methylphenidate has been researched along with Gelineau Syndrome in 97 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this new mother with narcolepsy, resuming methylphenidate did not reduce breastmilk volumes or negatively impact her infant." | 8.12 | Successful lactation after resuming methylphenidate in a woman with narcolepsy. ( Bello, G; Poirier, J; Sharkey, KM, 2022) |
| "The purpose of this study was to establish the effects of selegiline HCl on sleep parameters in narcolepsy and to contrast these effects with the effects of methylphenidate." | 7.69 | REM changes in narcolepsy with selegiline. ( MacFarlane, JG; Reinish, LW; Sandor, P; Shapiro, CM, 1995) |
| "We have studied the pharmacokinetics of methylphenidate enantiomers after the oral administration of different doses of racemic methylphenidate to one patient with narcolepsy and to four healthy volunteers." | 7.68 | Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers. ( Aoyama, T; Honda, Y; Iga, T; Kotaki, H; Sasaki, T; Sawada, Y, 1993) |
| "Methylphenidate, pemoline, and protriptyline were studied for their treatment efficacy in narcolepsy." | 7.67 | Treatment of narcolepsy: objective studies on methylphenidate, pemoline, and protriptyline. ( Browman, CP; Hajdukovich, R; Mitler, MM; Shafor, R; Timms, RM, 1986) |
| "A 25-year-old man with narcolepsy and cataplexy experienced partial relief of symptomatology following administration of methylphenidate." | 7.67 | Efficacy of trazodone in narcolepsy. ( Sandyk, R, 1985) |
| "A patient with severe narcolepsy and cataplexy had been treated with a high dosage of methylphenidate hydrochloride, but the drug was not effective." | 7.66 | Successful treatment of narcolepsy with propranolol: a case report. ( Cadieux, R; Kales, A; Soldatos, CR; Tan, TL, 1979) |
| "Patients ( n=40) with excessive daytime sleepiness related to narcolepsy, who had received previous treatment with methylphenidate, were switched from methylphenidate to modafinil (200 mg/day followed by 400 mg/day) without a washout period between treatments, with a 2-day washout period between treatments, or by using a taper-down/titrate-up protocol." | 5.10 | Initiating treatment with modafinil for control of excessive daytime sleepiness in patients switching from methylphenidate: an open-label safety study assessing three strategies. ( Hayduk, R; Kovacevic-Ristanovic, R; Schwartz, JR; Thorpy, MJ, 2003) |
| "To assess the efficacy and safety of modafinil for improving wakefulness in narcolepsy patients treated previously with psychostimulants." | 5.10 | Efficacy and safety of modafinil for improving daytime wakefulness in patients treated previously with psychostimulants. ( Feldman, NT; Fry, JM; Harsh, J; Schwartz, JR, 2003) |
| " The premise is that regulation of blood pressure and heart rate is altered and affected by methylphenidate, a stimulant drug in children with narcolepsy with cataplexy." | 4.31 | Diurnal changes in blood pressure and heart rate in children with narcolepsy with cataplexy. ( Dong, X; Han, F; Li, J; Lv, C; Strohl, KP; Wang, J; Yan, Z; Zhang, X; Zhao, L; Zhao, Z, 2023) |
| "Methylphenidate (MPH) is a central nervous stimulant, which is mainly used in attention deficit hyperactivity disorder (ADHD) and narcolepsy." | 4.31 | Characteristics and outcomes of cases with methylphenidate abuse, dependence or withdrawal: an analysis of spontaneous reports in EudraVigilance. ( Bachmann, CJ; Hartmayer, LT; Hoffmann, F; Jobski, K, 2023) |
| "In this new mother with narcolepsy, resuming methylphenidate did not reduce breastmilk volumes or negatively impact her infant." | 4.12 | Successful lactation after resuming methylphenidate in a woman with narcolepsy. ( Bello, G; Poirier, J; Sharkey, KM, 2022) |
| "To investigate the prevalence of core attention-deficit/hyperactivity disorder (ADHD) symptoms in Chinese narcolepsy type 1 (NT1) patients and to explore mood, quality of life, and executive function in narcolepsy patients with or without ADHD and the response to Methylphenidate Hydrochloride Extended-release tablets (ER-MPH) treatment." | 4.12 | A comparison of mood, quality of life and executive function among narcolepsy type 1 patients with or without ADHD symptoms in China. ( Dong, X; Han, F; Li, C; Qu, S; Wang, M; Wang, P; Xu, L, 2022) |
| "The aim of the present study was to characterize patterns of use of methylphenidate (MPH), a prescription stimulant medication recommended in the treatment of attention deficit hyperactivity disorder (ADHD) and of narcolepsy, in France, both in children and adults, over a 3-year period." | 3.88 | Patterns and profiles of methylphenidate use both in children and adults. ( Boucherie, Q; Frauger, E; Lepelley, M; Mallaret, M; Micallef, J; Pauly, V, 2018) |
