methylthiouracil and Hyperthyroidism

Topics: Animals; Antithyroid Agents; Dogs; Humans; Hyperthyroidism; Iodine; Methimazole; Methylthiouracil; Propylthiouracil; Radioimmunoassay; Rats; Thyroidectomy; Thyroxine; Triiodothyronine

Topics: Antithyroid Agents; Barbiturates; Carbimazole; Diiodotyrosine; Estrogens; Fluorides; Humans; Hyperthyroidism; Imidazoles; Iodine; Iodine Isotopes; Methylthiouracil; Perchlorates; Phenylacetates; Plant Extracts; Potassium; Propiophenones; Reserpine; Sodium; Sulfonamides; Thiazoles; Thiocyanates; Thiouracil; Tissue Extracts; Tyrosine; Vitamins

Topics: Basal Metabolism; Female; Fetal Death; Goiter; Humans; Hyperthyroidism; Infant; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methylthiouracil; Pregnancy; Pregnancy Complications; Propylthiouracil; Research; Thiouracil; Thyroid Function Tests; Thyrotropin; Thyroxine; Toxicology

To seek for a safe and effective drug to treat hyperthyroidism.. Sixty cases of hyperthyroidism with leukocytopenia induced by sulfourea drugs were divided into treatment and control groups by 31 cases who were treated by traditional medicine Syndrome Differentiation and 29 cases who were treated by conventional western medicine alone respectively at random. They were estimated by total effective rate, major symptoms, WBC and immunological tests after four weeks.. The total effective rate in the treatment group (96.8%) was more effective than that in the control group (86.2%, P < 0.05). The symptom recovery rate in the treatment group was better than that in the control group. The WBC in both were all increased, but in the treatment group, it was better than that in the control group (P < 0.05). The positive to negative rate of thyroglobulin antibody and thyromicrosome antibody in the treatment group was better than that in the control group (P < 0.01).. It can not only improve the symptoms and immune function, but also increase WBC by using western medicine in combination with traditional medicine in treating hyperthyroidism.

Topics: Adenine; Adolescent; Adult; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Hyperthyroidism; Leukopenia; Male; Methylthiouracil; Middle Aged

The postnatal development of rat microglia is marked by an important increase in the number of microglial cells and the growth of their ramified processes. We studied the role of thyroid hormone in microglial development. The distribution and morphology of microglial cells stained with isolectin B4 or monoclonal antibody ED1 were analyzed in cortical and subcortical forebrain regions of developing rats rendered hypothyroid by prenatal and postnatal treatment with methyl-thiouracil. Microglial processes were markedly less abundant in hypothyroid pups than in age-matched normal animals, from postnatal day 4 up to the end of the third postnatal week of life. A delay in process extension and a decrease in the density of microglial cell bodies, as shown by cell counts in the developing cingulate cortex of normal and hypothyroid animals, were responsible for these differences. Conversely, neonatal rat hyperthyroidism, induced by daily injections of 3,5,3'-triiodothyronine (T3), accelerated the extension of microglial processes and increased the density of cortical microglial cell bodies above physiological levels during the first postnatal week of life. Reverse transcription-PCR and immunological analyses indicated that cultured cortical ameboid microglial cells expressed the alpha1 and beta1 isoforms of nuclear thyroid hormone receptors. Consistent with the trophic and morphogenetic effects of thyroid hormone observed in situ, T3 favored the survival of cultured purified microglial cells and the growth of their processes. These results demonstrate that thyroid hormone promotes the growth and morphological differentiation of microglia during development.

Topics: Animals; Brain; Cell Count; Cell Division; Cell Survival; Cells, Cultured; Female; Hyperthyroidism; Hypothyroidism; Iodine; Methylthiouracil; Microglia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Thyroid Hormone; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Hormones; Triiodothyronine

1. Male Sprague-Dawley rats were made either hyper- or hypothyroid with thyroxine or 4-methyl-2-thiouracil, respectively. Bronchial smooth muscle (BSM) contractility and lung cyclic adenosine 3',5'-monophosphate (cAMP) content were measured in both conditions. 2. Bronchial smooth muscle contractility was significantly weaker in hyperthyroid rats, while the BSM contractility of hypothyroid rats was the same as controls. 3. The cAMP content of hyperthyroid rat lungs was similar to controls but was decreased in hypothyroid rats. 4. These studies demonstrated that both the hyper- and hypothyroid states affect respiration, although the mechanisms involved with different for each condition.

