methylprednisolone acetate and Spinal Diseases studies

Methylprednisolone Acetate: Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.
methylprednisolone acetate : An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid.

Research Excerpts

Excerpt	Relevance	Reference
"Clinical trials first began in 1960 with methylprednisolone acetate (Depo-Medrol) administered intrathecally, in an attempt to treat both disk disease and multiple sclerosis."	4.77	Dangers from methylprednisolone acetate therapy by intraspinal injection. ( Nelson, DA, 1988)
"Methylprednisolone acetate was injected into the L3-L4 disc, whereas methylprednisolone sodium succinate was injected into the L4-L5 disc."	1.30	Histologic changes in the intervertebral disc after intradiscal injections of methylprednisolone acetate in rabbits. ( Aoki, M; Iwata, H; Kato, F; Mimatsu, K, 1997)
"Spinal epidural lipomatosis has been reported frequently in association with chronic systemic corticosteroid therapy, but thus far only one case has been attributed to local epidural corticosteroid injections."	1.30	Symptomatic spinal epidural lipomatosis after local epidural corticosteroid injections: case report. ( Lavyne, MH; Sandberg, DI, 1999)
"A case is reported in which chemical meningism occurred after lumbar facet joint block with methylprednisolone acetate and bupivacaine."	1.28	Chemical meningism after lumbar facet joint block with local anaesthetic and steroids. ( Collett, BJ; Lomax, DM; Thomson, SJ, 1991)

Research

Studies (11)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Pain Disability Questionnaire

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (18.18)	18.7374
1990's	4 (36.36)	18.2507
2000's	3 (27.27)	29.6817
2010's	2 (18.18)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Scuderi, GJ	1
Cuellar, JM	1
Cuellar, VG	1
Yeomans, DC	1
Carragee, EJ	1
Angst, MS	1
Shoham, S	1
Marr, KA	1
Khot, A	1
Bowditch, M	1
Powell, J	1
Sharp, D	1
Amin, N	1
Brancaccio, R	1
Cohen, D	1
Carrera, GF	1
Williams, AL	1
Aoki, M	1
Kato, F	1
Mimatsu, K	1
Iwata, H	1
Sandberg, DI	1
Lavyne, MH	1
Rothbart, P	1
Thomson, SJ	1
Lomax, DM	1
Collett, BJ	1
Nelson, DA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Using Inflammatory Biomarkers and EMG Results to Predict Epidural Injection Response in Patients Diagnosed With Lumbar Stenosis[NCT03511053]		11 participants (Actual)	Interventional	2017-12-19	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Measures how pain is affecting the patients lifestyle on a scale from 0 to 10 as defined by each question. The questionnaire contains 15 questions that each range on a scale form 0 to 10. The total score of the questionnaire ranges from 0 to 150. Lower values represent a better outcome. (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection

Swiss Spinal Stenosis Questionnaire

Intervention	score on a scale (Mean)
	Average at baseline	Average at 1 month	Average at 2 months	Average at 1 month change	Average at 2 month change
All Participants	77.5	53.3	64.3	27.3	16.2

Measures how pain due to spinal stenosis is effected the patient based on quality of life/pain questions and satisfaction questions for months 1 and 2 (no scales are used) SSSQ scores are reported in percentages 0-100%, higher scores indicate worse outcomes. (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection

Visual Analogue Scale

Intervention	Percentage (Mean)
	Average at baseline	Average at 1 month	Average at 2 months	Average at 1 month change	Average at 2 month change
All Participants	64.1	53.2	53.5	11.7	10.3

Number rating of back/leg pain from 0 to 10, 0 being no pain/discomfort, 10 being extreme pain/discomfort (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection

Article	Year
Current concepts in evaluation of the lumbar facet joints. Critical reviews in diagnostic imaging, 1984, Volume: 21, Issue:2 Topics: Arthrography; Back Pain; Cartilage, Articular; Diagnosis, Differential; Humans; Joint Diseases; Lumb	1984
Dangers from methylprednisolone acetate therapy by intraspinal injection. Archives of neurology, 1988, Volume: 45, Issue:7 Topics: Demyelinating Diseases; Humans; Injections, Epidural; Injections, Spinal; Intervertebral Disc; Methy	1988

Article	Year
Spinal and paraspinal infections associated with contaminated methylprednisolone acetate injections - Michigan, 2012-2013. MMWR. Morbidity and mortality weekly report, 2013, May-17, Volume: 62, Issue:19 Topics: Aged; Anti-Inflammatory Agents; Disease Outbreaks; Drug Contamination; Female; Humans; Injections, E	2013
Epidural interferon gamma-immunoreactivity: a biomarker for lumbar nerve root irritation. Spine, 2009, Oct-01, Volume: 34, Issue:21 Topics: Adult; Aged; Biomarkers; Bupivacaine; Cohort Studies; Epidural Space; Female; Follow-Up Studies; Hum	2009
Treatment of iatrogenic fungal infections: a black mold defines a new gray zone in medicine. Annals of internal medicine, 2013, Feb-05, Volume: 158, Issue:3 Topics: Anti-Inflammatory Agents; Antifungal Agents; Arthritis; Centers for Disease Control and Prevention,	2013
Cutaneous reactions to injectable corticosteroids. Dermatitis : contact, atopic, occupational, drug, 2006, Volume: 17, Issue:3 Topics: Aged; Anti-Inflammatory Agents; Bupivacaine; Diagnosis, Differential; Drug Eruptions; Female; Humans	2006
Histologic changes in the intervertebral disc after intradiscal injections of methylprednisolone acetate in rabbits. Spine, 1997, Jan-15, Volume: 22, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Calcinosis; Injections, Spinal; Intervertebral Disc; Lumbar Verte	1997
Symptomatic spinal epidural lipomatosis after local epidural corticosteroid injections: case report. Neurosurgery, 1999, Volume: 45, Issue:1 Topics: Aged; Anti-Inflammatory Agents; Decompression, Surgical; Humans; Injections, Epidural; Laminectomy;	1999
Unilateral headache with features of hemicrania continua and cervicogenic headache--a case report. Headache, 1992, Volume: 32, Issue:9 Topics: Adult; Anti-Inflammatory Agents; Female; Headache; Humans; Injections, Spinal; Lidocaine; Methylpred	1992
Chemical meningism after lumbar facet joint block with local anaesthetic and steroids. Anaesthesia, 1991, Volume: 46, Issue:7 Topics: Adult; Anti-Inflammatory Agents; Chronic Disease; Dura Mater; Female; Humans; Lumbar Vertebrae; Meni	1991

methylprednisolone acetate and Spinal Diseases