metiamide and Acute-Disease

Aspirin, ketoprofen, ibuprofen, and naproxen all produced acute gastric erosions in rats. Aspirin produced significantly more erosions than ketoprofen, ibuprofen, or naproxen. There was no significant difference between the effects of ketoprofen, ibuprofen, and naproxen. Aspirin and naproxen produced a synergistic effect at higher dosage. Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis.

Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastritis; Guanidines; Histamine H2 Antagonists; Ibuprofen; Imidazoles; Ketoprofen; Male; Metiamide; Naproxen; Rats; Thiourea

Aspirin or bile administered by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion.

Topics: Acute Disease; Animals; Aspirin; Bile Acids and Salts; Gastric Mucosa; Gastritis; Male; Metiamide; Rats; Thiourea

Topics: Acute Disease; Animals; Antacids; Capsaicin; Fatty Acids, Unsaturated; Gastritis; Guanidines; Imidazoles; Male; Metiamide; Rats; Thiourea

Topics: Acute Disease; Animals; Antacids; Gastritis; Guanidines; Imidazoles; Male; Metiamide; Rats; Thiourea