methylselenic acid has been researched along with Cancer of Prostate in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 29 (65.91) | 29.6817 |
| 2010's | 13 (29.55) | 24.3611 |
| 2020's | 2 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Calvo, A; Moreno, E; Palop, JA; Plano, D; Prior, C; Sanmartín, C | 1 |
| Bosland, MC; Deng, Y; Lü, J; Schlicht, MJ | 1 |
| Bai, S; Cao, S; Gu, J; Hu, C; Kobelski, M; Lambert, JR; Wang, X; Zhan, Y; Zhang, W | 1 |
| Hu, H; Hu, W; Ma, Y; Yin, S; Zhao, C | 1 |
| Allen, JE; Pinto, JT; Sinha, I; Sinha, R | 1 |
| Ahmad, N; Havighurst, T; Kim, K; Mukhtar, H; Ndiaye, MA; Nihal, M; Siddiqui, IA; Singh, CK; Zhong, W | 1 |
| Bosland, MC; Deng, Y; Guo, X; Jiang, C; Lü, J; Wang, J; Wang, L | 1 |
| Chhabra, D; Gopalakrishna, R; Gundimeda, U; Schiffman, JE; Wong, J; Wu, A | 1 |
| Fabritius, M; Ip, C; Wu, Y | 1 |
| Gopalakrishna, R; Gottlieb, SN; Gundimeda, U; Roth, BI; Schiffman, JE | 1 |
| Chai, Y; Hu, H; Jiang, C; Lee, HJ; Lü, J; Wang, L; Wang, Z; Zhang, Y | 1 |
| Cheng, H; Dong, Y; Duplessis, T; Ge, Y; Horikawa, I; Ip, C; Liu, S; Lustig, AJ; Qi, Y; Rennie, PS; Rowan, BG; Yu, Q; Zhang, H | 1 |
| Dong, Y; Fang, J; Ip, C; Wu, Y; Yao, D; Zhang, H | 1 |
| Anderson, LB; Lü, J; Wang, L; Witthuhn, B; Xu, Y; Zhang, J | 1 |
| Dong, Y; Gao, L; Gao, R; Liu, X; Zhang, H; Zhao, L; Zhao, X; Zhao, Y | 1 |
| Cleary, MP; Liao, JD; Lü, J; Nkhata, K; Quealy, E; Wang, L; Zhang, J; Zhang, Y | 1 |
| King, T; Null, K; Pinto, JT; Sinha, I; Sinha, R; Suckow, MA; Wolter, W | 1 |
| Anderson, LB; Li, G; Lü, J; Wang, L; Witthuhn, B; Xu, Y; Zhang, J | 1 |
| Dong, Y; Fan, L; Guo, X; Hu, H; Lu, J; Ye, M; Yin, S | 1 |
| Ganther, H; Jiang, C; Lü, J; Wang, Z | 2 |
| Budunova, IV; Gasparian, AV; Lü, J; Lyakh, LA; Slaga, TJ; Yao, YJ; Yemelyanov, AY | 1 |
| Dong, Y; Ganther, HE; Hawthorn, L; Ip, C; Zhang, H | 1 |
| Botstein, D; Brooks, JD; Whitfield, ML; Xu, T; Zhao, H | 1 |
| Cho, SD; Dong, Y; Ip, C; Jiang, C; Kang, KS; Lee, YS; Lü, J; Malewicz, B; Young, CY | 1 |
| Hu, H; Ip, C; Jiang, C; Lü, J; Rustum, YM | 1 |
| Hu, H; Jiang, C; Li, G; Lü, J | 1 |
| Crispen, P; Golovine, K; Kolenko, VM; Makhov, P; Pimkina, J; Uzzo, RG; Yamaguchi, K | 1 |
| Dong, Y; Gao, AC; Ip, C; Marshall, JR; Zhang, H | 1 |
| Dong, Y; Ip, C; Park, YM; Wu, Y; Zhang, H | 1 |
| Bihani, T; Ip, C; Lin, A; Mori, K; Park, YM; Zu, K | 1 |
| Baek, SH; Choi, KS; Ip, C; Kim, YH; Lee, JS; Ma, YB; Park, EM; Park, SY; Park, YM; Zhang, H; Zu, K | 1 |
| Ip, C; Wallace, PK; Warren, MA; Wu, Y; Zu, K | 1 |
| Bhattacharyya, RS; Feldman, D; Husbeck, B; Knox, SJ | 1 |
| Dong, Y; Ip, C; Li, S; Lu, J; Malewicz, B; Marshall, J; Wu, Y; Zhang, H | 1 |
| Brooks, JD; Zhao, H | 1 |
| Hu, H; Jiang, C; Li, GX; Lü, J; Schuster, T | 1 |
| Christensen, MJ; Eggett, DL; Parker, TL | 1 |
| Calvo, A; de las Rivas, J; Gonzalez-Moreno, O; Nguewa, P; Segura, V; Serrano, D | 1 |
| Hu, H; Jiang, C; Kim, SH; Lee, HJ; Li, G; Lü, J; Wang, Z | 1 |
| Combs, GF; Hu, H; Li, GX; Lü, J; Wang, L; Watts, J | 1 |
| Combs, GF; Hu, H; Lee, HJ; Li, GX; Liao, JD; Lü, J; Wang, Z; Watts, JC | 1 |
| Dong, Y; Liu, S; Zhang, H; Zhao, L; Zhu, L | 1 |
| Jia, L; Kline, K; Sanders, BG; Snyder, RM; Yu, W | 1 |
1 trial(s) available for methylselenic acid and Cancer of Prostate
| Article | Year |
|---|---|
Effect of Dietary Methylseleninic Acid and Se-Methylselenocysteine on Carcinogen-Induced, Androgen-Promoted Prostate Carcinogenesis in Rats.