Topics: Animals; Bronchi; Cyclic AMP; Hyperthyroidism; Hypothyroidism; Lung; Male; Methylthiouracil; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Thyroxine

Topics: Adult; Body Weight; Energy Intake; Female; Humans; Hyperthyroidism; Male; Methimazole; Methylthiouracil; Middle Aged

Topics: Adult; Aged; Autoantibodies; Female; Humans; Hyperthyroidism; Male; Methylthiouracil; Middle Aged; Thyroglobulin; Thyroid Gland

In discussing undesirable therapy effects by thyrostatics one must issue from the fact that the possible side effects have a different genesis and appear in different frequency. While pharmacodynamically caused therapy effects are generally to be avoided, when considering the pathophysiology of the regulation of the thyroid gland, this is not the case as to allergic side effects and only to a limited extent with regard to toxic side effects. Allergic side effects abruptly and suddenly appear and do not show any dependence on dosage. But for the greater part these side effects are harmless. Severe side effects are nearly without exception of toxic genesis. The decrease of the initial dose and the early transition to a still effective maintenance dose reduce the possibility of toxic complications. In case that side effects lead to a discontinuation of the corresponding thyrostatic, a change to a thyrostatic of another chemical group is possible and necessary.

Topics: Antithyroid Agents; Dose-Response Relationship, Drug; Humans; Hyperthyroidism; Methimazole; Methylthiouracil; Thyroid Hormones

With reference to the indirect evidence showing that heart growth in the presence of a cardiac overload is modulated by the adrenal cortex, we studied heart reactions to overloading (ligation of the abdominal aorta or hyperthyroidism) with simultaneous administration of aminoglutethimide, an inhibitor of steroidogenesis. Aminoglutethimide (Elipten CIBA, 0.5% in the diet) markedly inhibited the growth reaction of the heart 14 days after ligation of the abdominal aorta (reducing the aortal blood flow to about 40%) or after the administration of dried thyroid (Thyreoidin SPOFA, 0.2% in the diet). The effect of aminoglutethimide is evidently not due to its simultaneous antithyroid action, because methylthiouracil (Alkiron SPOFA, 0.2% in the diet) did not limit heart growth after ligation of the abdominal aorta, despite its having a stronger goitrogenic effect than aminoglutethimide. The results are a further contribution to the series of indirect evidence of the modulating effect of the adrenal cortex on heart growth.

Topics: Aminoglutethimide; Animals; Aorta, Abdominal; Cardiomegaly; Heart; Hyperthyroidism; Male; Methylthiouracil; Rats; Rats, Inbred Strains

The studies were made in order to estimate the rate of tissue protein synthesis in euthyroid, hyperthyroid and hypothyroid rats (110 g body weight). Hyperthyroidism was simulated by daily oral application of 4,44 micrograms thyroxine (T4) and 0,89 micrograms triiodothyronine (T3)/100 g body weight. Hypothyroidism was induced by oral application of 17,8 mg of methylthiouracil (MTU) per day and 100 g body weight. In both cases the treatment lasted for 7 days. The concentration of both hormones in blood serum was twice that of the control group in the T3 + T4 treated group. The MTU application produced a decrease in T3 and T4 concentration to levels below the lower detection limits of the methods used. The fractional rate of tissue protein synthesis was estimated using the constant intravenous infusion technique with L-14C-leucine and L-14C-lysine simultaneously. The range of the fractional rate of protein synthesis was found to be higher in hyperthyroid than in control animals in all organs under study (liver, small intestine, large intestine, gastrocnemius muscle and pancreas). Protein synthesis was stimulated to the greatest extent in muscle (4,5--5,1% . d-1 in controls vs, 5,5--6,7% . d-1 in hyperthyroid animals). The influence of hypothyroidism on the rate of protein synthesis was uncertain.

Topics: Animals; Hyperthyroidism; Hypothyroidism; Leucine; Lysine; Male; Methylthiouracil; Protein Biosynthesis; Rats; Thyroxine; Tissue Distribution; Triiodothyronine

1. A trace amount of glucose labelled with 14C uniformly and with 3H at position 2, 3 or 6 was injected intravenously into starved rats to measure the turnover rate of blood glucose. 2. Reliable estimates were made based on the semilogarithmic plot of specific radioactivity of the glucose contained in whole blood samples taken from the tail vein. 3. Glucose turned over more rapidly in hyperthyroid and more slowly in hypothyroid than in euthyroid rats. The percentage contribution of glucose recycling (determined from the difference in replacement rates between [U-14C]glucose and [6-3H]glucose) to the glucose utilization increased on induction of hyperthyroidism. 4. Futile cycles between glucose and glucose 6-phosphate (determined from the difference between replacement rates of [2-3H]glucose and [6-3H]glucose) were activated and inactivated by induction of hyperthyroid and hypothyroid states respectively. 5. The hepatic content of glycogen was much lower in hyper- and hypo-thyroid than in euthyroid rats. The enhanced glucose production in hyperthyroid rats resulted from not only activationof hepatic gluconeogenesis but also diversion of the final product of gluconeogenesis from liver glycogen to blood glucose. In hypothyroidism, the inhibition of gluconeogensis led to suppression of both glucose production and glycogenesis in the liver.

