methylprednisolone acetate has been researched along with Osteoarthritis, Knee in 19 studies
Methylprednisolone Acetate: Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.
methylprednisolone acetate : An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid.
Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Knee pain (Numeric Rating Scale [NRS]), Oxford Knee Score, overall treatment effect (Global Perceived Effect), analgesic drug use, and adverse events were compared between CRFA and IAS cohorts at 1, 3, and 6 months after intervention." | 2.87 | Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in the Management of Knee Pain From Osteoarthritis. ( Buvanendran, A; Choi, D; Davis, T; DePalma, M; Desai, M; Gupta, A; Hunter, C; Kapural, L; Lindley, D; Loudermilk, E; Patel, N; Soloman, M, 2018) |
| "The aim of this study was to compare the effectiveness of triamcinolone hexacetonide (THA) and methylprednisolone acetate (MPA), given via the intra-articular route at equipotent dosage to patients with symptomatic knee OA with effusion, in a double-blind randomized comparative trial." | 2.71 | Intra-articular steroids in knee osteoarthritis: a comparative study of triamcinolone hexacetonide and methylprednisolone acetate. ( Bhanji, A; Ioannou, Y; Mootoo, R; Pyne, D, 2004) |
| "Fructosamine is a glycated protein that reflects blood glucose control over the last 2-3 weeks." | 1.43 | The impact of intra-articular methylprednisolone acetate injection on fructosamine levels in diabetic patients with osteoarthritis of the knee, a case-control study. ( Artul, S; Habib, G; Hakim, G; Jabaly-Habib, H; Jabbour, A; Khazin, F; Sakas, F, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 12 (63.16) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, T | 1 |
| Loudermilk, E | 1 |
| DePalma, M | 1 |
| Hunter, C | 1 |
| Lindley, D | 1 |
| Patel, N | 1 |
| Choi, D | 1 |
| Soloman, M | 1 |
| Gupta, A | 1 |
| Desai, M | 1 |
| Buvanendran, A | 1 |
| Kapural, L | 1 |
| Habib, G | 4 |
| Jabbour, A | 4 |
| Artul, S | 3 |
| Hakim, G | 2 |
| Leighton, R | 1 |
| Akermark, C | 1 |
| Therrien, R | 1 |
| Richardson, JB | 1 |
| Andersson, M | 1 |
| Todman, MG | 1 |
| Arden, NK | 1 |
| Khazin, F | 2 |
| Chernin, M | 1 |
| Badarny, S | 1 |
| Hakim, J | 1 |
| Henriksen, M | 1 |
| Christensen, R | 1 |
| Klokker, L | 1 |
| Bartholdy, C | 1 |
| Bandak, E | 1 |
| Ellegaard, K | 1 |
| Boesen, MP | 1 |
| Riis, RG | 1 |
| Bartels, EM | 1 |
| Bliddal, H | 1 |
| Orak, MM | 1 |
| Ak, D | 1 |
| Midi, A | 1 |
| Laçin, B | 1 |
| Purisa, S | 1 |
| Bulut, G | 1 |
| Sakas, F | 1 |
| Jabaly-Habib, H | 1 |
| McCrum, C | 2 |
| Fatimah, N | 1 |
| Salim, B | 1 |
| Raja, EU | 1 |
| Nasim, A | 1 |
| Habib, GS | 1 |
| Bashir, M | 1 |
| Di Sante, L | 1 |
| Paoloni, M | 1 |
| Ioppolo, F | 1 |
| Dimaggio, M | 1 |
| Di Renzo, S | 1 |
| Santilli, V | 1 |
| Joo, JH | 1 |
| Park, JW | 1 |
| Kim, JS | 1 |
| Kim, YH | 1 |
| Smith, MD | 1 |
| Wetherall, M | 1 |
| Darby, T | 1 |
| Esterman, A | 1 |
| Slavotinek, J | 1 |
| Roberts-Thomson, P | 1 |
| Coleman, M | 1 |
| Ahern, MJ | 1 |
| Pyne, D | 1 |
| Ioannou, Y | 1 |
| Mootoo, R | 1 |
| Bhanji, A | 1 |
| Amin, N | 1 |
| Brancaccio, R | 1 |
| Cohen, D | 1 |
| Kydd, AS | 1 |
| Reno, CR | 1 |
| Tsao, HW | 1 |
| Hart, DA | 1 |
| Guidolin, DD | 1 |
| Ronchetti, IP | 1 |
| Lini, E | 1 |
| Guerra, D | 1 |
| Frizziero, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Proof-of-Concept Study to Define the Safety, Efficacy and Feasibility of Cryoanalgesia (Iovera°®) for the Treatment of Pain in Subjects With Morton's Neuroma[NCT05604144] | 5 participants (Anticipated) | Interventional | 2022-08-22 | Active, not recruiting | |||