Topics: Androgens; Animals; Antioxidants; Carcinogenesis; Carcinogens; Diet; Disease Models, Animal; Humans; Male; Mice; Organoselenium Compounds; Prostate; Prostatic Neoplasms; Rats; Selenium; Selenocysteine; Selenomethionine | 2022 |
43 other study(ies) available for methylselenic acid and Cancer of Prostate
| Article | Year |
|---|---|
Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells.
Topics: Carbamates; Cell Line, Tumor; Cell Proliferation; Humans; Imides; Male; Molecular Structure; Organoselenium Compounds; Prostatic Neoplasms; Structure-Activity Relationship | 2007 |
Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 15; Humans; Male; Organoselenium Compounds; PC-3 Cells; Prostatic Neoplasms; Proteomics | 2019 |
Methylseleninic acid overcomes programmed death-ligand 1-mediated resistance of prostate cancer and lung cancer.
Topics: A549 Cells; Animals; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Humans; Interferon-gamma; Lung Neoplasms; Male; Mice; Organoselenium Compounds; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Xenograft Model Antitumor Assays | 2021 |
Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Humans; Male; Mice; Mice, Nude; Organoselenium Compounds; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
Methaneseleninic acid and γ-Tocopherol combination inhibits prostate tumor growth in Vivo in a xenograft mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; gamma-Tocopherol; Humans; Male; Mice; Mice, Nude; Organoselenium Compounds; Prostatic Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse.
Topics: Administration, Oral; Animals; Cellular Senescence; Disease Models, Animal; Disease Progression; Epithelium; Immunohistochemistry; Male; Mice; Mice, Knockout; Organoselenium Compounds; Prostate; Prostatic Neoplasms; PTEN Phosphohydrolase; Random Allocation; Signal Transduction; Tumor Suppressor Protein p53 | 2016 |
Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells.
Topics: Apoptosis; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Humans; Isoenzymes; Male; Organoselenium Compounds; Oxygen; Prostatic Neoplasms; Protein Kinase C; RNA, Small Interfering; Selenium | 2008 |
Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Death; Cell Line, Tumor; Docetaxel; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme-Linked Immunosorbent Assay; Formazans; Heat-Shock Proteins; Humans; Male; Molecular Chaperones; Organoselenium Compounds; Paclitaxel; Prostatic Neoplasms; RNA, Small Interfering; Taxoids; Tetrazolium Salts; Thapsigargin; Time Factors; Transcription Factor CHOP; Transfection | 2009 |
Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; Humans; Indoles; Male; Maleimides; Methylnitrosourea; Neoplasm Invasiveness; Organoselenium Compounds; Prostatic Neoplasms; Protein Kinase C-epsilon; Thioredoxin-Disulfide Reductase | 2009 |
Persistent p21Cip1 induction mediates G(1) cell cycle arrest by methylseleninic acid in DU145 prostate cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; G1 Phase; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Organoselenium Compounds; Prostatic Neoplasms; RNA Interference; RNA, Messenger; Time Factors; Transfection; Tumor Suppressor Protein p53; Up-Regulation; Xenograft Model Antitumor Assays | 2010 |
Telomerase as an important target of androgen signaling blockade for prostate cancer treatment.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Synergism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Nitriles; Organoselenium Compounds; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA Stability; RNA, Messenger; Telomerase; Tosyl Compounds | 2010 |
Activation of FOXO1 is critical for the anticancer effect of methylseleninic acid in prostate cancer cells.
Topics: Antineoplastic Agents; Cell Division; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Male; Organoselenium Compounds; Prostatic Neoplasms; RNA, Neoplasm; RNA, Small Interfering | 2010 |
Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model.