| "Four months after initiation of methylphenidate therapy the increased daytime sleepiness improved and excessive weight gain stopped." | 3.88 | Case report: narcolepsy type 1 in an adolescent with HIV infection-coincidence or potential trigger? ( Berger, C; Hackenberg, A; Paioni, P; Relly, C; Scherrer, KS, 2018) |
| " Withdrawal of the narcolepsy treatment and initiation of haloperidol 1 mg/day (the only antipsychotic treatment she could tolerate) improved the delusions, hallucinations and dysphoria but worsened the narcolepsy symptoms." | 3.85 | Narcolepsy-cataplexy and psychosis: a case study. ( Arango-Lopez, C; Canellas-Dols, F; Delgado, C; Peraita-Adrados, R, 2017) |
| "Methylphenidate (MPH; Ritalin: methyl-alpha-phenyl-2-piperidinacetate hydrochloride) is utilized for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy." | 3.70 | Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin) in human plasma. ( Bakhtiar, R; Ramos, L; Tse, FL, 2000) |
| " Methylphenidate hydrochloride ('Ritalin') was the prescribers' most popular agent and 'narcolepsy' was the most frequently cited clinical indication for psychostimulants." | 3.70 | Psychostimulants and psychiatrists: the Trent Adult Psychiatry Psychostimulant Survey. ( Bramble, D, 2000) |
| " The course of the patient's symptomatology and the favourable response of his symptoms to stimulants and imipramine support the theory that his intermittent loss of sphincter control is part of his narcolepsy-cataplexy." | 3.69 | Narcolepsy-cataplexy and loss of sphincter control. ( Bixler, EO; Kales, A; Sollenberger, SE; Vela-Bueno, A; Vgontzas, AN, 1996) |
| "The purpose of this study was to establish the effects of selegiline HCl on sleep parameters in narcolepsy and to contrast these effects with the effects of methylphenidate." | 3.69 | REM changes in narcolepsy with selegiline. ( MacFarlane, JG; Reinish, LW; Sandor, P; Shapiro, CM, 1995) |
| "We have studied the pharmacokinetics of methylphenidate enantiomers after the oral administration of different doses of racemic methylphenidate to one patient with narcolepsy and to four healthy volunteers." | 3.68 | Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers. ( Aoyama, T; Honda, Y; Iga, T; Kotaki, H; Sasaki, T; Sawada, Y, 1993) |
| "Methylphenidate, pemoline, and protriptyline were studied for their treatment efficacy in narcolepsy." | 3.67 | Treatment of narcolepsy: objective studies on methylphenidate, pemoline, and protriptyline. ( Browman, CP; Hajdukovich, R; Mitler, MM; Shafor, R; Timms, RM, 1986) |
| "A 25-year-old man with narcolepsy and cataplexy experienced partial relief of symptomatology following administration of methylphenidate." | 3.67 | Efficacy of trazodone in narcolepsy. ( Sandyk, R, 1985) |
| "A patient with severe narcolepsy and cataplexy had been treated with a high dosage of methylphenidate hydrochloride, but the drug was not effective." | 3.66 | Successful treatment of narcolepsy with propranolol: a case report. ( Cadieux, R; Kales, A; Soldatos, CR; Tan, TL, 1979) |
| "The clinical symptoms of cataplexy, sleep paralysis, hypnogogic hallucinations, daily naps, and sleep attacks all showed significant improvements." | 2.66 | The effects and effectiveness of gamma-hydroxybutyrate in patients with narcolepsy. ( Brown, D; Brown, L; Hirschowitz, J; Scharf, MB; Woods, M, 1985) |
| "Hypersomnia is a frequently occurring problem." | 2.50 | [Hypersomnia: a diagnostic problem]. ( Kranenburg, G; Teunissen, LL, 2014) |
| "Narcolepsy is an emblematic, unique disease within sleep disorders that is characterised by excessive daytime sleepiness, cataplexy and other abnormal manifestations of REM sleep." | 2.48 | [Diagnostic and therapeutic update in narcolepsy]. ( Santamaria-Cano, J, 2012) |
| "Narcolepsy is a serious neurological condition in which patients are overcome by persistent, excessive feelings of fatigue and drowsiness." | 2.45 | Narcolepsy: clinical decision making for the primary care physician. ( Hazin, R; Iqbal, M; Khan, F, 2009) |
| "Cataplexy is managed by medications whereas behavioral treatment, such as avoidance of emotion, was the only treatment available in the past." | 2.44 | Therapeutic advances in narcolepsy. ( Thorpy, M, 2007) |
| "Narcolepsy is a disabling disease with a prevalence of 0." | 2.44 | Pediatric narcolepsy. ( Husain, AM; Peterson, PC, 2008) |
