methylphenidate has been researched along with Pregnancy in 89 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aims of this review were to summarize the scientific evidence about the risks of using methylphenidate for ADHD in pregnancy and lactation, to present a case in which interruption of treatment after delivery and during breastfeeding was harmful and to discuss the implications of treating or not treating ADHD in pregnancy and lactation." | 8.90 | Methylphenidate use in pregnancy and lactation: a systematic review of evidence. ( Bolea-Alamanac, BM; Davies, SJ; Green, A; Maxwell, P; Verma, G, 2014) |
| "Rodents exposed prenatally to valproic acid (VPA) show autism-related behavioral abnormalities." | 7.83 | Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Katashiba, K; Matsuda, T; Onaka, Y; Takano, E; Takuma, K; Taruta, A, 2016) |
| "To report the effects of intravenous abuse of pentazocine hydrochloride and methylphenidate hydrochloride during pregnancy." | 7.68 | Intravenous pentazocine and methylphenidate abuse during pregnancy. Maternal lifestyle and infant outcome. ( Casiro, OG; Debooy, VD; Seshia, MM; Tenenbein, M, 1993) |
| "Methylphenidate (MPH) is a central nervous system stimulant drug that increases concentration and energy level." | 5.43 | Investigation of possible teratogenic effects in the offspring of mice exposed to methylphenidate during pregnancy. ( Bacchi, AD; Costa, Gde A; Galvão, TC; Moreira, EG; Salles, MJ, 2016) |
| "There was a higher rate of miscarriages and elective terminations of pregnancy in the methylphenidate group." | 5.43 | Methylphenidate in Pregnancy: A Multicenter, Prospective, Comparative, Observational Study. ( Arnon, J; Beck, E; Borisch, C; Bozzo, P; Diav-Citrin, O; Nulman, I; Ornoy, A; Richardson, JL; Shechtman, S; Wajnberg, R, 2016) |
| " The data on the effects of stimulants (methylphenidate and amphetamines) in pregnancy are generally reassuring, but methylphenidate might slightly increase the rate of cardiac malformations and of spontaneous abortions, while amphetamines might slightly increase the risk for premature birth, low birth weight and other pregnancy complications." | 5.12 | The Effects of Drugs used for the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) on Pregnancy Outcome and Breast-feeding: A Critical Review. ( Koren, G; Ornoy, A, 2021) |
| "The aims of this review were to summarize the scientific evidence about the risks of using methylphenidate for ADHD in pregnancy and lactation, to present a case in which interruption of treatment after delivery and during breastfeeding was harmful and to discuss the implications of treating or not treating ADHD in pregnancy and lactation." | 4.90 | Methylphenidate use in pregnancy and lactation: a systematic review of evidence. ( Bolea-Alamanac, BM; Davies, SJ; Green, A; Maxwell, P; Verma, G, 2014) |
| "Maternal smoking during pregnancy, a form of developmental nicotine exposure (DNE), is associated with increased nicotine use and neurodevelopmental disorders such as ADHD in children." | 3.91 | Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice. ( Buck, JM; Knopik, VS; O'Neill, HC; Sanders, KN; Stitzel, JA; Wageman, CR, 2019) |
| "Case 1: A 30-year-old woman with depression and ADHD took duloxetine 90 mg daily and methylphenidate 36 mg daily during pregnancy and breastfeeding." | 3.88 | Infant Exposure to Methylphenidate and Duloxetine During Lactation. ( Collin-Lévesque, L; El-Ghaddaf, Y; Ferreira, E; Genest, M; Jutras, M; Leclair, G; Panchaud, A; Weisskopf, E, 2018) |
| " Women who received amphetamine-dextroamphetamine or methylphenidate monotherapy in the first half of pregnancy were compared with unexposed women." | 3.85 | Placental Complications Associated With Psychostimulant Use in Pregnancy. ( Bateman, BT; Cohen, JM; Desai, RJ; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Park, Y; Patorno, E, 2017) |
