methylphenidate has been researched along with Disease Models, Animal in 185 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rodents exposed prenatally to valproic acid (VPA) show autism-related behavioral abnormalities." | 7.83 | Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Katashiba, K; Matsuda, T; Onaka, Y; Takano, E; Takuma, K; Taruta, A, 2016) |
| "The incremental dose of opioids used in chronic pain management often leads to a reduced opioid analgesic effect, opioid misuse, and addiction." | 5.56 | Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain. ( Chen, L; Ding, W; Doheny, JT; Mao, J; Shen, S; Yang, J; Yang, L; You, Z; Zhu, S, 2020) |
| "Maternal smoking during pregnancy, a form of developmental nicotine exposure (DNE), is associated with increased nicotine use and neurodevelopmental disorders such as ADHD in children." | 3.91 | Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice. ( Buck, JM; Knopik, VS; O'Neill, HC; Sanders, KN; Stitzel, JA; Wageman, CR, 2019) |
| "Methylphenidate (MP) is the most prescribed psychostimulant for ADHD patients, with clinically demonstrated detrimental effects on bone quality, potentially leading to early onset osteoporosis and higher fracture risk." | 3.88 | Methylphenidate regulation of osteoclasts in a dose- and sex-dependent manner adversely affects skeletal mechanical integrity. ( Chernoff, E; Fricke, D; Hadjiargyrou, M; Komatsu, DE; Robison, LS; Thanos, PK; Uddin, SMZ, 2018) |
| "Rodents exposed prenatally to valproic acid (VPA) show autism-related behavioral abnormalities." | 3.83 | Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Katashiba, K; Matsuda, T; Onaka, Y; Takano, E; Takuma, K; Taruta, A, 2016) |
| "Past research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder showed that adolescent methylphenidate treatment enhanced cocaine abuse risk in SHR during adulthood." | 3.81 | Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder. ( Baskin, BM; Dwoskin, LP; Kantak, KM, 2015) |
| " Ten days of restraint increased light compartment exploration, reduced body weight and sensitized the corticosterone response to swim stress." | 3.78 | Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice. ( Fitzgerald, PJ; Hefner, KR; Holmes, A; Ihne, JL, 2012) |
| "Cigarette smoking, nicotine replacement therapy, and smokeless tobacco use during pregnancy are associated with cognitive disabilities later in life in children exposed prenatally to nicotine." | 3.78 | Prenatal nicotine exposure mouse model showing hyperactivity, reduced cingulate cortex volume, reduced dopamine turnover, and responsiveness to oral methylphenidate treatment. ( Bhide, PG; Biederman, J; Spencer, TJ; Xu, Y; Zhang, X; Zhu, J, 2012) |
| "Narcolepsy is an emblematic, unique disease within sleep disorders that is characterised by excessive daytime sleepiness, cataplexy and other abnormal manifestations of REM sleep." | 2.48 | [Diagnostic and therapeutic update in narcolepsy]. ( Santamaria-Cano, J, 2012) |
| " The consequence of the long-term use of psychostimulants such as MPD as treatment for ADHD in the developing brain of children is unknown." | 2.43 | The role of age, genotype, sex, and route of acute and chronic administration of methylphenidate: a review of its locomotor effects. ( Dafny, N; Yang, PB, 2006) |
| " A high dosage of methylphenidate diminished both behavioral inflexibility and improved learning abilities in adult rats." | 1.72 | Former Training Relieves the Later Development of Behavioral Inflexibility in an Animal Model Overexpressing the Dopamine Transporter. ( Akinola, EO; Bernhardt, N; Edemann-Callesen, H; Glienke, M; Habelt, B; Hadar, R; Lieser, MK; Winter, C, 2022) |
| "Methylphenidate's effects were evident at 0." | 1.62 | Frontal Cortical Monoamine Release, Attention, and Working Memory in a Perinatal Nicotine Exposure Mouse Model Following Kappa Opioid Receptor Antagonism. ( Bhide, PG; Biederman, J; Eskow Jaunarajs, KL; McCarthy, DM; Spencer, TJ; Zhang, L, 2021) |
| "Although attention-deficit/hyperactivity disorder (ADHD) is widely studied, problems regarding the adverse effect risks and non-responder problems still need to be addressed." | 1.62 | Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications. ( Adil, KJ; Cheong, JH; Han, SH; Jeon, SJ; Kim, HJ; Kim, HY; Kim, R; Kwon, KJ; Mabunga, DFN; Park, D; Ryu, O; Shin, CY; Valencia, S, 2021) |
