methylphenidate has been researched along with Encephalopathy, Traumatic in 21 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Little is known about whether the beneficial effect of methylphenidate is persistent in individuals with other comorbid mental disorders and epilepsy." | 8.12 | Methylphenidate and TBI in ADHD and co-occurring epilepsy and mental disorders: a self-controlled case series study. ( Chen, VC; Chen, YL; Dewey, ME; Gossop, M; Lee, CT; Yang, YH, 2022) |
| "Thirty participants who suffered from long-term post-concussion symptoms after a mild TBI or moderate TBI and who had reported positive effects with methylphenidate during an initial phase of this follow-up study were treated with methylphenidate for a further six months." | 5.24 | Long-term treatment with methylphenidate for fatigue after traumatic brain injury. ( Andréll, P; Johansson, B; Mannheimer, C; Rönnbäck, L; Wentzel, AP, 2017) |
| " Little is known about whether the beneficial effect of methylphenidate is persistent in individuals with other comorbid mental disorders and epilepsy." | 4.12 | Methylphenidate and TBI in ADHD and co-occurring epilepsy and mental disorders: a self-controlled case series study. ( Chen, VC; Chen, YL; Dewey, ME; Gossop, M; Lee, CT; Yang, YH, 2022) |
| "The methylphenidate was administered using an uncontrolled, open label design." | 2.94 | Methylphenidate improves executive functions in patients with traumatic brain injuries: a feasibility trial via the idiographic approach. ( Al-Adawi, S; Al-Adawi, SSH; Al-Farsi, YM; Al-Maashani, A; Al-Naamani, A; Al-Sibani, N; Burke, DT; Dorvlo, ASS; Essa, MM; Jaju, S; Moustafa, AA; Qoronfleh, MW, 2020) |
| "Methylphenidate was associated with significant improvements in processing speed, sustained attention, and both lab-based and everyday executive functioning." | 2.90 | Influence of Methylphenidate on Long-Term Neuropsychological and Everyday Executive Functioning After Traumatic Brain Injury in Children with Secondary Attention Problems. ( Horn, PS; Kurowski, BG; LeBlond, E; Riemersma, JJ; Smith-Paine, J; Wade, SL, 2019) |
| "The outcome measurements included Mental Fatigue Scale, Choice Reaction Time, Compensatory Tracking Task, Mental Arithmetic Test, Digit Symbol Substitution Test, Mini-Mental State Examination (MMSE), Beck Depression Inventory (BDI), and Hamilton Rating Scale for Depression." | 2.84 | Efficacy of methylphenidate for the treatment of mental sequelae after traumatic brain injury. ( Wang, YF; Zhang, WT, 2017) |
| "Methylphenidate was associated with trends towards increased blood pressure and reported anxiety." | 2.84 | The efficacy and safety of extended-release methylphenidate following traumatic brain injury: a randomised controlled pilot study. ( Dymowski, AR; Olver, JH; Owens, JA; Ponsford, JL; Ponsford, M; Willmott, C, 2017) |
| "Depression is a common morbidity after traumatic brain injury." | 2.72 | Therapeutic benefits of pharmacologic and nonpharmacologic treatments for depressive symptoms after traumatic brain injury: a systematic review and network meta-analysis. ( Carvalho, AF; Chen, TY; Chen, YW; Cheng, YS; Chu, CS; Hsu, CW; Lei, WT; Li, DJ; Liang, CS; Lin, PY; Stubbs, B; Sun, CK; Tseng, PT; Tu, YK; Wu, CK; Wu, MK; Wu, YC; Yeh, TC, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (76.19) | 24.3611 |
| 2020's | 5 (23.81) | 2.80 |
| Authors | Studies |
|---|---|
| Johansson, B | 3 |
| Andréll, P | 3 |
| Rönnbäck, L | 3 |
| Mannheimer, C | 3 |
| Al-Adawi, S | 1 |
| Al-Naamani, A | 1 |
| Jaju, S | 1 |
| Al-Farsi, YM | 1 |
| Dorvlo, ASS | 1 |
| Al-Maashani, A | 1 |
| Al-Adawi, SSH | 1 |
| Moustafa, AA | 1 |
| Al-Sibani, N | 1 |
| Essa, MM | 1 |
| Burke, DT | 1 |