| "Rodents exposed prenatally to valproic acid (VPA) show autism-related behavioral abnormalities." | 3.83 | Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Katashiba, K; Matsuda, T; Onaka, Y; Takano, E; Takuma, K; Taruta, A, 2016) |
| "Cigarette smoking, nicotine replacement therapy, and smokeless tobacco use during pregnancy are associated with cognitive disabilities later in life in children exposed prenatally to nicotine." | 3.78 | Prenatal nicotine exposure mouse model showing hyperactivity, reduced cingulate cortex volume, reduced dopamine turnover, and responsiveness to oral methylphenidate treatment. ( Bhide, PG; Biederman, J; Spencer, TJ; Xu, Y; Zhang, X; Zhu, J, 2012) |
| "To report the effects of intravenous abuse of pentazocine hydrochloride and methylphenidate hydrochloride during pregnancy." | 3.68 | Intravenous pentazocine and methylphenidate abuse during pregnancy. Maternal lifestyle and infant outcome. ( Casiro, OG; Debooy, VD; Seshia, MM; Tenenbein, M, 1993) |
| "A second case of severe limb malformations was observed following maternal use of haloperidol early in the first trimester of pregnancy." | 3.65 | Limb malformations following maternal use of haloperidol. ( Heggeness, L; McCullar, FW, 1975) |
| "Methylphenidate has been a first line treatment for ADHD, with relatively large numbers of usage." | 2.66 | Fetal safety of methylphenidate-A scoping review and meta analysis. ( Barer, Y; Koren, G; Ornoy, A, 2020) |
| "Methylphenidate is a centrally acting sympathomimetic used for the treatment of attention deficit/hyperactivity disorder in children and adolescents and for narcolepsy in adults." | 2.49 | First trimester in utero exposure to methylphenidate. ( Aagaard, L; Damkier, P; Dideriksen, D; Hallas, J; Pottegård, A, 2013) |
| "Children with Fetal Alcohol Spectrum Disorders (FASD) may have significant neurobehavioural problems persisting into adulthood." | 2.45 | Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders. ( Bower, C; Elliott, EJ; Peadon, E; Rhys-Jones, B, 2009) |
| "Methylphenidate (2." | 1.91 | Complex Attention-Deficit/Hyperactivity Disorder in a Bilingual Child with Down Syndrome and Intellectual Disability. ( Carroll, G; Fogler, J; Froehlich, T; Moore, T; Nyp, SS; Soccorso, C, 2023) |
| "The main reason for pharmacological treatment of FASD children is attention deficit hyperactivity disorder (ADHD), and methylphenidate (MPH) is the drug of choice." | 1.72 | Influence of ( Białecka, M; Brzuchalski, B; Grzywacz, E; Machoy-Mokrzyńska, A; Malinowski, D; Pierzchlińska, A; Śmiarowska, M, 2022) |
| "Methylphenidate (MPH) is a central nervous system stimulant drug that increases concentration and energy level." | 1.43 | Investigation of possible teratogenic effects in the offspring of mice exposed to methylphenidate during pregnancy. ( Bacchi, AD; Costa, Gde A; Galvão, TC; Moreira, EG; Salles, MJ, 2016) |
| "There was a higher rate of miscarriages and elective terminations of pregnancy in the methylphenidate group." | 1.43 | Methylphenidate in Pregnancy: A Multicenter, Prospective, Comparative, Observational Study. ( Arnon, J; Beck, E; Borisch, C; Bozzo, P; Diav-Citrin, O; Nulman, I; Ornoy, A; Richardson, JL; Shechtman, S; Wajnberg, R, 2016) |
| "Methylphenidate (MPH) is a commonly-used medication for the treatment of children with Attention-Deficit/Hyperactivity Disorders (ADHD)." | 1.40 | Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats. ( Belzung, C; Castelnau, P; Chalon, S; Cortese, S; Emond, P; Faraone, SV; Galineau, L; Lepelletier, FX; Nicolas, C; Solinas, M; Tauber, C, 2014) |
| "Pretreatment with methylphenidate significantly impaired novel object recognition in wild-type mice." | 1.39 | Methylphenidate restores novel object recognition in DARPP-32 knockout mice. ( Fienberg, AA; Heyser, CJ; McNaughton, CH; Vishnevetsky, D, 2013) |