Topics: Animals; Blood Glucose; Carbon Radioisotopes; Glucose; Hyperthyroidism; Hypothyroidism; Kinetics; Liver; Liver Glycogen; Male; Methods; Methylthiouracil; Rats; Thyroxine; Tritium

Patients treated with 10 mCi of I-131 for toxic diffuse goiter in the period January 1974--June 1976 were evaluated for development of hypothyroidism. Fifty percent were hypothyroid within 3 mo and 69% within 1 yr of treatment. Our data suggest that there is a higher incidence of hypothyroidism after standard doses of I-131 in the 1970s as contrasted with treatment groups in the 1950s and 1960s. The pathophysiology of this increased incidence is not known with certainty; however, infrequent use of thionamide medication, together with recent increases in dietary iodine, may render the gland more radiosensitive.

Topics: Adolescent; Adult; Female; Humans; Hyperthyroidism; Hypothyroidism; Iodine Radioisotopes; Male; Methylthiouracil; Middle Aged; Radiotherapy; Retrospective Studies; Time Factors

Topics: Adolescent; Child; Humans; Hyperthyroidism; Methimazole; Methylthiouracil; Perchlorates; Potassium

In patients with hyperthyroidism the serum activities of the leucine aminopeptidase (LAP) and the alanine aminopeptidase (AAP) as well as the alanine aminopeptidase excretion in the urine were determined. A significantly increased activity of the leucine aminopeptidase in the serum and an increased excretion of alanine aminopeptidase in the urine were found. The AAP in the serum did not show a significant increase of activity. On account of the changes in the serum and in the urine before and during therapy a low-grade participation of the hepatobiliary and renal systems which are clinically not uppermost is to be assumed. Increased excretion of AAP and hyperthyroidism coincide nearly without exception in out patients. Correlation-statistical investigations make it probable to regard the increased excretion of AAP in the urine as an indirect parameter of the peripheral metabolism in hyperthyroidism.

Topics: Adult; Alkaline Phosphatase; Aminopeptidases; Female; gamma-Glutamyltransferase; Humans; Hyperthyroidism; Leucyl Aminopeptidase; Methylthiouracil

Topics: Adult; Humans; Hyperthyroidism; Male; Methylthiouracil; Myxedema; Substance Withdrawal Syndrome

Activity of alkaline and acid phosphatase was determined by the method of Bodansky in blood serum, homogenates of liver, kidney, lung, brain, liver mitochondrial fraction of normal, methylthiouracil-induced hypothyroid, and Thyroideum-induced hyperthyroid rats. The following results were obtained: an increase in both enzymes in all studied materials in hyperthyroidism, and a decrease in most of the studied materials in hypothyroidism.

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Brain; Hyperthyroidism; Hypothyroidism; Lung; Male; Methylthiouracil; Mitochondria, Liver; Rats; Thyroid Hormones

Thymic biopsies taken from women at the beginning of the operation of subtotal thyroidectomy were studied by the point-counting histometric technique. In all patients with primary thyrotoxicosis, the thymus is hyperplastic. After pretreatment with antithyroid drugs, the pattern of thymic involution with age is similar to, but at higher levels, than that in control groups of patients with non-toxic goitre in whom there is no evidence of immunological abnormality. By contrast, after propranolol pretreatment very little age involution is seen. The differences in the appearance of the thymus in female primary thyrotoxixosis patients prepared for operation with different drug treatment regimes are probably related to the pharmacological actions of the drugs and may indicate an interaction between primary immunological and secondary endocrinological factors in the disease process.

Topics: Adolescent; Adult; Age Factors; Biopsy; Carbimazole; Female; Humans; Hyperthyroidism; Methylthiouracil; Middle Aged; Propranolol; Thymus Gland; Thymus Hyperplasia

In homogenate supernatants of kidneys of male rats the extent of deiodination of L-diiodotyrosine (L-DJT) and L-thyroxine (L-T4) was investigated in dependence on the thyroid function (hypo- and hyperthyroidized) and also in dependence on age. In rats hypothyroidized by loading with Methylthiouracil (MTU) or Methimazol (MMI) the deiodination for L-DJT and L-T4 was significantly reduced, in rats loaded with 40 mug T4 sc. for 10 days, the deiodination was significantly enhanced compared with untreated control animals. With advancing age (6 weeks, 3 or 12 month) the deiodination activity is highly significantly reduced. The results underline relations between thyroid gland function and deiodination activity in kidney.