| Qoronfleh, MW | 1 |
| Womack, KB | 1 |
| Dubiel, R | 1 |
| Callender, L | 1 |
| Dunklin, C | 1 |
| Dahdah, M | 1 |
| Harris, TS | 1 |
| Devous, MD | 1 |
| Juengst, SB | 1 |
| Bell, K | 1 |
| Diaz-Arrastia, R | 1 |
| Ding, K | 1 |
| Chen, VC | 2 |
| Yang, YH | 2 |
| Lee, CT | 1 |
| Chen, YL | 1 |
| Dewey, ME | 1 |
| Gossop, M | 1 |
| Cheng, YS | 1 |
| Tseng, PT | 1 |
| Wu, YC | 1 |
| Tu, YK | 1 |
| Wu, CK | 1 |
| Hsu, CW | 1 |
| Lei, WT | 1 |
| Li, DJ | 1 |
| Chen, TY | 1 |
| Stubbs, B | 1 |
| Carvalho, AF | 1 |
| Liang, CS | 1 |
| Yeh, TC | 1 |
| Chu, CS | 1 |
| Chen, YW | 1 |
| Lin, PY | 1 |
| Wu, MK | 1 |
| Sun, CK | 2 |
| Zhang, WT | 1 |
| Wang, YF | 1 |
| Liao, YT | 1 |
| Kuo, TY | 1 |
| Liang, HY | 1 |
| Huang, KY | 1 |
| Wang, TN | 1 |
| Lee, Y | 1 |
| McIntyre, RS | 1 |
| Wentzel, AP | 2 |
| Dorer, CL | 1 |
| Manktelow, AE | 2 |
| Allanson, J | 1 |
| Sahakian, BJ | 2 |
| Pickard, JD | 1 |
| Bateman, A | 1 |
| Menon, DK | 2 |
| Stamatakis, EA | 2 |
| LeBlond, E | 1 |
| Smith-Paine, J | 1 |
| Riemersma, JJ | 1 |
| Horn, PS | 1 |
| Wade, SL | 1 |
| Kurowski, BG | 1 |
| Jenkins, PO | 1 |
| De Simoni, S | 1 |
| Bourke, NJ | 1 |
| Fleminger, J | 1 |
| Scott, G | 1 |
| Towey, DJ | 1 |
| Svensson, W | 1 |
| Khan, S | 1 |
| Patel, MC | 1 |
| Greenwood, R | 1 |
| Friedland, D | 1 |
| Hampshire, A | 1 |
| Cole, JH | 1 |
| Sharp, DJ | 1 |
| Fyfe, I | 1 |
| McAllister, TW | 2 |
| Zafonte, R | 1 |
| Jain, S | 1 |
| Flashman, LA | 2 |
| George, MS | 1 |
| Grant, GA | 1 |
| He, F | 1 |
| Lohr, JB | 1 |
| Andaluz, N | 1 |
| Summerall, L | 1 |
| Paulus, MP | 1 |
| Raman, R | 1 |
| Stein, MB | 1 |
| Huang, CH | 1 |
| Huang, CC | 1 |
| Lin, GH | 1 |
| Hou, WH | 1 |
| Leary, JB | 1 |
| Bondi, CO | 1 |
| LaPorte, MJ | 1 |
| Carlson, LJ | 1 |
| Radabaugh, HL | 1 |
| Cheng, JP | 1 |
| Kline, AE | 1 |
| Dymowski, AR | 1 |
| Ponsford, JL | 1 |
| Owens, JA | 1 |
| Olver, JH | 1 |
| Ponsford, M | 1 |
| Willmott, C | 1 |
| Maksimowski, MB | 1 |
| Tampi, RR | 1 |
| McDonald, BC | 1 |
| Arciniegas, DB | 1 |
| Ferguson, RJ | 1 |
| Xing, L | 1 |
| Harezlak, J | 1 |
| Sprehn, GC | 1 |
| Hammond, FM | 1 |
| Maerlender, AC | 1 |
| Kruck, CL | 1 |
| Gillock, KL | 1 |
| Frey, K | 1 |
| Wall, RN | 1 |
| Saykin, AJ | 1 |
| Ekinci, O | 1 |
| Direk, MÇ | 1 |
| Gunes, S | 1 |
| Teke, H | 1 |
| Ekinci, N | 1 |
| Yıldırım, F | 1 |
| Okuyaz, Ç | 1 |
| Moreno-López, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Relation Between Attentional, Sensory and Emotional Dysregulation in Adults With Posttraumatic Stress Disorder: a Double-blind, Placebo-controlled Randomized Controlled Trial of the Combined Treatment With Reboxetine and Methylphenidate[NCT05133804] | Phase 2 | 53 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| A Randomized Placebo-controlled Trial of Methylphenidate in Veterans With a Diagnosis of Post Traumatic Stress Disorder and Recent Cerebral Stroke.[NCT04885257] | Phase 2 | 60 participants (Anticipated) | Interventional | 2022-01-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for methylphenidate and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Therapeutic benefits of pharmacologic and nonpharmacologic treatments for depressive symptoms after traumatic brain injury: a systematic review and network meta-analysis.
Topics: Brain Injuries, Traumatic; Depression; Depressive Disorder, Major; Humans; Methylphenidate; Network | 2021 |
Methylphenidate on Cognitive Improvement in Patients with Traumatic Brain Injury: A Meta-Analysis.
Topics: Brain Injuries, Traumatic; Central Nervous System Stimulants; Cognition Disorders; Databases, Factua | 2016 |
Efficacy of stimulants for psychiatric symptoms in individuals with traumatic brain injury.
