Page last updated: 2024-10-31

methylphenidate and Hypertension

methylphenidate has been researched along with Hypertension in 25 studies

Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"Methylphenidate did not increase 24-h heart rates, whereas omega-3 fatty acid supplementation significantly decreased elevated heart rates and increased HRV in adolescents with IST."1.56Diagnosis and management of an inappropriate sinus tachycardia in adolescence based upon a Holter ECG: A retrospective analysis of 479 patients. ( Baumann, C; Buchhorn, R; Gündogdu, S; Rakowski, U; Willaschek, C, 2020)
"OROS-methylphenidate was reported as the most helpful methylphenidate class formulation, with 74% reporting it at least somewhat helpful."1.39Caregiver survey of pharmacotherapy to treat attention deficit/hyperactivity disorder in individuals with Williams syndrome. ( Andridge, RR; Coury, DL; Foster, JE; Martens, MA; McClure, KE; Seyfer, DL, 2013)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199013 (52.00)18.7374
1990's1 (4.00)18.2507
2000's4 (16.00)29.6817
2010's5 (20.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Buchhorn, R1
Baumann, C1
Gündogdu, S1
Rakowski, U1
Willaschek, C1
Cortese, S1
Espadas, M1
Insa, I1
Chamorro, M1
Alda-Diez, JA1
Dela Peña, I1
Kim, BN1
Han, DH1
Kim, Y1
Cheong, JH1
Martens, MA1
Seyfer, DL1
Andridge, RR1
Foster, JE1
McClure, KE1
Coury, DL1
Fernández-Fernández, MA1
Rufo-Campos, M1
Mateos-Checa, R1
Muñoz-Cabello, B1
Madruga-Garrido, M1
Blanco-Martínez, B1
Mick, E1
McGough, JJ1
Middleton, FA1
Neale, B1
Faraone, SV1
Klein-Schwartz, W1
McGrath, J1
Oster, MI1
HEYDECKE, KH2
CHRISTE, R2
ACHOR, RW1
BERGE, KG1
SCHLEGEL, G1
DAY, MD1
RAND, MJ1
RIU, J1
Wilens, TE1
Hammerness, PG1
Biederman, J1
Kwon, A1
Spencer, TJ1
Clark, S1
Scott, M1
Podolski, A1
Ditterline, JW1
Morris, MC1
Moore, H1
van den Bergh, FS1
Bloemarts, E1
Chan, JS1
Groenink, L1
Olivier, B1
Oosting, RS1
Deshmankar, BS1
Lewis, JA1
Blackman, JA1
Samson-Fang, L1
Gutgesell, H1
Kudrin, AN1
Davydova, ON1
Krendal', FP1
Brown, RT1
Sexson, SB1
Brichard, G1
Guilleminault, C1
Carskadon, M1
Dement, WC1
Fischer, KC1
Wilson, WP1
Meyer, JS1
Eadie, GA1
Ericsson, AD1
Hoobler, SW1
MacMahon, HR1

Reviews

3 reviews available for methylphenidate and Hypertension

ArticleYear
Pharmacologic Treatment of Attention Deficit-Hyperactivity Disorder.
    The New England journal of medicine, 2020, 09-10, Volume: 383, Issue:11

    Topics: Adolescent; Adult; Amphetamines; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperact

2020
[Side effects of methylphenidate in children and the young].
    Revista de neurologia, 2018, Mar-01, Volume: 66, Issue:5

    Topics: Adolescent; Anorexia; Attention Deficit Disorder with Hyperactivity; Bone Diseases, Developmental; C

2018
Abuse and dependence liability analysis of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder (ADHD): what have we learned?
    Archives of pharmacal research, 2013, Volume: 36, Issue:4

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Addictive; Behavior, Animal; Blood

2013

Trials

5 trials available for methylphenidate and Hypertension

ArticleYear
Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Mar-30, Volume: 35, Issue:2

    Topics: Administration, Cutaneous; Attention Deficit Disorder with Hyperactivity; Blood Pressure; Central Ne

2011
Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:2

    Topics: Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Blood Pre

2005
Effects of methylphenidate on cardiovascular responses in attention deficit hyperactivity disordered adolescents.
    Journal of adolescent health care : official publication of the Society for Adolescent Medicine, 1989, Volume: 10, Issue:3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Black People; Blood Pressure; Child; Dose

1989
[Practolol in anesthesia (ICI 50.172, Eraldin)].
    Acta anaesthesiologica Belgica, 1972, Volume: 23, Issue:1

    Topics: Acetanilides; Adolescent; Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Amino Alcohols; Ane

1972
A pilot study of antihypertensive therapy in cerebrovascular disease.
    Journal of the American Geriatrics Society, 1967, Volume: 15, Issue:4

    Topics: Adult; Cerebrovascular Disorders; Clinical Trials as Topic; Depression; Female; Humans; Hypertension

1967

Other Studies

17 other studies available for methylphenidate and Hypertension

ArticleYear
Diagnosis and management of an inappropriate sinus tachycardia in adolescence based upon a Holter ECG: A retrospective analysis of 479 patients.
    PloS one, 2020, Volume: 15, Issue:8

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Electrocardiography, Ambulatory; Fatty Ac

