methylthiouracil and Thyroiditis

The hypothalamic serotonin content in the altered pituitary thyrotropic function was determined in mature male rabbits by the fluorescent method. No distinct correlation was found between the intensity of the pituitary thyrotropic function and serotonin level in the hypothalamus. Intensification of the hypophysial thyrotropic function under the effect of 6-methylthiouracil or partial thyroidectomy was accompanied by a rise in serotonin concentration, while in aseptic inflammation in the thyroid gland, or in combination of the upper cervical sympathetic ganglia ablation with chlorpromazine administration this adenohypophysial function proved to increase without any significant shifts in the hypothalamic serotonin level. The mentioned findings suggest that the role of serotonin in the hypothalamic regulation of the hypophysial thyrotropic function could not be considered as determining.

Topics: Animals; Chlorpromazine; Ganglia, Autonomic; Histocytochemistry; Hypothalamus; Male; Methylthiouracil; Pituitary Gland; Pituitary Gland, Anterior; Rabbits; Serotonin; Thyroidectomy; Thyroiditis; Thyrotropin

Case 1 showed recurrence of hyperthyroidism accompanied by pretibial myxedema and digital clubbing 14 years after thyroidectomy for Graves' disease. Case 2 had had pretibial myxedema for the past 20 years and myxedema tuberosum at the right shoulder for the past 10 years, and on admission showed exophthalmos and digital clubbing with thyroid gland demonstrating histological picture of chronic thyroiditis. This case was in slight hypothyroidism and serum LATS was highly positive. Eight cases of E.M.O. syndrome have so far been reported in Japan, including our own. Six cases of these were males. Two cases did not show any sign of hyperthyroidism throughout their entire courses, including our Case 2 described here. Three cases had never received treatment for Graves' disease prior to the occurrence of this syndrome. The serum LATS was positive in all 5 cases thus far reported.

Topics: Biopsy; Graves Disease; Humans; Hyaluronoglucosaminidase; Iodine Radioisotopes; Japan; Male; Methylthiouracil; Middle Aged; Myxedema; Osteoarthropathy, Secondary Hypertrophic; Recurrence; Shoulder; Syndrome; Thyroid Gland; Thyroiditis; Tibia

Topics: Adolescent; Female; Goiter; Hemorrhage; Humans; Hyperthyroidism; Hypoparathyroidism; Hypothyroidism; Iodine; Methylthiouracil; Postoperative Care; Postoperative Complications; Potassium Iodide; Preoperative Care; Propylthiouracil; Thyroid Diseases; Thyroidectomy; Thyroiditis; Time Factors; Vocal Cord Paralysis

Topics: Adult; Aged; Anthropometry; Antithyroid Agents; Autoimmune Diseases; Chronic Disease; Female; Goiter; Humans; Hyperthyroidism; Male; Methylthiouracil; Middle Aged; Thymus Gland; Thyroiditis

Topics: Aging; Blood Cell Count; Blood Chemical Analysis; Blood Proteins; Blood Sedimentation; Cholesterol; Clinical Laboratory Techniques; Cortisone; Diagnosis; Female; Glucose Tolerance Test; Humans; Liver Function Tests; Menstruation Disturbances; Methylthiouracil; Pituitary-Adrenal Function Tests; Potassium; Precipitin Tests; Sex; Skin Tests; Sodium; Thyroid Function Tests; Thyroiditis; Thyroiditis, Subacute; Thyrotropin

Topics: Bismuth; Drug Therapy; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Syphilis; Syphilis Serodiagnosis; Syphilis, Latent; Thyroiditis

Topics: Methylthiouracil; Thiouracil; Thyroiditis; Thyroiditis, Subacute

Topics: Methylthiouracil; Thiouracil; Thyroiditis; Thyroiditis, Subacute

Topics: Humans; Inflammation; Methylthiouracil; Penicillins; Thiouracil; Thyroiditis