metiamide and Enteritis

metiamide has been researched along with Enteritis* in 3 studies

Trials

2 trial(s) available for metiamide and Enteritis

Article	Year
Nocturnal metiamide treatment in the management of healed duodenal ulceration. Gut, 1977, Volume: 18, Issue:6 This paper presents the results of a pilot study to investigate whether the administration of a nocturnal dose of metiamide (the first orally active H2 receptor antagonist) would prevent or delay the relapse of duodenal ulceration after initial ulcer healing. Sixteen patients took part in a double-blind trial to compare metiamide (400 mg) with placebo. Endoscopically confirmed duodenal ulcer relapses occurred in two out of eight on metiamide and six out of eight on placebo. There was a significant prolongation of remission in those in those on the active drug with an apparent reduction in duodenitis. Topics: Adult; Aged; Clinical Trials as Topic; Duodenal Diseases; Duodenal Ulcer; Enteritis; Humans; Metiamide; Middle Aged; Recurrence; Remission, Spontaneous; Thiourea; Time Factors	1977
Treatment of duodenal ulcer by metiamide. A multicentre trial. Lancet (London, England), 1975, Oct-25, Volume: 2, Issue:7939 In a multicentre double-blind trial 68 patients with endoscopically confirmed duodenal ulceration received metiamide (36 patients) or placebo (32 patients) for four weeks. Healing of duodenal ulcers was significantly increased in patients receiving metiamide (67%) compared with those on placebo (25%). There was also an assoicated significant decrease in daytime pain and antacid consumption in those on metiamide. Topics: Antacids; Clinical Trials as Topic; Drug Evaluation; Duodenal Diseases; Duodenal Ulcer; Enteritis; Humans; Metiamide; Pain; Thiourea	1975

Article

Year

Nocturnal metiamide treatment in the management of healed duodenal ulceration.

Gut, 1977, Volume: 18, Issue:6

This paper presents the results of a pilot study to investigate whether the administration of a nocturnal dose of metiamide (the first orally active H2 receptor antagonist) would prevent or delay the relapse of duodenal ulceration after initial ulcer healing. Sixteen patients took part in a double-blind trial to compare metiamide (400 mg) with placebo. Endoscopically confirmed duodenal ulcer relapses occurred in two out of eight on metiamide and six out of eight on placebo. There was a significant prolongation of remission in those in those on the active drug with an apparent reduction in duodenitis.

Topics: Adult; Aged; Clinical Trials as Topic; Duodenal Diseases; Duodenal Ulcer; Enteritis; Humans; Metiamide; Middle Aged; Recurrence; Remission, Spontaneous; Thiourea; Time Factors

1977

Treatment of duodenal ulcer by metiamide. A multicentre trial.

Lancet (London, England), 1975, Oct-25, Volume: 2, Issue:7939

In a multicentre double-blind trial 68 patients with endoscopically confirmed duodenal ulceration received metiamide (36 patients) or placebo (32 patients) for four weeks. Healing of duodenal ulcers was significantly increased in patients receiving metiamide (67%) compared with those on placebo (25%). There was also an assoicated significant decrease in daytime pain and antacid consumption in those on metiamide.

Topics: Antacids; Clinical Trials as Topic; Drug Evaluation; Duodenal Diseases; Duodenal Ulcer; Enteritis; Humans; Metiamide; Pain; Thiourea

1975

Other Studies

1 other study(ies) available for metiamide and Enteritis

Article	Year
Treatment of stress-induced upper gastrointestinal/hemorrhage with metiamide. Lancet (London, England), 1976, Jan-10, Volume: 1, Issue:7950 The H-2-blocking antihistamine metiamide was used to treat 14 episodes of bleeding from the stomach or duodenum in eleven patients. In 11 instances bleeding was due to erosive gastritis or duodenitis and bleeding promptly ceased after one or two doses of 300 mg at 6 h intervals and did not recur as long as the drug was continued. In the 2 instances in which bleeding continued, chronic ulcers had eroded into major blood-vessels. There were no complications from the drug even in five patients with severe bone-marrow suppression after renal transplantation. Metiamide seems to be a safe and highly effective agent in the control of bleeding due to erosive gastritis. Topics: Adolescent; Adult; Aged; Child; Duodenum; Enteritis; Female; Gastric Juice; Gastritis; Gastrointestinal Hemorrhage; Humans; Intubation, Gastrointestinal; Male; Metiamide; Middle Aged; Peptic Ulcer Hemorrhage; Stress, Physiological; Thiourea	1976

Article

Year

Treatment of stress-induced upper gastrointestinal/hemorrhage with metiamide.

Lancet (London, England), 1976, Jan-10, Volume: 1, Issue:7950

The H-2-blocking antihistamine metiamide was used to treat 14 episodes of bleeding from the stomach or duodenum in eleven patients. In 11 instances bleeding was due to erosive gastritis or duodenitis and bleeding promptly ceased after one or two doses of 300 mg at 6 h intervals and did not recur as long as the drug was continued. In the 2 instances in which bleeding continued, chronic ulcers had eroded into major blood-vessels. There were no complications from the drug even in five patients with severe bone-marrow suppression after renal transplantation. Metiamide seems to be a safe and highly effective agent in the control of bleeding due to erosive gastritis.

Topics: Adolescent; Adult; Aged; Child; Duodenum; Enteritis; Female; Gastric Juice; Gastritis; Gastrointestinal Hemorrhage; Humans; Intubation, Gastrointestinal; Male; Metiamide; Middle Aged; Peptic Ulcer Hemorrhage; Stress, Physiological; Thiourea

1976