| "Modafinil may increase wakefulness through activation of noradrenergic and dopaminergic systems, possibly through interaction with the hypocretin/orexin system." | 2.42 | What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. ( Boutrel, B; Koob, GF, 2004) |
| "Treatment with methylphenidate has been advocated in patients with traumatic brain injury and stroke, cancer patients, and those with human immunodeficiency virus infection." | 2.41 | Methylphenidate: its pharmacology and uses. ( Challman, TD; Lipsky, JJ, 2000) |
| "Narcolepsy is a disorder of sleep with uncontrolled sleepiness and cataplexy." | 2.40 | [Narcolepsy]. ( Shimizu, T, 1998) |
| "Narcolepsy is a commonly under diagnosed or misdiagnosed problem that results in severe daytime sleepiness." | 2.39 | Narcolepsy. ( Ware, JC, 1996) |
| "A 67-year-old woman with neuromyelitis optica spectrum disorder (NMOSD) developed severe somnolence." | 1.56 | Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder. ( Ando, M; Daida, K; Hattori, N; Hayashida, A; Kanbayashi, T; Noda, K; Ogaki, K; Okuma, Y; Yokoyama, K, 2020) |
| "Childhood narcolepsy is associated with various emotional, behavioural and cognitive dysfunctions as well as with psychiatric and neurodevelopmental disorders: anxiety, depression, attention deficit hyperactivity disorder and psychosis." | 1.48 | Childhood narcolepsy and autism spectrum disorders: four case reports. ( Dudova, I; Hrdlicka, M; Mohaplova, M; Nevsimalova, S; Prihodova, I, 2018) |
| "Narcolepsy is a rare, multifactorial disease of the hypothalamus characterized by its leading symptoms of excessive daytime sleepiness and cataplexy." | 1.46 | [Narcolepsy in childhood and adolescence: symptoms, diagnosis, and therapy. A case report]. ( Gehrmann, J; Ignacy, E; Reimer, I; Siegler, D, 2017) |
| "Alopecia areata is an autoimmune dermatological disorder characterised by loss of hair in one or more discrete patches over the scalp." | 1.43 | Alopecia areata and narcolepsy: a tale of obscure autoimmunity. ( Nigam, G; Pathak, C; Riaz, M, 2016) |
| "Methylphenidate is excreted in breast milk only in small amounts, and to date there have been no reports of breastfed infants demonstrating any adverse effects." | 1.42 | Is it safe to breastfeed while taking methylphenidate? ( Bozzo, P; Koren, G; Marchese, M, 2015) |
| "She was diagnosed with obstructive sleep apnea (OSA) and underwent tonsillectomy and adenoidectomy." | 1.39 | Narcolepsy with obstructive sleep apnea in a 4-year-old Korean girl: a case report. ( Cho, M; Hwang, S; Jang, K; Kwon, S; Seo, H, 2013) |
| "Methylphenidate was used significantly more in the aged group, and modafinil in the younger group." | 1.31 | Comparison in symptoms between aged and younger patients with narcolepsy. ( Furuta, H; Temple, HM; Thorpy, MJ, 2001) |
| "Treatment with methylphenidate and clomipramine was effective; methylphenidate (30 mg/day) improved his wakefulness and alertness throughout the day, and clomipramine (20 mg/day) reduced the number of cataplexic episodes." | 1.31 | [Narcolepsy in a prepubertal boy]. ( Chang, S; Ishikawa, T; Mizuno, K; Tsukamoto, H, 2001) |
| " Data obtained from a screening questionnaire, sleep diaries, and medical records showed that 22 of our 43 treated narcoleptic subjects reduced their dosage of stimulant medications or had not taken any stimulant medications during a 24-hour monitoring period during which they were expected to be on medication." | 1.30 | Compliance with stimulant medications in patients with narcolepsy. ( Aldrich, MS; Berrios, AM; Rogers, AE; Rosenberg, RS, 1997) |
| "We encountered two cases expressing excessive daytime sleepiness (EDS) and manifesting two or more sleep-onset rapid eye movement (REM) periods in the multiple sleep latency test." | 1.30 | Two cases of HLA-DR2-negative hypersomnia manifesting sleep-onset rapid eye movement periods in the multiple sleep latency test. ( Emura, N; Kuroda, K; Mandai, M; Matsumura, H; Satani, S; Ueda, S; Yoneda, H; Yoshida, Y, 1999) |
| "Treatment with methylphenidate resulted in complete resolution of symptoms in two patients and significant improvement in the other two." | 1.29 | Consideration of narcolepsy in the differential diagnosis of chronic fatigue syndrome. ( Ambrogetti, A; Olson, LG, 1994) |
| "The morbidity of narcolepsy is high and early diagnosis is therefore important, as treatment is effective." | 1.29 | Narcolepsy in a 2-year-old boy. ( Green, A; Prendergast, M; Winter, E, 1996) |
| "Narcolepsy is characterized by excessive daytime sleepiness and cataplexy, which may be accompanied by hypnogogic or hypnopompic hallucinations and sleep paralysis." | 1.26 | Narcolepsy and automatic behavior: a case report. ( Kramer, M; Roth, T; Salis, PJ; Zorick, FJ, 1979) |