Topics: Age Factors; Animals; Diiodotyrosine; Hyperthyroidism; Hypothyroidism; Iodine; Kidney; Male; Methimazole; Methylthiouracil; Monoiodotyrosine; Rats; Thyroid Diseases; Thyroid Hormones; Thyroxine; Triiodothyronine

The comparative study of the in vivo synthesis of thyroglobulin and proteins other than thyroglobulin was carried out in thyroid glands from animals submitted to different levels of TSH stimulation. The different levels of hormonal stimulation modify neither the rate of labeling after injection of the isotope, nor the level of the free labeled amino acid in the glands (percent of the total uptake), but they have a very significant effect on the level of incorporation of the isotope into total proteins. In hypostimulated thyroids the total protein synthesis is very much reduced, while in hyperstimulated glands it is significantly increased. In both hyper- and hypostimulated animals, the proportion of radioactivity bound to the particulate protein fraction is higher than in control rats. However, the solubilization by digitonine of these proteins is lower in hypostimulated and higher in hyperstimulated animals than in controls. Thyroglobulin synthesis is significantly modified qualitatively and quantitatively in both hypo- and hyperstimulated glands. Qualitative modifications are characterized by a changed ratio of 19 S/12 S molecules with respect to the controls. This is probably caused by a more important dissociation of 19S molecules, due to the lower level of halogenation in both hypo- and MTU treated glands. The quantitative modifications of thyroglobulin synthesis, expressed either in absolute values (DPM/mg of tissue), or relatively to the total proteins (percent of total newly formed proteins), are characterized by a very important inhibition of this synthesis in hypostimulated glands, and its stimulation in glands chronically submitted to the TSH action. The modifications of synthesis observed for the proteins other than thyroglobulin are less significant in both types of treated glands than are those observed for thyroglobulin. The level of hormonal stimulation has no effect on the distribution of these proteins between soluble and the particulate fraction, but seems to have a slight effect on the solubilization of the latter ones. Comparative evaluation of the TSH effect on the synthesis of different thyroidal proteins shows that it has a much more specific and significant action on thyroglobulin than on other proteins. The differential effect of TSH on the synthesis of thyroglobulin and proteins other than thyroglobulin suggests that different mechanisms may exist by which TSH regulates the synthesis of these two types of proteins.

Topics: Animals; Digitonin; Hyperthyroidism; Hypophysectomy; Hypothyroidism; Kinetics; Methylthiouracil; Protein Biosynthesis; Rats; Thyroglobulin; Thyroid Gland; Thyroxine

Topics: Adult; Aged; Animals; Erythrocytes; Female; Guinea Pigs; Hemagglutination Inhibition Tests; Hemagglutination Tests; Humans; Hyperthyroidism; Immune Sera; Iodine Radioisotopes; Long-Acting Thyroid Stimulator; Male; Methylthiouracil; Middle Aged; Rabbits; Sheep; Stimulation, Chemical; Thyroglobulin; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Time Factors

Topics: Child; Chloramphenicol; Female; Goiter; Humans; Hyperthyroidism; Methylthiouracil; Triiodothyronine

Topics: Animals; Blood Glucose; Disease Models, Animal; Gluconeogenesis; Glucose Tolerance Test; Hyperthyroidism; Hypothyroidism; Male; Methimazole; Methylthiouracil; Rats; Thyroid Gland; Thyroxine

Topics: Animals; Antithyroid Agents; Hyperthyroidism; Hypothyroidism; Male; Methylthiouracil; Neuraminic Acids; Rats; Thyroid Hormones; Thyroidectomy; Thyroxine; Triiodothyronine

Topics: Adolescent; Female; Goiter; Hemorrhage; Humans; Hyperthyroidism; Hypoparathyroidism; Hypothyroidism; Iodine; Methylthiouracil; Postoperative Care; Postoperative Complications; Potassium Iodide; Preoperative Care; Propylthiouracil; Thyroid Diseases; Thyroidectomy; Thyroiditis; Time Factors; Vocal Cord Paralysis

Topics: Animals; Brain Chemistry; Catecholamines; Hyperthyroidism; Hypothyroidism; Male; Methylthiouracil; Rats; Serotonin; Spectrometry, Fluorescence; Triiodothyronine

