methylphenidate has been researched along with Seizures in 42 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this open trial methylphenidate was safely used in patients with epilepsy and adult ADHD." | 9.12 | Effectiveness and safety of methylphenidate in adult attention deficit hyperactivity disorder in patients with epilepsy: an open treatment trial. ( Aldenkamp, AP; van der Feltz-Cornelis, CM, 2006) |
| " Methylphenidate was administered intraperitoneally to examine its effects on developmental disorder-like behaviors and hyperthermia-induced seizures." | 7.80 | Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation. ( Asanuma, M; Kawakami, N; Liu, S; Mashimo, T; Matsui, H; Michiue, H; Miyazaki, I; Ohmori, I; Ouchida, M; Wang, H, 2014) |
| "A 76-year-old male with poststroke depression, seizure disorder, and global aphasia improved markedly when treated with methylphenidate." | 7.69 | Methylphenidate treatment of poststroke depression in a patient with global aphasia. ( Chaudhary, P; Masand, P, 1994) |
| "Methylphenidate (MPH) is a stimulant, FDA-approved for the treatment of ADHD, and often used for ADHD in the setting of pediatric epilepsy." | 6.72 | Methylphenidate for attention problems in epilepsy patients: Safety and efficacy. ( Adams, J; Devinsky, O; Leeman-Markowski, BA; Martin, SP; Meador, KJ, 2021) |
| "Inclusion criteria were at least two epileptic seizures in the previous 6 months and a diagnosis of ADHD based on DSM-IV criteria." | 6.47 | Efficacy and safety of methylphenidate in treating ADHD symptoms in children and adolescents with uncontrolled seizures: a Brazilian sample study and literature review. ( Agertt, F; Casella, EB; Ferreira, MG; Koneski, JA, 2011) |
| "After a 3 month period in which antiepileptic drugs were adjusted, 22 patients recruited from a specialist outpatient clinic for severe epilepsy (16 males, six females; mean age 11 y 2 mo, SD 3 y 2 mo) received methylphenidate for 3 months in an open label, non-controlled trial; four with generalized or multifocal (symptomatic/cryptogenic) epilepsy, one with generalized (idiopathic) epilepsy, 17 with partial (symptomatic/cryptogenic) epilepsy; five with partial seizures only, 17 with primarily or secondarily generalized seizures)." | 5.17 | The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies. ( Bastos, F; Booij, L; Fernandes, BS; Palmini, A; Radziuk, AL; Rotert, R; Santos, K, 2013) |
| "In this open trial methylphenidate was safely used in patients with epilepsy and adult ADHD." | 5.12 | Effectiveness and safety of methylphenidate in adult attention deficit hyperactivity disorder in patients with epilepsy: an open treatment trial. ( Aldenkamp, AP; van der Feltz-Cornelis, CM, 2006) |
| " There are no studies which demonstrate that short or long-term treatment with methylphenidate increases the risk of seizures." | 4.86 | Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment. ( Casella, EB; Koneski, JA, 2010) |
| " Methylphenidate (MPH) has shown high response rates and no increase in seizures in small trials." | 4.84 | Attention-deficit/hyperactivity disorder in pediatric patients with epilepsy: review of pharmacological treatment. ( Gonzalez-Heydrich, J; Torres, AR; Whitney, J, 2008) |
| "Of 29 604 individuals prescribed methylphenidate between Jan 1, 2001, and Dec 31, 2017, 269 (199 males and 70 females) had incident seizures." | 3.96 | Association between methylphenidate treatment and risk of seizure: a population-based, self-controlled case-series study. ( Besag, FMC; Coghill, D; Cross, JH; Ip, P; Lau, WCY; Man, KKC; Wong, ICK, 2020) |