| "Methylphenidate (MPH) is a psychostimulant effective in treating attention-deficit/hyperactivity disorder (ADHD)." | 1.33 | Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment. ( Choong, KC; Shen, RY, 2006) |
| "Corticosterone levels were increased in methamphetamine-, fenfluramine-, methylenedioxymethamphetamine- and methylphenidate-treated rats relative to levels in saline-treated rats, whereas cocaine-treated rats were unaffected." | 1.33 | Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. ( Ehrman, LA; Gudelsky, GA; Schaefer, TL; Vorhees, CV; Williams, MT, 2006) |
| "Methylphenidate is a central nervous system stimulant approved by the U." | 1.33 | NTP-CERHR monograph on the potential human reproductive and developmental effects of methylphenidate. ( , 2005) |
| " The present report describes the determination of plasma concentrations of D-threo- and L-threo-enantiomers of MPH in toxicokinetic (TK) studies in pregnant Wistar Hannover rats and New Zealand white rabbits following repeated daily oral dosing of D,L-MPH (racemate)." | 1.32 | Toxicokinetic assessment of methylphenidate (Ritalin) enantiomers in pregnant rats and rabbits. ( Bakhtiar, R; Tse, FL, 2004) |
| "The granulomas are associated with a history of intravenous injection of medications (Ritalin and Talwin) intended for oral use." | 1.27 | Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse. ( Edland, JF; Lundquest, DE; Young, WK, 1987) |
| " A dose-response analysis of the effect of methylphenidate revealed no differences among the dietary groups." | 1.26 | Effect of dietary lipid on locomotor activity and response to psychomotor stimulants. ( Brenneman, DE; Rutledge, CO, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (22.47) | 18.7374 |
| 1990's | 4 (4.49) | 18.2507 |
| 2000's | 19 (21.35) | 29.6817 |
| 2010's | 34 (38.20) | 24.3611 |
| 2020's | 12 (13.48) | 2.80 |
| Authors | Studies |
|---|---|
| Śmiarowska, M | 1 |
| Brzuchalski, B | 1 |
| Grzywacz, E | 1 |
| Malinowski, D | 1 |
| Machoy-Mokrzyńska, A | 1 |
| Pierzchlińska, A | 1 |
| Białecka, M | 1 |
| Contreras, D | 1 |
| Piña, R | 1 |
| Carvallo, C | 1 |
| Godoy, F | 1 |
| Ugarte, G | 1 |
| Zeise, M | 1 |
| Rozas, C | 1 |
| Morales, B | 1 |
| da Costa Nunes Gomes, AC | 1 |
| Bellin, CS | 1 |
| da Silva Dias, S | 1 |
| de Queiroz de Rosa, T | 1 |
| de Araújo, MP | 1 |
| Miraglia, SM | 1 |
| Mendes, TB | 1 |
| Vendramini, V | 1 |
| Cohen, JM | 4 |
| Srinivas, C | 3 |
| Furu, K | 4 |
| Cesta, CE | 3 |
| Reutfors, J | 4 |
| Karlstad, Ø | 4 |
| Bang Madsen, K | 1 |
| Robakis, TK | 1 |
| Liu, X | 1 |
| Momen, N | 1 |
| Larsson, H | 1 |
| Dreier, JW | 1 |
| Kildegaard, H | 1 |
| Groth, JB | 1 |
| Newcorn, JH | 1 |
| Hove Thomsen, P | 1 |
| Munk-Olsen, T | 1 |
| Bergink, V | 1 |
| Richardson, JL | 2 |
| George, N | 1 |
| Greenall, AJ | 1 |
| Oliver, AM | 1 |
| Stephens, S | 1 |
| Hodson, KK | 1 |
| Moore, T | 1 |
| Soccorso, C | 1 |
| Fogler, J | 1 |
| Carroll, G | 1 |
| Froehlich, T | 1 |
| Nyp, SS | 1 |
| Damkier, P | 4 |
| Broe, A | 1 |
| Koren, G | 3 |
| Barer, Y | 1 |
| Ornoy, A | 3 |
| Kittel-Schneider, S | 1 |
| Quednow, BB | 1 |
| Leutritz, AL | 1 |
| McNeill, RV | 1 |
| Reif, A | 1 |
| Aoki, S | 1 |
| Kaizaki-Mitsumoto, A | 1 |
| Hattori, N | 1 |
| Numazawa, S | 1 |
| Hernández-Díaz, S | 2 |
| Bateman, BT | 2 |
| Park, Y | 1 |
| Desai, RJ | 1 |
| Gray, KJ | 1 |
| Patorno, E | 1 |
| Mogun, H | 2 |
| Huybrechts, KF | 2 |
| Bröms, G | 1 |
| Christensen, LB | 1 |
| Einarsdóttir, K | 1 |
| Engeland, A | 1 |
| Gissler, M | 1 |
| Karlsson, P | 1 |
| Kieler, H | 1 |
| Lahesmaa-Korpinen, AM | 1 |
| Nørgaard, M | 1 |
| Sørensen, HT | 1 |
| Zoega, H | 1 |
| Cooper, WO | 1 |
| Collin-Lévesque, L | 1 |
| El-Ghaddaf, Y | 1 |
| Genest, M | 1 |
| Jutras, M | 1 |
| Leclair, G | 1 |
| Weisskopf, E | 1 |
| Panchaud, A | 1 |
| Ferreira, E | 1 |
| Poulton, AS | 1 |
