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metoclopramide and Acathisia, Drug-Induced

metoclopramide has been researched along with Acathisia, Drug-Induced in 42 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research Excerpts

ExcerptRelevanceReference
"To compare the effects of metoclopramide infusion in emergency department (ED) patients complaining of nausea to determine the changes in its therapeutic effect and prevention of side effects such as akathisia and sedation."9.16Slow infusion metoclopramide does not affect the improvement rate of nausea while reducing akathisia and sedation incidence. ( Aydin, B; Erdur, B; Parlak, I; Tura, P; Turkcuer, I, 2012)
" Patients who presented to our emergency department with a primary or secondary chief complaint of nausea were randomized to one of the following 4 groups: (1) metoclopramide 10 mg+diphenhydramine 25 mg; (2) metoclopramide 10 mg+placebo; (3) metoclopramide 20 mg+diphenhydramine 25 mg; (4) metoclopramide 20 mg+placebo."9.14A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients. ( Bender, B; Bijur, P; Davitt, M; Esses, D; Friedman, BW; Gallagher, EJ; Paternoster, J; Solorzano, C, 2009)
"In a randomized, double-blind study, we compared the efficacy of metoclopramide hydrochloride with that of low-dose droperidol for prevention of nausea and vomiting during and after elective cesarean section with epidural anesthesia."9.06Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section. ( Bates, JN; Chestnut, DH; Choi, WW; Geiger, M; Ostman, PL; Owen, CL, 1989)
"Metoclopramide was ineffective."6.68The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. ( Clark, K; Cronin, MK; Darvish, AH; Desilva, PH; McDonald, SM, 1995)
" The case presented is an aged male who developed impotence and akathisia after long-term use of metoclopramide."5.29Metoclopramide-induced impotence and akathisia: a case report. ( Tsai, SJ, 1996)
"To compare the effects of metoclopramide infusion in emergency department (ED) patients complaining of nausea to determine the changes in its therapeutic effect and prevention of side effects such as akathisia and sedation."5.16Slow infusion metoclopramide does not affect the improvement rate of nausea while reducing akathisia and sedation incidence. ( Aydin, B; Erdur, B; Parlak, I; Tura, P; Turkcuer, I, 2012)
" Patients who presented to our emergency department with a primary or secondary chief complaint of nausea were randomized to one of the following 4 groups: (1) metoclopramide 10 mg+diphenhydramine 25 mg; (2) metoclopramide 10 mg+placebo; (3) metoclopramide 20 mg+diphenhydramine 25 mg; (4) metoclopramide 20 mg+placebo."5.14A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients. ( Bender, B; Bijur, P; Davitt, M; Esses, D; Friedman, BW; Gallagher, EJ; Paternoster, J; Solorzano, C, 2009)
"Ondansetron, a new 5-HT3 receptor antagonist, has been compared with high-dose metoclopramide in the control of acute emesis (24 h) induced by cisplatin (greater than or equal to 100 mg/m2)."5.07Progress in the control of acute and delayed emesis induced by cisplatin. ( Gandara, DR, 1991)
"In a randomized, double-blind study, we compared the efficacy of metoclopramide hydrochloride with that of low-dose droperidol for prevention of nausea and vomiting during and after elective cesarean section with epidural anesthesia."5.06Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section. ( Bates, JN; Chestnut, DH; Choi, WW; Geiger, M; Ostman, PL; Owen, CL, 1989)
