Humans; Infusions, Intrave | 2013 |
A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients.
Topics: Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Dopamine Antagonists; Double-Bli | 2009 |
A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Double-Blind Method; Female; Humans; H | 2012 |
Metoclopramide for acute migraine: a dose-finding randomized clinical trial.
Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Analgesics; Dose-Response Relationship, Drug; Double- | 2011 |
Slow infusion metoclopramide does not affect the improvement rate of nausea while reducing akathisia and sedation incidence.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Deep Sedation; Double-Blind Method; Female; Humans; Inf | 2012 |
A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines.
Topics: Adult; Akathisia, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dizziness; | 2005 |
Rate of metoclopramide infusion affects the severity and incidence of akathisia.
Topics: Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Double-Blind Method; Drug Administration Schedule | 2005 |
Midazolam vs. diphenhydramine for the treatment of metoclopramide-induced akathisia: a randomized controlled trial.
Topics: Adult; Akathisia, Drug-Induced; Analysis of Variance; Diphenhydramine; Dose-Response Relationship, D | 2007 |
Intravenous administration of metoclopramide by 2 min bolus vs 15 min infusion: does it affect the improvement of headache while reducing the side effects?
Topics: Adult; Akathisia, Drug-Induced; Dopamine Antagonists; Double-Blind Method; Drug Administration Sched | 2007 |
The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery.
Topics: Akathisia, Drug-Induced; Consciousness; Double-Blind Method; Droperidol; Female; Humans; Hypotension | 1995 |
Progress in the control of acute and delayed emesis induced by cisplatin.
Topics: Akathisia, Drug-Induced; Cisplatin; Dystonia; Humans; Imidazoles; Metoclopramide; Ondansetron; Serot | 1991 |
Pharmacological characterization of tardive akathisia.
Topics: Administration, Oral; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Arousal; Atenolol; Benztr | 1990 |
Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section.
Topics: Adult; Akathisia, Drug-Induced; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Dou | 1989 |
29 other studies available for metoclopramide and Acathisia, Drug-Induced
| Article | Year |
|---|---|
[Tardive akathisia after long-term metoclopramide treatment].
Topics: Akathisia, Drug-Induced; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactions; Huma | 2021 |
Chest pain a manifestation of migraine.
Topics: Adult; Akathisia, Drug-Induced; Analgesics, Opioid; Chest Pain; Dopamine Antagonists; Electrocardiog | 2014 |
Warning on treating depression.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Aripiprazole; Depression; Dopamine Antagonists; Gastr | 2010 |
Severe akathisia as a side effect of metoclopramide.
Topics: Akathisia, Drug-Induced; Breast Neoplasms; Female; Humans; Metoclopramide; Middle Aged; Severity of | 2010 |
Case of acute akathisia from intravenous metoclopramide.
Topics: Abdominal Pain; Adult; Akathisia, Drug-Induced; Diphenhydramine; Emergency Service, Hospital; Female | 2011 |
Akathisia, panic, agoraphobia, and major depression following brief exposure to metoclopramide.
Topics: Agoraphobia; Akathisia, Drug-Induced; Depressive Disorder; Humans; Male; Metoclopramide; Middle Aged | 2002 |
Acute akathisia after oral droperidol and metoclopramide preoperative medication.
Topics: Acute Disease; Akathisia, Drug-Induced; Droperidol; Eye Diseases; Female; Humans; Male; Metocloprami | 1982 |
Akathisia and metoclopramide.
Topics: Akathisia, Drug-Induced; Humans; Metoclopramide | 1982 |
Tardive akathisia and agitated depression during metoclopramide therapy.
Topics: Akathisia, Drug-Induced; Depressive Disorder; Dyskinesia, Drug-Induced; Female; Gastroesophageal Ref | 1984 |
Metoclopramide-induced extra pyramidal symptoms in a diabetic patient.
Topics: Aged; Akathisia, Drug-Induced; Diabetes Mellitus, Type 2; Dyskinesia, Drug-Induced; Gastroesophageal | 1994 |
Adverse reaction to metoclopramide during enteroclysis.
Topics: Adult; Akathisia, Drug-Induced; Barium Sulfate; Dystonia; Enema; Female; Humans; Intubation, Gastroi | 1994 |
Antiemetic-induced akathisia in cancer patients receiving chemotherapy.
Topics: Akathisia, Drug-Induced; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans; Male; Met | 1994 |
The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders.
Topics: Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Basal Ganglia Diseases; Diabetes Complicati | 1993 |
Adverse reactions to metoclopramide (Reglan) presenting as depression in a bone marrow transplant patient.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Antineoplastic Agents; Bone Marrow Transplantation; Dep | 1995 |
Metoclopramide-induced impotence and akathisia: a case report.
Topics: Aged; Akathisia, Drug-Induced; Antiemetics; Erectile Dysfunction; Humans; Male; Metoclopramide | 1996 |
[The pills are to blame!].
Topics: Aged; Akathisia, Drug-Induced; Antidepressive Agents; Antiemetics; Antipsychotic Agents; Depression; | 1997 |
Akathisia and anesthesia: refusal of surgery after the administration of metoclopramide.
Topics: Adult; Akathisia, Drug-Induced; Anesthesia; Dopamine Antagonists; Humans; Male; Metoclopramide; Trea | 1998 |
Metoclopramide and akathisia.
Topics: Adult; Akathisia, Drug-Induced; Dopamine Antagonists; Humans; Male; Metoclopramide; Nursing Assessme | 1998 |
Lesson of the week: Akathisia: overlooked at a cost.
Topics: Akathisia, Drug-Induced; Antidepressive Agents, Second-Generation; Antiemetics; Female; Fluoxetine; | 2002 |
Extrapyramidal side effects of antiemetics presenting as psychiatric illness.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Anxiety Disor | 1992 |
Prevention of metoclopramide-induced akathisia during gastric emptying imaging.
Topics: Akathisia, Drug-Induced; Female; Gastric Emptying; Humans; Male; Metoclopramide; Middle Aged | 1991 |
[Akathisia, a diagnosis to keep in mind].
Topics: Adult; Akathisia, Drug-Induced; Humans; Male; Metoclopramide | 1990 |
Extrapyramidal reactions to metoclopramide and prochlorperazine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Basal Ganglia Diseases; Child; | 1989 |
Akathisia and antipsychotic drugs.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Humans; Male; Metoclopramide | 1987 |
Metoclopramide-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Gastroesophageal Reflux; Humans; Male; Metoclopramide | 1987 |
An unusual reaction to preoperative metoclopramide.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Female; Humans; Metoclopramide; Premedication | 1987 |
Organic affective syndrome associated with metoclopramide: case report.
Topics: Akathisia, Drug-Induced; Depressive Disorder; Humans; Male; Metoclopramide; Middle Aged; Psychiatric | 1986 |
Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antineoplastic Agents; Basal Ganglia Diseases; Child; Di | 1985 |
High-dose oral metoclopramide. An effective antiemetic agent.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antineoplastic Combined Chemotherapy Protocols; Ci | 1985 |