metiamide and Edema

Intra-arterial fusions of histamine cause vasodilation of resistance vessels, extravasation of albumin and oedema in cat skeletal muscle. Treatment with either mepyramine or metiamide significantly reduced the extravasation of albumin and rate of oedema formation. The doses of mepyramine and metiamide used did not modify the vascular responses to bradykinin.

Topics: Animals; Bradykinin; Capillary Permeability; Cats; Edema; Female; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Metiamide; Muscles; Pyrilamine; Regional Blood Flow; Serum Albumin; Vasodilation

The effects of the H2-antagonists, metiamide and cimetidine, on the oedema following limb ischaemia or scald have been investigated in two strains of rat. No inhibition of oedema formation was found except when large doses of cimetidine were given before scalding. This effect was attributed to the fall in body temperature. Our results do not support the view that H2-receptors are concerned in the vascular response to injury.

Topics: Animals; Body Temperature; Burns; Cimetidine; Depression, Chemical; Edema; Guanidines; Male; Metiamide; Rats; Receptors, Histamine H2; Thiourea

The present experiments were designed to test the effect of antihistamines on the formation of post-traumatic edema of the spinal cord. Ten rhesus monkeys received 600 gm cm injuries to the T10 level of the spinal cord. Five animals received antihistamine treatment and five animals acted as untreated controls. Posttraumatic edema was estimated using radio-active tagged serum albumin. A significant increase in radioactivity of the injured segment was demonstrated in both groups when compared to noninjured issue, but no difference was demonstrated in the radioactivity of the injured segment in the treated versus the nontreated group.

Topics: Animals; Blood-Brain Barrier; Chlorpheniramine; Disease Models, Animal; Edema; Haplorhini; Histamine H1 Antagonists; Macaca mulatta; Metiamide; Spinal Cord Injuries