"A case of severe metoclopramide-induced akathisia in a breast cancer patient being treated with chemotherapy is presented, eventually culminating in hospital admission."3.76Severe akathisia as a side effect of metoclopramide. ( Doorduijn, JK; Seynaeve, C; Van Gool, AR, 2010)
" Metoclopramide-treated patients had significantly greater severity of tardive dyskinesia, drug-induced parkinsonism, and subjective akathisia than controls."3.68The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders. ( Casey, DE; Ganzini, L; Hoffman, WF; McCall, AL, 1993)
"Metoclopramide was administered as a 2-minute bolus infusion."2.77A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. ( Aydin, B; Erdur, B; Ergin, A; Kabay, B; Ozen, M; Parlak, I; Tura, P, 2012)
"34) and no adverse reactions in the study period."2.73Intravenous administration of metoclopramide by 2 min bolus vs 15 min infusion: does it affect the improvement of headache while reducing the side effects? ( Ayrik, C; Erdur, B; Ergin, A; Ergin, N; Parlak, I; Parlak, M; Tomruk, O; Turkcuer, I, 2007)
"When compared at 2 and 24 hours, aggressive (20 mg dosed up to four times) IV metoclopramide and 6 mg of subcutaneous sumatriptan relieved migraine headache pain comparably."2.71A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. ( Bijur, PE; Corbo, J; Esses, D; Friedman, BW; Gallagher, EJ; Lipton, RB; Solorzano, C, 2005)
"Metoclopramide was ineffective."2.68The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. ( Clark, K; Cronin, MK; Darvish, AH; Desilva, PH; McDonald, SM, 1995)
"As metoclopramide is a dopamine receptor antagonist, it has the potential to cause drug-induced movement disorders, including akathisia, which is characterised by an inner restlessness resulting in a need for constant movement."1.62[Tardive akathisia after long-term metoclopramide treatment]. ( Andersen, CU; Hjelholt, AJ; Steffensen, C, 2021)
"Chest pain is an alarming symptom; it justifies many visits to the emergency department (ED)."1.40Chest pain a manifestation of migraine. ( Roldan, CJ, 2014)
" Extrapyramidal side effects like tardive dyskinesia are known to develop with chronic use of metoclopramide, while acute akathisia is a lesser known side effect following IV administration."1.37Case of acute akathisia from intravenous metoclopramide. ( Lim, BL; Qiu, LM, 2011)
" The case presented is an aged male who developed impotence and akathisia after long-term use of metoclopramide."1.29Metoclopramide-induced impotence and akathisia: a case report. ( Tsai, SJ, 1996)
"The authors describe two cases of tardive akathisia following metoclopramide therapy, in which there were concomitant symptoms of agitated depression."1.27Tardive akathisia and agitated depression during metoclopramide therapy. ( Bownes, IT; Curran, P; Shearer, RM, 1984)
" Before studying the efficacy of MCP as an antiemetic in children, we first had to establish the safe dose range."1.27Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy. ( Allen, JC; Gralla, R; Kellick, M; Reilly, L; Young, C, 1985)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199011 (26.19)18.7374
1990's15 (35.71)18.2507
2000's7 (16.67)29.6817
2010's8 (19.05)24.3611
2020's1 (2.38)2.80

