metiamide and Gastritis

metiamide has been researched along with Gastritis* in 8 studies

Reviews

2 review(s) available for metiamide and Gastritis

ArticleYear
Histamine H2-receptor antagonists.
    Advances in internal medicine, 1978, Volume: 23

    Development of histamine H2-receptor antagonists has enhanced the understanding of histamine physiology and pharmacology. The effect of H2-receptor antagonists on gastrointestinal physiology has been studied extensively. These compounds inhibit gastric acid secretion in response to all known secretagogues and, in contrast to anticholinergic drugs, markedly inhibit food-stimulated acid secretion in duodenal ulcer patients. The relative roles of H2-receptor antagonists, anticholinergic drugs and antacids in the treatment of duodenal ulcer remain to be defined. Cimetidine currently is under investigation for the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, gastrointestinal bleeding and hypersecretory states. Although the long-term safety of cimetidine has not been established, in short-term clinical trials there have been no significant subjective or objective side-effects. Assuming that toxic effects do not develop, H2-receptor antagonists should improve the treatment of acid-peptic disease.

    Topics: Cimetidine; Cyclic AMP; Duodenal Ulcer; Esophagitis, Peptic; Gastric Juice; Gastrins; Gastritis; Gastrointestinal Hemorrhage; Histamine; Histamine H2 Antagonists; Humans; Intrinsic Factor; Metiamide; Pepsin A; Stomach Ulcer

1978
[Cimetidine; new hope for ulcer patients?].
    Nederlands tijdschrift voor geneeskunde, 1978, Jun-17, Volume: 122, Issue:24

    Topics: Burimamide; Cimetidine; Creatinine; Duodenal Ulcer; Esophagitis, Peptic; Gastric Juice; Gastritis; Guanidines; Humans; Metiamide; Peptic Ulcer; Receptors, Histamine; Transaminases; Zollinger-Ellison Syndrome

1978

Other Studies

6 other study(ies) available for metiamide and Gastritis

ArticleYear
Symposium on intensive care: 3. Upper gastrointestinal bleeding in the intensive care unit.
    Canadian journal of surgery. Journal canadien de chirurgie, 1978, Volume: 21, Issue:1

    Bleeding from hemorrhagic erosions in the stomach or duodenum of seriously ill patients is associated with a high mortality. While the pathogenesis of such lesions is by no means certain, it is known that they are universal after shock, sepsis or severe burns. Fiberoptic endoscopy has become the most valuable means of diagnosis. This should be preceded by gastric irrigaiton, which usually sufficies to control bleeding caused by acetylsalicylic acid or alcohol, or both. Neutralization of gastric acidity is essential. The histamine HI-receptor antagonist, cimetidine, was used in 27 patients with erosive gastritis, and bleeding ceased in 24. There is a prospect that sugh agents will obviate the necessity of total gastrectomy in the occasional resistant cases in favour of conservative surgery.

    Topics: Antacids; Bacterial Infections; Cimetidine; Critical Care; Endoscopy; Gastritis; Histamine H2 Antagonists; Humans; Metiamide; Peptic Ulcer Hemorrhage; Therapeutic Irrigation

1978
Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: its prevention by metiamide and cimetidine.
    Southern medical journal, 1977, Volume: 70, Issue:5

    Aspirin, ketoprofen, ibuprofen, and naproxen all produced acute gastric erosions in rats. Aspirin produced significantly more erosions than ketoprofen, ibuprofen, or naproxen. There was no significant difference between the effects of ketoprofen, ibuprofen, and naproxen. Aspirin and naproxen produced a synergistic effect at higher dosage. Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis.

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastritis; Guanidines; Histamine H2 Antagonists; Ibuprofen; Imidazoles; Ketoprofen; Male; Metiamide; Naproxen; Rats; Thiourea

1977
Aspirin- and bile- induced acute erosive gastritis: its prevention by metiamide therapy.
    Archives of pathology & laboratory medicine, 1977, Volume: 101, Issue:4

    Aspirin or bile administered by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion.

    Topics: Acute Disease; Animals; Aspirin; Bile Acids and Salts; Gastric Mucosa; Gastritis; Male; Metiamide; Rats; Thiourea

1977
Capsaicin induced acute erosive gastritis: its prevention by antacid, metiamide and cimetidine.
    The Journal of the Kentucky Medical Association, 1977, Volume: 75, Issue:2

    Topics: Acute Disease; Animals; Antacids; Capsaicin; Fatty Acids, Unsaturated; Gastritis; Guanidines; Imidazoles; Male; Metiamide; Rats; Thiourea

1977
Drug induced acute erosive gastritis. Its prevention by antacid, metiamide and cimetidine.
    American journal of proctology, 1977, Volume: 28, Issue:2

    Topics: Acute Disease; Animals; Antacids; Gastritis; Guanidines; Imidazoles; Male; Metiamide; Rats; Thiourea

1977
Treatment of stress-induced upper gastrointestinal/hemorrhage with metiamide.
    Lancet (London, England), 1976, Jan-10, Volume: 1, Issue:7950

    The H-2-blocking antihistamine metiamide was used to treat 14 episodes of bleeding from the stomach or duodenum in eleven patients. In 11 instances bleeding was due to erosive gastritis or duodenitis and bleeding promptly ceased after one or two doses of 300 mg at 6 h intervals and did not recur as long as the drug was continued. In the 2 instances in which bleeding continued, chronic ulcers had eroded into major blood-vessels. There were no complications from the drug even in five patients with severe bone-marrow suppression after renal transplantation. Metiamide seems to be a safe and highly effective agent in the control of bleeding due to erosive gastritis.

    Topics: Adolescent; Adult; Aged; Child; Duodenum; Enteritis; Female; Gastric Juice; Gastritis; Gastrointestinal Hemorrhage; Humans; Intubation, Gastrointestinal; Male; Metiamide; Middle Aged; Peptic Ulcer Hemorrhage; Stress, Physiological; Thiourea

1976