| "This study investigated whether interictal epileptiform discharges (IED) on a baseline routine EEG in children with ADHD was associated with the occurrence of epileptic seizures (Sz) or influenced the use of methylphenidate (MPH) during 2 years follow-up." | 3.81 | Attention deficit/hyperactivity disorder and interictal epileptiform discharges: it is safe to use methylphenidate? ( Aurlien, D; Herigstad, A; Larsen, TK; Socanski, D; Thomsen, PH, 2015) |
| " Methylphenidate was administered intraperitoneally to examine its effects on developmental disorder-like behaviors and hyperthermia-induced seizures." | 3.80 | Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation. ( Asanuma, M; Kawakami, N; Liu, S; Mashimo, T; Matsui, H; Michiue, H; Miyazaki, I; Ohmori, I; Ouchida, M; Wang, H, 2014) |
| "A 76-year-old male with poststroke depression, seizure disorder, and global aphasia improved markedly when treated with methylphenidate." | 3.69 | Methylphenidate treatment of poststroke depression in a patient with global aphasia. ( Chaudhary, P; Masand, P, 1994) |
| "Methylphenidate can be safely used in brain injured patients, even those at high risk for seizures, as it was associated with a trend toward reduction (rather than increase) in seizure frequency in this population." | 3.68 | Methylphenidate and seizure frequency in brain injured patients with seizure disorders. ( Leary, JM; Manning, K; Phelan, AM; Whyte, J; Wroblewski, BA, 1992) |
| "Methylphenidate (MPH) is a stimulant, FDA-approved for the treatment of ADHD, and often used for ADHD in the setting of pediatric epilepsy." | 2.72 | Methylphenidate for attention problems in epilepsy patients: Safety and efficacy. ( Adams, J; Devinsky, O; Leeman-Markowski, BA; Martin, SP; Meador, KJ, 2021) |
| " While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs." | 2.49 | Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013) |
| "Inclusion criteria were at least two epileptic seizures in the previous 6 months and a diagnosis of ADHD based on DSM-IV criteria." | 2.47 | Efficacy and safety of methylphenidate in treating ADHD symptoms in children and adolescents with uncontrolled seizures: a Brazilian sample study and literature review. ( Agertt, F; Casella, EB; Ferreira, MG; Koneski, JA, 2011) |
| "Methylphenidate is still the treatment of choice for the condition and, although it has been shown that neither methylphenidate nor other psychostimulants provoke seizures, there is still a possibility that seizure frequency may increase in children with active epilepsy." | 2.43 | Optimizing therapy of seizures in children and adolescents with ADHD. ( Aldenkamp, AP; Arzimanoglou, A; Reijs, R; Van Mil, S, 2006) |
| "However, in patients with active seizures, the results are somewhat contradictory." | 1.39 | Methylphenidate and continuous spike and wave during sleep in a child with attention deficit hyperactivity disorder. ( Bridgemohan, CH; Marin-Valencia, I; Shankar, M; Sheen, VL; Torres, AR, 2013) |
| "Khat lowers seizure threshold." | 1.35 | Proconvulsant effect of khat (Catha edulis) in Sprague dawley rats. ( Kioy, PG; Oyungu, E; Patel, NB, 2009) |
| "The comorbidity of seizures, epilepsy, and attention-deficit-hyperactivity disorder (ADHD) prompted the examination of whether atomoxetine use for ADHD is associated with an increased risk of seizures." | 1.34 | Seizure risk in patients with attention-deficit-hyperactivity disorder treated with atomoxetine. ( Allen, AJ; Ball, S; Bangs, ME; Dunn, D; Edison, T; Holdridge, KC; Jin, L; Wernicke, JF; Zhang, S, 2007) |