Authors

AuthorsStudies
Hjelholt, AJ1
Andersen, CU1
Steffensen, C1
Egerton-Warburton, D1
Povey, K1
Roldan, CJ1
Friedman, BW3
Bender, B1
Davitt, M1
Solorzano, C3
Paternoster, J2
Esses, D3
Bijur, P1
Gallagher, EJ3
Friedman, JH1
Van Gool, AR1
Doorduijn, JK1
Seynaeve, C1
Erdur, B5
Tura, P2
Aydin, B2
Ozen, M1
Ergin, A3
Parlak, I5
Kabay, B1
Mulvey, L1
Lipton, RB2
Turkcuer, I3
Qiu, LM1
Lim, BL1
Anfinson, TJ1
Corbo, J1
Bijur, PE1
Atilla, R1
Cicek, M1
Parlak, M3
Guryay, M1
Sever, M1
Karaduman, S1
Ayrik, C2
Tomruk, O2
Ergin, N2
Barnes, TR1
Braude, WM1
Hill, DJ1
Jungmann, E1
Schöffling, K1
Shearer, RM1
Bownes, IT1
Curran, P1
Desilva, PH1
Darvish, AH1
McDonald, SM1
Cronin, MK1
Clark, K1
Robinson, D1
Omar, SJ1
Dangel, C1
Fenn, H1
Tinklenberg, J1
Cory, DA1
Fleishman, SB1
Lavin, MR1
Sattler, M1
Szarka, H1
Ganzini, L1
Casey, DE1
Hoffman, WF1
McCall, AL1
Masters, JC1
O'Grady, M1
Tsai, SJ1
Gualthérie van Weezel, L1
LaGorio, J1
Thompson, VA1
Sternberg, D1
Dorje, P1
Shuster, J1
Akagi, H1
Kumar, TM1
Rodgers, C1
Gandara, DR1
Beightol, RW1
Coupal, JJ1
Shih, WJ1
Sachdev, P1
Chee, KY1
Martínez Rodés, P1
Tres Sánchez, A1
Bateman, DN2
Darling, WM1
Boys, R1
Rawlins, MD1
Chestnut, DH1
Owen, CL1
Geiger, M1
Bates, JN1
Choi, WW1
Ostman, PL1
Isah, AO1
Hamilton, FA1
Caldwell, C1
Rains, G1
McKiterick, K1
Weddington, WW1
Banner, A1
Allen, JC1
Gralla, R1
Reilly, L1
Kellick, M1
Young, C1
Alavi, JB1
Torri, S1
Glover, D1
Hurwitz, S1
Glick, JH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Oral v. Parenteral Medications for the Emergency Management of Acute Migraine: a Pilot Randomized Control Trial[NCT05983354]55 participants (Anticipated)Interventional2024-01-01Not yet recruiting
Acute Mountain Sickness Treatment: A Double-blind Comparison of Metoclopramide vs. Ibuprofen[NCT01522326]300 participants (Anticipated)Interventional2012-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

13 trials available for metoclopramide and Acathisia, Drug-Induced

ArticleYear
Administration of metoclopramide by infusion or bolus does not affect the incidence of drug-induced akathisia.
    Emergency medicine Australasia : EMA, 2013, Volume: 25, Issue:3

    Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Double-Blind Method; Female; Humans; Infusions, Intrave

2013
A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients.
    Annals of emergency medicine, 2009, Volume: 53, Issue:3

    Topics: Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Dopamine Antagonists; Double-Bli

2009
A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:1

    Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Double-Blind Method; Female; Humans; H

2012
Metoclopramide for acute migraine: a dose-finding randomized clinical trial.
    Annals of emergency medicine, 2011, Volume: 57, Issue:5

    Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Analgesics; Dose-Response Relationship, Drug; Double-

2011
Slow infusion metoclopramide does not affect the improvement rate of nausea while reducing akathisia and sedation incidence.
    Emergency medicine journal : EMJ, 2012, Volume: 29, Issue:2

    Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Deep Sedation; Double-Blind Method; Female; Humans; Inf

2012
A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines.
    Neurology, 2005, Feb-08, Volume: 64, Issue:3

    Topics: Adult; Akathisia, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dizziness;

2005
Rate of metoclopramide infusion affects the severity and incidence of akathisia.
    Emergency medicine journal : EMJ, 2005, Volume: 22, Issue:9

    Topics: Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Double-Blind Method; Drug Administration Schedule

2005
Midazolam vs. diphenhydramine for the treatment of metoclopramide-induced akathisia: a randomized controlled trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2007, Volume: 14, Issue:8

    Topics: Adult; Akathisia, Drug-Induced; Analysis of Variance; Diphenhydramine; Dose-Response Relationship, D

2007
Intravenous administration of metoclopramide by 2 min bolus vs 15 min infusion: does it affect the improvement of headache while reducing the side effects?
    Postgraduate medical journal, 2007, Volume: 83, Issue:984

    Topics: Adult; Akathisia, Drug-Induced; Dopamine Antagonists; Double-Blind Method; Drug Administration Sched