2020
Caregiver survey of pharmacotherapy to treat attention deficit/hyperactivity disorder in individuals with Williams syndrome.
    Research in developmental disabilities, 2013, Volume: 34, Issue:5

    Topics: Adolescent; Amphetamines; Aortic Stenosis, Subvalvular; Attention Deficit Disorder with Hyperactivit

2013
[Cardiovascular side effects secondary to treatment with methylphenidate].
    Revista de neurologia, 2010, May-01, Volume: 50, Issue:9

    Topics: Central Nervous System Stimulants; Child; Humans; Hypertension; Male; Methylphenidate; Tachycardia

2010
Poison centers' experience with methylphenidate abuse in pre-teens and adolescents.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2003, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Child; Female; Humans; Hypertension; Male; Methylphenidate; Poison Control Center

2003
Efficacy or effectiveness: which comes first, the cure or the treatment?
    The American journal of clinical hypnosis, 2003, Volume: 46, Issue:1

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans

2003
[Hypertension management in Los; experiences with serpatonil].
    Svenska lakartidningen, 1956, Oct-19, Volume: 53, Issue:42

    Topics: Disease Management; Hypertension; Methylphenidate; Reserpine

1956
[Hypertension management in Los; experiences with serpatonil].
    Svenska lakartidningen, 1956, Oct-19, Volume: 53, Issue:42

    Topics: Disease Management; Hypertension; Methylphenidate; Reserpine

1956
[Hypertension management in Los; experiences with serpatonil].
    Svenska lakartidningen, 1956, Oct-19, Volume: 53, Issue:42

    Topics: Disease Management; Hypertension; Methylphenidate; Reserpine

1956
[Hypertension management in Los; experiences with serpatonil].
    Svenska lakartidningen, 1956, Oct-19, Volume: 53, Issue:42

    Topics: Disease Management; Hypertension; Methylphenidate; Reserpine

1956
[Comparative therapeutic effect of serpasil-ritalin combination].
    Schweizerische medizinische Wochenschrift, 1956, Nov-17, Volume: 86, Issue:46

    Topics: Hypertension; Methylphenidate; Reserpine

1956
[Comparative therapeutic effect of serpasil-ritalin combination].
    Schweizerische medizinische Wochenschrift, 1956, Nov-17, Volume: 86, Issue:46

    Topics: Hypertension; Methylphenidate; Reserpine

1956
[Comparative therapeutic effect of serpasil-ritalin combination].
    Schweizerische medizinische Wochenschrift, 1956, Nov-17, Volume: 86, Issue:46

    Topics: Hypertension; Methylphenidate; Reserpine

1956
[Comparative therapeutic effect of serpasil-ritalin combination].
    Schweizerische medizinische Wochenschrift, 1956, Nov-17, Volume: 86, Issue:46

    Topics: Hypertension; Methylphenidate; Reserpine

1956
Treatment of hypertension using reserpine combined with a new analeptic agent, methyl-phenidylacetate hydrochloride; limitations of usefulness.
    Antibiotic medicine & clinical therapy (New York, NY), 1957, Volume: 4, Issue:10

    Topics: Central Nervous System Stimulants; Hypertension; Methylphenidate; Reserpine; Salts

1957
[Ritalin, an adjuvant in the therapy of hypertension].
    Therapeutische Umschau. Revue therapeutique, 1958, Volume: 15, Issue:9

    Topics: Adjuvants, Immunologic; Hypertension; Methylphenidate

1958
Antagonism of guanethidine and bretylium by various agents.
    Lancet (London, England), 1962, Dec-15, Volume: 2, Issue:7268

    Topics: Bretylium Compounds; Cocaine; Guanethidine; Hypertension; Methylphenidate; Monoamine Oxidase Inhibit

1962
[Clinical experience with an association of reserpine and methylphenidylacetate].
    La Semana medica, 1959, Sep-10, Volume: 115

    Topics: Hypertension; Methylphenidate; Reserpine

1959
Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 83, Issue:3

    Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervo

2006
Ventricular tachycardia associated with the administration of methylphenidate during guanethidine therapy.
    Canadian Medical Association journal, 1967, Nov-04, Volume: 97, Issue:19

    Topics: Drug Synergism; Electrocardiography; Guanethidine; Humans; Hypertension; Male; Methylphenidate; Midd

1967
Clonidine and electrocardiograms.
    Pediatrics, 1996, Volume: 98, Issue:6 Pt 1

    Topics: Adult; Child; Clonidine; Drug Interactions; Electrocardiography; Humans; Hypertension; Methylphenida

1996
[Pharmacologic incompatibility of neuroleptics and tranquilizers with other medicines].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1977, Volume: 77, Issue:4

    Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anticonvulsants; Antipsychotic Ag

1977
On the treatment of rapid eye movement narcolepsy.
    Archives of neurology, 1974, Volume: 30, Issue:1

    Topics: Adult; Amphetamine; Antidepressive Agents; Cataplexy; Depression; Desipramine; Electroencephalograph

1974
Methylphenidate and the hyperkinetic state.
    Diseases of the nervous system, 1971, Volume: 32, Issue:10

    Topics: Ataxia; Child; Drug Synergism; Feeding and Eating Disorders; Humans; Hyperkinesis; Hypertension; Met

1971