| Armstrong, B | 1 |
| Nanan, RK | 1 |
| Baker, AS | 1 |
| Freeman, MP | 1 |
| Jiang, HY | 1 |
| Zhang, X | 2 |
| Jiang, CM | 1 |
| Fu, HB | 1 |
| Buck, JM | 1 |
| Sanders, KN | 1 |
| Wageman, CR | 1 |
| Knopik, VS | 1 |
| Stitzel, JA | 1 |
| O'Neill, HC | 1 |
| Bolea-Alamanac, BM | 1 |
| Green, A | 1 |
| Verma, G | 1 |
| Maxwell, P | 1 |
| Davies, SJ | 2 |
| Lloyd, SA | 1 |
| Oltean, C | 1 |
| Pass, H | 1 |
| Phillips, B | 1 |
| Staton, K | 1 |
| Robertson, CL | 1 |
| Shanks, RA | 1 |
| Heyser, CJ | 1 |
| McNaughton, CH | 1 |
| Vishnevetsky, D | 1 |
| Fienberg, AA | 1 |
| Bolea-Alamanac, B | 1 |
| Pottegård, A | 2 |
| Hallas, J | 2 |
| Andersen, JT | 1 |
| Løkkegaard, EC | 1 |
| Dideriksen, D | 2 |
| Aagaard, L | 3 |
| Warrer, P | 1 |
| Hansen, EH | 1 |
| Lepelletier, FX | 1 |
| Tauber, C | 1 |
| Nicolas, C | 1 |
| Solinas, M | 1 |
| Castelnau, P | 1 |
| Belzung, C | 1 |
| Emond, P | 1 |
| Cortese, S | 1 |
| Faraone, SV | 1 |
| Chalon, S | 1 |
| Galineau, L | 1 |
| Zubedat, S | 1 |
| Aga-Mizrachi, S | 1 |
| Cymerblit-Sabba, A | 1 |
| Ritter, A | 1 |
| Nachmani, M | 1 |
| Avital, A | 1 |
| Kung, TS | 1 |
| Richardson, JR | 1 |
| Cooper, KR | 1 |
| White, LA | 1 |
| Juárez, J | 1 |
| Guerrero-Álvarez, Á | 1 |
| Lazzaretti, C | 1 |
| Kincheski, GC | 1 |
| Pandolfo, P | 1 |
| Krolow, R | 1 |
| Toniazzo, AP | 1 |
| Arcego, DM | 1 |
| Couto-Pereira, Nde S | 1 |
| Zeidán-Chuliá, F | 1 |
| Galvalisi, M | 1 |
| Costa, G | 1 |
| Scorza, C | 1 |
| Souza, TM | 1 |
| Dalmaz, C | 1 |
| Costa, Gde A | 1 |
| Galvão, TC | 1 |
| Bacchi, AD | 1 |
| Moreira, EG | 1 |
| Salles, MJ | 1 |
| Hara, Y | 1 |
| Ago, Y | 1 |
| Taruta, A | 1 |
| Katashiba, K | 1 |
| Hasebe, S | 1 |
| Takano, E | 1 |
| Onaka, Y | 1 |
| Hashimoto, H | 1 |
| Matsuda, T | 1 |
| Takuma, K | 1 |
| Pagerols, M | 1 |
| Richarte, V | 1 |
| Sánchez-Mora, C | 1 |
| Garcia-Martínez, I | 1 |
| Corrales, M | 1 |
| Corominas, M | 1 |
| Cormand, B | 1 |
| Casas, M | 1 |
| Ribasés, M | 1 |
| Ramos-Quiroga, JA | 1 |
| Diav-Citrin, O | 1 |
| Shechtman, S | 1 |
| Arnon, J | 1 |
| Wajnberg, R | 1 |
| Borisch, C | 1 |
| Beck, E | 1 |
| Bozzo, P | 1 |
| Nulman, I | 1 |
| Cummins, ED | 1 |
| Leedy, KK | 1 |
| Dose, JM | 1 |
| Peterson, DJ | 1 |
| Kirby, SL | 1 |
| Hernandez, LJ | 1 |
| Brown, RW | 1 |
| Zhu, J | 2 |
| Fan, F | 1 |
| McCarthy, DM | 1 |
| Zhang, L | 1 |
| Cannon, EN | 1 |
| Spencer, TJ | 2 |
| Biederman, J | 2 |
| Bhide, PG | 2 |
| Lipton, JW | 1 |
| Tolod, EG | 1 |
| Thompson, VB | 1 |
| Pei, L | 1 |
| Paumier, KL | 1 |
| Terpstra, BT | 1 |
| Lynch, KA | 1 |
| Collier, TJ | 1 |
| Sortwell, CE | 1 |
| Torres-Reveron, A | 3 |
| Gray, JD | 2 |
| Melton, JT | 2 |
| Punsoni, M | 2 |
| Tabori, NE | 2 |
| Ward, MJ | 2 |
| Frys, K | 1 |
| Iadecola, C | 1 |
| Milner, TA | 2 |
| Oldani, MJ | 1 |
| Peadon, E | 1 |
| Rhys-Jones, B | 1 |
| Bower, C | 1 |
| Elliott, EJ | 1 |
| Weedon, J | 1 |
| Dow-Edwards, DL | 1 |
| Rowles, BM | 1 |
| Findling, RL | 1 |
| Martín Fernández-Mayoralas, D | 1 |
| Fernández-Jaén, A | 1 |
| Amos-Kroohs, RM | 1 |
| Williams, MT | 2 |
| Vorhees, CV | 2 |
| Xu, Y | 1 |
| Thakur, GA | 1 |
| Sengupta, SM | 1 |
| Grizenko, N | 1 |
| Choudhry, Z | 1 |
| Joober, R | 1 |
| Ferguson, SA | 2 |
| Cada, AM | 2 |
| BRET, AJ | 1 |
| SIMON, S | 1 |
| Choong, KC | 2 |
| Shen, RY | 2 |
| McFadyen-Leussis, MP | 1 |
| Lewis, SP | 1 |
| Bond, TL | 1 |
| Carrey, N | 1 |
| Brown, RE | 1 |
| Bakhtiar, R | 1 |
| Tse, FL | 1 |
| Adriani, W | 1 |
| Leo, D | 1 |
| Greco, D | 1 |
| Rea, M | 1 |
| di Porzio, U | 1 |
| Laviola, G | 1 |
| Perrone-Capano, C | 1 |
| Guerriero, RM | 1 |
| Hayes, MM | 1 |
| Dhaliwal, SK | 1 |
| Ren, JQ | 1 |
| Kosofsky, BE | 1 |
| Lagace, DC | 1 |
| Yee, JK | 1 |
| Bolaños, CA | 1 |
| Eisch, AJ | 1 |
| Muneoka, K | 1 |
| Kuwagata, M | 1 |
| Iwata, M | 1 |
| Shirayama, Y | 1 |
| Ogawa, T | 1 |
| Takigawa, M | 1 |
| Schaefer, TL | 1 |
| Ehrman, LA | 1 |