| "Cerebral ischemia is the main cause of permanent adult disabilities worldwide." | 1.62 | Methylphenidate exerts neuroprotective effects through the AMPK signaling pathway. ( Huang, X; Huang, Y; Li, P; Yang, Y, 2021) |
| "The findings suggest that the IN-DA treatment has potential for use in the treatment of ADHD; however, caution must be exercised when determining the dosage to be administered, because too much dopamine may have negative effects." | 1.62 | Acute intranasal dopamine application counteracts the reversal learning deficit of spontaneously hypertensive rats in an attentional set-shifting task. ( Chao, OY; Huston, JP; Li, JS; Mattern, C; Yang, SS; Yang, YM, 2021) |
| "Methylphenidate (MP) is a commonly prescribed psychostimulant to individuals with Attention Deficit Hyperactivity Disorder, and is often used illicitly among healthy individuals with intermittent breaks to coincide with breaks from school." | 1.56 | Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects. ( Carias, E; Connor, C; Hadjiargyrou, M; Kalinowski, L; Komatsu, DE; Mackintosh, M; Martin, C; Popoola, D; Richer, K; Smith, L; Somanesan, R; Thanos, PK, 2020) |
| " Previously, it has been shown that long-term administration of psychostimulants (Methylphenidate and Modafinil) induced locomotor sensitization effect that was more pronounced after 13 days of drug administration and was greater at high dose." | 1.56 | Repeated restraint stress potentiates methylphenidate and modafinil-induced behavioral sensitization in rats. ( Alam, N; Chaudhary, K, 2020) |
| "The incremental dose of opioids used in chronic pain management often leads to a reduced opioid analgesic effect, opioid misuse, and addiction." | 1.56 | Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain. ( Chen, L; Ding, W; Doheny, JT; Mao, J; Shen, S; Yang, J; Yang, L; You, Z; Zhu, S, 2020) |
| "Fatigue is a common symptom in many diseases and disorders and can reduce quality of life, yet lacks an adequate pharmacological intervention." | 1.51 | Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays. ( Cullen, MJ; Dougherty, JP; Gershengorn, MC; Springer, DA, 2019) |
| "Methylphenidate (MPD) is a psychostimulant used for the treatment of ADHD and works by increasing the bioavailability of dopamine (DA) in the brain." | 1.51 | Acute and chronic methylphenidate administration in intact and VTA-specific and nonspecific lesioned rats. ( Dafny, N; Ihezie, SA; Thomas, MM, 2019) |
| "We propose a novel semi-automatic approach to design biomarkers for capturing pharmacodynamic effects induced by pharmacological agents on the spectral power of electroencephalography (EEG) recordings." | 1.48 | Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models. ( Cichocki, A; Hasegawa, M; Hiroyama, S; Horiuchi, M; Jurica, P; Li, J; Nishitomi, K; Ogawa, K; Struzik, ZR; Takahara, Y; Yokota, T, 2018) |
| "Treatment with methylphenidate and/or atomoxetine increased choice of the large, delayed reward in SHR/NCrl and Wistar rats and changed, in varying degrees, mRNA levels of Nr4a2, Btg2, and Homer2, genes with previously described roles in neuropsychiatric disorders characterized by impulsivity." | 1.46 | Methylphenidate and Atomoxetine-Responsive Prefrontal Cortical Genetic Overlaps in "Impulsive" SHR/NCrl and Wistar Rats. ( Cheong, JH; de la Peña, JB; Dela Peña, I; Dela Peña, IJ; Han, DH; Kim, BN; Kim, HJ; Ryu, JH; Shin, CY, 2017) |
| "The treatment with methylphenidate had no beneficial effect on the rats' performance regardless of the DSP4 treatment." | 1.46 | Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). ( Hauser, J; Lange, KW; Reissmann, A; Sontag, TA; Tucha, O, 2017) |
| "Methylphenidate (MPH) is a neural stimulant with unclear neurochemical and behavioral effects." | 1.43 | The neuroprotective effect of lithium against high dose methylphenidate: Possible role of BDNF. ( Asadi, M; Motaghinejad, M; Motevalian, M; Seyedjavadein, Z, 2016) |
| "The treatment with methylphenidate (10mg/kg, ip) increased locomotion in the open field test." | 1.43 | Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test. ( Asth, L; Gavioli, EC; Lobão-Soares, B; Medeiros, IU; Santos, WB; Silva, EF; Soares-Rachetti, VP; Souza, LS, 2016) |
