methylphenidate has been researched along with Growth Disorders in 22 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Growth Disorders: Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dosage was significantly associated with the decrease in height and weight percentile." | 2.65 | Growth of hyperactive children on maintenance regimen of methylphenidate. ( Gittelman, R; Mattes, JA, 1983) |
| " While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs." | 2.49 | Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013) |
| "Methylphenidate is an amphetamine psychostimulant used as a symptomatic treatment for attention-deficit hyperactivity disorder." | 1.37 | Methylphenidate: growth retardation. ( , 2011) |
| "To determine whether treatment of attention deficit hyperactivity disorder (ADHD) with methylphenidate hydrochloride or pemoline diminishes the response to growth hormone (GH) therapy in patients with idiopathic GH deficiency (IGHD) or idiopathic short stature (ISS)." | 1.30 | Response to growth hormone in attention deficit hyperactivity disorder: effects of methylphenidate and pemoline therapy. ( Blethen, SL; Breen, TJ; Julius, JR; Rao, JK, 1998) |
| " This temporary effect on growth is present during the first few years of treatment and seems related to drug dosage and to the presence or absence of drug holidays." | 1.26 | The effects of stimulant medication on the growth of hyperkinetic children. ( Hung, W; Lipman, RS; Overall, JE; Roche, AF, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (36.36) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Espadas, M | 1 |
| Insa, I | 1 |
| Chamorro, M | 1 |
| Alda-Diez, JA | 1 |
| Poulton, AS | 1 |
| Bui, Q | 1 |
| Melzer, E | 1 |
| Evans, R | 1 |
| Biederman, J | 1 |
| Spencer, TJ | 1 |
| Monuteaux, MC | 1 |
| Faraone, SV | 1 |
| Cortese, S | 1 |
| Holtmann, M | 1 |
| Banaschewski, T | 1 |
| Buitelaar, J | 1 |
| Coghill, D | 1 |
| Danckaerts, M | 1 |
| Dittmann, RW | 1 |
| Graham, J | 1 |
| Taylor, E | 1 |
| Sergeant, J | 1 |
| Renes, JS | 1 |
| de Ridder, MA | 1 |
| Breukhoven, PE | 1 |
| Lem, AJ | 1 |
| Hokken-Koelega, AC | 1 |
| Poulton, A | 1 |
| Cowell, CT | 1 |
| Lisska, MC | 1 |
| Rivkees, SA | 1 |
| Weiss, G | 1 |
| Golinko, BE | 1 |
| Mattes, JA | 2 |
| Gittelman, R | 1 |
| Greenhill, LL | 1 |
| Puig-Antich, J | 1 |
| Halpern, F | 1 |
| Sachar, EJ | 1 |
| Rubinstein, B | 1 |
| Chambers, W | 1 |
| Fiscina, B | 1 |
| Florea, J | 1 |
| Lurie, S | 1 |
| O'Quinn, A | 1 |
| Rao, JK | 1 |
| Julius, JR | 1 |
| Breen, TJ | 1 |
| Blethen, SL | 1 |
| Joshi, SV | 1 |
| Sund, AM | 1 |
| Zeiner, P | 1 |
| Holtkamp, K | 1 |
| Peters-Wallraf, B | 1 |
| Wüller, S | 1 |
| Pfäaffle, R | 1 |
| Herpertz-Dahlmann, B | 1 |
| Roche, AF | 1 |
| Lipman, RS | 1 |
| Overall, JE | 1 |
| Hung, W | 1 |
| Barter, M | 1 |
| Kammer, H | 1 |
| Klein, RG | 1 |
| Landa, B | 1 |
| Klein, DF | 1 |
| Safer, DJ | 1 |
| Allen, RP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323] | 80 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for methylphenidate and Growth Disorders
| Article | Year |
|---|---|
[Side effects of methylphenidate in children and the young].
Topics: Adolescent; Anorexia; Attention Deficit Disorder with Hyperactivity; Bone Diseases, Developmental; C | 2018 |
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure | 2013 |
Neuroendocrine responses to methylphenidate and d-amphetamine: applications to attention-deficit disorder.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 1991 |
ADHD, growth deficits, and relationships to psychostimulant use.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2002 |
3 trials available for methylphenidate and Growth Disorders
| Article | Year |
|---|---|
Controversial issues of the pharmacotherapy of the hyperactive child.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 1981 |
Growth of hyperactive children on maintenance regimen of methylphenidate.
Topics: Attention Deficit Disorder with Hyperactivity; Body Height; Body Weight; Child; Child Development; D | 1983 |
Methylphenidate and growth in hyperactive children. A controlled withdrawal study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Body Height; Body Weight; Child; Child De | 1988 |
15 other studies available for methylphenidate and Growth Disorders
| Article | Year |
|---|---|
Stimulant medication effects on growth and bone age in children with attention-deficit/hyperactivity disorder: a prospective cohort study.
Topics: Absorptiometry, Photon; Adiposity; Age Factors; Anthropometry; Attention Deficit Disorder with Hyper | 2016 |
A naturalistic 10-year prospective study of height and weight in children with attention-deficit hyperactivity disorder grown up: sex and treatment effects.
Topics: Adolescent; Age Factors; Aging; Attention Deficit Disorder with Hyperactivity; Body Height; Body Wei | 2010 |
Methylphenidate: growth retardation.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2011 |
Methylphenidate and the response to growth hormone treatment in short children born small for gestational age.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Body Height; Central Nervous System Stimu | 2012 |
Slowing of growth in height and weight on stimulants: a characteristic pattern.
Topics: Adolescent; Age Distribution; Attention Deficit Disorder with Hyperactivity; Body Height; Body Weigh | 2003 |
Daily methylphenidate use slows the growth of children: a community based study.
Topics: Attention Deficit Disorder with Hyperactivity; Body Height; Central Nervous System Stimulants; Child | 2003 |
ADHD update: new data on the risks of medication.
Topics: Adrenergic Uptake Inhibitors; Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hype | 2006 |
Side effects of dextroamphetamine and methylphenidate in hyperactive children--a brief review.
Topics: Anorexia; Attention Deficit Disorder with Hyperactivity; Body Weight; Child; Dextroamphetamine; Grow | 1984 |
Growth disturbances in hyperkinetic children.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Growth Disorders; Humans; H | 1980 |
Response to growth hormone in attention deficit hyperactivity disorder: effects of methylphenidate and pemoline therapy.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Female; Gro | 1998 |
Does extended medication with amphetamine or methylphenidate reduce growth in hyperactive children?
Topics: Adolescent; Amphetamine; Attention Deficit Disorder with Hyperactivity; Body Height; Body Weight; Ce | 2002 |
Methylphenidate-related growth impairment.
Topics: Attention Deficit Disorder with Hyperactivity; Body Height; Central Nervous System Stimulants; Child | 2002 |
The effects of stimulant medication on the growth of hyperkinetic children.
Topics: Adolescent; Body Height; Body Weight; Child Behavior Disorders; Dextroamphetamine; Growth; Growth Di | 1979 |
Methylphenidate and growth retardation.
Topics: Child; Growth Disorders; Growth Hormone; Humans; Hyperkinesis; Male; Methylphenidate | 1978 |
Factors influencing the suppressant effects of two stimulant drugs on the growth of hyperactive children.
Topics: Analysis of Variance; Body Height; Body Weight; Child; Dextroamphetamine; Growth Disorders; Humans; | 1973 |