| Gudelsky, GA | 1 |
| Fanslow, V | 1 |
| Zupan, B | 1 |
| Menzer, D | 1 |
| Rice, J | 1 |
| Drake, CT | 1 |
| Romeo, RD | 1 |
| Brake, WG | 1 |
| Humphreys, C | 1 |
| Garcia-Bournissen, F | 1 |
| Ito, S | 1 |
| Kiguchi, M | 1 |
| Fujita, S | 1 |
| Oki, H | 1 |
| Shimizu, N | 1 |
| Cools, AR | 1 |
| Koshikawa, N | 1 |
| Brenneman, DE | 1 |
| Rutledge, CO | 1 |
| Dickerson, JW | 1 |
| Pepler, F | 1 |
| Greeley, GH | 1 |
| Kizer, JS | 1 |
| Genazzani, AR | 2 |
| De Leo, V | 2 |
| Murru, S | 1 |
| Cocchi, D | 2 |
| Camanni, F | 2 |
| Müller, EE | 2 |
| Haglund, RM | 1 |
| Howerton, LL | 1 |
| Molinatti, GM | 1 |
| Campagnoli, C | 1 |
| Debooy, VD | 1 |
| Seshia, MM | 1 |
| Tenenbein, M | 1 |
| Casiro, OG | 1 |
| Herning, RI | 1 |
| Kayser, KH | 1 |
| Wacker, DP | 1 |
| Derby, KM | 1 |
| Andelman, MS | 1 |
| Golonka, Z | 1 |
| Stoner, EA | 1 |
| Gray, EP | 1 |
| Paule, MG | 1 |
| Rafales, LS | 1 |
| Bornschein, RL | 1 |
| Michaelson, IA | 1 |
| Loch, RK | 1 |
| Barker, GF | 1 |
| Loney, J | 1 |
| Prinz, RJ | 1 |
| Mishalow, J | 1 |
| Joad, J | 1 |
| Klorman, R | 1 |
| Salzman, LF | 1 |
| Pass, HL | 1 |
| Borgstedt, AD | 1 |
| Dainer, KB | 1 |
| Gittelman-Klein, R | 1 |
| Klein, DF | 1 |
| Katz, S | 1 |
| Saraf, K | 1 |
| Pollack, E | 1 |
| Denson, R | 1 |
| Nanson, JL | 1 |
| McWatters, MA | 1 |
| McCullar, FW | 1 |
| Heggeness, L | 1 |
| Lundquest, DE | 1 |
| Young, WK | 1 |
| Edland, JF | 1 |
| Moggian, G | 2 |
| Cervellati, I | 2 |
| Tamburini, E | 2 |
| O'Malley, JE | 1 |
| Eisenberg, L | 1 |
| Rapoport, JL | 1 |
| Quinn, PO | 1 |
| Lamprecht, F | 1 |
| Silbergeld, EK | 2 |
| Goldberg, AM | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical and Pharmacogenetic Study of Attention Deficit With Hyperactivity Disorder (ADHD)[NCT00483106] | Phase 4 | 885 participants (Actual) | Interventional | 1999-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for methylphenidate and Pregnancy
| Article | Year |
|---|---|
Fetal safety of methylphenidate-A scoping review and meta analysis.
Topics: Abnormalities, Drug-Induced; Central Nervous System Stimulants; Female; Fetus; Heart Defects, Congen | 2020 |
The Effects of Drugs used for the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) on Pregnancy Outcome and Breast-feeding: A Critical Review.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Breast Feeding; Central Nervous System Stimula | 2021 |
Parental ADHD in pregnancy and the postpartum period - A systematic review.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Fema | 2021 |
Management of Attention Deficit Hyperactivity Disorder During Pregnancy.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognitive B | 2018 |
Maternal and neonatal outcomes after exposure to ADHD medication during pregnancy: A systematic review and meta-analysis.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cohort Studies; Fe | 2019 |
Jornay PM -- evening-dosed methylphenidate for ADHD.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dela | 2019 |
Methylphenidate use in pregnancy and lactation: a systematic review of evidence.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Breast Feeding; Child Development; Female | 2014 |
Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders.
Topics: Alcohol-Induced Disorders, Nervous System; Antipsychotic Agents; Attention Deficit Disorder with Hyp | 2009 |
Review of pharmacotherapy options for the treatment of attention-deficit/hyperactivity disorder (ADHD) and ADHD-like symptoms in children and adolescents with developmental disorders.
Topics: Adolescent; Amphetamines; Antipsychotic Agents; Atomoxetine Hydrochloride; Attention Deficit Disorde | 2010 |
[Alcoholic foetopathy: an update].
Topics: Adrenergic Uptake Inhibitors; Alcoholism; Atomoxetine Hydrochloride; Central Nervous System Stimulan | 2011 |
First trimester in utero exposure to methylphenidate.
Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Fe | 2013 |
Exposure to attention deficit hyperactivity disorder medications during pregnancy.
Topics: Abnormalities, Drug-Induced; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivit | 2007 |
Diet and hyperactivity.
Topics: Adolescent; Aging; Amphetamines; Child; Child Behavior Disorders; Child, Preschool; Diet; Dietary Ca | 1980 |
4 trials available for methylphenidate and Pregnancy
| Article | Year |
|---|---|
A rapid method for evaluating the necessity for both a behavioral intervention and methylphenidate.
Topics: Aggression; Attention; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Central Nerv | 1997 |
Comparative effects of methylphenidate and thioridazine in hyperkinetic children. I. Clinical results.
Topics: Administration, Oral; Ambulatory Care; Child; Drug Combinations; Drug Evaluation; Female; Humans; Hy | 1976 |
[Critical study of the post-partum pain by means of a clinical pharmacology experiment].
Topics: Adult; Aspirin; Clinical Trials as Topic; Female; Humans; Methylphenidate; Pain; Phenobarbital; Plac | 1972 |
[Comparative study of a psychostimulating drug in the treatment of post-partum pain].
Topics: Adult; Analgesics; Aspirin; Clinical Trials as Topic; Female; Humans; Methylphenidate; Pain; Phenoba | 1973 |
72 other studies available for methylphenidate and Pregnancy
| Article | Year |
|---|---|
Influence of
Topics: Attention Deficit Disorder with Hyperactivity; Catechol O-Methyltransferase; Child; Female; Fetal Al | 2022 |
Methylphenidate Restores Behavioral and Neuroplasticity Impairments in the Prenatal Nicotine Exposure Mouse Model of ADHD: Evidence for Involvement of AMPA Receptor Subunit Composition and Synaptic Spine Morphology in the Hippocampus.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Female; Hippocampus; | 2022 |
Increased sperm deoxyribonucleic acid damage leads to poor embryo quality and subfertility of male rats treated with methylphenidate hydrochloride in adolescence.
Topics: Animals; Central Nervous System Stimulants; Chromatin; Female; Infertility; Male; Methylphenidate; P | 2022 |
Prevalence trends and individual patterns of ADHD medication use in pregnancy in Norway and Sweden, 2010-2019.
Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti | 2023 |
Prevalence trends and individual patterns of ADHD medication use in pregnancy in Norway and Sweden, 2010-2019.
Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti | 2023 |
Prevalence trends and individual patterns of ADHD medication use in pregnancy in Norway and Sweden, 2010-2019.
Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti | 2023 |
Prevalence trends and individual patterns of ADHD medication use in pregnancy in Norway and Sweden, 2010-2019.
Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti | 2023 |
In utero exposure to ADHD medication and long-term offspring outcomes.
Topics: Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child, Preschool; Clonidine; Coh | 2023 |
Cardiac Malformation Risks Following Maternal First Trimester Methylphenidate Use.
Topics: Central Nervous System Stimulants; Family; Female; Heart Defects, Congenital; Humans; Methylphenidat | 2023 |
Complex Attention-Deficit/Hyperactivity Disorder in a Bilingual Child with Down Syndrome and Intellectual Disability.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cesarean Section; Child; Down Syndrome; Female | 2023 |
First-Trimester Pregnancy Exposure to Modafinil and Risk of Congenital Malformations.
Topics: Abnormalities, Drug-Induced; Adult; Central Nervous System Stimulants; Denmark; Female; Humans; Logi | 2020 |
Fetal methylphenidate exposure induced ADHD-like phenotypes and decreased Drd2 and Slc6a3 expression levels in mouse offspring.
Topics: Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Dopamine Plasma Membrane T | 2021 |
Placental Complications Associated With Psychostimulant Use in Pregnancy.
Topics: Abruptio Placentae; Adrenergic Uptake Inhibitors; Adult; Amphetamine; Atomoxetine Hydrochloride; Att | 2017 |
Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations: A Cohort Study From the International Pregnancy Safety Study Consortium.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amphetamine; Attention Deficit Disorder with Hyperac | 2018 |
Shedding Light on the Risks of Methylphenidate and Amphetamine in Pregnancy.
Topics: Amphetamine; Cohort Studies; Dextroamphetamine; Methylphenidate; Pregnancy | 2018 |
Infant Exposure to Methylphenidate and Duloxetine During Lactation.
Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Breast Feeding; Depress | 2018 |
Perinatal Outcomes of Women Diagnosed with Attention-Deficit/Hyperactivity Disorder: An Australian Population-Based Cohort Study.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Australia; Central Nervous System | 2018 |
Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.
Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Corpus Striatu | 2019 |
Prenatal exposure to psychostimulants increases impulsivity, compulsivity, and motivation for rewards in adult mice.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Compulsive Behavior; Female; Impulsive | 2013 |
Methylphenidate restores novel object recognition in DARPP-32 knockout mice.
Topics: Analysis of Variance; Animals; Central Nervous System Stimulants; Data Interpretation, Statistical; | 2013 |
Response to Damkier.
