methylthiouracil and Lead-Poisoning

Male white Wistar-rats are treated alone and in combination with methylthiouracil and lead acetate. The histologic-cytological and the caryometrical results and the weights of the thyroids show an increase thyroid activity following as well methylthiouracil as lead application. The thyroxin-iodine blood level and the cholesterol blood level are altered. The strongest enhancement of the activity is obtained in the combination group methylthiouracil plus lead acetate. More slow activations are present in the groups with singular application methylthiouracil or lead acetate application. The findings are caused by encymatic inhibition of the applicated substances.

Topics: Animals; Cell Nucleus; Hypothyroidism; Karyometry; Lead; Lead Poisoning; Male; Methylthiouracil; Organometallic Compounds; Rats; Rats, Inbred Strains; Thyroid Gland

In a chronic experiment, male white Wistar-rats are treated with methylthriouracil and lead acetate alone and in combination. Additionally the animals of 2 groups are thyroidectomised. The pineal glands are investigated gravimetrically, histologic-cytologically, and caryometrically. The rank correlation analysis of the gravimetrical and caryometrical results proves the significance. The results show a decrease pineal activity following as well methylthiouracil application as thyroidectomy. The strongest decrease of the activity in the combination group thyroidectomy plus lead acetate is obtained. Changes in the pineal glands are not obtained neither after lead acetate application alone nor in combination with methylthiouracil. The results allow to draw the following conclusion: Lead acetate reduced the effect of methylthiouracil, in our opinion a hypothetic methylthiouracil-lead-compound is built. This interpretation is supported by the persistent effect of thyroidectomy whenever lead acetate is combined with thyroidectomy. These results and the results of the suprarenal cortex (Peschke et al. 1981) show clearly, that there is an interference between the methylthiouracil and lead acetate. Under these experimental conditions, one can speak of an ineffectual methylthiouracil-lead-compound.

Topics: Animals; Cell Nucleus; Hypothyroidism; Lead Poisoning; Male; Methylthiouracil; Pineal Gland; Rats; Rats, Inbred Strains

In a chronic experiment, male Wistar-rats were treated alone and in combination with methylthiouracil and lead acetate. Additionally, the animals of 2 groups were thyroidectomised. The suprarenal organs were investigated gravimetrically. Histologic-cytological and caryometrical investigations were made on the suprarenal cortex. After lead acetate application in the cortex, strong histologic-cytological alterations were obtained. There are marked damages especially in the zona fasciculata; a great number of pycnotic nuclei, a small subcapsular blastem, and a spreading out of the zona reticularis are observed. The size of nuclei is significantly diminished. These results indicated a regressive transformation and a toxic effect is discussed. After application of methylthiouracil or thyroidectomy, a regression transformation is found too. Cellular degenerations in all zones of the cortex are rarely or not obtained. As well methylthiourail as thyroidectomy diminish the weights of suprarenal organs high significantly. These results are not found after combined application of methylthiouracil and lead acetate. Methylthiouracil reduced the effect of lead acetate. The results allow to draw the following conclusion: In our opinion, a hypothetic methylthiouracil-lead-compound is built. This interpretation is supported by the persistent effect of lead acetate whenever lead acetate is combined with thyroidectomy.

Topics: Adrenal Cortex; Animals; Hypothyroidism; Lead Poisoning; Male; Methylthiouracil; Rats; Rats, Inbred Strains