| "A characteristic history of cataplexy establishes the diagnosis." | 1.26 | Narcolepsy. Diagnosis and treatment. ( Carskadon, MA; Dement, WC; Guilleminault, C; Zarcone, VP, 1976) |
| "In patients with sleep apnea, brainstem functional activity is low in the awake state but becomes critically reduced during sleep, culminating in apnea-stimulated arousal followed by repetitive cycles as sleep recurs." | 1.26 | Sleep apnea, narcolepsy, and dreaming: regional cerebral hemodynamics. ( Derman, S; Karacan, I; Meyer, JS; Sakai, F; Yamamoto, M, 1980) |
| "Narcolepsy may affect as many as 250,000 Americans." | 1.26 | The treatment of narcolepsy and cataplexy. ( Campbell, RK, 1981) |
| "NARCOLEPSY IS A DISORDER OF SLEEP CONTROL CHARACTERIZED BY A TETRAD OF SYMPTOMS: sleep attacks, cataplexy, sleep paralysis and hypnagogic hallucinations." | 1.25 | Narcolepsy. ( Foley, A; Murray, TJ, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (37.11) | 18.7374 |
| 1990's | 17 (17.53) | 18.2507 |
| 2000's | 21 (21.65) | 29.6817 |
| 2010's | 16 (16.49) | 24.3611 |
| 2020's | 7 (7.22) | 2.80 |
| Authors | Studies |
|---|---|
| Bello, G | 1 |
| Poirier, J | 1 |
| Sharkey, KM | 1 |
| Qu, S | 1 |
| Wang, P | 1 |
| Wang, M | 1 |
| Li, C | 1 |
| Dong, X | 2 |
| Xu, L | 1 |
| Han, F | 2 |
| Wang, J | 1 |
| Yan, Z | 1 |
| Li, J | 1 |
| Zhao, L | 1 |
| Zhang, X | 1 |
| Lv, C | 1 |
| Zhao, Z | 1 |
| Strohl, KP | 1 |
| Hartmayer, LT | 1 |
| Hoffmann, F | 1 |
| Bachmann, CJ | 1 |
| Jobski, K | 1 |
| Daida, K | 1 |
| Ogaki, K | 1 |
| Hayashida, A | 1 |
| Ando, M | 1 |
| Yokoyama, K | 1 |
| Noda, K | 1 |
| Kanbayashi, T | 1 |
| Hattori, N | 1 |
| Okuma, Y | 1 |
| Thorpy, MJ | 3 |
| Bogan, RK | 1 |
| Sivam, S | 1 |
| Chamula, K | 1 |
| Swieca, J | 1 |
| Frenkel, S | 1 |
| Saini, B | 1 |
| Gehrmann, J | 1 |
| Siegler, D | 1 |
| Ignacy, E | 1 |
| Reimer, I | 1 |
| Canellas-Dols, F | 1 |
| Delgado, C | 1 |
| Arango-Lopez, C | 1 |
| Peraita-Adrados, R | 1 |
| Pauly, V | 1 |
| Frauger, E | 1 |
| Lepelley, M | 1 |
| Mallaret, M | 1 |
| Boucherie, Q | 1 |
| Micallef, J | 1 |
| Scherrer, KS | 1 |
| Relly, C | 1 |
| Hackenberg, A | 1 |
| Berger, C | 1 |
| Paioni, P | 1 |
| Prihodova, I | 1 |
| Dudova, I | 1 |
| Mohaplova, M | 1 |
| Hrdlicka, M | 1 |
| Nevsimalova, S | 1 |
| Aguilar, AC | 1 |
| Brant, PHRC | 1 |
| Tufik, S | 1 |
| Coelho, FM | 1 |
| Kwon, S | 1 |
| Jang, K | 1 |
| Hwang, S | 1 |
| Cho, M | 1 |
| Seo, H | 1 |
| Kranenburg, G | 1 |
| Teunissen, LL | 1 |
| Tagaya, H | 2 |
| Murayama, N | 1 |
| Fukase, Y | 1 |
| Marchese, M | 1 |
| Koren, G | 1 |
| Bozzo, P | 1 |
| Nigam, G | 1 |
| Pathak, C | 1 |
| Riaz, M | 1 |
| Barateau, L | 1 |
| Lopez, R | 1 |
| Dauvilliers, Y | 1 |
| Guerrero, IL | 1 |
| Sander, C | 1 |
| Khan, F | 1 |
| Hazin, R | 1 |
| Iqbal, M | 1 |
| Quinnell, TG | 1 |
| Smith, IE | 1 |
| Santamaria-Cano, J | 1 |
| Witmans, MB | 1 |
| Kirk, VG | 1 |
| Schwartz, JR | 2 |
| Kovacevic-Ristanovic, R | 1 |
| Hayduk, R | 1 |
| DALY, DD | 3 |
| YOSS, RE | 4 |
| DALY, D | 1 |
| DEVIC, M | 1 |
| REVOL, M | 1 |
| MICHEL, F | 1 |
| ROBERTS, HJ | 2 |
| CRUMP, GP | 1 |
| SOURS, JA | 1 |
| SINISI, C | 1 |
| Feldman, NT | 1 |
| Fry, JM | 1 |
| Harsh, J | 1 |
| Kishi, Y | 1 |
| Konishi, S | 1 |
| Koizumi, S | 1 |
| Kudo, Y | 1 |
| Kurosawa, H | 1 |
| Kathol, RG | 1 |
| Leonard, BE | 1 |
| McCartan, D | 1 |
| White, J | 1 |
| King, DJ | 1 |
| Boutrel, B | 1 |
| Koob, GF | 1 |
| Derry, C | 1 |
| Benjamin, C | 1 |
| Bladin, P | 1 |
| le Bars, D | 1 |
| Tochon-Danguy, H | 1 |
| Berkovic, SF | 1 |
| Zimmer, L | 1 |
| Costes, N | 1 |
| Mulligan, R | 1 |
| Reutens, D | 1 |
| Mahowald, MW | 2 |
| Bornemann, MA | 1 |
| Spigset, O | 1 |
| Brede, WR | 1 |
| Zahlsen, K | 1 |
| Thorpy, M | 1 |
| Peterson, PC | 1 |
| Husain, AM | 1 |
| Regestein, QR | 1 |
| Reich, P | 1 |
| Mufson, MJ | 1 |
| Soldatos, CR | 3 |
| Kales, A | 4 |
| Cadieux, RJ | 1 |
| Hagel, K | 1 |
| Dyer, JA | 2 |
| Eisenberg, ES | 1 |
| Campbell, RK | 1 |
| Broughton, R | 2 |
| Mamelak, M | 1 |
| Meyer, JS | 1 |
| Sakai, F | 1 |
| Karacan, I | 2 |
| Derman, S | 1 |
| Yamamoto, M | 1 |
| Gernaat, HB | 1 |
| Haffmans, PM | 1 |
| Knegtering, H | 1 |
| Birkenhäger, TK | 1 |
| Reinish, LW | 1 |
| MacFarlane, JG | 1 |
| Sandor, P | 1 |
| Shapiro, CM | 1 |
| Mitler, MM | 4 |
| Pawluk, LK | 1 |
| Hurwitz, TD | 1 |
| Schluter, JL | 1 |
| Ullevig, C | 1 |
| Sood, RK | 1 |
| Kirkwood, CK | 1 |
| Sood, B | 1 |
| Ambrogetti, A | 1 |
| Olson, LG | 1 |
| Aoyama, T | 1 |
| Kotaki, H | 1 |
| Sasaki, T | 1 |
| Sawada, Y | 1 |
| Honda, Y | 1 |
| Iga, T | 1 |
| Winter, E | 1 |
| Prendergast, M | 1 |
| Green, A | 1 |
| Vgontzas, AN | 1 |
