methylthiouracil and Graves-Disease

To investigate the cellular and molecular mechanisms of some Chinese herbs on apoptosis of thyrocytes in Graves' disease.. Thirteen patients of Graves' disease were treated by anti-thyroid drugs and Chinese herbs were added in the therapeutic period for 2-10 weeks. Thyroid tissue of patient was sucked by percutaneous aspiration before and after adding Chinese herbs for observing the cellular morphology by fast red tablet staining, monitoring the cell apoptotic ratio by flow cytometry and terminal uridine deoxynucleotidyl end labelling (TUNEL) method to observe the effect of anti-thyroid drugs combined with Chinese herbs on Graves' disease.. Compared with that treated with anti-thyroid drugs alone, after the combined therapy, the size of thyroid decreased significantly, P < 0.01. Typical apoptosis appearance, such as vacuolated cell, marginal nuclei, chromatin condensation and nuclear fragmentation, could be seen under light microscopy. The apoptotic rate before and after adding Chinese herbs was (2.11 +/- 1.78)% and (18.66 +/- 20.01)% respectively (P < 0.01). TUNEL positive cells were detectable for up to 2-20 weeks after Chinese herbal treatment.. Some Chinese herbs could induce cell apoptosis when used in combination with antithyroid drugs in treating Graves' disease.

Topics: Adult; Antithyroid Agents; Apoptosis; Biopsy, Needle; Drugs, Chinese Herbal; Female; Graves Disease; Humans; Male; Methylthiouracil; Middle Aged; Phytotherapy; Thyroid Gland

Case 1 showed recurrence of hyperthyroidism accompanied by pretibial myxedema and digital clubbing 14 years after thyroidectomy for Graves' disease. Case 2 had had pretibial myxedema for the past 20 years and myxedema tuberosum at the right shoulder for the past 10 years, and on admission showed exophthalmos and digital clubbing with thyroid gland demonstrating histological picture of chronic thyroiditis. This case was in slight hypothyroidism and serum LATS was highly positive. Eight cases of E.M.O. syndrome have so far been reported in Japan, including our own. Six cases of these were males. Two cases did not show any sign of hyperthyroidism throughout their entire courses, including our Case 2 described here. Three cases had never received treatment for Graves' disease prior to the occurrence of this syndrome. The serum LATS was positive in all 5 cases thus far reported.

Topics: Biopsy; Graves Disease; Humans; Hyaluronoglucosaminidase; Iodine Radioisotopes; Japan; Male; Methylthiouracil; Middle Aged; Myxedema; Osteoarthropathy, Secondary Hypertrophic; Recurrence; Shoulder; Syndrome; Thyroid Gland; Thyroiditis; Tibia

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Antithyroid Agents; Bromides; Codeine; DNA; Female; Glycosaminoglycans; Graves Disease; Histocytochemistry; Humans; Hyperthyroidism; Iodine; Male; Methylthiouracil; Middle Aged; Morpholines; Phytotherapy; Plants, Medicinal; Preoperative Care; RNA; Sodium; Succinate Dehydrogenase; Thyroid Gland; Tranquilizing Agents

Topics: Adult; Arrhythmias, Cardiac; Back; Chronic Disease; Electromyography; Extremities; Female; Graves Disease; Humans; Hyperthyroidism; Male; Methimazole; Methylthiouracil; Middle Aged; Muscular Diseases; Paralyses, Familial Periodic; Sex Factors

Topics: Adult; Graves Disease; Humans; Hyperthyroidism; Methimazole; Methylthiouracil; Propylthiouracil; Radioimmunoassay; Thyroxine; Triiodothyronine

Topics: Adult; Aged; Cholelithiasis; Goiter; Graves Disease; Humans; Methylthiouracil; Middle Aged; Postoperative Care; Postoperative Complications

Topics: Diagnosis; Drug Therapy; Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Thyroid Function Tests; Thyrotoxicosis

Topics: Drug Therapy; Goiter; Graves Disease; Humans; Hyperthyroidism; Methylthiouracil; Thyroid Hormones; Thyronines

Topics: Adenoma; Goiter; Graves Disease; Iodine; Methylthiouracil; Pathology; Pharmacology; Pituitary Gland; Rats; Research; Thyroid Neoplasms; Thyrotrophs; Triiodothyronine

Topics: Adolescent; Agranulocytosis; Exophthalmos; Goiter; Graves Disease; Hydroxyzine; Methylthiouracil; Toxicology

Topics: Antithyroid Agents; Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Perchlorates; Radiotherapy; Thiouracil; Thiourea; Thyroidectomy

Topics: Graves Disease; Humans; Hyperthyroidism; Iodides; Iodine; Metabolism; Methylthiouracil; Potassium; Thyroid Gland

Topics: Graves Disease; Humans; Hyperthyroidism; Immunologic Tests; Iodides; Iodine; Methylthiouracil; Thiouracil

Topics: 17-Ketosteroids; Body Fluids; Graves Disease; Hyperthyroidism; Methylthiouracil; Steroids; Thiouracil; Urine

Topics: Graves Disease; Humans; Hyperthyroidism; Methylthiouracil; Thiouracil; Tuberculosis; Tuberculosis, Miliary

Topics: Graves Disease; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Graves Disease; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Goiter; Graves Disease; Humans; Methylthiouracil; Sulfanilamide; Sulfanilamides; Sulfonamides; Thiouracil; Thyroid Gland

Topics: Graves Disease; Humans; Iodides; Iodine; Methylthiouracil; Thiourea; Thyroid Diseases