| "As a presumptive side effect, a lowered seizure threshold due to medication with methylphenidate remains controversial." | 1.34 | [Quantitative effect of treatment with methylphenidate on EEG--a pilot study]. ( Kerdar, MS; Romanos, M; Scheuerpflug, P; Srdinko, P; Warnke, A; Wewetzer, C, 2007) |
| "N-methyl-D-aspartate-induced convulsions in mice were antagonized by PCP, ketamine and MK-801, but not by BTCP or cocaine." | 1.28 | The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801. ( Colpaert, FC; Kamenka, JM; Koek, W; Woods, JH, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (21.43) | 18.7374 |
| 1990's | 4 (9.52) | 18.2507 |
| 2000's | 11 (26.19) | 29.6817 |
| 2010's | 14 (33.33) | 24.3611 |
| 2020's | 4 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Russell, D | 1 |
| Stein, MA | 1 |
| Man, KKC | 1 |
| Lau, WCY | 1 |
| Coghill, D | 2 |
| Besag, FMC | 1 |
| Cross, JH | 1 |
| Ip, P | 1 |
| Wong, ICK | 1 |
| Andrade, C | 1 |
| Leeman-Markowski, BA | 1 |
| Adams, J | 1 |
| Martin, SP | 1 |
| Devinsky, O | 1 |
| Meador, KJ | 1 |
| Miller, JW | 1 |
| Shalev, R | 1 |
| Santos, K | 2 |
| Palmini, A | 2 |
| Radziuk, AL | 1 |
| Rotert, R | 1 |
| Bastos, F | 1 |
| Booij, L | 1 |
| Fernandes, BS | 1 |
| Brunklaus, A | 1 |
| Dorris, L | 1 |
| Zuberi, SM | 1 |
| Sheen, VL | 1 |
| Shankar, M | 1 |
| Marin-Valencia, I | 1 |
| Bridgemohan, CH | 1 |
| Torres, AR | 2 |
| Reinhardt, D | 1 |
| Ohmori, I | 1 |
| Kawakami, N | 1 |
| Liu, S | 1 |
| Wang, H | 1 |
| Miyazaki, I | 1 |
| Asanuma, M | 1 |
| Michiue, H | 1 |
| Matsui, H | 1 |
| Mashimo, T | 1 |
| Ouchida, M | 1 |
| Socanski, D | 1 |
| Aurlien, D | 1 |
| Herigstad, A | 1 |
| Thomsen, PH | 1 |
| Larsen, TK | 1 |
| Peña Guerrero, P | 1 |
| Magro Fernández, C | 1 |
| Durán Ferreras, E | 1 |
| Schertz, M | 1 |
| Steinberg, T | 1 |
| Oyungu, E | 2 |
| Kioy, PG | 2 |
| Patel, NB | 2 |
| Koneski, JA | 2 |
| Casella, EB | 2 |
| Agertt, F | 1 |
| Ferreira, MG | 1 |
| Karila, L | 1 |
| Cortese, S | 1 |
| Holtmann, M | 1 |
| Banaschewski, T | 1 |
| Buitelaar, J | 1 |
| Danckaerts, M | 1 |
| Dittmann, RW | 1 |
| Graham, J | 1 |
| Taylor, E | 1 |
| Sergeant, J | 1 |
| FIER, M | 1 |
| GOLDBERG, MA | 1 |
| GROSS, MD | 1 |
| WILSON, WC | 1 |
| Pedro, VM | 1 |
| Leisman, G | 1 |
| Mendhekar, DN | 1 |
| van der Feltz-Cornelis, CM | 1 |
| Aldenkamp, AP | 2 |
| Arzimanoglou, A | 1 |
| Reijs, R | 1 |
| Van Mil, S | 1 |
| Wernicke, JF | 1 |
| Holdridge, KC | 1 |
| Jin, L | 1 |
| Edison, T | 1 |
| Zhang, S | 1 |
| Bangs, ME | 1 |
| Allen, AJ | 1 |
| Ball, S | 1 |
| Dunn, D | 1 |
| Kerdar, MS | 1 |
| Scheuerpflug, P | 1 |
| Srdinko, P | 1 |
| Wewetzer, C | 1 |
| Warnke, A | 1 |
| Romanos, M | 1 |
| Whitney, J | 1 |
| Gonzalez-Heydrich, J | 1 |
| Masand, P | 1 |
| Chaudhary, P | 1 |
| Kleven, M | 1 |
| Prinssen, EP | 1 |
| Koek, W | 2 |
| Feeney, DJ | 1 |
| Klykylo, WM | 1 |
| Hemmer, SA | 1 |
| Pasternak, JF | 1 |
| Zecker, SG | 1 |
| Trommer, BL | 1 |
| Konthikamee, W | 1 |
| Sprecher, RL | 1 |
| Moore, PA | 1 |
| Wroblewski, BA | 1 |
| Leary, JM | 1 |
| Phelan, AM | 1 |
| Whyte, J | 1 |
| Manning, K | 1 |
| Colpaert, FC | 1 |
| Woods, JH | 1 |
| Kamenka, JM | 1 |
| Brichard, G | 1 |
| Millichap, JG | 1 |
| Chiba, S | 1 |
| Nagawa, Y | 1 |
| Yui, T | 1 |
| Chamberlain, RW | 1 |
| Nishizawa, Y | 1 |
| Kodama, T | 1 |