Topics: Brain Injuries, Traumatic; Central Nervous System Stimulants; Depression; Humans; Methylphenidate; R | 2016 |
10 trials available for methylphenidate and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Methylphenidate improves executive functions in patients with traumatic brain injuries: a feasibility trial via the idiographic approach.
Topics: Adolescent; Adult; Brain Injuries, Traumatic; Central Nervous System Stimulants; Executive Function; | 2020 |
Efficacy of methylphenidate for the treatment of mental sequelae after traumatic brain injury.
Topics: Adult; Brain Injuries, Traumatic; Cognition Disorders; Depression; Double-Blind Method; Female; Huma | 2017 |
Methylphenidate-mediated motor control network enhancement in patients with traumatic brain injury.
Topics: Adult; Brain Injuries, Traumatic; Brain Mapping; Case-Control Studies; Central Nervous System Stimul | 2018 |
Influence of Methylphenidate on Long-Term Neuropsychological and Everyday Executive Functioning After Traumatic Brain Injury in Children with Secondary Attention Problems.
Topics: Adolescent; Attention; Brain Injuries, Traumatic; Central Nervous System Stimulants; Child; Cognitiv | 2019 |
Stratifying drug treatment of cognitive impairments after traumatic brain injury using neuroimaging.
Topics: Adult; Brain; Brain Injuries, Traumatic; Central Nervous System Stimulants; Cognitive Dysfunction; C | 2019 |
Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.
Topics: Adult; Affective Symptoms; Brain Injuries, Traumatic; Cognition Disorders; Double-Blind Method; Fema | 2016 |
Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.
Topics: Adult; Affective Symptoms; Brain Injuries, Traumatic; Cognition Disorders; Double-Blind Method; Fema | 2016 |
Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.
Topics: Adult; Affective Symptoms; Brain Injuries, Traumatic; Cognition Disorders; Double-Blind Method; Fema | 2016 |
Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.
Topics: Adult; Affective Symptoms; Brain Injuries, Traumatic; Cognition Disorders; Double-Blind Method; Fema | 2016 |
Long-term treatment with methylphenidate for fatigue after traumatic brain injury.
Topics: Adult; Attention; Brain Injuries, Traumatic; Central Nervous System Stimulants; Cognition; Female; H | 2017 |
The efficacy and safety of extended-release methylphenidate following traumatic brain injury: a randomised controlled pilot study.
Topics: Adult; Brain Injuries, Traumatic; Central Nervous System Stimulants; Cross-Over Studies; Double-Blin | 2017 |
Methylphenidate and Memory and Attention Adaptation Training for Persistent Cognitive Symptoms after Traumatic Brain Injury: A Randomized, Placebo-Controlled Trial.
Topics: Adult; Attention; Brain Injuries, Traumatic; Central Nervous System Stimulants; Cognition Disorders; | 2017 |
Anything goes? Regulation of the neural processes underlying response inhibition in TBI patients.
Topics: Adult; Brain; Brain Injuries, Traumatic; Brain Mapping; Central Nervous System Stimulants; Cross-Ove | 2017 |
8 other studies available for methylphenidate and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Follow-up after 5.5 years of treatment with methylphenidate for mental fatigue and cognitive function after a mild traumatic brain injury.
Topics: Brain Concussion; Brain Injuries, Traumatic; Central Nervous System Stimulants; Cognition; Follow-Up | 2020 |
Topics: Adult; Biomarkers; Brain Injuries, Traumatic; Dopamine; Dopamine Plasma Membrane Transport Proteins; | 2020 |
Methylphenidate and TBI in ADHD and co-occurring epilepsy and mental disorders: a self-controlled case series study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Brain Injuries, Traumatic; Central Nervou | 2022 |
Dosage of methylphenidate and traumatic brain injury in ADHD: a population-based study in Taiwan.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Brain Injuries, Traumatic; Central Nervou | 2018 |
Two-Year Methylphenidate Treatment of Mental Fatigue and Cognitive Function After a Traumatic Brain Injury: A Clinical Prospective Study.
Topics: Adult; Brain Injuries, Traumatic; Central Nervous System Stimulants; Cognitive Dysfunction; Female; | 2018 |
Predicting treatment response in post-TBI cognitive impairment.
Topics: Brain Injuries, Traumatic; Cognitive Dysfunction; Dopamine Uptake Inhibitors; Humans; Methylphenidat | 2019 |
The Therapeutic Efficacy of Environmental Enrichment and Methylphenidate Alone and in Combination after Controlled Cortical Impact Injury.
Topics: Animals; Brain Injuries, Traumatic; Cognition; Combined Modality Therapy; Dopamine Uptake Inhibitors | 2017 |
Short-term efficacy and tolerability of methylphenidate in children with traumatic brain injury and attention problems.
Topics: Attention Deficit Disorder with Hyperactivity; Brain Injuries, Traumatic; Central Nervous System Sti | 2017 |