Topics: Adenocarcinoma; Animals; Biomarkers, Pharmacological; Biomarkers, Tumor; Cysteine; Disease Models, Animal; Male; Metabolome; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Organoselenium Compounds; Prostatic Neoplasms; Proteomics; Selenium Compounds; Selenocysteine; Selenomethionine | 2010 |
Survivin gene silencing sensitizes prostate cancer cells to selenium growth inhibition.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cysteine; Down-Regulation; Drug Synergism; Gene Silencing; Humans; Immunoenzyme Techniques; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Organoselenium Compounds; Prognosis; Prostatic Neoplasms; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Selenocysteine; Survival Rate; Survivin | 2010 |
Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Cell Lineage; Cysteine; Disease Models, Animal; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Metastasis; Organoselenium Compounds; Prostatic Neoplasms; Proteomics; Selenocysteine; Seminal Vesicles | 2011 |
Methylseleninic acid downregulates hypoxia-inducible factor-1α in invasive prostate cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Down-Regulation; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Lung Neoplasms; Male; Neoplasm Metastasis; Organoselenium Compounds; Procollagen-Proline Dioxygenase; Prostatic Neoplasms; Rats; Rats, Wistar; Selenium; Vascular Endothelial Growth Factor A | 2012 |
Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds.
Topics: Animals; Anticarcinogenic Agents; Cysteine; Gene Expression Profiling; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Organoselenium Compounds; Prostate; Prostatic Neoplasms; Protein Biosynthesis; Proteomics; RNA, Messenger; Selenium Compounds; Selenocysteine; Selenomethionine; Sodium Selenite; Xenograft Model Antitumor Assays | 2011 |
Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Inducing Factor; Breast Neoplasms; Cell Line, Tumor; Curcumin; Female; Focal Adhesion Kinase 1; Humans; Male; Myeloid Cell Leukemia Sequence 1 Protein; Organoselenium Compounds; Prostatic Neoplasms; Reactive Oxygen Species; Up-Regulation | 2013 |
Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Death; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; DNA Fragmentation; G1 Phase; Humans; Immunoblotting; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Organoselenium Compounds; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Protein Kinases; S Phase; Selenium; Sodium Selenite; Superoxides; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Selenium compounds inhibit I kappa B kinase (IKK) and nuclear factor-kappa B (NF-kappa B) in prostate cancer cells.
Topics: Active Transport, Cell Nucleus; Adenoviridae; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Nucleus; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; I-kappa B Kinase; Luciferases; Male; NF-kappa B; Organoselenium Compounds; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Protein Binding; Protein Serine-Threonine Kinases; Selenium; Time Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2002 |
Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array.
Topics: Apoptosis; Bromodeoxyuridine; Cell Cycle; Cell Division; Humans; Kinetics; Male; Oligonucleotide Array Sequence Analysis; Organoselenium Compounds; Prostatic Neoplasms; Time Factors; Tumor Cells, Cultured | 2003 |
Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells.
Topics: Adenocarcinoma; Cell Cycle; Cell Division; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Male; NADPH Dehydrogenase; Oligonucleotide Array Sequence Analysis; Organoselenium Compounds; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 2004 |
Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription.
Topics: Androgens; Cell Death; Cell Line, Tumor; Humans; Male; Organoselenium Compounds; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Processing, Post-Translational; Receptors, Androgen; RNA, Messenger; Selenomethionine; Sodium Selenite; Time Factors; Transcription, Genetic | 2004 |
Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells.
Topics: Androgens; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspases; Drug Therapy, Combination; Enzyme Activation; Etoposide; Humans; JNK Mitogen-Activated Protein Kinases; Male; Organoselenium Compounds; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Tumor Cells, Cultured | 2005 |
PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells.
Topics: Apoptosis; Butadienes; Caspases; Cell Line, Tumor; Chromones; Humans; Kinetics; Male; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Organoselenium Compounds; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt | 2005 |
Methylseleninic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caspase 8; Caspases; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; Humans; Male; Membrane Glycoproteins; Membrane Potentials; Mitochondria; Organoselenium Compounds; Phosphorylation; Prostatic Neoplasms; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2005 |
Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers.
Topics: Biomarkers, Tumor; Cell Proliferation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Luciferases; Male; Organoselenium Compounds; Prostatic Neoplasms; Receptors, Androgen; Selenium; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured | 2005 |
Endoplasmic reticulum stress signal mediators are targets of selenium action.
Topics: Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Male; Molecular Chaperones; Organoselenium Compounds; Prostatic Neoplasms; Signal Transduction; Transcription Factor CHOP | 2005 |
Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells.