| "Alzheimer's disease is a neurodegenerative disorder characterized by a loss of memory and spatial orientation." | 1.42 | Effects of methylphenidate on the behavior of male 5xFAD mice. ( Baldauf, K; Reymann, KG; Schneider, F; Wetzel, W, 2015) |
| "Methylphenidate (MPH) is a commonly-used medication for the treatment of children with Attention-Deficit/Hyperactivity Disorders (ADHD)." | 1.40 | Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats. ( Belzung, C; Castelnau, P; Chalon, S; Cortese, S; Emond, P; Faraone, SV; Galineau, L; Lepelletier, FX; Nicolas, C; Solinas, M; Tauber, C, 2014) |
| "We observed that both acute and chronic use of methylphenidate hydrochloride (MPH) in adult spontaneously hypertensive rats (SHRs) was associated with increased oxidative stress and energetic metabolism alterations." | 1.40 | Methylphenidate treatment causes oxidative stress and alters energetic metabolism in an animal model of attention-deficit hyperactivity disorder. ( Comim, CM; Dal-Pizzol, F; Ferreira, GK; Gomes, KM; Petronilho, F; Quevedo, J; Réus, GZ; Streck, EL, 2014) |
| "The defining symptoms of PTSD include re-experiencing, avoidance and hyperarousal." | 1.40 | Methylphenidate and desipramine combined treatment improves PTSD symptomatology in a rat model. ( Aga-Mizrachi, S; Avital, A; Balan, A; Cymerblit-Sabba, A; Deshe, R; Gorodetsky, N; Grinstein, D; Gurman, O; Heinrich, N; Miller, L; Shwam, G; Tzezana, O; Zubedat, S, 2014) |
| "Carbamazepine was used as a positive control." | 1.39 | The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels. ( Andreatini, R; Biojone, C; Casarotto, PC; Correia, D; Guimarães, FS; Joca, SL; Martynhak, BJ; Pereira, M; Siba, IP; Tonelli, DA, 2013) |
| "Treatment with methylphenidate or nisoxetine ameliorated CAR impairments in DAT-KO mice." | 1.39 | Impaired cliff avoidance reaction in dopamine transporter knockout mice. ( Hall, FS; Kasahara, Y; Kobayashi, H; Numachi, Y; Sakakibara, Y; Sora, I; Uchiumi, O; Uhl, GR; Yamashita, M; Yoshida, S, 2013) |
| "Methylphenidate is a psychostimulant given for extended periods of time as a treatment of attention-deficit/hyperactivity disorder (ADHD)." | 1.38 | Methylphenidate treatment in the spontaneously hypertensive rat: influence on methylphenidate self-administration and reinstatement in comparison with Wistar rats. ( Cheong, JH; dela Peña, I; dela Peña, JB; Lee, JC; Ryu, JH; Shin, CY; Sohn, AR; Yoon, SY, 2012) |
| "Methylphenidate (MPH) has long been used to treat attention-deficit/hyperactivity disorder (ADHD); however, its cellular mechanisms of action and potential effects on prefrontal cortical circuitry are not well understood, particularly in the developing brain system." | 1.38 | Distinct age-dependent effects of methylphenidate on developing and adult prefrontal neurons. ( Gao, WJ; Urban, KR; Waterhouse, BD, 2012) |
| " Neither chronic administration of ABT-418 nor MPH affected the learning performance during training in the Morris water maze." | 1.38 | A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. ( Guo, L; Guo, T; Liu, K; Yang, C, 2012) |
| " Chronic administration did not cause any effect on memory, but decreased adenosine A(1) receptors immunocontent in the frontal cortex." | 1.37 | Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice. ( Ardais, AP; Botton, PH; Costa, MS; Espinosa, J; Matte, VL; Mioranzza, S; Porciúncula, LO; Souza, DO, 2011) |
| "MPH and ATM generally produced inverted-U dose-response curves, with improvement occurring at moderate doses, but not at higher doses." | 1.36 | Methylphenidate and atomoxetine enhance prefrontal function through α2-adrenergic and dopamine D1 receptors. ( Arnsten, AF; Gamo, NJ; Wang, M, 2010) |
| " Second, the long-term effect of chronic administration of 2 mg/kg per day MPH at two different developmental stages (days 25-39 or 50-64) on the striatal 5-HTT density was examined in both rat strains at day 90." | 1.35 | Development of 5-HT transporter density and long-term effects of methylphenidate in an animal model of ADHD. ( Becker, A; Bock, N; Manzke, T; Roessner, V; Rothenberger, A, 2009) |