| Tsujino, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323] | 80 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for methylphenidate and Seizures
| Article | Year |
|---|---|
Methylphenidate for attention problems in epilepsy patients: Safety and efficacy.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Double-Blin | 2021 |
Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Electroencephalogr | 2010 |
Efficacy and safety of methylphenidate in treating ADHD symptoms in children and adolescents with uncontrolled seizures: a Brazilian sample study and literature review.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Brazil; Central Nervous System Stimulants | 2011 |
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure | 2013 |
Optimizing therapy of seizures in children and adolescents with ADHD.
Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Central Nervous System S | 2006 |
Attention-deficit/hyperactivity disorder in pediatric patients with epilepsy: review of pharmacological treatment.
Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst | 2008 |
3 trials available for methylphenidate and Seizures
| Article | Year |
|---|---|
The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2013 |
Effectiveness and safety of methylphenidate in adult attention deficit hyperactivity disorder in patients with epilepsy: an open treatment trial.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2006 |
[Practolol in anesthesia (ICI 50.172, Eraldin)].
Topics: Acetanilides; Adolescent; Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Amino Alcohols; Ane | 1972 |
33 other studies available for methylphenidate and Seizures
| Article | Year |
|---|---|
Seizure risk, methylphenidate, and ADHD: reassuring news.
Topics: Attention Deficit Disorder with Hyperactivity; Epilepsy; Humans; Methylphenidate; Seizures | 2020 |
Association between methylphenidate treatment and risk of seizure: a population-based, self-controlled case-series study.
Topics: Adolescent; Age Distribution; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 2020 |
Methylphenidate and the Risk of New-Onset Seizures.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Methylphen | 2020 |
Comment: Has the relationship between ADHD medications and seizures been settled?
Topics: Attention Deficit Disorder with Hyperactivity; Cognition; Double-Blind Method; Epilepsy; Humans; Met | 2018 |
Good news: methylphenidate for ADHD in epilepsy.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Epilepsy; Female; | 2013 |
The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Epilepsy; Female; | 2013 |
Methylphenidate and continuous spike and wave during sleep in a child with attention deficit hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Female; Hum | 2013 |
Santos et al. reply.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Epilepsy; Female; | 2013 |
[ADHD: Methylphenidate for epileptics?].
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Epilepsy; Female; | 2013 |
Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Fever; Hype | 2014 |
Attention deficit/hyperactivity disorder and interictal epileptiform discharges: it is safe to use methylphenidate?
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimul | 2015 |
Epileptic seizure due to drug interaction between sertraline and methylphenidate.
Topics: Adolescent; Antidepressive Agents; Central Nervous System Stimulants; Drug Interactions; Humans; Mal | 2016 |
Seizures induced by the combination treatment of methylphenidate and sertraline.
