methylthiouracil and Escherichia-coli-Infections

Efficacy of kanamycin, ampicillin and their combinations with methyluracyl and pyrogenal in experimental Coli infections was studied. The antibiotics were administered an hour after the infection. Methyluracyl and pyrogenal were used according to 2 schemes. Scheme No. I: the drug is used daily for 7 days in increasing doses, the last dose is administered 24 hours before the infection. Scheme No. 2: the drug is used once at the moment of the infection. The methyluracyl doses were: 0.5, 1.0, 2.5 mg and 5 mg and 5 mg per a mouse during the following 4 days. The pyrrogenal doses were: 5, 10, 15, 25, 30 and 35 minimum pyrogenic doses. 5 mg of methyluracyl and 35 minimum pyrogenic doses of pyrogenal were used according to scheme No. 2. The most pronounced increase in the efficacy of kanamycin, ampicillin and their combination was observed in the animals treated simultaneously with methyluracyl and pyrogenal according to scheme No. 1. The efficacy of kanamycin and ampicillin increased 3 and 2.68 times respectively. ED50 of kanamycin and ampicillin used in combination in the animals treated with methyluracyl and pyrogenal was lowered 4 and 2.9 times respectively as compared to that in the animal groups treated only with the antibiotic combination and 21 and 15.2 times respectively when the antibiotics were used alone. Sanation of the animal organs was also rather successful. A single administration of methyluracyl and pyrogenal simultaneously with the infection (scheme No. 2) had a lower effect on the efficacy.

Topics: Ampicillin; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Escherichia coli Infections; Kanamycin; Methylthiouracil; Mice; Pyrogens; Sepsis

Topics: Animals; Antineoplastic Agents; Bone Regeneration; Escherichia coli Infections; Humans; Macrophages; Methylthiouracil; Mice; Phagocytosis; Polysaccharides, Bacterial; Serratia marcescens; Staphylococcal Infections; Stimulation, Chemical; Time Factors; Tonsillectomy; Uracil; Wound Healing; Wound Infection