Topics: Adult; Aged; Antithyroid Agents; Chemical Phenomena; Chemistry; Female; Humans; Hyperthyroidism; Imidazoles; Male; Methylthiouracil; Perchlorates; Propylthiouracil; Sympatholytics; Thiouracil; Thyroid Hormones; Thyronines

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Antithyroid Agents; Bromides; Codeine; DNA; Female; Glycosaminoglycans; Graves Disease; Histocytochemistry; Humans; Hyperthyroidism; Iodine; Male; Methylthiouracil; Middle Aged; Morpholines; Phytotherapy; Plants, Medicinal; Preoperative Care; RNA; Sodium; Succinate Dehydrogenase; Thyroid Gland; Tranquilizing Agents

Topics: Antithyroid Agents; Electrocardiography; Female; Heart Diseases; Humans; Hyperthyroidism; Male; Methylthiouracil

Topics: Adult; Arrhythmias, Cardiac; Back; Chronic Disease; Electromyography; Extremities; Female; Graves Disease; Humans; Hyperthyroidism; Male; Methimazole; Methylthiouracil; Middle Aged; Muscular Diseases; Paralyses, Familial Periodic; Sex Factors

Topics: Adult; Graves Disease; Humans; Hyperthyroidism; Methimazole; Methylthiouracil; Propylthiouracil; Radioimmunoassay; Thyroxine; Triiodothyronine

Topics: Adrenergic beta-Antagonists; Antithyroid Agents; Carbimazole; Chemical Phenomena; Chemistry; Humans; Hyperthyroidism; Hypothyroidism; Imidazoles; Iodine Isotopes; Methimazole; Methylthiouracil; Myocardial Infarction; Perchlorates; Potassium; Potassium Iodide; Propranolol; Propylthiouracil; Psychotic Disorders; Thiourea; Thyroxine; Time Factors

Topics: Animals; Gastric Mucosa; Glycosaminoglycans; Histocytochemistry; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Rats; Thyroid Hormones; Thyroidectomy

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Histocytochemistry; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Rats; Stomach

Topics: Animals; Antigens; Brucella; Brucellosis; Guinea Pigs; Hypersensitivity, Delayed; Hyperthyroidism; Hypothyroidism; Leukocyte Count; Lymphocytes; Methylthiouracil; Skin Tests; Thyroid Hormones; Thyroidectomy

Topics: Aged; Drug Hypersensitivity; Erythema Multiforme; Female; Humans; Hyperthyroidism; Methylthiouracil

Topics: Aminophylline; Animals; Enzyme Induction; Glycerolphosphate Dehydrogenase; Histocytochemistry; Hyperthyroidism; Liver; Male; Methylthiouracil; Rats; Tetrazolium Salts; Vitamin K

Topics: Animals; Autoantibodies; Carbimazole; Female; Humans; Hyperthyroidism; Immunoglobulins; Long-Acting Thyroid Stimulator; Male; Methylthiouracil; Mice; Thyroid Gland

Topics: Adolescent; Adult; Diagnosis, Differential; Female; Heart Block; Heart Conduction System; Humans; Hyperthyroidism; Methylthiouracil; Middle Aged

Topics: Animals; Hyperthyroidism; Hypothyroidism; Immobilization; Methylthiouracil; Mice; Stomach Ulcer; Stress, Physiological; Thyroid Gland; Thyroidectomy; Thyroxine

Topics: Blood Proteins; Carbimazole; Centrifugation, Density Gradient; Chromatography, Gel; Hemagglutination Tests; Humans; Hyperthyroidism; Iodine; Methylthiouracil; Molecular Weight; Protein Binding; Thyroglobulin; Thyroidectomy; Thyroxine; Triiodothyronine

Topics: Adolescent; Child; Child, Preschool; Diagnosis, Differential; Germany, East; Humans; Hyperthyroidism; Hypothyroidism; Infant; Infant, Newborn; Methimazole; Methylthiouracil; Thyroid Diseases; Thyroid Hormones; Thyroidectomy

Topics: Adult; Antithyroid Agents; Biopsy; Celiac Disease; Female; Humans; Hyperthyroidism; Imidazoles; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Methylthiouracil; Middle Aged; Radiography; Thyroidectomy; Vitamin A; Xylose

Topics: Albumins; Animals; Beta-Globulins; Cattle; Electrophoresis; Female; gamma-Globulins; Hyperthyroidism; Hypothyroidism; Lactoglobulins; Methylthiouracil; Milk; Thyroxine

