metiamide has been researched along with Mast-Cell-Sarcoma* in 1 studies
1 other study(ies) available for metiamide and Mast-Cell-Sarcoma
| Article | Year |
|---|---|
Interaction of histamine H1-and H2-receptor antagonists with histamine uptake and metabolism by guinea-pig isolated atrium and mouse neoplastic mast cells cells in vitro.
1. Burimamide, metiamide, chlorpheniramine, triprolidine and cocaine, were tested as inhibitors of histamine uptake and metabolism in the guinea-pig atrium and in mouse neoplastic mast cells. 2. Cocaine did not affect the uptake and metabolism of histamine, either in the atrium or in the mast cells. All the antihistamines tested blocked the uptake and metabolism of histamine in both preparations. The order of potency was burimamide greater than chlorpheniramine greater than triprolidine greater than metiamide in the atrium; and burimamide greater than metiamide greater than triprolidine greater than chlorpheniramine, in the mase cells. 3. Comparison of the present results with the antihistamine activity of these blocking agents suggests that no correlation exists between the receptor blocking activity and the ability of these substances to act as inhibitors of histamine uptake and metabolism. Topics: Animals; Burimamide; Chlorpheniramine; Cocaine; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Mast Cells; Mast-Cell Sarcoma; Metiamide; Mice; Neoplasms, Experimental; Receptors, Drug; Triprolidine | 1975 |