methylphenidate has been researched along with Obsessive-Compulsive Disorder in 25 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the clinical efficacy of dopamine modulator methylphenidate (MPH) of extended-release formulations (MPH-ER) augmentation of ongoing fluvoxamine treatment in refractory obsessive-compulsive disorder (OCD) and its effects on patient's anxiety and sleep quality." | 9.27 | [Efficacy of fluvoxamine combined with extended-release methylphenidate on treatment-refractory obsessive-compulsive disorder]. ( Guo, G; Huang, H; Jia, F; Li, G; Quan, D; Zheng, H, 2018) |
| "We describe a case whereby a 15-year-old female with treatment-resistant obsessive-compulsive disorder (OCD) was treated with methylphenidate for co-morbid attention deficit hyperactivity disorder (ADHD)." | 7.85 | Methylphenidate in the treatment of an adolescent female with obsessive-compulsive disorder and attention deficit hyperactivity disorder: a case report. ( Dowling, N; King, J; Leow, F, 2017) |
| "An acute methylphenidate challenge was performed on 13 patients with primary obsessive-compulsive disorder." | 7.67 | Methylphenidate in primary obsessive-compulsive disorder. ( Joffe, RT; Swinson, RP, 1987) |
| "To observe the clinical efficacy of dopamine modulator methylphenidate (MPH) of extended-release formulations (MPH-ER) augmentation of ongoing fluvoxamine treatment in refractory obsessive-compulsive disorder (OCD) and its effects on patient's anxiety and sleep quality." | 5.27 | [Efficacy of fluvoxamine combined with extended-release methylphenidate on treatment-refractory obsessive-compulsive disorder]. ( Guo, G; Huang, H; Jia, F; Li, G; Quan, D; Zheng, H, 2018) |
| "The effects of acute oral administration of methylphenidate 40 mg versus dextroamphetamine 30 mg versus matched placebo were compared in 11 patients with primary obsessive-compulsive disorder." | 5.07 | Acute psychostimulant challenge in primary obsessive-compulsive disorder. ( Joffe, RT; Levitt, AJ; Swinson, RP, 1991) |
| "We describe a case whereby a 15-year-old female with treatment-resistant obsessive-compulsive disorder (OCD) was treated with methylphenidate for co-morbid attention deficit hyperactivity disorder (ADHD)." | 3.85 | Methylphenidate in the treatment of an adolescent female with obsessive-compulsive disorder and attention deficit hyperactivity disorder: a case report. ( Dowling, N; King, J; Leow, F, 2017) |
| "An acute methylphenidate challenge was performed on 13 patients with primary obsessive-compulsive disorder." | 3.67 | Methylphenidate in primary obsessive-compulsive disorder. ( Joffe, RT; Swinson, RP, 1987) |
| "Dextroamphetamine tended to produce more compulsive behaviors, which were also more likely to resemble clinical obsessive-compulsive disorder (OCD), than did methylphenidate." | 2.67 | Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability? ( Amass, J; Borcherding, BG; Elia, J; Keysor, CS; Rapoport, JL, 1990) |
| "2." | 1.27 | Biological challenges in obsessive compulsive disorder. ( Joffe, RT; Swinson, RP, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, H | 2 |
| Jia, F | 2 |
| Han, H | 1 |
| Wang, S | 1 |
| Guo, G | 2 |
| Quan, D | 2 |
| Li, G | 2 |
| Huang, H | 2 |
| Piacentino, D | 1 |
| Pasquini, M | 1 |
| Cappelletti, S | 1 |
| Chetoni, C | 1 |
| Sani, G | 1 |
| Kotzalidis, GD | 1 |
| King, J | 1 |
| Dowling, N | 1 |
| Leow, F | 1 |
| Purper-Ouakil, D | 1 |
| Vitiello, B | 2 |
| Gürkan, K | 1 |
| Bilgiç, A | 1 |
| Türkoglu, S | 1 |
| Kiliç, BG | 1 |
| Aysev, A | 1 |
| Uslu, R | 1 |
| Rösler, M | 1 |
| Retz, W | 1 |
| Fischer, R | 1 |
| Ose, C | 1 |
| Alm, B | 1 |
| Deckert, J | 1 |
| Philipsen, A | 1 |
| Herpertz, S | 1 |
| Ammer, R | 1 |
| Green, T | 1 |
| Avda, S | 1 |
| Dotan, I | 1 |
| Zarchi, O | 1 |
| Basel-Vanagaite, L | 1 |
| Zalsman, G | 1 |
| Weizman, A | 1 |
| Gothelf, D | 1 |
| Rickards, H | 1 |
| Cavanna, AE | 1 |
| Worrall, R | 1 |
| Woolley, JB | 1 |
| Heyman, I | 1 |
| Serby, M | 1 |
| BURKLEN, R | 1 |
| JOHNSEN, G | 1 |
| Scahill, L | 1 |
| McDougle, CJ | 1 |
| Williams, SK | 1 |
| Dimitropoulos, A | 1 |
| Aman, MG | 1 |
| McCracken, JT | 1 |
| Tierney, E | 1 |
| Arnold, LE | 1 |
| Cronin, P | 1 |
| Grados, M | 1 |
| Ghuman, J | 1 |
| Koenig, K | 1 |
| Lam, KS | 1 |
| McGough, J | 1 |
| Posey, DJ | 1 |
| Ritz, L | 1 |
| Swiezy, NB | 1 |
| Kouris, S | 1 |
| van der Feltz-Cornelis, CM | 1 |
| Kolko, DJ | 1 |
| Bukstein, OG | 1 |
| Barron, J | 1 |
| Kotsopoulos, S | 1 |
| Spivak, M | 1 |
| Brandrup, E | 1 |
| Vanggaard, T | 1 |
| Joffe, RT | 3 |
| Swinson, RP | 3 |
| Levitt, AJ | 1 |
| Borcherding, BG | 1 |
| Keysor, CS | 1 |
| Rapoport, JL | 1 |
| Elia, J | 1 |
| Amass, J | 1 |
| Caine, ED | 1 |
| McBride, MC | 1 |
| Chiverton, P | 1 |
| Bamford, KA | 1 |
| Rediess, S | 1 |
| Shiao, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methylphenidate for Hyperactivity and Impulsiveness in Children and Adolescents With Pervasive Developmental Disorders[NCT00025779] | 60 participants | Interventional | 2001-10-31 | Completed | |||
| Multimodal Treatment Study of Children With ADHD[NCT00000388] | Phase 4 | 0 participants | Interventional | 1998-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for methylphenidate and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Pharmacotherapy for Hoarding Disorder: How did the Picture Change since its Excision from OCD?