Topics: Adrenal Glands; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Body Weight; Cricetinae; Drug Synergism; Female; Hyperthyroidism; Hypertrophy; Male; Methylthiouracil; Organ Size; Ovarian Diseases; Ovary; Pituitary Gland; Pyridones; Rats; Testicular Diseases; Thyroid Gland; Thyroid Hormones; Thyroidectomy; Uterus

Topics: Animals; Cerebral Cortex; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Organ Size; Rats; Thyroxine

Topics: Animals; Hyperthyroidism; Hypothyroidism; Leukocytes; Methylthiouracil; Peritonitis; Phagocytosis; Rabbits; Thyroid Hormones; Vitamin B 12

Topics: Adult; Aged; Animals; Exophthalmos; Female; Guinea Pigs; Humans; Hyperthyroidism; Iodine Isotopes; Long-Acting Thyroid Stimulator; Male; Methylthiouracil; Middle Aged; Thyrotropin; Triiodothyronine

Topics: Arthritis, Rheumatoid; Calcitonin; Humans; Hyperthyroidism; Male; Methylthiouracil; Thyroidectomy; Thyroxine

Topics: Allantoin; Animals; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Purines; Rats; Thyroid Hormones; Thyroxine; Uric Acid

Topics: Adolescent; Child; Female; Humans; Hyperthyroidism; Menstruation; Methylthiouracil; Puberty

Topics: Animals; Cornea; Epinephrine; Hyperthyroidism; Intestine, Small; Male; Methylthiouracil; Mitosis; Parathyroid Glands; Rats; Thyroid Gland

Topics: Animals; Brain; Conditioning, Classical; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Mice; Motor Activity; Thyroid Hormones

Topics: Adolescent; Adult; Antithyroid Agents; Blood Cell Count; Diagnosis, Differential; Diagnostic Errors; Female; Goiter; Heart Auscultation; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Methylthiouracil; Myxedema; Nervous System Diseases; Neurotic Disorders; Propylthiouracil; Radioisotope Dilution Technique; Thiazoles; Thiouracil; Thiourea; Thyrotropin

Topics: Adult; Aged; Anthropometry; Antithyroid Agents; Autoimmune Diseases; Chronic Disease; Female; Goiter; Humans; Hyperthyroidism; Male; Methylthiouracil; Middle Aged; Thymus Gland; Thyroiditis

Topics: Animals; Antithyroid Agents; Calcitonin; Calcium; Hypercalcemia; Hyperthyroidism; Methylthiouracil; Secretory Rate; Swine; Thyroid Gland

Topics: Adolescent; Adult; Aged; Antithyroid Agents; Child; Female; Humans; Hyperthyroidism; Imidazoles; Male; Methylthiouracil; Middle Aged

Topics: Fibrinogen; Fibrinolysin; Fibrinolysis; Humans; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Plasminogen; Thyroid Function Tests; Thyroid Gland; Thyroxine

Topics: Adolescent; Adult; Age Factors; Animals; Basal Metabolism; Carnitine; Female; Humans; Hydroxyproline; Hyperthyroidism; Iodine Isotopes; Iodine Radioisotopes; Methylthiouracil; Middle Aged; Postoperative Complications; Thyroid Function Tests; Thyroidectomy

Topics: Adolescent; Adult; Female; Goiter; Humans; Hyperthyroidism; Male; Methylthiouracil; Middle Aged; Vitamins

Topics: Animals; Connective Tissue; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Muscle Denervation; Muscle Proteins; Myofibrils; Nitrogen; Rabbits; Rats; Sciatic Nerve; Solubility; Thyroid Hormones; Time Factors

Topics: Animals; Asphyxia; Diabetes Mellitus, Experimental; Female; Fetal Heart; Heart; Heart Defects, Congenital; Humans; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Myocardial Infarction; Myocardium; Obstetric Labor Complications; Pregnancy; Pregnancy Complications; Rabbits; Radiation Effects; Thyroid Hormones

Topics: Achilles Tendon; Adult; Aged; Creatine Kinase; Female; Humans; Hyperthyroidism; Hypothyroidism; Iodine Radioisotopes; Male; Methylthiouracil; Middle Aged; Myxedema; Reflex, Abnormal; Thyroid Function Tests; Thyroxine

Topics: Animals; Blood; Hyperthyroidism; Iodine; Iodine Isotopes; Methylthiouracil; Rats; Thyroid Function Tests; Thyroidectomy

Topics: Adult; Antithyroid Agents; Blood; Female; Follow-Up Studies; Humans; Hyperthyroidism; In Vitro Techniques; Iodine; Iodine Radioisotopes; Male; Methylthiouracil; Middle Aged; Thyroid Function Tests; Thyroxine