| " Since therapeutic MPH in humans is typically administered orally, oral dosing methods that have been verified in the rodent model are of value." | 1.34 | A novel method for oral stimulant administration in the neonate rat and similar species. ( Eppolito, AK; Huff, TB; Smith, LN; Smith, RF; Wheeler, TL, 2007) |
| "The causes of nigrostriatal neuron degeneration in Parkinson's disease (PD) are not known, but it has been suggested that exogenous or endogenous factors or neurotoxins may play a role." | 1.33 | An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate. ( Delville, Y; Fleming, SM; Schallert, T, 2005) |
| "Methylphenidate (MPH) is a psychostimulant effective in treating attention-deficit/hyperactivity disorder (ADHD)." | 1.33 | Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment. ( Choong, KC; Shen, RY, 2006) |
| " Thus, the objective of the present study was to determine whether acute and chronic administration of MPD (0." | 1.33 | Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains. ( Dafny, N; Swann, AC; Yang, PB, 2006) |
| "Methylphenidate treatment (3 mg/kg daily for 14 days) did not normalize the decreased electrically-stimulated release of [(3)H]dopamine from SHR caudate-putamen slices nor did it affect postsynaptic D(2) receptor function." | 1.31 | Methylphenidate affects striatal dopamine differently in an animal model for attention-deficit/hyperactivity disorder--the spontaneously hypertensive rat. ( de Villiers, AS; Lamm, MC; Russell, VA; Sagvolden, T; Taljaard, JJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (7.03) | 18.7374 |
| 1990's | 6 (3.24) | 18.2507 |
| 2000's | 54 (29.19) | 29.6817 |
| 2010's | 96 (51.89) | 24.3611 |
| 2020's | 16 (8.65) | 2.80 |
| Authors | Studies |
|---|---|
| Robinson, AM | 3 |
| Eggleston, RL | 2 |
| Bucci, DJ | 3 |
| Lages, YV | 1 |
| Maisonnette, SS | 1 |
| Rosseti, FP | 1 |
| Galvão, BO | 1 |
| Landeira-Fernandez, J | 1 |
| Contreras, D | 1 |
| Piña, R | 1 |
| Carvallo, C | 1 |
| Godoy, F | 1 |
| Ugarte, G | 1 |
| Zeise, M | 1 |
| Rozas, C | 1 |
| Morales, B | 1 |
| Edemann-Callesen, H | 1 |
| Glienke, M | 1 |
| Akinola, EO | 1 |
| Lieser, MK | 1 |
| Habelt, B | 1 |
| Hadar, R | 1 |
| Bernhardt, N | 1 |
| Winter, C | 1 |
| Liu, Y | 1 |
| Yang, C | 2 |
| Meng, Y | 1 |
| Dang, Y | 1 |
| Yang, L | 2 |
| Yates, JR | 2 |
| Broderick, MR | 1 |
| Berling, KL | 1 |
| Gieske, MG | 1 |
| Osborn, E | 1 |
| Nelson, MR | 1 |
| Wright, MR | 1 |
| Kalinowski, L | 1 |
| Connor, C | 1 |
| Somanesan, R | 1 |
| Carias, E | 1 |
| Richer, K | 1 |
| Smith, L | 1 |
| Martin, C | 1 |
| Mackintosh, M | 1 |
| Popoola, D | 1 |
| Hadjiargyrou, M | 2 |
| Komatsu, DE | 2 |
| Thanos, PK | 2 |
| Yuan, H | 2 |
| Ni, X | 2 |
| Zheng, M | 1 |
| Han, X | 2 |
| Song, Y | 1 |
| Yu, M | 1 |
| Alam, N | 1 |
| Chaudhary, K | 1 |
| Chen, T | 1 |
| Sun, YB | 1 |
| Song, YC | 1 |
| Lu, M | 1 |
| Seeley, SL | 1 |
| D'Souza, MS | 1 |
| Stoops, TS | 1 |
| Rorabaugh, BR | 1 |
| Jhang, CL | 1 |
| Lee, HY | 1 |
| Chen, JC | 1 |
| Liao, W | 1 |
| Zhang, L | 1 |
| McCarthy, DM | 1 |
| Eskow Jaunarajs, KL | 1 |
| Biederman, J | 3 |
| Spencer, TJ | 3 |
| Bhide, PG | 3 |
| Park, D | 1 |
| Mabunga, DFN | 1 |
| Adil, KJ | 1 |
| Ryu, O | 1 |
| Valencia, S | 1 |
| Kim, R | 1 |
| Kim, HJ | 3 |
| Cheong, JH | 8 |
| Kwon, KJ | 1 |
| Kim, HY | 1 |
| Han, SH | 1 |
| Jeon, SJ | 1 |
| Shin, CY | 6 |
| Li, P | 1 |
| Huang, Y | 1 |
| Yang, Y | 1 |
| Huang, X | 1 |
| Li, JS | 2 |
| Yang, SS | 1 |
| Huston, JP | 1 |
| Chao, OY | 1 |
| Yang, YM | 1 |
| Mattern, C | 1 |
| Motaghinejad, M | 4 |
| Motevalian, M | 4 |
| Babalouei, F | 1 |
| Abdollahi, M | 1 |
| Heidari, M | 2 |
| Madjd, Z | 1 |
| Íbias, J | 1 |
| Daniels, CW | 1 |
| Miguéns, M | 1 |
| Pellón, R | 1 |
| Sanabria, F | 1 |
| Dela Peña, I | 6 |
| Dela Peña, IJ | 1 |
| de la Peña, JB | 2 |
| Han, DH | 4 |
| Kim, BN | 5 |
| Ryu, JH | 4 |
| Fatima, S | 1 |
| Beiranvand, T | 1 |
| Mozaffari, S | 1 |
| Zhu, S | 2 |
| Cordner, ZA | 1 |
| Xiong, J | 1 |
| Chiu, CT | 1 |
| Artola, A | 1 |
| Zuo, Y | 1 |
| Nelson, AD | 1 |
| Kim, TY | 1 |
| Zaika, N | 1 |
| Woolums, BM | 1 |
| Hess, EJ | 1 |
| Wang, X | 1 |
| Chuang, DM | 1 |
| Pletnikov, MM | 1 |
| Jenkins, PM | 1 |
| Tamashiro, KL | 1 |
| Ross, CA | 1 |
| Coelho-Santos, V | 1 |
