methylprednisolone acetate and Low Back Ache studies

Methylprednisolone Acetate: Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.
methylprednisolone acetate : An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid.

Research Excerpts

Excerpt	Relevance	Reference
"Epidural corticosteroid injection of methylprednisolone acetate in both groups was associated with very high rates of secondary adrenal insufficiency, but significantly more so in Group 1 at week one."	5.17	The effect of epidural methylprednisolone acetate injection on the hypothalamic-pituitary-adrenal axis. ( Habib, G; Haddad, H; Hakim, G; Jabbour, A; Salman, J, 2013)
"This study was a negative study, though there was a suggestion of benefit of methylprednisolone acetate in a population of young adults with acute radicular low back pain."	5.13	A randomized placebo-controlled trial of single-dose IM corticosteroid for radicular low back pain. ( Bijur, PE; Choi, HK; Cole, M; Davitt, M; Esses, D; Friedman, BW; Gallagher, EJ; Solorzano, C, 2008)
"Low back pain is the leading cause of worldwide disability, with lumbosacral radiculopathy accounting for over one-third of these cases."	1.51	Lumbosacral Radiculopathy: Inciting Events and Their Association with Epidural Steroid Injection Outcomes. ( Abrams, WB; Adekoya, P; Chen, Y; Cohen, SP; Cohen, ZO; Engle, AM; He, C; Marascalchi, B; Wilkinson, I; Yao, AL, 2019)

Research

Studies (20)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Pain Disability Questionnaire

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (15.00)	18.2507
2000's	7 (35.00)	29.6817
2010's	10 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Engle, AM	1
Chen, Y	1
Marascalchi, B	1
Wilkinson, I	1
Abrams, WB	1
He, C	1
Yao, AL	1
Adekoya, P	1
Cohen, ZO	1
Cohen, SP	1
Habib, G	1
Jabbour, A	1
Salman, J	1
Hakim, G	1
Haddad, H	1
Murphy, DT	1
Kavanagh, EC	1
Poynton, A	1
Chan, VO	1
Moynagh, MR	1
Eustace, S	1
Ekedahl, H	1
Jönsson, B	1
Annertz, M	1
Frobell, RB	1
Loewen, K	1
McKillop, C	1
Matsumoto, CL	1
Minty, R	1
Morgan, J	1
Kelly, L	1
Sartoris, R	1
Orlandi, D	1
Corazza, A	1
Sconfienza, LM	1
Arcidiacono, A	1
Bernardi, SP	1
Schiaffino, S	1
Turtulici, G	1
Caruso, P	1
Silvestri, E	1
Friedman, BW	1
Esses, D	1
Solorzano, C	1
Choi, HK	1
Cole, M	1
Davitt, M	1
Bijur, PE	1
Gallagher, EJ	1
Scuderi, GJ	1
Cuellar, JM	1
Cuellar, VG	1
Yeomans, DC	1
Carragee, EJ	1
Angst, MS	1
McCahon, RA	1
Ravenscroft, A	1
Hodgkinson, V	1
Evley, R	1
Hardman, J	1
Hart, R	1
Wendsche, P	1
Kočiš, J	1
Komzák, M	1
Okál, F	1
Krejzla, J	1
Celik, B	1
Er, U	1
Simsek, S	1
Altug, T	1
Bavbek, M	1
Civelek, E	1
Cansever, T	1
Kabatas, S	1
Kircelli, A	1
Yilmaz, C	1
Musluman, M	1
Ofluoglu, D	1
Caner, H	1
Khot, A	1
Bowditch, M	1
Powell, J	1
Sharp, D	1
Amin, N	1
Brancaccio, R	1
Cohen, D	1
Anand, S	1
Butt, MS	1
Landau, WM	1
Nelson, DA	2
Armon, C	1
Argoff, CE	1
Samuels, J	1
Backonja, MM	1
Lehmann, LJ	1
Pallares, VS	1
Glasser, RS	1
Knego, RS	1
Delashaw, JB	1
Fessler, RG	1
Manchikanti, L	1
Pampati, V	1
Fellows, B	1
Bakhit, CE	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Using Inflammatory Biomarkers and EMG Results to Predict Epidural Injection Response in Patients Diagnosed With Lumbar Stenosis[NCT03511053]		11 participants (Actual)	Interventional	2017-12-19	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Measures how pain is affecting the patients lifestyle on a scale from 0 to 10 as defined by each question. The questionnaire contains 15 questions that each range on a scale form 0 to 10. The total score of the questionnaire ranges from 0 to 150. Lower values represent a better outcome. (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection

Swiss Spinal Stenosis Questionnaire

Intervention	score on a scale (Mean)
	Average at baseline	Average at 1 month	Average at 2 months	Average at 1 month change	Average at 2 month change
All Participants	77.5	53.3	64.3	27.3	16.2

Measures how pain due to spinal stenosis is effected the patient based on quality of life/pain questions and satisfaction questions for months 1 and 2 (no scales are used) SSSQ scores are reported in percentages 0-100%, higher scores indicate worse outcomes. (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection

Visual Analogue Scale

Intervention	Percentage (Mean)
	Average at baseline	Average at 1 month	Average at 2 months	Average at 1 month change	Average at 2 month change
All Participants	64.1	53.2	53.5	11.7	10.3