| Sollenberger, SE | 1 |
| Bixler, EO | 2 |
| Vela-Bueno, A | 1 |
| Ware, JC | 1 |
| Rogers, AE | 1 |
| Aldrich, MS | 1 |
| Berrios, AM | 1 |
| Rosenberg, RS | 1 |
| Shimizu, T | 1 |
| Yoshida, Y | 1 |
| Kuroda, K | 1 |
| Mandai, M | 1 |
| Satani, S | 1 |
| Emura, N | 1 |
| Ueda, S | 1 |
| Matsumura, H | 1 |
| Yoneda, H | 1 |
| Bramble, D | 1 |
| Ramos, L | 1 |
| Bakhtiar, R | 1 |
| Tse, FL | 1 |
| Challman, TD | 1 |
| Lipsky, JJ | 1 |
| Furuta, H | 1 |
| Temple, HM | 1 |
| Tsukamoto, H | 1 |
| Ishikawa, T | 1 |
| Chang, S | 1 |
| Mizuno, K | 1 |
| Greenhill, LL | 1 |
| Pliszka, S | 1 |
| Dulcan, MK | 1 |
| Bernet, W | 1 |
| Arnold, V | 1 |
| Beitchman, J | 1 |
| Benson, RS | 1 |
| Bukstein, O | 1 |
| Kinlan, J | 1 |
| McClellan, J | 1 |
| Rue, D | 1 |
| Shaw, JA | 1 |
| Stock, S | 1 |
| Bhat, SK | 1 |
| Galang, R | 1 |
| Takahashi, Y | 1 |
| Zorick, FJ | 1 |
| Salis, PJ | 1 |
| Roth, T | 1 |
| Kramer, M | 1 |
| Dement, WC | 3 |
| Cadieux, R | 2 |
| Tan, TL | 2 |
| Scharf, MB | 2 |
| Montplaisir, J | 1 |
| Carskadon, MA | 1 |
| Guilleminault, C | 2 |
| Zarcone, VP | 1 |
| Taylor, CI | 1 |
| Miller, WC | 1 |
| Ruel, JM | 1 |
| Hickey, CP | 1 |
| Hajdukovic, R | 1 |
| Lange, KW | 1 |
| Egeler-Peerdeman, SM | 1 |
| Visscher, F | 1 |
| Taphoorn, MJ | 1 |
| Leong, GB | 1 |
| Shaner, AL | 1 |
| Silva, JA | 1 |
| Shafor, R | 1 |
| Hajdukovich, R | 1 |
| Timms, RM | 1 |
| Browman, CP | 1 |
| Norman, ME | 1 |
| Brown, D | 1 |
| Woods, M | 1 |
| Brown, L | 1 |
| Hirschowitz, J | 1 |
| Aguirre, M | 1 |
| Stuss, D | 1 |
| Sandyk, R | 1 |
| Carskadon, M | 1 |
| Murray, TJ | 1 |
| Foley, A | 1 |
| Berti Ceroni, G | 1 |
| Coccagna, G | 1 |
| Lugaresi, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methylphenidate Effect on Performing Humphrey Visual Fields[NCT02162381] | 32 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| A Parallel-group, Double-blind, Placebo-controlled Study of Methylphenidate as an Add on Therapy for Mirtazapine in the Treatment of Major Depressive Disorder in Cancer Patients Under Palliative Care[NCT01497548] | Phase 3 | 120 participants (Anticipated) | Interventional | 2011-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 reviews available for methylphenidate and Gelineau Syndrome
| Article | Year |
|---|---|
Update on the pharmacologic management of narcolepsy: mechanisms of action and clinical implications.
Topics: Adult; Cataplexy; Humans; Methylphenidate; Modafinil; Narcolepsy; Sodium Oxybate | 2020 |
[Hypersomnia: a diagnostic problem].
Topics: Adolescent; Cataplexy; Central Nervous System Stimulants; Diagnosis, Differential; Disorders of Exce | 2014 |
[Methylphenidate].
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; J | 2015 |
Treatment Options for Narcolepsy.
Topics: Animals; Antidepressive Agents; Central Nervous System Stimulants; Humans; Methylphenidate; Narcolep | 2016 |
[Falling sleep inopportunely: treatment of narcolepsy].
Topics: Adolescent; Adult; Amphetamines; Antidepressive Agents; Benzhydryl Compounds; Central Nervous System | 2008 |
Narcolepsy: clinical decision making for the primary care physician.
Topics: Benzhydryl Compounds; Biomarkers; Cataplexy; Central Nervous System Stimulants; Decision Making; Dia | 2009 |
[Methylphenidate: pharmacology, indication and potential of abuse].
Topics: Adult; Attention Deficit and Disruptive Behavior Disorders; Humans; Male; Methylphenidate; Narcoleps | 2010 |
[Diagnostic and therapeutic update in narcolepsy].
Topics: Adolescent; Adult; Age of Onset; Animals; Autoimmune Diseases; Benzhydryl Compounds; Cataplexy; Chil | 2012 |
NARCOLEPSY AND OTHER DISTURBANCES IN THE SLEEP-WAKING RHYTHM: A STUDY OF 115 CASES WITH REVIEW OF THE LITERATURE.
Topics: Black People; Cataplexy; Craniocerebral Trauma; Depression; Dextroamphetamine; Encephalitis; Halluci | 1963 |
Schizophrenia and narcolepsy: a review with a case report.
Topics: Adult; Antipsychotic Agents; Cataplexy; Central Nervous System Stimulants; Comorbidity; Diagnosis, D | 2004 |
Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects.
Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Behavior; Brain Injuries; Central Ner | 2004 |
What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.
Topics: Amphetamine; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cocaine; Dopamine Uptak | 2004 |
Therapeutic advances in narcolepsy.
Topics: Benzhydryl Compounds; Cataplexy; Central Nervous System Stimulants; Humans; Immunotherapy; Methylphe | 2007 |
Pediatric narcolepsy.
Topics: Benzhydryl Compounds; Cataplexy; Central Nervous System Stimulants; Child; Dextroamphetamine; Ghreli | 2008 |
Narcolepsy.
