methylprednisolone acetate and Neuralgia, Sciatic studies

Methylprednisolone Acetate: Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.
methylprednisolone acetate : An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid.

Research Excerpts

Excerpt	Relevance	Reference
"In a randomized, double-blind trial, we administered up to three epidural injections of methylprednisolone acetate (80 mg in 8 ml of isotonic saline) or isotonic saline (1 ml) to 158 patients with sciatica due to a herniated nucleus pulposus."	5.08	Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. ( Bergeron, V; Blaise, GA; Blanchette, C; Carette, S; Leclaire, R; Levésque, J; Marcoux, S; Montminy, P; Morin, F; Parent, F; St-Pierre, A; Truchon, R, 1997)
"Adrenocortical function was tested in 12 patients following a single lumbar extradural injection of methylprednisolone acetate ('Depo-Medrol') 80 mg as treatment for chronic sciatica."	3.66	Adrenal suppression following extradural steroids. ( Jacobs, S; Potter, JM; Pullan, PT; Shenfield, GM, 1983)
"Sciatica is one of the most incapacitating and difficult to treat of all benign pains."	2.65	Management of lumbar nerve-root pain by intrathecal and epidural injections of depot methylprednisolone acetate. ( Ryan, MD; Taylor, TK, 1981)

Research

Studies (13)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Global Perceived Effect

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (69.23)	18.7374
1990's	3 (23.08)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (7.69)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Cohen, SP	1
White, RL	1
Kurihara, C	1
Larkin, TM	1
Chang, A	1
Griffith, SR	1
Gilligan, C	1
Larkin, R	1
Morlando, B	1
Pasquina, PF	1
Yaksh, TL	1
Nguyen, C	1
Carrera, GF	1
Williams, AL	1
Jacobs, S	1
Pullan, PT	1
Potter, JM	1
Shenfield, GM	1
Klenerman, L	1
Greenwood, R	1
Davenport, HT	1
White, DC	1
Peskett, S	1
Ryan, MD	1
Taylor, TK	1
Corrigan, AB	1
Carr, G	1
Tugwell, S	1
Gdakowicz, B	1
Nelson, DA	1
Carette, S	1
Leclaire, R	1
Marcoux, S	1
Morin, F	1
Blaise, GA	1
St-Pierre, A	1
Truchon, R	1
Parent, F	1
Levésque, J	1
Bergeron, V	1
Montminy, P	1
Blanchette, C	1
Mohs, JC	1
Newton, WP	1
Niesyty, M	1
Moskal, J	1
Rosen, CD	1
Kahanovitz, N	1
Bernstein, R	1
Viola, K	1
Cuckler, JM	1
Bernini, PA	1
Wiesel, SW	1
Booth, RE	1
Rothman, RH	1
Pickens, GT	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
[NCT00733096]	Phase 2/Phase 3	84 participants (Actual)	Interventional	2008-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Satisfaction. Number of participants with positive perceived global satisfaction. (NCT00733096)
Timeframe: 1 month

Medication Reduction

Numerical Rating Leg Pain Score

Intervention	participants (Number)
Steroid	23
Etanercept	15
Saline	17

Intervention	participants (Number)
Steroid	17
Etanercept	9
Saline	14

0-10 pain score. 0= no pain, 10= worst imaginable pain. (NCT00733096)
Timeframe: 1 month

Oswestry Disability Score

Intervention	units on a scale (Mean)
Steroid	2.54
Etanercept	3.56
Saline	3.78

0-100%. 0= no disability, 100% is complete disability (NCT00733096)
Timeframe: 1 month

Article	Year
Current concepts in evaluation of the lumbar facet joints. Critical reviews in diagnostic imaging, 1984, Volume: 21, Issue:2 Topics: Arthrography; Back Pain; Cartilage, Articular; Diagnosis, Differential; Humans; Joint Diseases; Lumb	1984
Intraspinal corticosteroid injections. The Medical journal of Australia, 1982, Mar-06, Volume: 1, Issue:5 Topics: Abscess; Adrenal Cortex Hormones; Arachnoiditis; Dura Mater; Fistula; Humans; Injections; Interverte	1982

Article	Year
Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial. Annals of internal medicine, 2012, Apr-17, Volume: 156, Issue:8 Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bupiva	2012
Lumbar epidural injections in the treatment of sciatica. British journal of rheumatology, 1984, Volume: 23, Issue:1 Topics: Acupuncture Therapy; Bupivacaine; Female; Humans; Male; Methylprednisolone; Methylprednisolone Aceta	1984
Management of lumbar nerve-root pain by intrathecal and epidural injections of depot methylprednisolone acetate. The Medical journal of Australia, 1981, Nov-14, Volume: 2, Issue:10 Topics: Adult; Cerebrospinal Fluid Proteins; Clinical Trials as Topic; Delayed-Action Preparations; Female;	1981
Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. The New England journal of medicine, 1997, Jun-05, Volume: 336, Issue:23 Topics: Adult; Anti-Inflammatory Agents; Double-Blind Method; Female; Humans; Injections, Epidural; Interver	1997
[Analysis of the effectiveness of treating severe cases of sciatica of radicular origin by intrathecal administration of Depo-Medrol]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1989, Dec-01, Volume: 41, Issue:23 Topics: Acute Disease; Adult; Clinical Trials as Topic; Female; Humans; Injections, Spinal; Male; Methylpred	1989
The use of epidural steroids in the treatment of lumbar radicular pain. A prospective, randomized, double-blind study. The Journal of bone and joint surgery. American volume, 1985, Volume: 67, Issue:1 Topics: Adrenal Cortex Hormones; Anesthesia, Epidural; Back Pain; Clinical Trials as Topic; Double-Blind Met	1985

Article	Year
Adrenal suppression following extradural steroids. Anaesthesia, 1983, Volume: 38, Issue:10 Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Chronic Disease; Depression,	1983
[Preliminary evaluation of therapeutic value of depot-medrol, administered extradurally, in lumbar discopathy]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1980, Oct-15, Volume: 33, Issue:20 Topics: Adult; Aged; Delayed-Action Preparations; Female; Humans; Lumbosacral Region; Male; Methylprednisolo	1980
Intraspinal therapy using methylprednisolone acetate. Twenty-three years of clinical controversy. Spine, 1993, Volume: 18, Issue:2 Topics: Anesthesiology; Anti-Inflammatory Agents; Arachnoiditis; History, 20th Century; Humans; Low Back Pai	1993
Epidural injections for sciatica. The Journal of family practice, 1997, Volume: 45, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Double-Blind Method; Humans; Injections, E	1997
A retrospective analysis of the efficacy of epidural steroid injections. Clinical orthopaedics and related research, 1988, Issue:228 Topics: Adult; Aged; Back Pain; Female; Humans; Injections, Epidural; Intervertebral Disc Displacement; Male	1988

methylprednisolone acetate and Neuralgia, Sciatic