| Cardoso, FL | 1 |
| Leitão, RA | 1 |
| Fontes-Ribeiro, CA | 1 |
| Silva, AP | 1 |
| McLaurin, KA | 1 |
| Li, H | 1 |
| Booze, RM | 1 |
| Fairchild, AJ | 1 |
| Mactutus, CF | 1 |
| Uddin, SMZ | 1 |
| Robison, LS | 1 |
| Fricke, D | 1 |
| Chernoff, E | 1 |
| Miller, EM | 1 |
| Quintero, JE | 1 |
| Pomerleau, F | 1 |
| Huettl, P | 1 |
| Gerhardt, GA | 1 |
| Glaser, PEA | 1 |
| Yokota, T | 1 |
| Struzik, ZR | 1 |
| Jurica, P | 1 |
| Horiuchi, M | 1 |
| Hiroyama, S | 1 |
| Li, J | 1 |
| Takahara, Y | 1 |
| Ogawa, K | 1 |
| Nishitomi, K | 1 |
| Hasegawa, M | 1 |
| Cichocki, A | 1 |
| Ramon-Duaso, C | 1 |
| Gener, T | 1 |
| Consegal, M | 1 |
| Fernández-Avilés, C | 1 |
| Gallego, JJ | 1 |
| Castarlenas, L | 1 |
| Swanson, MS | 1 |
| de la Torre, R | 1 |
| Maldonado, R | 1 |
| Puig, MV | 1 |
| Robledo, P | 1 |
| Dougherty, JP | 1 |
| Springer, DA | 1 |
| Cullen, MJ | 1 |
| Gershengorn, MC | 1 |
| Stewart, A | 1 |
| Davis, GL | 2 |
| Gresch, PJ | 1 |
| Katamish, RM | 1 |
| Peart, R | 1 |
| Rabil, MJ | 1 |
| Gowrishankar, R | 2 |
| Carroll, FI | 1 |
| Hahn, MK | 2 |
| Blakely, RD | 3 |
| Ihezie, SA | 1 |
| Thomas, MM | 1 |
| Dafny, N | 4 |
| Buck, JM | 1 |
| Sanders, KN | 1 |
| Wageman, CR | 1 |
| Knopik, VS | 1 |
| Stitzel, JA | 1 |
| O'Neill, HC | 1 |
| Leffa, DT | 1 |
| Panzenhagen, AC | 1 |
| Salvi, AA | 1 |
| Bau, CHD | 1 |
| Pires, GN | 1 |
| Torres, ILS | 1 |
| Rohde, LA | 1 |
| Rovaris, DL | 1 |
| Grevet, EH | 1 |
| Zoratto, F | 2 |
| Franchi, F | 1 |
| Macrì, S | 1 |
| Laviola, G | 4 |
| You, Z | 1 |
| Ding, W | 1 |
| Doheny, JT | 1 |
| Shen, S | 1 |
| Yang, J | 1 |
| Chen, L | 1 |
| Mao, J | 1 |
| Tonelli, DA | 1 |
| Pereira, M | 1 |
| Siba, IP | 1 |
| Martynhak, BJ | 1 |
| Correia, D | 1 |
| Casarotto, PC | 1 |
| Biojone, C | 1 |
| Guimarães, FS | 1 |
| Joca, SL | 1 |
| Andreatini, R | 2 |
| Kim, Y | 1 |
| Somkuwar, SS | 3 |
| Darna, M | 2 |
| Kantak, KM | 5 |
| Dwoskin, LP | 6 |
| Humby, T | 2 |
| Eddy, JB | 2 |
| Good, MA | 1 |
| Reichelt, AC | 1 |
| Wilkinson, LS | 2 |
| Umehara, M | 1 |
| Ago, Y | 2 |
| Kawanai, T | 1 |
| Fujita, K | 1 |
| Hiramatsu, N | 1 |
| Takuma, K | 2 |
| Matsuda, T | 2 |
| Mergy, MA | 1 |
| Jessen, TN | 1 |
| Wright, J | 1 |
| Stanwood, GD | 1 |
| Parker, MO | 1 |
| Brock, AJ | 1 |
| Sudwarts, A | 1 |
| Brennan, CH | 1 |
| Zhu, J | 2 |
| Lee, KP | 1 |
| Yabuki, Y | 1 |
| Shioda, N | 1 |
| Maeda, T | 1 |
| Hiraide, S | 1 |
| Togashi, H | 3 |
| Fukunaga, K | 1 |
| Zimmermann, AM | 1 |
| Jene, T | 1 |
| Wolf, M | 1 |
| Görlich, A | 1 |
| Gurniak, CB | 1 |
| Sassoè-Pognetto, M | 1 |
| Witke, W | 1 |
| Friauf, E | 1 |
| Rust, MB | 1 |
| Davies, W | 1 |
| Trent, S | 1 |
| Ojarikre, OA | 1 |
| Comim, CM | 1 |
| Gomes, KM | 1 |
| Réus, GZ | 1 |
| Petronilho, F | 1 |
| Ferreira, GK | 1 |
| Streck, EL | 1 |
| Dal-Pizzol, F | 1 |
| Quevedo, J | 1 |
| Tomlinson, A | 1 |
| Grayson, B | 1 |
| Marsh, S | 1 |
| Harte, MK | 1 |
| Barnes, SA | 1 |
| Marshall, KM | 1 |
| Neill, JC | 1 |
| Sohn, A | 1 |
| Noh, M | 1 |
| Radiloff, D | 1 |
| Zhao, Y | 1 |
| Boico, A | 1 |
| Blueschke, G | 1 |
| Palmer, G | 1 |
| Fontanella, A | 1 |
| Dewhirst, M | 1 |
| Piantadosi, CA | 1 |
| Noveck, R | 1 |
| Irwin, D | 1 |
| Hamilton, K | 1 |
| Klitzman, B | 1 |
| Schroeder, T | 1 |
| Steiner, H | 1 |
| Warren, BL | 1 |
| Van Waes, V | 1 |
| Bolaños-Guzmán, CA | 1 |
| Kasahara, Y | 2 |
| Kubo, Y | 1 |
| Sora, I | 2 |
| Kishikawa, Y | 1 |
| Kawahara, Y | 1 |
| Yamada, M | 1 |
| Kaneko, F | 1 |
| Kawahara, H | 1 |
| Nishi, A | 1 |
| Gonzales, EL | 1 |
| Aga-Mizrachi, S | 1 |
| Cymerblit-Sabba, A | 1 |
| Gurman, O | 1 |
| Balan, A | 1 |
| Shwam, G | 1 |
| Deshe, R | 1 |
| Miller, L | 1 |
| Gorodetsky, N | 1 |
| Heinrich, N | 1 |
| Tzezana, O | 1 |
| Zubedat, S | 1 |
| Grinstein, D | 1 |
| Avital, A | 1 |
| Schneider, F | 1 |
| Baldauf, K | 1 |
| Wetzel, W | 1 |
| Reymann, KG | 1 |
| Söderlund, GB | 1 |
| Eckernäs, D | 1 |
| Holmblad, O | 1 |
| Bergquist, F | 2 |
| Lepelletier, FX | 1 |
| Tauber, C | 1 |
| Nicolas, C | 1 |
| Solinas, M | 1 |
| Castelnau, P | 1 |
| Belzung, C | 1 |
| Emond, P | 1 |
| Cortese, S | 1 |
| Faraone, SV | 1 |
| Chalon, S | 1 |
| Galineau, L | 1 |
| Baskin, BM | 1 |
| Ota, M | 2 |
| Ogawa, S | 2 |
| Kato, K | 2 |
| Wakabayashi, C | 1 |
| Kunugi, H | 2 |
