methylprednisolone acetate has been researched along with Multiple Sclerosis in 12 studies
Methylprednisolone Acetate: Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.
methylprednisolone acetate : An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical trials first began in 1960 with methylprednisolone acetate (Depo-Medrol) administered intrathecally, in an attempt to treat both disk disease and multiple sclerosis." | 4.77 | Dangers from methylprednisolone acetate therapy by intraspinal injection. ( Nelson, DA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GOLDSTEIN, NP | 1 |
| McKENZIE, BF | 1 |
| McGUCKIN, WF | 1 |
| BOINES, GJ | 1 |
| Rocchelli, B | 1 |
| Poloni, M | 1 |
| Mazzarello, P | 1 |
| Piccolo, G | 1 |
| Delodovici, M | 1 |
| Pinelli, P | 1 |
| Bernat, JL | 1 |
| Nelson, DA | 3 |
| Wilkinson, HA | 1 |
| Rivera, VM | 1 |
| Baumhefner, RW | 1 |
| Tourtellotte, WW | 1 |
| Syndulko, K | 1 |
| Staugaitis, A | 1 |
| Shapshak, P | 1 |
| Carta, F | 1 |
| Canu, C | 1 |
| Datti, R | 1 |
| Guiducci, G | 1 |
| Pisani, R | 1 |
| Silvestro, C | 1 |
| Bixenman, WW | 1 |
| Buchsbaum, HW | 1 |
3 reviews available for methylprednisolone acetate and Multiple Sclerosis
| Article | Year |
|---|---|
Intraspinal steroid therapy.
Topics: Glycols; Humans; Injections; Injections, Spinal; Intervertebral Disc Displacement; Meningitis; Methy | 1981 |
Intrathecal Depo-Medrol: a literature review.
Topics: Animals; Arachnoiditis; Back Pain; Humans; Injections, Spinal; Methylprednisolone; Methylprednisolon | 1992 |
Dangers from methylprednisolone acetate therapy by intraspinal injection.
Topics: Demyelinating Diseases; Humans; Injections, Epidural; Injections, Spinal; Intervertebral Disc; Methy | 1988 |
9 other studies available for methylprednisolone acetate and Multiple Sclerosis
| Article | Year |
|---|---|
Changes in cerebrospinal fluid of patients with multiple sclerosis after treatment with intrathecal methylprednisolone acetate: a preliminary report.
Topics: Cerebrospinal Fluid Proteins; gamma-Globulins; Humans; Methylprednisolone; Methylprednisolone Acetat | 1962 |
ERRATIC PERSISTANCE OF INTRATHECALLY INJECTED METHYLPREDNISOLONE ACETATE.
Topics: 17-Hydroxycorticosteroids; Cerebrospinal Fluid; Diet; Diet Therapy; Humans; Injections, Spinal; Meth | 1964 |
Intrathecal methylprednisolone acetate in multiple sclerosis treatment: effect on the blood-CSF barrier and on the intrathecal IgG production.
Topics: Adult; Biological Transport; Blood Proteins; Cerebrospinal Fluid Proteins; Female; Humans; Immunoglo | 1982 |
Intraspinal therapy using methylprednisolone acetate. Twenty-three years of clinical controversy.
Topics: Anesthesiology; Anti-Inflammatory Agents; Arachnoiditis; History, 20th Century; Humans; Low Back Pai | 1993 |
Safety of intrathecal steroids in multiple sclerosis.
Topics: Anti-Inflammatory Agents; Humans; Methylprednisolone; Methylprednisolone Acetate; Multiple Sclerosis | 1989 |
Pain in multiple sclerosis.
Topics: Anti-Inflammatory Agents; Humans; Methylprednisolone; Methylprednisolone Acetate; Multiple Sclerosis | 1989 |
Multiple sclerosis intra-blood-brain-barrier IgG synthesis: effect of pulse intravenous and intrathecal corticosteroids.
Topics: Adult; Aged; Blood-Brain Barrier; Humans; Immunoglobulin G; Injections, Spinal; Leukocyte Count; Mal | 1989 |
Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.
Topics: Adult; Anti-Inflammatory Agents; Arachnoid; Calcinosis; Female; Humans; Injections, Spinal; Methylpr | 1987 |
Multiple sclerosis, euthyroid restrictive Grave's ophthalmopathy, and myasthenia gravis. A case report.
Topics: Blepharoptosis; Diplopia; Graves Disease; Humans; Injections; Male; Methylprednisolone; Methylpredni | 1988 |