2007
The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:1

    Topics: Akathisia, Drug-Induced; Consciousness; Double-Blind Method; Droperidol; Female; Humans; Hypotension

1995
Progress in the control of acute and delayed emesis induced by cisplatin.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27 Suppl 1

    Topics: Akathisia, Drug-Induced; Cisplatin; Dystonia; Humans; Imidazoles; Metoclopramide; Ondansetron; Serot

1991
Pharmacological characterization of tardive akathisia.
    Biological psychiatry, 1990, Nov-01, Volume: 28, Issue:9

    Topics: Administration, Oral; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Arousal; Atenolol; Benztr

1990
Metoclopramide versus droperidol for prevention of nausea and vomiting during epidural anesthesia for cesarean section.
    Southern medical journal, 1989, Volume: 82, Issue:10

    Topics: Adult; Akathisia, Drug-Induced; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Dou

1989

Other Studies

29 other studies available for metoclopramide and Acathisia, Drug-Induced

ArticleYear
[Tardive akathisia after long-term metoclopramide treatment].
    Ugeskrift for laeger, 2021, 05-24, Volume: 183, Issue:21

    Topics: Akathisia, Drug-Induced; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactions; Huma

2021
Chest pain a manifestation of migraine.
    The Journal of emergency medicine, 2014, Volume: 46, Issue:3

    Topics: Adult; Akathisia, Drug-Induced; Analgesics, Opioid; Chest Pain; Dopamine Antagonists; Electrocardiog

2014
Warning on treating depression.
    Medicine and health, Rhode Island, 2010, Volume: 93, Issue:3

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Aripiprazole; Depression; Dopamine Antagonists; Gastr

2010
Severe akathisia as a side effect of metoclopramide.
    Pharmacy world & science : PWS, 2010, Volume: 32, Issue:6

    Topics: Akathisia, Drug-Induced; Breast Neoplasms; Female; Humans; Metoclopramide; Middle Aged; Severity of

2010
Case of acute akathisia from intravenous metoclopramide.
    Singapore medical journal, 2011, Volume: 52, Issue:1

    Topics: Abdominal Pain; Adult; Akathisia, Drug-Induced; Diphenhydramine; Emergency Service, Hospital; Female

2011
Akathisia, panic, agoraphobia, and major depression following brief exposure to metoclopramide.
    Psychopharmacology bulletin, 2002,Winter, Volume: 36, Issue:1

    Topics: Agoraphobia; Akathisia, Drug-Induced; Depressive Disorder; Humans; Male; Metoclopramide; Middle Aged

2002
Acute akathisia after oral droperidol and metoclopramide preoperative medication.
    Lancet (London, England), 1982, Jul-03, Volume: 2, Issue:8288

    Topics: Acute Disease; Akathisia, Drug-Induced; Droperidol; Eye Diseases; Female; Humans; Male; Metocloprami

1982
Akathisia and metoclopramide.
    Lancet (London, England), 1982, Jul-24, Volume: 2, Issue:8291

    Topics: Akathisia, Drug-Induced; Humans; Metoclopramide

1982
Tardive akathisia and agitated depression during metoclopramide therapy.
    Acta psychiatrica Scandinavica, 1984, Volume: 70, Issue:5

    Topics: Akathisia, Drug-Induced; Depressive Disorder; Dyskinesia, Drug-Induced; Female; Gastroesophageal Ref

1984
Metoclopramide-induced extra pyramidal symptoms in a diabetic patient.
    Journal of the American Geriatrics Society, 1994, Volume: 42, Issue:12

    Topics: Aged; Akathisia, Drug-Induced; Diabetes Mellitus, Type 2; Dyskinesia, Drug-Induced; Gastroesophageal

1994
Adverse reaction to metoclopramide during enteroclysis.
    AJR. American journal of roentgenology, 1994, Volume: 163, Issue:2

    Topics: Adult; Akathisia, Drug-Induced; Barium Sulfate; Dystonia; Enema; Female; Humans; Intubation, Gastroi