| van der Voet, M | 1 |
| Harich, B | 1 |
| Franke, B | 1 |
| Schenck, A | 1 |
| Masuda, C | 1 |
| dos Santos Pereira, M | 1 |
| Sathler, MF | 1 |
| Valli, Tda R | 1 |
| Marques, RS | 1 |
| Ventura, AL | 1 |
| Peccinalli, NR | 1 |
| Fraga, MC | 1 |
| Manhães, AC | 1 |
| Kubrusly, R | 1 |
| Juárez, J | 1 |
| Guerrero-Álvarez, Á | 1 |
| Lazzaretti, C | 1 |
| Kincheski, GC | 1 |
| Pandolfo, P | 3 |
| Krolow, R | 1 |
| Toniazzo, AP | 1 |
| Arcego, DM | 1 |
| Couto-Pereira, Nde S | 1 |
| Zeidán-Chuliá, F | 1 |
| Galvalisi, M | 1 |
| Costa, G | 1 |
| Scorza, C | 1 |
| Souza, TM | 1 |
| Dalmaz, C | 1 |
| Bardo, MT | 4 |
| Hara, Y | 1 |
| Taruta, A | 1 |
| Katashiba, K | 1 |
| Hasebe, S | 1 |
| Takano, E | 1 |
| Onaka, Y | 1 |
| Hashimoto, H | 1 |
| Pillidge, K | 1 |
| Porter, AJ | 1 |
| Young, JW | 1 |
| Stanford, SC | 1 |
| Bock, J | 3 |
| Breuer, S | 1 |
| Poeggel, G | 1 |
| Braun, K | 3 |
| Seyedjavadein, Z | 1 |
| Asadi, M | 1 |
| Souza, LS | 1 |
| Silva, EF | 1 |
| Santos, WB | 1 |
| Asth, L | 1 |
| Lobão-Soares, B | 1 |
| Soares-Rachetti, VP | 1 |
| Medeiros, IU | 1 |
| Gavioli, EC | 1 |
| Lukkes, JL | 1 |
| Freund, N | 1 |
| Thompson, BS | 1 |
| Meda, S | 1 |
| Andersen, SL | 1 |
| Niijima-Yaoita, F | 1 |
| Nagasawa, Y | 1 |
| Tsuchiya, M | 1 |
| Arai, Y | 1 |
| Tadano, T | 1 |
| Tan-No, K | 1 |
| Falak, R | 1 |
| Sharzad, M | 1 |
| Kalantari, E | 1 |
| Hauser, J | 1 |
| Reissmann, A | 1 |
| Sontag, TA | 1 |
| Tucha, O | 1 |
| Lange, KW | 1 |
| Cheng, J | 1 |
| Liu, A | 1 |
| Shi, MY | 1 |
| Yan, Z | 1 |
| Woolley, ML | 1 |
| Waters, KA | 1 |
| Reavill, C | 1 |
| Bull, S | 1 |
| Lacroix, LP | 1 |
| Martyn, AJ | 1 |
| Hutcheson, DM | 1 |
| Valerio, E | 1 |
| Bate, S | 1 |
| Jones, DN | 1 |
| Dawson, LA | 1 |
| Wagner, AK | 1 |
| Drewencki, LL | 1 |
| Chen, X | 1 |
| Santos, FR | 1 |
| Khan, AS | 1 |
| Harun, R | 1 |
| Torres, GE | 1 |
| Michael, AC | 1 |
| Dixon, CE | 1 |
| Torres-Reveron, A | 1 |
| Gray, JD | 1 |
| Melton, JT | 1 |
| Punsoni, M | 1 |
| Tabori, NE | 1 |
| Ward, MJ | 1 |
| Frys, K | 1 |
| Iadecola, C | 1 |
| Milner, TA | 1 |
| Barron, E | 1 |
| Yang, PB | 3 |
| Swann, AC | 2 |
| Roessner, V | 1 |
| Manzke, T | 1 |
| Becker, A | 1 |
| Rothenberger, A | 2 |
| Bock, N | 1 |
| Leo, D | 1 |
| Adriani, W | 3 |
| Cavaliere, C | 1 |
| Cirillo, G | 1 |
| Marco, EM | 2 |
| Romano, E | 1 |
| di Porzio, U | 1 |
| Papa, M | 1 |
| Perrone-Capano, C | 1 |
| Pires, VA | 2 |
| Pamplona, FA | 2 |
| Fernandes, D | 1 |
| Prediger, RD | 2 |
| Takahashi, RN | 4 |
| Pasini, A | 1 |
| D'agati, E | 1 |
| Orduña, V | 1 |
| Valencia-Torres, L | 1 |
| Bouzas, A | 1 |
| Vendruscolo, LF | 2 |
| Izídio, GS | 2 |
| Hong, Q | 1 |
| Zhang, M | 1 |
| Pan, XQ | 1 |
| Guo, M | 1 |
| Li, F | 1 |
| Tong, ML | 1 |
| Chen, RH | 1 |
| Guo, XR | 1 |
| Chi, X | 1 |
| Warton, FL | 1 |
| Howells, FM | 1 |
| Russell, VA | 2 |
| Ruocco, LA | 2 |
| Carnevale, UA | 1 |
| Treno, C | 1 |
| Sadile, AG | 3 |
| Melisi, D | 1 |
| Arra, C | 1 |
| Ibba, M | 1 |
| Schirru, C | 1 |
| Carboni, E | 2 |
| Banaschewski, T | 1 |
| Konrad, K | 1 |
| Hebebrand, J | 1 |
| Krapacher, FA | 1 |
| Mlewski, EC | 1 |
| Ferreras, S | 1 |
| Pisano, V | 1 |
| Paolorossi, M | 1 |
| Hansen, C | 1 |
| Paglini, G | 1 |
| Simchon, Y | 1 |
| Weizman, A | 1 |
| Rehavi, M | 1 |
| Drerup, JM | 1 |
| Hayashi, K | 1 |
| Cui, H | 1 |
| Mettlach, GL | 1 |
| Long, MA | 1 |
| Marvin, M | 1 |
| Sun, X | 1 |
| Goldberg, MS | 1 |
| Lutter, M | 1 |
| Bibb, JA | 1 |
| Gamo, NJ | 1 |
| Wang, M | 1 |
| Arnsten, AF | 1 |
| Mioranzza, S | 1 |
| Costa, MS | 1 |
| Botton, PH | 1 |
| Ardais, AP | 1 |
| Matte, VL | 1 |
| Espinosa, J | 1 |
| Souza, DO | 1 |
| Porciúncula, LO | 1 |
| Pålsson, E | 1 |
| Söderlund, G | 1 |
| Klamer, D | 1 |
| dela Peńa, IC | 1 |
| Ahn, HS | 1 |
| Choi, JY | 1 |
| Canese, R | 1 |
| Barbosa, FJ | 1 |
| Hesse, B | 1 |
| de Almeida, RB | 1 |
| Baretta, IP | 1 |
| Boerngen-Lacerda, R | 1 |
| Won, H | 1 |
| Mah, W | 1 |
| Kim, E | 2 |
| Kim, JW | 1 |
| Hahm, EK | 1 |
| Kim, MH | 1 |
| Cho, S | 1 |
| Kim, J | 1 |
| Jang, H | 1 |
| Cho, SC | 1 |
| Shin, MS | 2 |
| Seo, J | 1 |
| Jeong, J | 1 |
| Choi, SY | 1 |
| Kim, D | 1 |
| Kang, C | 1 |
| Wooters, TE | 1 |
| Amos-Kroohs, RM | 1 |
| Williams, MT | 1 |
| Vorhees, CV | 1 |
| Ihne, JL | 1 |