Topics: Amphetamines; Cataplexy; Central Nervous System Stimulants; Diagnosis, Differential; Humans; Methylp | 1996 |
[Narcolepsy].
Topics: Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Clomipramine; Diagnosis, Differ | 1998 |
Methylphenidate: its pharmacology and uses.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries; Central Nervous System Stimulants; De | 2000 |
Methylphenidate: its pharmacology and uses.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries; Central Nervous System Stimulants; De | 2000 |
Methylphenidate: its pharmacology and uses.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries; Central Nervous System Stimulants; De | 2000 |
Methylphenidate: its pharmacology and uses.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries; Central Nervous System Stimulants; De | 2000 |
Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults.
Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervo | 2002 |
[Narcolepsy].
Topics: Adolescent; Adult; Amphetamine; Cataplexy; Child; Clomipramine; Diagnosis, Differential; Female; Hum | 1990 |
5 trials available for methylphenidate and Gelineau Syndrome
| Article | Year |
|---|---|
Initiating treatment with modafinil for control of excessive daytime sleepiness in patients switching from methylphenidate: an open-label safety study assessing three strategies.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Central Nervous System Stimulants; Drug Administratio | 2003 |
Efficacy and safety of modafinil for improving daytime wakefulness in patients treated previously with psychostimulants.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Central Nervous System Stimulants; Dextroamphetamine; | 2003 |
Relative efficacy of drugs for the treatment of sleepiness in narcolepsy.
Topics: Adult; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Codeine; Dextroamphetamine; | 1991 |
Alerting drugs: do they really work?
Topics: Adult; Attention; Central Nervous System Stimulants; Female; Humans; Male; Methylphenidate; Middle A | 1987 |
The effects and effectiveness of gamma-hydroxybutyrate in patients with narcolepsy.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Cataplexy; Clinical Trials as Topic; Dextroamphetamin | 1985 |
73 other studies available for methylphenidate and Gelineau Syndrome
| Article | Year |
|---|---|
Successful lactation after resuming methylphenidate in a woman with narcolepsy.
Topics: Adult; Breast Feeding; Cataplexy; Female; Humans; Infant; Lactation; Methylphenidate; Narcolepsy | 2022 |
A comparison of mood, quality of life and executive function among narcolepsy type 1 patients with or without ADHD symptoms in China.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2022 |
Diurnal changes in blood pressure and heart rate in children with narcolepsy with cataplexy.
Topics: Adolescent; Blood Pressure; Cataplexy; Child; Child, Preschool; Female; Heart Rate; Humans; Male; Me | 2023 |
Characteristics and outcomes of cases with methylphenidate abuse, dependence or withdrawal: an analysis of spontaneous reports in EudraVigilance.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity | 2023 |
Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder.
Topics: Aged; Central Nervous System Stimulants; Female; Humans; Japan; Magnetic Resonance Imaging; Methylph | 2020 |
Narcolepsy management in Australia: time to wake up.
Topics: Australia; Dextroamphetamine; Drug Costs; Health Expenditures; Health Services Accessibility; Humans | 2021 |
[Narcolepsy in childhood and adolescence: symptoms, diagnosis, and therapy. A case report].
Topics: Adolescent; Catalepsy; Cognitive Behavioral Therapy; Combined Modality Therapy; Diagnosis, Different | 2017 |
Narcolepsy-cataplexy and psychosis: a case study.
Topics: Adolescent; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compound | 2017 |
Patterns and profiles of methylphenidate use both in children and adults.
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste | 2018 |
Case report: narcolepsy type 1 in an adolescent with HIV infection-coincidence or potential trigger?
Topics: Adolescent; Central Nervous System Stimulants; Drug Monitoring; HIV Infections; Humans; Male; Methyl | 2018 |
Childhood narcolepsy and autism spectrum disorders: four case reports.
Topics: Age of Onset; Antidepressive Agents; Anxiety Disorders; Asperger Syndrome; Attention Deficit Disorde | 2018 |
Finding a needle in the haystack-narcolepsy and obstructive sleep apnea.
Topics: Adult; Cephalometry; Diagnosis, Differential; Disorders of Excessive Somnolence; Humans; Male; Methy | 2019 |
Narcolepsy with obstructive sleep apnea in a 4-year-old Korean girl: a case report.
Topics: Adenoidectomy; Asian People; Child, Preschool; Disorders of Excessive Somnolence; Female; Humans; Me | 2013 |
Is it safe to breastfeed while taking methylphenidate?
Topics: Breast Feeding; Central Nervous System Stimulants; Female; Humans; Infant; Methylphenidate; Milk, Hu | 2015 |
Alopecia areata and narcolepsy: a tale of obscure autoimmunity.
Topics: Adult; Alopecia Areata; Autoimmune Diseases; Central Nervous System Stimulants; Humans; Male; Methyl | 2016 |
Narcolepsy, idiopathic hypersomnolence and related conditions.
Topics: Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Catalepsy; Central Nervous System Stimulants | 2011 |
Methylphenidate: abuse and addiction.
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste | 2012 |
Infancy onset of symptoms of narcolepsy in a child.
Topics: Age of Onset; Central Nervous System Stimulants; Child; Child, Preschool; Dextroamphetamine; Female; | 2002 |
The treatment of narcolepsy with methyl phenylpiperidylacetate: a preliminary report.
Topics: Health Services; Humans; Methylphenidate; Narcolepsy; Sleep Wake Disorders | 1956 |
The treatment of narcolepsy with methyl phenylpiperidylacetate: a preliminary report.
Topics: Health Services; Humans; Methylphenidate; Narcolepsy; Sleep Wake Disorders | 1956 |
The treatment of narcolepsy with methyl phenylpiperidylacetate: a preliminary report.