Topics: CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Male; Molecular Chaperones; Organoselenium Compounds; Prostatic Neoplasms; Protein Folding; Signal Transduction; Transcription Factor CHOP; Tumor Suppressor Protein p53 | 2006 |
Neural network-based analysis of thiol proteomics data in identifying potential selenium targets.
Topics: Antineoplastic Agents; Biotin; Cell Line, Tumor; Electrophoresis, Gel, Two-Dimensional; Ethylenediamines; Humans; Male; Neural Networks, Computer; Organoselenium Compounds; Oxidation-Reduction; Prostatic Neoplasms; Proteins; Proteome; Proteomics; Selenium; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfhydryl Compounds | 2006 |
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Antineoplastic Agents; Calcineurin; Calcium; Cell Membrane; Humans; Male; Organoselenium Compounds; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Selenium; Threonine | 2006 |
Inhibition of androgen receptor signaling by selenite and methylseleninic acid in prostate cancer cells: two distinct mechanisms of action.
Topics: Acetylcysteine; Androgen Receptor Antagonists; Dose-Response Relationship, Drug; Down-Regulation; Glutathione; Humans; Male; Metalloporphyrins; Metribolone; Organoselenium Compounds; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Signal Transduction; Sodium Selenite; Sp1 Transcription Factor; Superoxides; Tumor Cells, Cultured | 2006 |
Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid.
Topics: Androgen Receptor Antagonists; Cell Line, Tumor; Down-Regulation; Drug Synergism; Humans; Male; Organoselenium Compounds; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Signal Transduction; Tocopherols; Vitamin E | 2006 |
Selenomethionine induced transcriptional programs in human prostate cancer cells.
Topics: Humans; Male; Organoselenium Compounds; Prostatic Neoplasms; Selenomethionine; Transcription, Genetic; Tumor Cells, Cultured | 2007 |
Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells.
Topics: Acetylcysteine; Androgens; Antioxidants; Apoptosis; Caspases; Cell Line, Tumor; DNA Breaks; Humans; Male; Organoselenium Compounds; Prostatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Sodium Selenite; Tumor Suppressor Protein p53 | 2007 |
Estrogen receptor activation and estrogen-regulated gene expression are unaffected by methylseleninic acid in LNCaP prostate cancer cells.
Topics: Cathepsin D; Cyclin-Dependent Kinase 2; Cysteine-Rich Protein 61; Electrophoretic Mobility Shift Assay; Estrogens; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Male; Organoselenium Compounds; Prostatic Neoplasms; Receptors, Estrogen; Response Elements; RNA, Messenger | 2007 |
Methylseleninic acid enhances the effect of etoposide to inhibit prostate cancer growth in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Docetaxel; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; Gene Expression; Gene Expression Profiling; Humans; Male; Metabolic Networks and Pathways; Mice; Mice, Nude; Oligonucleotide Array Sequence Analysis; Organoselenium Compounds; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Taxoids; Xenograft Model Antitumor Assays | 2007 |
Methylseleninic acid inhibits microvascular endothelial G1 cell cycle progression and decreases tumor microvessel density.
Topics: Animals; Apoptosis; Bromodeoxyuridine; Cell Proliferation; Cells, Cultured; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase; Humans; Immunoblotting; Immunoprecipitation; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Oncogene Proteins; Organoselenium Compounds; Prostatic Neoplasms; Retinoblastoma Protein; S Phase | 2008 |
Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down-regulates antiapoptotic proteins Bcl-XL and survivin.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Cell Line, Tumor; Docetaxel; Down-Regulation; Drug Synergism; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins; Male; Mice; Microtubule-Associated Proteins; Neoplasm Proteins; Organoselenium Compounds; Paclitaxel; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Taxoids; Xenograft Model Antitumor Assays | 2008 |
Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Comet Assay; DNA Damage; Humans; Lymphocytes; Male; Mice; Mice, Nude; Neoplasm Transplantation; Organoselenium Compounds; Prostatic Neoplasms; Selenomethionine; Transplantation, Heterologous | 2008 |
Kruppel-like factor 4 is a novel mediator of selenium in growth inhibition.
Topics: Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Male; Organoselenium Compounds; Prostatic Neoplasms; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Messenger; RNA, Small Interfering; Selenium; Transcription, Genetic; Up-Regulation | 2008 |
Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Caspases; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Male; Organoselenium Compounds; Prostatic Neoplasms; Resveratrol; Stilbenes; Tocopherols; Vitamin E | 2008 |
Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells.
Topics: Anoikis; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Cytochrome c Group; DNA Fragmentation; Enzyme Activation; Humans; Isoenzymes; Male; Mitochondria; Nucleosomes; Organoselenium Compounds; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Sodium Selenite; Substrate Specificity; Tumor Cells, Cultured | 2001 |