Topics: Attention Deficit Disorder with Hyperactivity; Female; Humans; Methylphenidate; Pregnancy | 2014 |
Methylphenidate and pregnancy.
Topics: Attention Deficit Disorder with Hyperactivity; Female; Humans; Methylphenidate; Pregnancy | 2014 |
First-trimester exposure to methylphenidate: a population-based cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Central Nervous System Stimulants; Cohort Studies; Denmark; Fema | 2014 |
Comparison of pregnancy and lactation labeling for attention-deficit hyperactivity disorder drugs marketed in Australia, the USA, Denmark, and the UK.
Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Australia; Benzhydryl Comp | 2014 |
Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats.
Topics: Animals; Brain; Central Nervous System Stimulants; Cocaine; Dietary Sucrose; Disease Models, Animal; | 2014 |
Methylphenidate and environmental enrichment ameliorate the deleterious effects of prenatal stress on attention functioning.
Topics: Animals; Anxiety; Attention; Behavior, Animal; Central Nervous System Stimulants; Environment; Femal | 2015 |
Developmental Deltamethrin Exposure Causes Persistent Changes in Dopaminergic Gene Expression, Neurochemistry, and Locomotor Activity in Zebrafish.
Topics: Animals; Female; Gene Expression Regulation, Developmental; In Vitro Techniques; Insecticides; Methy | 2015 |
Effects of methylphenidate and atomoxetine on impulsivity and motor activity in preadolescent rats prenatally-treated with alcohol.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Central Nervous System Depressants | 2015 |
Neonatal handling causes impulsive behavior and decreased pharmacological response to methylphenidate in male adult wistar rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Biogenic Monoamines; Body Weight; Cent | 2016 |
Investigation of possible teratogenic effects in the offspring of mice exposed to methylphenidate during pregnancy.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Central Nervous System Stimulants; Female; Gestatio | 2016 |
Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism.
Topics: Animals; Atomoxetine Hydrochloride; Autistic Disorder; Behavior, Animal; Dendritic Spines; Disease M | 2016 |
Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Chi-Sq | 2017 |
Methylphenidate in Pregnancy: A Multicenter, Prospective, Comparative, Observational Study.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Spontaneous; Cardiovascular Abnormalities; | 2016 |
The effects of adolescent methylphenidate exposure on the behavioral and brain-derived neurotrophic factor response to nicotine.
Topics: Age Factors; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Female; Hippocampus; Male | 2017 |
A prenatal nicotine exposure mouse model of methylphenidate responsive ADHD-associated cognitive phenotypes.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Attention Deficit Disorder with Hypera | 2017 |
3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in culture.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Dopamine; Dopamine | 2008 |
Early postnatal exposure to methylphenidate alters stress reactivity and increases hippocampal ectopic granule cells in adult rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Beha | 2009 |
Uncanny scripts: understanding pharmaceutical emplotment in the aboriginal context.
Topics: Adolescent; Adult; Anthropology, Cultural; Attention Deficit Disorder with Hyperactivity; Central Ne | 2009 |
Methylphenidate response in prenatal cocaine-exposed rats: a behavioral and brain functional study.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibi | 2010 |
Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats.
Topics: Aging; Animals; Animals, Newborn; Central Nervous System Stimulants; Disease Models, Animal; Female; | 2011 |
Prenatal nicotine exposure mouse model showing hyperactivity, reduced cingulate cortex volume, reduced dopamine turnover, and responsiveness to oral methylphenidate treatment.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine; Female; Gy | 2012 |
Comprehensive phenotype/genotype analyses of the norepinephrine transporter gene (SLC6A2) in ADHD: relation to maternal smoking during pregnancy.
Topics: Alleles; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior; Cognition; Double-Bli | 2012 |
A longitudinal study of short- and long-term activity levels in male and female spontaneously hypertensive, Wistar-Kyoto, and Sprague-Dawley rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Central Nervous System Stimul | 2003 |
[Obesity in pregnancy. Trial of RP 8228. 1-Phenyl-1-(2-piperidyl)-1-acetoxymethane HCi. Threolevogyric form].
Topics: Female; Humans; Methylphenidate; Obesity; Pregnancy; Pregnancy Complications | 1963 |
Methylphenidate restores ventral tegmental area dopamine neuron activity in prenatal ethanol-exposed rats by augmenting dopamine neurotransmission.
Topics: Amphetamine; Animals; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Elec | 2004 |
Prenatal exposure to methylphenidate hydrochloride decreases anxiety and increases exploration in mice.
Topics: Animals; Anxiety; Exploratory Behavior; Female; Male; Maze Learning; Methylphenidate; Mice; Pregnanc | 2004 |
Toxicokinetic assessment of methylphenidate (Ritalin) enantiomers in pregnant rats and rabbits.
Topics: Animals; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Female; Methylphenidat | 2004 |
Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment.
Topics: Action Potentials; Animals; Animals, Newborn; Apomorphine; Attention Deficit Disorder with Hyperacti | 2006 |
Methylphenidate administration to adolescent rats determines plastic changes on reward-related behavior and striatal gene expression.