| Fitzgerald, PJ | 1 |
| Hefner, KR | 1 |
| Holmes, A | 1 |
| Kim, H | 1 |
| Heo, HI | 1 |
| Kim, DH | 1 |
| Ko, IG | 1 |
| Lee, SS | 1 |
| Kim, SE | 1 |
| Kim, BK | 1 |
| Kim, TW | 1 |
| Ji, ES | 1 |
| Kim, JD | 1 |
| Choi, YW | 1 |
| Kim, CJ | 1 |
| Marusich, JA | 1 |
| McCuddy, WT | 1 |
| Beckmann, JS | 1 |
| Gipson, CD | 2 |
| Yoon, SY | 1 |
| Lee, JC | 2 |
| dela Peña, JB | 1 |
| Sohn, AR | 2 |
| Furuse, T | 1 |
| Yamada, I | 1 |
| Kushida, T | 1 |
| Masuya, H | 1 |
| Miura, I | 1 |
| Kaneda, H | 1 |
| Kobayashi, K | 1 |
| Wada, Y | 1 |
| Yuasa, S | 1 |
| Wakana, S | 1 |
| Cao, AH | 1 |
| Yu, L | 1 |
| Wang, YW | 1 |
| Wang, JM | 1 |
| Yang, LJ | 1 |
| Lei, GF | 1 |
| Lee, HL | 1 |
| Woo, TS | 1 |
| Lee, HC | 1 |
| Sossi, V | 1 |
| Dinelle, K | 1 |
| Jivan, S | 1 |
| Fischer, K | 1 |
| Holden, JE | 1 |
| Doudet, D | 1 |
| Chadman, KK | 1 |
| Guariglia, SR | 1 |
| Yoo, JH | 1 |
| Lange, M | 1 |
| Norton, W | 1 |
| Coolen, M | 1 |
| Chaminade, M | 1 |
| Merker, S | 1 |
| Proft, F | 1 |
| Schmitt, A | 1 |
| Vernier, P | 1 |
| Lesch, KP | 1 |
| Bally-Cuif, L | 1 |
| Santamaria-Cano, J | 1 |
| Urban, KR | 1 |
| Waterhouse, BD | 1 |
| Gao, WJ | 1 |
| Zhang, X | 1 |
| Xu, Y | 1 |
| Guo, T | 1 |
| Guo, L | 1 |
| Liu, K | 1 |
| Sánchez-Pérez, AM | 1 |
| García-Avilés, Á | 1 |
| Albert Gascó, H | 1 |
| Sanjuán, J | 1 |
| Olucha-Bordonau, FE | 1 |
| Ouchi, H | 1 |
| Ono, K | 1 |
| Murakami, Y | 1 |
| Matsumoto, K | 1 |
| Cheng, JT | 1 |
| Yamashita, M | 1 |
| Sakakibara, Y | 1 |
| Hall, FS | 1 |
| Numachi, Y | 1 |
| Yoshida, S | 1 |
| Kobayashi, H | 1 |
| Uchiumi, O | 1 |
| Uhl, GR | 1 |
| McFadyen, MP | 1 |
| Brown, RE | 1 |
| Carrey, N | 1 |
| Rhodes, JS | 1 |
| Garland, T | 1 |
| Ueno, K | 1 |
| Yoshioka, M | 2 |
| Ferguson, SA | 1 |
| Cada, AM | 1 |
| Volkow, ND | 1 |
| Insel, TR | 1 |
| Hyman, SE | 1 |
| Avale, ME | 1 |
| Falzone, TL | 1 |
| Gelman, DM | 1 |
| Low, MJ | 1 |
| Grandy, DK | 1 |
| Rubinstein, M | 1 |
| Silvagni, A | 1 |
| Gasior, M | 1 |
| Bergman, J | 1 |
| Kallman, MJ | 1 |
| Paronis, CA | 1 |
| Fleming, SM | 1 |
| Delville, Y | 1 |
| Schallert, T | 1 |
| Hewitt, KN | 1 |
| Shah, YB | 1 |
| Prior, MJ | 1 |
| Morris, PG | 1 |
| Hollis, CP | 1 |
| Fone, KC | 1 |
| Marsden, CA | 1 |
| Kuczenski, R | 1 |
| Segal, DS | 1 |
| Siesser, WB | 2 |
| Cheng, SY | 2 |
| McDonald, MP | 2 |
| Shen, RY | 1 |
| Choong, KC | 1 |
| Augustyniak, PN | 1 |
| Kourrich, S | 1 |
| Rezazadeh, SM | 1 |
| Stewart, J | 1 |
| Arvanitogiannis, A | 1 |
| van den Bergh, FS | 1 |
| Bloemarts, E | 1 |
| Chan, JS | 1 |
| Groenink, L | 1 |
| Olivier, B | 1 |
| Oosting, RS | 1 |
| Zhao, J | 1 |
| Miller, LR | 1 |
| Mazei-Robinson, MS | 1 |
| Guerriero, RM | 1 |
| Hayes, MM | 1 |
| Dhaliwal, SK | 1 |
| Ren, JQ | 1 |
| Kosofsky, BE | 1 |
| Muneoka, K | 1 |
| Kuwagata, M | 1 |
| Iwata, M | 1 |
| Shirayama, Y | 1 |
| Ogawa, T | 1 |
| Takigawa, M | 1 |
| Wheeler, TL | 1 |
| Eppolito, AK | 1 |
| Smith, LN | 1 |
| Huff, TB | 1 |
| Smith, RF | 1 |
| Blondeau, C | 1 |
| Dellu-Hagedorn, F | 1 |
| Eagle, DM | 1 |
| Tufft, MR | 1 |
| Goodchild, HL | 1 |
| Robbins, TW | 1 |
| Morice, E | 1 |
| Billard, JM | 1 |
| Denis, C | 1 |
| Mathieu, F | 1 |
| Betancur, C | 1 |
| Epelbaum, J | 1 |
| Giros, B | 1 |
| Nosten-Bertrand, M | 1 |
| Bizot, JC | 1 |
| Chenault, N | 1 |
| Houzé, B | 1 |
| Herpin, A | 1 |
| David, S | 1 |
| Pothion, S | 1 |
| Trovero, F | 1 |
| Zehle, S | 2 |
| Jezierski, G | 2 |
| Gruss, M | 2 |
| Müller Smith, K | 1 |
| Fagel, DM | 1 |
| Stevens, HE | 1 |
| Rabenstein, RL | 1 |
| Maragnoli, ME | 1 |
| Ohkubo, Y | 1 |
| Picciotto, MR | 1 |
| Schwartz, ML | 1 |
| Vaccarino, FM | 1 |
| Ramos, A | 1 |
| Kiguchi, M | 1 |
| Fujita, S | 1 |
| Oki, H | 1 |
| Shimizu, N | 1 |
| Cools, AR | 1 |
| Koshikawa, N | 1 |
| Singh, T | 1 |
| Kerstetter, KA | 1 |
| Dembro, KA | 1 |
| Mutebi, MM | 1 |
| Harvey, RC | 1 |
| Deschepper, CF | 1 |
| Heal, DJ | 1 |
| Smith, SL | 1 |
| Kulkarni, RS | 1 |
| Rowley, HL | 1 |
| Solanto, MV | 1 |
| Anderson, GM | 1 |
| Shaywitz, BA | 2 |
| Leckman, JF | 1 |
| Hunt, RD | 1 |
| Shaywitz, SE | 1 |
| Cohen, DJ | 1 |
| Schechter, MD | 1 |
| Concannon, JT | 1 |
| Puumala, T | 1 |
| Ruotsalainen, S | 1 |
| Jäkälä, P | 1 |
| Koivisto, E | 1 |
| Riekkinen, P | 1 |
| Sirviö, J | 1 |