Topics: Adrenal Glands; Animals; Antithyroid Agents; Body Weight; Erythromycin; Hyperthyroidism; Male; Methylthiouracil; Organ Size; Rabbits; Rats; Thyroid Gland; Thyroid Hormones

Topics: Animals; Female; Glycosaminoglycans; Hyaluronoglucosaminidase; Hyperthyroidism; Methylthiouracil; Rabbits; Thyroid Function Tests; Thyroid Hormones

Topics: Adult; Female; Humans; Hyperthyroidism; Methylthiouracil; Pregnancy; Pregnancy Complications

Topics: Animals; Cartilage; Epiphyses; Hyperthyroidism; Hypothyroidism; Male; Metacarpus; Methylthiouracil; Osteogenesis; Rats; Thyroxine

Topics: Adolescent; Antithyroid Agents; Child; Drug Therapy; Follow-Up Studies; Humans; Hyperthyroidism; Methylthiouracil; Perchlorates; Prognosis; Statistics as Topic; Thyroidectomy; Thyrotoxicosis

Topics: Blood; Chlorides; Creatine; Creatinine; Drug Therapy; Galvanic Skin Response; Humans; Hyperthyroidism; Magnesium; Magnesium Sulfate; Methylthiouracil; Paralyses, Familial Periodic; Paralysis; Potassium Chloride

Topics: Diagnosis; Drug Therapy; Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Thyroid Function Tests; Thyrotoxicosis

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Female; Humans; Hyperthyroidism; Iodine; Male; Methylthiouracil; Middle Aged; Urine

Topics: Adult; Humans; Hyperthyroidism; Leg; Methylthiouracil; Middle Aged; Myxedema; Skin Manifestations

Topics: Adult; Female; Humans; Hyperthyroidism; Male; Methylthiouracil; Postoperative Complications; Thyroid Crisis

Topics: Basal Metabolism; Blood Glucose; Cholesterol; Electrocardiography; Extremities; Humans; Hyperthyroidism; Imidazoles; Iodine Isotopes; Methylthiouracil; Paralysis; Potassium; Sodium; Sodium, Dietary; Spasm; Thyroid Function Tests; Thyroidectomy

Topics: Anesthesia; Anesthesia, Local; Anesthesia, Spinal; Antithyroid Agents; Barbiturates; Chloroform; Ether; Hyperthyroidism; Hypothermia, Induced; Iodine; Metabolism; Methylthiouracil; Refrigeration; Surgical Procedures, Operative; Thyroid Function Tests; Thyroid Neoplasms

Topics: Drug Therapy; Goiter; Graves Disease; Humans; Hyperthyroidism; Methylthiouracil; Thyroid Hormones; Thyronines

Topics: Autoradiography; Electrophoresis; Goiter; Humans; Hyperthyroidism; Iodates; Iodides; Iodine; Iodine Isotopes; Methylthiouracil; Proteins; Thiouracil; Thyroglobulin; Thyroid Gland

Topics: Electrophoresis; Goiter; Humans; Hyperthyroidism; Iodides; Iodine; Methylthiouracil; Pharmacology; Proteins; Thyroglobulin; Thyroid Gland; Thyroid Hormones

Topics: Bismuth; Drug Therapy; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Syphilis; Syphilis Serodiagnosis; Syphilis, Latent; Thyroiditis

Topics: Amenorrhea; Contraceptive Agents, Female; Estradiol Congeners; Estrogens; Female; Humans; Hyperthyroidism; Metabolism; Methylthiouracil; Pharmacology; Urine

Topics: Adolescent; Antithyroid Agents; Child; Drug Therapy; Goiter; Humans; Hyperthyroidism; Methylthiouracil; Perchlorates; Reserpine; Thyrotoxicosis

Topics: Goiter; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Radiotherapy; Thyroid Function Tests; Thyroidectomy

Topics: Antithyroid Agents; Humans; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Propylthiouracil

Topics: Antithyroid Agents; Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Perchlorates; Radiotherapy; Thiouracil; Thiourea; Thyroidectomy

Topics: Graves Disease; Humans; Hyperthyroidism; Iodides; Iodine; Metabolism; Methylthiouracil; Potassium; Thyroid Gland

Topics: Aged; Antithyroid Agents; Basal Metabolism; Carbimazole; Cholesterol; Humans; Hyperthyroidism; Methylthiouracil; Propylthiouracil; Toxicology

