methylthiouracil and Liver-Neoplasms

Topics: Animals; Benz(a)Anthracenes; Bone Neoplasms; Carbon Tetrachloride Poisoning; Carcinogens; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Chemical and Drug Induced Liver Injury; Cobalt Isotopes; Fibrosarcoma; Fluorenes; Gold Isotopes; Guinea Pigs; Liver Neoplasms; Methylcholanthrene; Methylthiouracil; Mice; Neoplasms, Radiation-Induced; Nitrosamines; Osteosarcoma; p-Dimethylaminoazobenzene; Papilloma; Phosphorus Isotopes; Precancerous Conditions; Radiation Injuries, Experimental; Radium; Sarcoma, Experimental; Time Factors; Urethane; Yttrium Isotopes

The nature of tumors appearing in the thyroid gland and in the lungs of mice fed two standard goitrogenic drugs (MTU and MII) has been studied. These tumors have been considered malignant on the basis of their morphological appearance and their occurrence in abnormal locations. Some investigatiors, however, have questioned that they are actually malignant. The present results indicate that these tumors are most likely not malignant even if it is shown that the pulmonary nodules are of thyroid origin. The thyroid adenomas disappear once the goitrogen is withdrawn, but thryoid enlargement pesists, and event 6 months after discontinuation of the goitrogenic treatment , pulmonary nodules are still produced. Evidence is presented that these nodules are emoli from hyperplastic thyroid tissue and not tumors.

Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diet; Glycolysis; Hyperplasia; Iodine; Liver Neoplasms; Lung Neoplasms; Male; Methimazole; Methylthiouracil; Mice; Mice, Inbred Strains; Oxygen Consumption; Thyroid Gland; Thyroid Neoplasms

Topics: Adenoma; Animals; Antithyroid Agents; Carcinogens; Carcinoma, Hepatocellular; Cysts; Female; Glucose; Goiter; Imidazoles; Kidney Diseases; Lactates; Liver Neoplasms; Male; Methimazole; Methylthiouracil; Mice; Mice, Inbred Strains; Ovarian Cysts; Oxygen Consumption; Thyroid Diseases; Thyroid Gland; Thyroid Neoplasms; Triiodothyronine

Topics: Adenocarcinoma; Animals; Basophils; Female; Hypothyroidism; Liver Neoplasms; Mammary Neoplasms, Experimental; Methylthiouracil; Neoplasms, Experimental; Ovarian Neoplasms; Pituitary Gland; Rats; Thyroid Neoplasms; Thyroidectomy

Topics: Adrenal Glands; Animals; Carcinoma, Hepatocellular; Deoxyribonucleases; DNA; Electric Stimulation; Hypothalamus; Liver Neoplasms; Melphalan; Methylthiouracil; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Ribonucleases; RNA; Sarcoma, Experimental