Number rating of back/leg pain from 0 to 10, 0 being no pain/discomfort, 10 being extreme pain/discomfort (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection

Article	Year
The effect of epidural methylprednisolone acetate injection on the hypothalamic-pituitary-adrenal axis. Journal of clinical anesthesia, 2013, Volume: 25, Issue:8 Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Dose-Response Re	2013
Three week results of transforaminal epidural steroid injection in patients with chronic unilateral low back related leg pain: The relation to MRI findings and clinical features. Journal of back and musculoskeletal rehabilitation, 2016, Nov-21, Volume: 29, Issue:4 Topics: Aged; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Female; Humans; Injections, Epidura	2016
A randomized placebo-controlled trial of single-dose IM corticosteroid for radicular low back pain. Spine, 2008, Aug-15, Volume: 33, Issue:18 Topics: Adrenal Cortex Hormones; Adult; Double-Blind Method; Female; Humans; Injections, Intramuscular; Low	2008
A pilot study of the dose-response of caudal methylprednisolone with levobupivacaine in chronic lower back pain. Anaesthesia, 2011, Volume: 66, Issue:7 Topics: Activities of Daily Living; Aged; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Chronic	2011
Effectiveness of lumbar zygapophysial joint blockage for low back pain. Turkish neurosurgery, 2011, Volume: 21, Issue:4 Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bed Re	2011
Comparison of effectiveness of facet joint injection and radiofrequency denervation in chronic low back pain. Turkish neurosurgery, 2012, Volume: 22, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents; Catheter Ablation; Chronic Pain; Denervation; Female; Follow-	2012
The use of intradiscal steroid therapy for lumbar spinal discogenic pain: a randomized controlled trial. Spine, 2004, Apr-15, Volume: 29, Issue:8 Topics: Chronic Disease; Disability Evaluation; Female; Humans; Injections, Intralesional; Intervertebral Di	2004
The diagnostic validity and therapeutic value of lumbar facet joint nerve blocks with or without adjuvant agents. Current review of pain, 2000, Volume: 4, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents; Female; Hu	2000

Article	Year
Lumbosacral Radiculopathy: Inciting Events and Their Association with Epidural Steroid Injection Outcomes. Pain medicine (Malden, Mass.), 2019, 12-01, Volume: 20, Issue:12 Topics: Accidental Falls; Accidents, Traffic; Adult; Aged; Analgesics, Opioid; Dexamethasone; Female; Glucoc	2019
MR epidurography: distribution of injectate at caudal epidural injection. Skeletal radiology, 2015, Volume: 44, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Contrast Media; Dose-Response Relationship	2015
Interlaminar epidural steroid injections for low back pain in rural Ontario. Canadian journal of rural medicine : the official journal of the Society of Rural Physicians of Canada = Journal canadien de la medecine rurale : le journal officiel de la Societe de medecine rurale du Canada, 2016,Fall, Volume: 21, Issue:4 Topics: Adult; Cohort Studies; Female; Glucocorticoids; Humans; Injections, Epidural; Low Back Pain; Male; M	2016
In vivo feasibility of real-time MR-US fusion imaging lumbar facet joint injections. Journal of ultrasound, 2017, Volume: 20, Issue:1 Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anesthetics, Local; Anti-Inflammatory Agents; Chro	2017
Epidural interferon gamma-immunoreactivity: a biomarker for lumbar nerve root irritation. Spine, 2009, Oct-01, Volume: 34, Issue:21 Topics: Adult; Aged; Biomarkers; Bupivacaine; Cohort Studies; Epidural Space; Female; Follow-Up Studies; Hum	2009
[Injection of anaesthetic-corticosteroid to relieve sacroiliac joint pain after lumbar stabilisation]. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, 2011, Volume: 78, Issue:4 Topics: Aged; Anesthetics, Local; Female; Humans; Injections, Intra-Articular; Low Back Pain; Lumbar Vertebr	2011
Cutaneous reactions to injectable corticosteroids. Dermatitis : contact, atopic, occupational, drug, 2006, Volume: 17, Issue:3 Topics: Aged; Anti-Inflammatory Agents; Bupivacaine; Diagnosis, Differential; Drug Eruptions; Female; Humans	2006
Patients' response to facet joint injection. Acta orthopaedica Belgica, 2007, Volume: 73, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Glucocorticoids; Humans; Injections, Intra-	2007
Assessment: use of epidural steroid injections to treat radicular lumbosacral pain: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology, 2007, Aug-07, Volume: 69, Issue:6 Topics: Anti-Inflammatory Agents; Contraindications; Humans; Iatrogenic Disease; Injections, Epidural; Injec	2007
Subdural injection of a local anesthetic with steroids: complication of epidural anesthesia. Southern medical journal, 1995, Volume: 88, Issue:4 Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Female; Humans; Hypotension; Injections	1995
The perioperative use of corticosteroids and bupivacaine in the management of lumbar disc disease. Journal of neurosurgery, 1993, Volume: 78, Issue:3 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Bupivacaine; Drug Therapy, Combination; Humans; I	1993
Intraspinal therapy using methylprednisolone acetate. Twenty-three years of clinical controversy. Spine, 1993, Volume: 18, Issue:2 Topics: Anesthesiology; Anti-Inflammatory Agents; Arachnoiditis; History, 20th Century; Humans; Low Back Pai	1993

methylprednisolone acetate and Low Back Ache