Topics: Bronchopneumonia; Hyperthyroidism; Lupus Erythematosus, Systemic; Methylthiouracil; Neutrophils; Pathology; Toxicology

Topics: Animals; Constipation; Diarrhea; Dogs; Gastric Juice; Hyperthyroidism; Hypothyroidism; Methylthiouracil; Pharmacology; Physiology; Research; Stomach; Thyroid Hormones

Topics: Antithyroid Agents; Humans; Hyperthyroidism; Methylthiouracil; Perchlorates; Preoperative Care; Reserpine; Thyroidectomy

Topics: Antithyroid Agents; Exophthalmos; Humans; Hyperthyroidism; Iodides; Iodine; Iodine Isotopes; Methylthiouracil; Perchlorates; Propylthiouracil; Radioisotopes; Radionuclide Imaging; Thyroid Neoplasms; Toxicology

Topics: Castration; Female; Humans; Hyperthyroidism; Iodine Isotopes; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Radiation-Induced; Methylthiouracil; Ovarian Diseases; Ovary; Radiation Effects; Radiation, Ionizing; Toxicology

Topics: Animals; Chorionic Gonadotropin; Estrogens; Female; Gonadotropins; Gonadotropins, Equine; Horses; Humans; Hyperthyroidism; Hypophysectomy; Hypothyroidism; Methylthiouracil; Ovary; Pharmacology; Pregnancy; Rats; Research; Thyroid Hormones; Thyroidectomy; Thyroxine; Uterus

Topics: Humans; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Reserpine; Thiouracil; Thyrotoxicosis

Topics: Combined Modality Therapy; Goiter; Hyperthyroidism; Iodine; Iodine Radioisotopes; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Iodine; Iodine Radioisotopes; Methylthiouracil; Radioisotopes; Thiouracil

Topics: Antineoplastic Agents, Hormonal; Antithyroid Agents; Carbimazole; Humans; Hyperthyroidism; Methylthiouracil; Perchlorates; Potassium Compounds; Thiouracil; Thyrotoxicosis

Topics: Graves Disease; Humans; Hyperthyroidism; Immunologic Tests; Iodides; Iodine; Methylthiouracil; Thiouracil

Topics: Animals; Bromides; Bromine; Guinea Pigs; Hyperthyroidism; Methylthiouracil; Rats; Thiouracil; Thyroid Gland; Viscera

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyroxine

Topics: Goiter; Humans; Hyperthyroidism; Methylthiouracil; Syndrome; Thiouracil

Topics: Goiter; Hyperkinesis; Hyperthyroidism; Hypothalamus; Methylthiouracil; Neurosecretion; Pharmaceutical Preparations; Thiouracil

Topics: 17-Ketosteroids; Body Fluids; Graves Disease; Hyperthyroidism; Methylthiouracil; Steroids; Thiouracil; Urine

Topics: Hyperthyroidism; Methylthiouracil; Radiotherapy; Thiouracil; X-Ray Therapy; X-Rays

Topics: Hyperthyroidism; Methylthiouracil; Pregnancy; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Neoplasms; Thiazoles; Thiouracil

Topics: Diabetes Complications; Diabetes Mellitus; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Graves Disease; Humans; Hyperthyroidism; Methylthiouracil; Thiouracil; Tuberculosis; Tuberculosis, Miliary

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyrotoxicosis; Thyroxine

Topics: Agranulocytosis; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Endocrine System Diseases; Hyperthyroidism; Methylthiouracil; Musculoskeletal Diseases; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Iodine; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Exophthalmos; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Blood Proteins; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Graves Disease; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Blood Cells; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Bone Marrow; Eosinophils; Hyperthyroidism; Methylthiouracil; Propylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Skin Temperature; Thiouracil

Topics: Animals; Dogs; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Estrogens; Hexestrol; Hyperthyroidism; Leadership; Methylthiouracil; Thiouracil

Topics: Blood; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Iodides; Iodine; Iodine Isotopes; Methylthiouracil; Thiouracil; Thyroid Gland

Topics: Cardiomyopathies; Heart; Hyperthyroidism; Methylthiouracil; Propylthiouracil; Thiouracil; Thiourea; Thyroid Gland

Topics: Humans; Hyperthyroidism; Methylthiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Heart Failure; Hyperthyroidism; Methylthiouracil; Thiourea; Thyroid Diseases

Topics: Humans; Hyperthyroidism; Methylthiouracil; Thyroid Gland

Topics: Humans; Hyperthyroidism; Methylthiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyroid Gland

Topics: Humans; Hyperthyroidism; Methylthiouracil; Thyroid Gland; Thyrotoxicosis