Topics: Health Services; Humans; Methylphenidate; Narcolepsy; Sleep Wake Disorders | 1956 |
The treatment of narcolepsy with methyl phenylpiperidylacetate: a preliminary report.
Topics: Health Services; Humans; Methylphenidate; Narcolepsy; Sleep Wake Disorders | 1956 |
Treatment of narcolepsy with ritalin.
Topics: Health Services; Humans; Methylphenidate; Narcolepsy; Sleep Wake Disorders | 1959 |
[Apropos of the treatment of narcolepsy: trial use of a new psychoactive agent, R.P. 8228].
Topics: Health Services; Humans; Methylphenidate; Narcolepsy; Psychotropic Drugs; Sleep Wake Disorders | 1962 |
THE SYNDROME OF NARCOLEPSY AND DIABETOGENIC (FUNCTIONAL) HYPERINSULINISM. OBSERVATIONS ON 190 PATIENTS, WITH EMPHASIS UPON ITS RELATIONSHIP TO OBESITY, DIABETES MELLITUS AND CEREBRAL DYSRHYTHMIAS.
Topics: Adolescent; Alcoholism; Arrhythmias, Cardiac; Brain; Diabetes Mellitus; Diet; Diet, Reducing; Electr | 1963 |
NARCOLEPSY. A DISCUSSION AND CASE PRESENTATION.
Topics: Amphetamine; Amphetamines; Cataplexy; Diagnosis, Differential; Genetics, Medical; Hallucinations; Hu | 1963 |
[ON THE PICKWICK SYNDROME AND ITS DISTURBANCES OF A NARCOLEPTIC TYPE].
Topics: Carbon Dioxide; Diagnosis, Differential; Diet; Diet Therapy; Diuretics; Electroencephalography; Huma | 1963 |
THE SYNDROME OF NARCOLEPSY AND DIABETOGENIC ("FUNCTIONAL") HYPERINSULINISM, WITH SPECIAL REFERENCE TO OBESITY, DIABETES, IDIOPATHIC EDEMA, CEREBRAL DYSRHYTHMIAS AND MULTIPLE SCLEROSIS (200 PATIENTS).
Topics: Alcoholism; Arrhythmias, Cardiac; Cerebrovascular Disorders; Diabetes Mellitus; Drug Therapy; Edema; | 1964 |
Increased serotonin receptor availability in human sleep: evidence from an [18F]MPPF PET study in narcolepsy.
Topics: Adult; Aged; Animals; Blood Pressure; Brain; Central Nervous System Stimulants; Female; Humans; Kine | 2006 |
Stimulants and narcolepsy.
Topics: Central Nervous System Stimulants; Dose-Response Relationship, Drug; Humans; Methylphenidate; Narcol | 2005 |
Excretion of methylphenidate in breast milk.
Topics: Adult; Breast Feeding; Central Nervous System Stimulants; Female; Humans; Infant; Methylphenidate; M | 2007 |
Narcolepsy: an initial clinical approach.
Topics: Adult; Antidepressive Agents; Dextroamphetamine; Female; Humans; Male; Medical History Taking; Methy | 1983 |
Treatment of sleep disorders II: narcolepsy.
Topics: Cataplexy; Female; Humans; Imipramine; Male; Methylphenidate; Narcolepsy | 1983 |
[Narcolepsy (morbus Gélineau) (author's transl)].
Topics: Electroencephalography; Female; Hallucinations; Humans; Imipramine; Male; Methylphenidate; Narcoleps | 1980 |
The ophthalmologist and narcolepsy, or why are so many ophthalmologists caught napping?
Topics: Adolescent; Adult; Aged; Blepharoptosis; Cataplexy; Child; Diplopia; Female; Hallucinations; Humans; | 1982 |
The treatment of narcolepsy and cataplexy.
Topics: Cataplexy; Female; Humans; Imipramine; Methylphenidate; Middle Aged; Narcolepsy; Pharmacists; Sleep | 1981 |
Effects of nocturnal gamma-hydroxybutyrate on sleep/waking patterns in narcolepsy-cataplexy.
Topics: Adult; Cataplexy; Drug Therapy, Combination; Female; Humans; Hydroxybutyrates; Male; Methylphenidate | 1980 |
Sleep apnea, narcolepsy, and dreaming: regional cerebral hemodynamics.
Topics: Adult; Brain Stem; Cerebellum; Cerebrovascular Circulation; Dreams; Humans; Methylphenidate; Middle | 1980 |
Tranylcypromine in narcolepsy.
Topics: Adult; Central Nervous System Stimulants; Female; Humans; Methylphenidate; Monoamine Oxidase Inhibit | 1995 |
REM changes in narcolepsy with selegiline.
Topics: Adult; Aged; Catalepsy; Female; Humans; Male; Methylphenidate; Middle Aged; Narcolepsy; Polysomnogra | 1995 |
Evaluation of treatment with stimulants in narcolepsy.
Topics: Adult; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Humans; Male; Methamphetamine; M | 1994 |
Psychiatric morbidity in narcoleptics on chronic high dose methylphenidate therapy.
Topics: Adult; Causality; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Male; Methy | 1995 |
MPH and thrombocytosis.
Topics: Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Male; Methylphenidate | 1994 |
Consideration of narcolepsy in the differential diagnosis of chronic fatigue syndrome.
Topics: Adolescent; Diagnosis, Differential; Fatigue Syndrome, Chronic; Female; Humans; Male; Methylphenidat | 1994 |
Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Male; Methylphenidate; Narcolepsy; Stereoisomeris | 1993 |
Narcolepsy in a 2-year-old boy.
Topics: Cataplexy; Follow-Up Studies; Humans; Male; Methylphenidate; Narcolepsy; Prospective Studies; Tyrosi | 1996 |
Narcolepsy-cataplexy and loss of sphincter control.