Topics: Atomoxetine Hydrochloride; Hoarding Disorder; Humans; Methylphenidate; Obsessive-Compulsive Disorder | 2019 |
[Use of psychotropic drugs in children].
Topics: Adolescent; Age Factors; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Anxiety Dis | 2008 |
8 trials available for methylphenidate and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Combined fluvoxamine and extended-release methylphenidate improved treatment response compared to fluvoxamine alone in patients with treatment-refractory obsessive-compulsive disorder: A randomized double-blind, placebo-controlled study.
Topics: Adult; Dopamine Uptake Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Fluvoxami | 2019 |
[Efficacy of fluvoxamine combined with extended-release methylphenidate on treatment-refractory obsessive-compulsive disorder].
Topics: Adult; Double-Blind Method; Drug Therapy, Combination; Fluvoxamine; Humans; Methylphenidate; Obsessi | 2018 |
Depression, anxiety and obsessive-compulsive symptoms and quality of life in children with attention-deficit hyperactivity disorder (ADHD) during three-month methylphenidate treatment.
Topics: Adolescent; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 2010 |
Twenty-four-week treatment with extended release methylphenidate improves emotional symptoms in adult ADHD.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Delayed-Act | 2010 |
Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disorders.
Topics: Antipsychotic Agents; Central Nervous System Stimulants; Child; Child Development Disorders, Pervasi | 2006 |
Methylphenidate and behavior modification in children with ADHD and comorbid ODD or CD: main and incremental effects across settings.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Central Nervous System | 1999 |
Acute psychostimulant challenge in primary obsessive-compulsive disorder.
Topics: Adult; Behavior; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Male; Methylp | 1991 |
Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability?
Topics: Attention Deficit Disorder with Hyperactivity; Child; Compulsive Behavior; Dextroamphetamine; Double | 1990 |
15 other studies available for methylphenidate and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Methylphenidate in the treatment of an adolescent female with obsessive-compulsive disorder and attention deficit hyperactivity disorder: a case report.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorb | 2017 |
Recent NIMH clinical trials and implications for practice.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Central Nervous System | 2008 |
Phenotypic psychiatric characterization of children with Williams syndrome and response of those with ADHD to methylphenidate treatment.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Case-Control Studies; Central Nervous Sys | 2012 |
Treatment practices in Tourette syndrome: the European perspective.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Atomoxetine Hydrochloride | 2012 |
Dexamphetamine for obsessive-compulsive disorder.
Topics: Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2003 |
Methylphenidate-induced obsessive-compulsive symptoms in an elderly man.
Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety Diso | 2003 |
[A new central stimulant in states of psychic fatigue (psychasthenia)].
Topics: Central Nervous System Stimulants; Fatigue; Humans; Methylphenidate; Neurotic Disorders; Obsessive-C | 1957 |
[CLINICAL ASPECTS OF MODEL PSYCHOSES].
Topics: Anorexia Nervosa; Convulsive Therapy; Hospitals, Psychiatric; Humans; Insulin; Lysergic Acid Diethyl | 1964 |
Methylphenidate-induced obsessive-compulsiveness.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Mal | 1998 |
Intractable obsessive-compulsive disorder: comorbidity with unrecognized adult attention-deficit hyperactivity disorder?
Topics: Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Comorbidity; Humans; Male; Methyl | 1999 |
Obsessive-compulsive symptoms secondary to methylphenidate treatment.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; Female; Huma | 2001 |
LSD treatment in a severe case of compulsive neurosis.
Topics: Adult; Humans; Injections; Interview, Psychological; Lysergic Acid Diethylamide; Male; Methylphenida | 1977 |
Tourette's syndrome in Monroe County school children.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior; Child; Child, Preschool; Clonid | 1988 |
Biological challenges in obsessive compulsive disorder.
Topics: Adult; Affect; Behavior; Female; Humans; Male; Methylphenidate; Obsessive-Compulsive Disorder; Sleep | 1988 |
Methylphenidate in primary obsessive-compulsive disorder.
Topics: Adult; Aged; Female; Humans; Male; Methylphenidate; Obsessive-Compulsive Disorder | 1987 |