Topics: Animals; Central Nervous System Stimulants; Conditioning, Operant; Data Interpretation, Statistical; | 2006 |
Preadolescent methylphenidate versus cocaine treatment differ in the expression of cocaine-induced locomotor sensitization during adolescence and adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cocaine; Cocaine-Rel | 2006 |
Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesis.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Bromodeoxyuridine; Cell Prolifera | 2006 |
Dopamine transporter density and behavioral response to methylphenidate in a hyperlocomotor rat model.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Bromodeoxyuridine; Disease | 2006 |
Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat.
Topics: 3,4-Methylenedioxyamphetamine; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Bi | 2006 |
NTP-CERHR monograph on the potential human reproductive and developmental effects of methylphenidate.
Topics: Animals; Central Nervous System Stimulants; Female; Fetus; Humans; Male; Methylphenidate; Neoplasms; | 2005 |
Methylphenidate administration to juvenile rats alters brain areas involved in cognition, motivated behaviors, appetite, and stress.
Topics: Age Factors; Animals; Appetite; Behavior, Animal; Brain; Cognition; Female; Male; Methylphenidate; M | 2007 |
Behavioural characterisation of rats exposed neonatally to bisphenol-A: responses to a novel environment and to methylphenidate challenge in a putative model of attention-deficit hyperactivity disorder.
Topics: Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Benzhydr | 2008 |
Effect of dietary lipid on locomotor activity and response to psychomotor stimulants.
Topics: Animals; Atropine; Central Nervous System Stimulants; Dextroamphetamine; Dietary Fats; Female; Gesta | 1982 |
The effects of chronic methylphenidate treatment on growth and endocrine function in the developing rat.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Bone Development; Endocrine Glands; Estrus; F | 1980 |
Dynamic tests of prolactin secretion in hyperprolactinemic states: carbidopa-L-dopa and indirectly acting dopamine agonists.
Topics: Adenoma; Adult; Carbidopa; Dopamine; Female; Humans; Kinetics; Levodopa; Methylphenidate; Nomifensin | 1982 |
Ritalin: consequences of abuse in a clinical population.
Topics: Adult; Female; Humans; Injections, Intravenous; Male; Methadone; Methylphenidate; Opioid-Related Dis | 1982 |
Effect of two indirectly acting dopamine agonists on prolactin secretion in normo- and hyperprolactinemic subjects: comparison with the effect of nomifensine.
Topics: Adult; Depression, Chemical; Dibenzocycloheptenes; Dopamine; Female; Humans; Isoquinolines; Male; Me | 1981 |
Intravenous pentazocine and methylphenidate abuse during pregnancy. Maternal lifestyle and infant outcome.
Topics: Adolescent; Adult; Developmental Disabilities; Female; Fetal Growth Retardation; Follow-Up Studies; | 1993 |
Cognitive event-related potentials in populations at risk for substance abuse.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 1996 |
Reproductive toxicology. Methylphenidate hydrochloride.
Topics: Animals; Body Weight; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Female; K | 1997 |
No alterations in the performance of two interval timing operant tasks after alpha-difluoromethylornithine (DFMO)-induced cerebellar stunting.
Topics: Animals; Animals, Newborn; Association Learning; Brain Mapping; Cerebellum; Choice Behavior; Conditi | 2001 |
Drug induced activity in lead-exposed mice.
Topics: Age Factors; Animals; Apomorphine; Body Weight; Brain Chemistry; Dextroamphetamine; Drinking Behavio | 1979 |
Hyperkinetic/aggressive boys in treatment: predictors of clinical response to methylphenidate.
Topics: Age Factors; Aggression; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Fem | 1978 |
Effects of methylphenidate on hyperactive children's evoked responses during passive and active attention.
Topics: Attention; Child; Electroencephalography; Electrooculography; Evoked Potentials; Female; Humans; Hyp | 1979 |
Hyperkinesis and maternal smoking.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Hyperkinesis; Male; Methylphenidate; Pre | 1975 |
Limb malformations following maternal use of haloperidol.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Drug Therapy, Combination; Female; Fetus; Halo | 1975 |
Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse.
Topics: Adult; Dextropropoxyphene; Female; Granuloma; Humans; Liver; Lung; Methylphenidate; Myocardium; Pent | 1987 |
The hyperkinetic syndrome.
Topics: Birth Order; Child; Child Behavior Disorders; Child, Preschool; Dextroamphetamine; Female; Humans; H | 1973 |
Minor physical anomalies and plasma dopamine-beta-hydroxylase activity in hyperactive boys.
Topics: Abnormalities, Multiple; Child; Dopamine beta-Hydroxylase; Female; Humans; Hyperkinesis; Imipramine; | 1974 |
Lead-induced behavioral dysfunction: an animal model of hyperactivity.
Topics: Amphetamine; Animals; Chloral Hydrate; Dextroamphetamine; Disease Models, Animal; Female; Humans; Hy | 1974 |
Hyperactivity: a lead-induced behavior disorder.
Topics: Amphetamine; Animals; Animals, Newborn; Chloral Hydrate; Diet; Dose-Response Relationship, Drug; Fem | 1974 |