methylphenidate has been researched along with Inflammation in 11 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylphenidate (MPH) is a stimulatory agent in brain with unknown long-term consequences." | 5.46 | Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats. ( Fatima, S; Motaghinejad, M; Motevalian, M; Shabab, B, 2017) |
| "Methylphenidate (MPH) is a central stimulant, prescribed for the treatment of attention deficit/hyperactivity disorder." | 5.43 | Effects of chronic treatment with methylphenidate on oxidative stress and inflammation in hippocampus of adult rats. ( Motaghinejad, M; Motevalian, M; Shabab, B, 2016) |
| "Methylphenidate (MPH) is a central nervous system (CNS) stimulant known for its effectiveness in the treatment of Attention Deficit Hyperactivity Disorder (ADHD), a neuropsychiatric condition that has a high incidence in childhood and affects behavior and cognition." | 2.82 | Evidence of methylphenidate effect on mitochondria, redox homeostasis, and inflammatory aspects: Insights from animal studies. ( Foschiera, LN; Schmitz, F; Wyse, ATS, 2022) |
| "Whether long-term methylphenidate (MPH) results in any changes in cardiovascular function or structure can only be properly addressed through a randomized trial using an animal model which permits elevated dosing over an extended period of time." | 1.51 | A randomized controlled laboratory study on the long-term effects of methylphenidate on cardiovascular function and structure in rhesus monkeys. ( Bodien, A; Callicott, R; Czachor, J; Dauphin, DD; Davis, K; Greenhaw, J; Jones, Y; Lipshultz, SE; Paredes, A; Paule, MG; Rusconi, PG; Salminen, WF; Sandhu, SK; Slikker, W; Westphal, JA; Wilkinson, JD, 2019) |
| "Methylphenidate (MPH) is a stimulatory agent in brain with unknown long-term consequences." | 1.46 | Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats. ( Fatima, S; Motaghinejad, M; Motevalian, M; Shabab, B, 2017) |
| "Methylphenidate (MPH) is a central stimulant, prescribed for the treatment of attention deficit/hyperactivity disorder." | 1.43 | Effects of chronic treatment with methylphenidate on oxidative stress and inflammation in hippocampus of adult rats. ( Motaghinejad, M; Motevalian, M; Shabab, B, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Foschiera, LN | 1 |
| Schmitz, F | 1 |
| Wyse, ATS | 1 |
| Raoofi, A | 1 |
| Aliaghaei, A | 1 |
| Abdollahifar, MA | 1 |
| Eskandarian Boroujeni, M | 1 |
| Javadinia, SS | 1 |
| Atabati, H | 1 |
| Abouhamzeh, B | 1 |
| Khalid, A | 1 |
| Abbasi, UA | 1 |
| Amber, S | 1 |
| Mirza, FJ | 1 |
| Asif, M | 1 |
| Javed, A | 1 |
| Zahid, S | 1 |
| Petrulli, JR | 1 |
| Kalish, B | 1 |
| Nabulsi, NB | 1 |
| Huang, Y | 1 |
| Hannestad, J | 1 |
| Morris, ED | 1 |
| Wilkinson, JD | 1 |
| Callicott, R | 1 |
| Salminen, WF | 1 |
| Sandhu, SK | 1 |
| Greenhaw, J | 1 |
| Paredes, A | 1 |
| Davis, K | 1 |
| Jones, Y | 1 |
| Paule, MG | 1 |
| Slikker, W | 1 |
| Rusconi, PG | 1 |
| Czachor, J | 1 |
| Bodien, A | 1 |
| Westphal, JA | 1 |
| Dauphin, DD | 1 |
| Lipshultz, SE | 1 |
| Motaghinejad, M | 4 |
| Motevalian, M | 4 |
| Shabab, B | 3 |
| Fatima, S | 1 |
| Crawford, SA | 1 |
| Evans, JA | 1 |
| Crawford, GE | 1 |
| Sugar, HS | 1 |
| Mandell, GH | 1 |
| Shalev, J | 1 |
1 review available for methylphenidate and Inflammation
| Article | Year |
|---|---|
Evidence of methylphenidate effect on mitochondria, redox homeostasis, and inflammatory aspects: Insights from animal studies.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Homeostas | 2022 |
1 trial available for methylphenidate and Inflammation
| Article | Year |
|---|---|
Systemic inflammation enhances stimulant-induced striatal dopamine elevation.
Topics: Adult; Carbon Radioisotopes; Case-Control Studies; Central Nervous System Stimulants; Dopamine; Dopa | 2017 |
9 other studies available for methylphenidate and Inflammation
| Article | Year |
|---|---|
Long-term administration of high-dose methylphenidate-induced cerebellar morphology and function damage in adult rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 8; Central Nervous System Stimulants; Cerebe | 2020 |
Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCl
Topics: Aluminum Chloride; Animals; Cognition; Gene Expression Regulation; Inflammation; Male; Methylphenida | 2020 |
A randomized controlled laboratory study on the long-term effects of methylphenidate on cardiovascular function and structure in rhesus monkeys.
Topics: Animals; Behavior, Animal; Biopsy; Cardiovascular System; Central Nervous System Stimulants; Echocar | 2019 |
Effects of chronic treatment with methylphenidate on oxidative stress and inflammation in hippocampus of adult rats.
Topics: Animals; Cell Count; Central Nervous System Stimulants; Dentate Gyrus; Dose-Response Relationship, D | 2016 |
Involvement of AMPA/kainate and GABAA receptors in topiramate neuroprotective effects against methylphenidate abuse sequels involving oxidative stress and inflammation in rat isolated hippocampus.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fructose; Glutathione Disulfide | 2016 |
Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats.
Topics: Animals; Anxiety; Cerebral Cortex; Depression; Dose-Response Relationship, Drug; Hippocampus; Inflam | 2017 |
Possible involvements of glutamate and adrenergic receptors on acute toxicity of methylphenidate in isolated hippocampus and cerebral cortex of adult rats.
Topics: Animals; Antioxidants; Central Nervous System Stimulants; Cerebral Cortex; Dose-Response Relationshi | 2017 |
Necrotizing fasciitis associated with Haemophilus aphrophilus. Report of a case.
Topics: Adult; Anti-Bacterial Agents; Drainage; Fascia; Haemophilus Infections; Humans; Inflammation; Male; | 1978 |
Metastatic endophthalmitis associated with injection of addictive drugs.
Topics: Adult; Amphetamine; Aspergillosis; Cannabis; Eye Diseases; Heroin; Humans; Inflammation; Injections, | 1971 |