| Cooled Genicular Radiofrequency Ablation Versus Conventional Genicular Radiofrequency Ablation for the Treatment of Chronic Knee Pain: A Prospective Study[NCT04275128] | 1 participants (Actual) | Observational | 2020-07-11 | Terminated (stopped due to Insurance companies no longer cover this procedure) | |||
| Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With OA of the Hip Compared to Intra-articular Steroid Injections[NCT04329884] | 60 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting | |||
| A Prospective, Multi-Center, RCT Evaluating the Safety and Effectiveness of Coolief™ Cooled Radiofrequency Probe to Create Lesions of the Genicular Nerves and Comparing Corticosteroid Injection in the Management of Knee Pain[NCT02343003] | 151 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Randomized, Double-blinded, Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections[NCT06000709] | Phase 4 | 40 participants (Anticipated) | Interventional | 2023-10-20 | Not yet recruiting | ||
| The Influence of Hyaluronic Acid Injection Following Knee Arthroscopy[NCT02640144] | Phase 4 | 60 participants (Anticipated) | Interventional | 2017-02-28 | Not yet recruiting | ||
| Double-Blind, Randomized, Parallel Group, Multicenter Study of Durolane Compared to Methylprednisolone in Subjects With Osteoarthritis of the Knee[NCT01209364] | Phase 3 | 442 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Combined Intra Articular Corticosteroid and Physiotherapeutic Exercise in Patients With Osteoarthritis of the Knee: A Random-ised Clinical Trial[NCT01945749] | 100 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis: a Non-inferiority Randomized Controlled Double-blind Study[NCT05806021] | Phase 4 | 327 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | ||
| Clinical Evidence Regarding The Dynamic of Baker Cyst Dimensions After Intermittent Vacuum Therapy As Rehabilitation Treatment In Patients With Knee Osteoarthritis[NCT06079684] | 65 participants (Actual) | Interventional | 2022-11-01 | Completed | |||
| Optimal Anesthetic for Corticosteroid Injections for Knee Osteoarthritis.[NCT05906433] | Phase 1 | 75 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The number of subjects whose knee pain is reduced from baseline by ≥ 50% based on the Numeric Rating Scale (NRS) at 12 months. The NRS is an 11-point scale (0 points to 10 points), where 0 points equals no pain and 10 points equals the worst pain." (NCT02343003)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Cooled Radiofrequency | 34 |
| Corticosteroid Injection | 2 |
"The number of subjects whose knee pain is reduced by ≥ 50% based on the Numeric Rating Scale (NRS). The NRS is an 11-point scale (0 points to 10 points), where 0 points equals no pain and 10 points equals the worst pain." (NCT02343003)
Timeframe: 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Cooled Radiofrequency | 43 |
| Corticosteroid Injection | 11 |
Reduction in pain medication usage from baseline as measured by subject self-reported average daily dosage. (NCT02343003)
Timeframe: 6 months and 12 months
| Intervention | milligrams (Mean) | |
|---|---|---|
| 6 months post-intervention | 12 months post-intervention | |
| Cooled Radiofrequency | 2.4 | 1 |
| Corticosteroid Injection | -0.6 | 2.5 |
"Improvement in global outcome from baseline as measured by the Oxford Knee Score at 6 months and 12 months. The Oxford Knee Score is determined by a 12-question survey that measures knee function, and is scored on a scale that ranges from 0 - 48 points, with scores of 0 - 19 = severe arthritis, 20 - 29 = moderate to severe arthritis, 30 - 39 = mild to moderate arthritis, and 40 - 48 = satisfactory joint function." (NCT02343003)
Timeframe: 6 months and 12 months