1994
Antiemetic-induced akathisia in cancer patients receiving chemotherapy.
    The American journal of psychiatry, 1994, Volume: 151, Issue:5

    Topics: Akathisia, Drug-Induced; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans; Male; Met

1994
The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders.
    Archives of internal medicine, 1993, Jun-28, Volume: 153, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Basal Ganglia Diseases; Diabetes Complicati

1993
Adverse reactions to metoclopramide (Reglan) presenting as depression in a bone marrow transplant patient.
    Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses, 1995, Volume: 4, Issue:6

    Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Antineoplastic Agents; Bone Marrow Transplantation; Dep

1995
Metoclopramide-induced impotence and akathisia: a case report.
    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 1996, Volume: 57, Issue:6

    Topics: Aged; Akathisia, Drug-Induced; Antiemetics; Erectile Dysfunction; Humans; Male; Metoclopramide

1996
[The pills are to blame!].
    Oncologica, 1997, Volume: 14, Issue:2

    Topics: Aged; Akathisia, Drug-Induced; Antidepressive Agents; Antiemetics; Antipsychotic Agents; Depression;

1997
Akathisia and anesthesia: refusal of surgery after the administration of metoclopramide.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:1

    Topics: Adult; Akathisia, Drug-Induced; Anesthesia; Dopamine Antagonists; Humans; Male; Metoclopramide; Trea

1998
Metoclopramide and akathisia.
    Nursing, 1998, Volume: 28, Issue:12

    Topics: Adult; Akathisia, Drug-Induced; Dopamine Antagonists; Humans; Male; Metoclopramide; Nursing Assessme

1998
Lesson of the week: Akathisia: overlooked at a cost.
    BMJ (Clinical research ed.), 2002, Jun-22, Volume: 324, Issue:7352

    Topics: Akathisia, Drug-Induced; Antidepressive Agents, Second-Generation; Antiemetics; Female; Fluoxetine;

2002
Extrapyramidal side effects of antiemetics presenting as psychiatric illness.
    General hospital psychiatry, 1992, Volume: 14, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Anxiety Disor

1992
Prevention of metoclopramide-induced akathisia during gastric emptying imaging.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1991, Volume: 32, Issue:8

    Topics: Akathisia, Drug-Induced; Female; Gastric Emptying; Humans; Male; Metoclopramide; Middle Aged

1991
[Akathisia, a diagnosis to keep in mind].
    Revista clinica espanola, 1990, Volume: 187, Issue:2

    Topics: Adult; Akathisia, Drug-Induced; Humans; Male; Metoclopramide

1990
Extrapyramidal reactions to metoclopramide and prochlorperazine.
    The Quarterly journal of medicine, 1989, Volume: 71, Issue:264

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Basal Ganglia Diseases; Child;

1989
Akathisia and antipsychotic drugs.
    Lancet (London, England), 1987, Jan-03, Volume: 1, Issue:8523

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Humans; Male; Metoclopramide

1987
Metoclopramide-induced akathisia.
    Military medicine, 1987, Volume: 152, Issue:11

    Topics: Adult; Akathisia, Drug-Induced; Gastroesophageal Reflux; Humans; Male; Metoclopramide

1987
An unusual reaction to preoperative metoclopramide.
    Anesthesiology, 1987, Volume: 67, Issue:5

    Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Female; Humans; Metoclopramide; Premedication

1987
Organic affective syndrome associated with metoclopramide: case report.
    The Journal of clinical psychiatry, 1986, Volume: 47, Issue:4

    Topics: Akathisia, Drug-Induced; Depressive Disorder; Humans; Male; Metoclopramide; Middle Aged; Psychiatric

1986
Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:8

    Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antineoplastic Agents; Basal Ganglia Diseases; Child; Di

1985
High-dose oral metoclopramide. An effective antiemetic agent.
    American journal of clinical oncology, 1985, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antineoplastic Combined Chemotherapy Protocols; Ci

1985