Topics: Adult; Antidepressive Agents, Tricyclic; Cataplexy; Central Nervous System Stimulants; Fecal Inconti | 1996 |
Compliance with stimulant medications in patients with narcolepsy.
Topics: Adolescent; Adult; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Male; Methy | 1997 |
Two cases of HLA-DR2-negative hypersomnia manifesting sleep-onset rapid eye movement periods in the multiple sleep latency test.
Topics: Adult; Central Nervous System Stimulants; Circadian Rhythm; Diagnosis, Differential; Disorders of Ex | 1999 |
Psychostimulants and psychiatrists: the Trent Adult Psychiatry Psychostimulant Survey.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Attitude of Health Personnel; Cent | 2000 |
Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin) in human plasma.
Topics: Attention Deficit Disorder with Hyperactivity; Calibration; Chromatography, Liquid; Humans; Mass Spe | 2000 |
Comparison in symptoms between aged and younger patients with narcolepsy.
Topics: Adolescent; Adult; Aged; Aging; Central Nervous System Stimulants; Female; Humans; Male; Methylpheni | 2001 |
Methylphenidate and narcolepsy: new indication. When modafinil fails.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Clinical Trials as Topic; France; Humans; M | 2001 |
[Narcolepsy in a prepubertal boy].
Topics: Child; Clomipramine; HLA-DQ Antigens; HLA-DQ beta-Chains; HLA-DR2 Antigen; Humans; Male; Methylpheni | 2001 |
Narcolepsy presenting as schizophrenia.
Topics: Cataplexy; Central Nervous System Stimulants; Diagnosis, Differential; Drug Therapy, Combination; Hu | 2002 |
Editorial: Narcolepsy and cataplexy.
Topics: Brain; Catalepsy; Catecholamines; Clomipramine; Dextroamphetamine; Humans; Metabolism, Inborn Errors | 1975 |
Proceedings: Treatment of narcolepsy, a REM sleep disorder, with psychotropic drugs.
Topics: Antidepressive Agents, Tricyclic; Humans; Hypnotics and Sedatives; Methylphenidate; Narcolepsy; Slee | 1975 |
Narcolepsy and automatic behavior: a case report.
Topics: Automatism; Cataplexy; Criminal Psychology; Drug Therapy, Combination; Electroencephalography; Femal | 1979 |
Narcolepsy--not as rare as we believed!
Topics: Adult; Child; Humans; Imipramine; Methamphetamine; Methylphenidate; Narcolepsy | 1979 |
Successful treatment of narcolepsy with propranolol: a case report.
Topics: Female; Humans; Methylphenidate; Middle Aged; Narcolepsy; Propranolol | 1979 |
Propranolol in the treatment of narcolepsy.
Topics: Adult; Aged; Cataplexy; Female; Humans; Male; Methylphenidate; Middle Aged; Narcolepsy; Placebos; Pr | 1979 |
[Hypersomnias. 1. Narcolepsy].
Topics: Amphetamines; Clomipramine; Humans; Imipramine; Methylphenidate; Monoamine Oxidase Inhibitors; Narco | 1977 |
Narcolepsy. Diagnosis and treatment.
Topics: Adolescent; Adult; Behavior; Cataplexy; Child; Diagnosis, Differential; Female; Humans; Hypoglycemia | 1976 |
Narcolepsy: a case report.
Topics: Humans; Male; Methylphenidate; Middle Aged; Narcolepsy; Time Factors | 1976 |
Are too many children being treated with methylphenidate?
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; British Columbia; Child; Cross-Sec | 1992 |
[Too weak with laughing].
Topics: Adult; Cataplexy; Clomipramine; Emotions; Female; Humans; Imipramine; Male; Methylphenidate; Middle | 1990 |
Narcolepsy, paranoid psychosis, and analeptic abuse.
Topics: Adult; Dextroamphetamine; Dose-Response Relationship, Drug; Humans; Male; Methylphenidate; Middle Ag | 1989 |
Erectile dysfunction in narcoleptic patients.
Topics: Adult; Cataplexy; Erectile Dysfunction; Humans; Imipramine; Male; Methylphenidate; Middle Aged; Narc | 1986 |
Treatment of narcolepsy: objective studies on methylphenidate, pemoline, and protriptyline.
Topics: Adult; Dibenzocycloheptenes; Female; Humans; Male; Methylphenidate; Middle Aged; Narcolepsy; Pemolin | 1986 |
Ophthalmic manifestations of narcolepsy.
Topics: Adult; Automobile Driving; Eye Diseases; Female; Humans; Male; Methylphenidate; Middle Aged; Narcole | 1987 |
Does memory impairment exist in narcolepsy-cataplexy?
Topics: Adult; Aged; Cataplexy; Clomipramine; Desipramine; Drug Therapy, Combination; Female; Humans; Male; | 1985 |
Efficacy of trazodone in narcolepsy.
Topics: Adult; Drug Combinations; Humans; Irritable Mood; Male; Methylphenidate; Narcolepsy; Serotonin; Slee | 1985 |
On the treatment of rapid eye movement narcolepsy.
Topics: Adult; Amphetamine; Antidepressive Agents; Cataplexy; Depression; Desipramine; Electroencephalograph | 1974 |
Narcolepsy.
Topics: Accidents, Traffic; Adult; Amphetamine; Automobile Driving; Cataplexy; Female; Hallucinations; Human | 1974 |
On the treatment of narcolepsy.
Topics: Dextroamphetamine; Feeding and Eating Disorders; Humans; Methamphetamine; Methylphenidate; Narcoleps | 1968 |
[Hypnic nyctohemeral organisation in narcoleptic patients].
Topics: Adolescent; Adult; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Methylphenidate; | 1967 |