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 6 months post-intervention | 12 months post-intervention | |
| Cooled Radiofrequency | 18.5 | 17.3 |
| Corticosteroid Injection | 5.7 | 8.7 |
Safety Endpoint: Number of subjects experiencing adverse events through final follow up. (NCT02343003)
Timeframe: 6 months and 12 months
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| 6 months post-intervention | 12 months post-intervention | |
| Cooled Radiofrequency | 34 | 12 |
| Corticosteroid Injection | 31 | 3 |
"Subject satisfaction as measured by the Global Perceived Effect Score at 6 months and 12 months. The study subjects' perception of treatment effect was reflected by the Global Perceived Effect (GPE). The Global Perceived Effect is a 7-point scale: 1 point = worst ever, 2 points = much worse, 3 points = worse, 4 points = not improved but not worse, 5 points = improved, 6 points = much improved, 7 points = best ever." (NCT02343003)
Timeframe: 6 months and 12 months
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| 6 months post-intervention | 12 months post-intervention | |
| Cooled Radiofrequency | 53 | 39 |
| Corticosteroid Injection | 16 | 2 |
2 reviews available for methylprednisolone acetate and Osteoarthritis, Knee
| Article | Year |
|---|---|
Therapeutic Review of Methylprednisolone Acetate Intra-Articular Injection in the Management of Osteoarthritis of the Knee - Part 1: Clinical Effectiveness.
Topics: Animals; Anti-Inflammatory Agents; Humans; Injections, Intra-Articular; Methylprednisolone; Methylpr | 2017 |
Therapeutic Review of Methylprednisolone Acetate Intra-Articular Injection in the Management of Osteoarthritis of the Knee - Part 2: Clinical and Procedural Considerations.
Topics: Anesthesia, Local; Anti-Inflammatory Agents; Anticoagulants; Contraindications; Drug Interactions; H | 2016 |
9 trials available for methylprednisolone acetate and Osteoarthritis, Knee
8 other studies available for methylprednisolone acetate and Osteoarthritis, Knee
| Article | Year |
|---|---|
Simultaneous bilateral knee injection of methylprednisolone acetate and the hypothalamic-pituitary adrenal axis: a single-blind case-control study.
Topics: Adult; Aged; Case-Control Studies; Female; Humans; Hypothalamo-Hypophyseal System; Injections, Intra | 2014 |
Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diclofenac; Female; Injectio | 2015 |
The impact of intra-articular methylprednisolone acetate injection on fructosamine levels in diabetic patients with osteoarthritis of the knee, a case-control study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; C-Reactive Protein; Case-Control Studi | 2016 |
Predictors of response to intra-articular steroid injections in patients with osteoarthritis of the knee joint.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Female; Humans; Injections, Intra-Arti | 2016 |
Polyuria and polydipsia following an intra-articular steroid injection.
Topics: Anti-Inflammatory Agents; Drinking Behavior; Humans; Injections, Intra-Articular; Male; Methylpredni | 2009 |
Ultrasound-guided aspiration and corticosteroid injection of Baker's cysts in knee osteoarthritis: a prospective observational study.
Topics: Aged; Analysis of Variance; Female; Glucocorticoids; Humans; Injections, Intra-Articular; Male; Meth | 2010 |
Cutaneous reactions to injectable corticosteroids.
Topics: Aged; Anti-Inflammatory Agents; Bupivacaine; Diagnosis, Differential; Drug Eruptions; Female; Humans | 2006 |
Impact of age, systemic glucocorticoids, and progressive knee arthritis on specific mRNA levels in different areas of the rabbit cornea.
Topics: Actins; Aging; Animals; Cornea; Cyclooxygenase 2; Decorin; Extracellular Matrix Proteins; Female; Fi | 2007 |