Topics: Child; Drug Therapy, Combination; Female; Humans; Methylphenidate; Seizures; Sertraline | 2008 |
Proconvulsant effect of khat (Catha edulis) in Sprague dawley rats.
Topics: Animals; Anticonvulsants; Catha; Central Nervous System Stimulants; Cerebral Cortex; Convulsants; Ma | 2009 |
[Atomoxetine in ADHD: caution].
Topics: Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivi | 2011 |
CONVULSIVE SEIZURES IN CHLORPROTHIXENE OVERDOSE.
Topics: Black People; Chlorprothixene; Drug Overdose; Humans; Methylphenidate; Phenytoin; Seizures; Toxicolo | 1964 |
BEHAVIOR DISORDERS OF CHILDREN WITH CEREBRAL DYSRHYTHMIAS; SUCCESSFUL TREATMENT OF SUBCONVULSIVE DYSRHYTHMIA WITH ANTICONVULSANTS.
Topics: Acetazolamide; Amphetamine; Amphetamines; Anticonvulsants; Child; Child Behavior Disorders; Conduct | 1964 |
Hemispheric integrative therapy in Landau-Kleffner syndrome: applications for rehabilitation sciences.
Topics: Adolescent; Anticonvulsants; Brain; Central Nervous System Stimulants; Electroencephalography; Femal | 2005 |
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child.
Topics: Age Factors; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Comor | 2005 |
Seizure risk in patients with attention-deficit-hyperactivity disorder treated with atomoxetine.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with | 2007 |
Effect of Catha edulis (khat) on behaviour and its potential to induce seizures in Sprague Dawley rats.
Topics: Alkaloids; Analysis of Variance; Animals; Behavior, Animal; Catha; Dose-Response Relationship, Drug; | 2007 |
[Quantitative effect of treatment with methylphenidate on EEG--a pilot study].
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cerebr | 2007 |
Methylphenidate treatment of poststroke depression in a patient with global aphasia.
Topics: Aged; Aphasia; Cerebrovascular Disorders; Depressive Disorder; Dose-Response Relationship, Drug; Dru | 1994 |
Role of 5-HT1A receptors in the ability of mixed 5-HT1A receptor agonist/dopamine D2 receptor antagonists to inhibit methylphenidate-induced behaviors in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Dopamine | 1996 |
Medication-induced seizures.
Topics: 1-Naphthylamine; Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; C | 1997 |
Stimulant therapy and seizure risk in children with ADHD.
Topics: Adolescent; Adult; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bra | 2001 |
Effects of acute and chronic administration of methylphenidate on lidocaine convulsions in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Lidocaine; Male; Methylphenidate; Mice | 1978 |
Methylphenidate and seizure frequency in brain injured patients with seizure disorders.
Topics: Adult; Brain Injuries; Contraindications; Humans; Incidence; Methylphenidate; Middle Aged; Retrospec | 1992 |
The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801.
Topics: Animals; Behavior, Animal; Cocaine; Columbidae; Dextroamphetamine; Dibenzocycloheptenes; Dizocilpine | 1989 |
Drugs in management of hyperkinetic and perceptually handicapped children.
Topics: Anticonvulsants; Central Nervous System Stimulants; Child; Child, Preschool; Chlordiazepoxide; Chlor | 1968 |
[Pharmacological studies on 2-methyl-4-amino-6-methoxy-s-triazine (CV399); with special reference to its central effects].
Topics: Amphetamine; Analgesics; Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Body Tempera | 1970 |
Letter: convulsions and ritalin?
Topics: Child; Humans; Hyperkinesis; Male; Methylphenidate; Seizures | 1974 |
Effect of gamma-aminobutyric acid derivatives, especially homopantothenic acid, on the excitability of the brain.
Topics: Aminobutyrates; Animals; Brain; Chemical Phenomena; Chemistry; Depression, Chemical; Drug Antagonism | 1968 |