methylphenidate has been researched along with Neurodegenerative Diseases in 7 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylphenidate (MPH) is a stimulatory agent in brain with unknown long-term consequences." | 5.46 | Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats. ( Fatima, S; Motaghinejad, M; Motevalian, M; Shabab, B, 2017) |
| "Methylphenidate (MPH) is a stimulatory agent in brain with unknown long-term consequences." | 1.46 | Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats. ( Fatima, S; Motaghinejad, M; Motevalian, M; Shabab, B, 2017) |
| "Spinocerebellar ataxia type 17 (SCA17) is a rare autosomal dominantly inherited neurodegenerative disorder presenting with a variable phenotype including ataxia, dystonia, chorea, and parkinsonism, as well as cognitive impairment." | 1.38 | PET and MRI reveal early evidence of neurodegeneration in spinocerebellar ataxia type 17. ( Brockmann, K; Globas, C; Hauser, TK; Machulla, HJ; Reimold, M; Rolfs, A; Schöls, L; Walter, U, 2012) |
| "At 14 years after smoke inhalation injury, he had persistent cognitive impairment." | 1.38 | Progressive neuropsychiatric and brain abnormalities after smoke inhalation. ( Tobe, E, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Motaghinejad, M | 3 |
| Motevalian, M | 3 |
| Babalouei, F | 1 |
| Abdollahi, M | 1 |
| Heidari, M | 1 |
| Madjd, Z | 1 |
| Shabab, B | 1 |
| Fatima, S | 1 |
| Drijgers, RL | 1 |
| Aalten, P | 1 |
| Winogrodzka, A | 1 |
| Verhey, FR | 1 |
| Leentjens, AF | 1 |
| Brockmann, K | 1 |
| Reimold, M | 1 |
| Globas, C | 1 |
| Hauser, TK | 1 |
| Walter, U | 1 |
| Machulla, HJ | 1 |
| Rolfs, A | 1 |
| Schöls, L | 1 |
| Tobe, E | 1 |
| Hanson, GR | 1 |
| Sandoval, V | 1 |
| Riddle, E | 1 |
| Fleckenstein, AE | 1 |
1 review available for methylphenidate and Neurodegenerative Diseases
| Article | Year |
|---|---|
Pharmacological treatment of apathy in neurodegenerative diseases: a systematic review.
Topics: Aged; Case-Control Studies; Central Nervous System Stimulants; Cholinesterase Inhibitors; Cohort Stu | 2009 |
6 other studies available for methylphenidate and Neurodegenerative Diseases
| Article | Year |
|---|---|
Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Glutathione | 2022 |
Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; | 2017 |
Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats.
Topics: Animals; Anxiety; Cerebral Cortex; Depression; Dose-Response Relationship, Drug; Hippocampus; Inflam | 2017 |
PET and MRI reveal early evidence of neurodegeneration in spinocerebellar ataxia type 17.
Topics: Adult; Age of Onset; Brain; Dopamine Agents; Dopamine Antagonists; Dopaminergic Neurons; Female; Flu | 2012 |
Progressive neuropsychiatric and brain abnormalities after smoke inhalation.
Topics: Activities of Daily Living; Brain; Cognition Disorders; Depressive Disorder, Major; DNA Damage; Fluo | 2012 |
Psychostimulants and vesicle trafficking: a novel mechanism and therapeutic implications.
Topics: Animals; Central Nervous System Stimulants; Corpus Striatum; Male; Membrane Glycoproteins; Membrane | 2004 |