| Russell, V | 1 |
| de Villiers, A | 1 |
| Sagvolden, T | 4 |
| Lamm, M | 1 |
| Taljaard, J | 1 |
| Marx, J | 1 |
| Aspide, R | 1 |
| Fresiello, A | 1 |
| de Filippis, G | 1 |
| Gironi Carnevale, UA | 1 |
| Sarkis, EH | 1 |
| de Villiers, AS | 1 |
| Lamm, MC | 1 |
| Taljaard, JJ | 1 |
| Ruskin, DN | 1 |
| Bergstrom, DA | 1 |
| Shenker, A | 1 |
| Freeman, LE | 1 |
| Baek, D | 1 |
| Walters, JR | 1 |
| Denney, CB | 1 |
| Fox, GB | 1 |
| Pan, JB | 1 |
| Esbenshade, TA | 1 |
| Bennani, YL | 1 |
| Black, LA | 1 |
| Faghih, R | 1 |
| Hancock, AA | 1 |
| Decker, MW | 1 |
| Ueno, KI | 1 |
| Mori, K | 1 |
| Matsumoto, M | 1 |
| Ohashi, S | 1 |
| Hoshino, A | 1 |
| Fujita, T | 1 |
| Saito, H | 1 |
| Minami, M | 1 |
| Margolin, DI | 1 |
| Sharma, JN | 1 |
| Snider, SR | 1 |
| Fahn, S | 1 |
| Hiesiger, E | 1 |
| Klopper, JH | 1 |
| Gordon, JW | 1 |
| Reese, WG | 1 |
| Risner, ME | 1 |
| Jones, BE | 1 |
| Costall, B | 1 |
| Naylor, RJ | 1 |
| Metzger, MA | 1 |
| Schiørbeck, HK | 1 |
| Rugland, AL | 1 |
| Spinnangr, I | 1 |
| Sagvolden, G | 1 |
| Jinnah, HA | 1 |
| Langlais, PJ | 1 |
| Friedmann, T | 1 |
| Wultz, B | 1 |
| Moser, EI | 1 |
| Moser, MB | 1 |
| Sackler, AM | 1 |
| Weltman, AS | 1 |
| Archer, T | 1 |
| Fredriksson, A | 1 |
| Sundström, E | 1 |
| Luthman, J | 1 |
| Lewander, T | 1 |
| Söderberg, U | 1 |
| Jonsson, G | 1 |
| Fog, R | 1 |
| Silbergeld, EK | 1 |
| Goldberg, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Relative Efficacy of Aerobic Exercise in the Treatment of Adults With Attention Deficit Hyperactivity Disorder (ADHD) Versus Medication Only and the Combination of the Two: A Pilot Study[NCT02788851] | 70 participants (Anticipated) | Interventional | 2016-04-30 | Active, not recruiting | |||
| The Relation Between Attentional, Sensory and Emotional Dysregulation in Adults With Posttraumatic Stress Disorder: a Double-blind, Placebo-controlled Randomized Controlled Trial of the Combined Treatment With Reboxetine and Methylphenidate[NCT05133804] | Phase 2 | 53 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| Candidate Gene Screening for 6-14 Year Old Patients With ADHD (Attention Deficit/ Hyperactivity Disorder)[NCT03018574] | 100 participants (Actual) | Observational | 2016-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 reviews available for methylphenidate and Disease Models, Animal
| Article | Year |
|---|---|
Systematic review and meta-analysis of the behavioral effects of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous | 2019 |
Abuse and dependence liability analysis of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder (ADHD): what have we learned?
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Addictive; Behavior, Animal; Blood | 2013 |
Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder.
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2014 |
Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior.
Topics: Aging; Animals; Behavior, Animal; Brain; Child; Disease Models, Animal; Fluoxetine; Humans; Methylph | 2014 |
[Analysis of dopamine transporter knockout mice as an animal model of AD/HD].
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine Plasma Memb | 2013 |
Pathophysiology of NSS in ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain Damage, Chronic; Central Nervous Syste | 2009 |
Drug reinforcement in a rat model of attention deficit/hyperactivity disorder--the Spontaneously Hypertensive Rat (SHR).
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M | 2009 |
[Attention deficit hyperactivity disorder].
Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System St | 2009 |
Neurobehavioral adaptations to methylphenidate: the issue of early adolescent exposure.
Topics: Adaptation, Physiological; Adolescent; Adolescent Development; Adult; Animals; Brain; Central Nervou | 2011 |
Brain processes in discounting: consequences of adolescent methylphenidate exposure.
Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System St | 2012 |
New directions in the treatment of autism spectrum disorders from animal model research.
Topics: Adolescent; Adolescent Behavior; Animals; Antipsychotic Agents; Aripiprazole; Brain; Central Nervous | 2012 |
[Diagnostic and therapeutic update in narcolepsy].
Topics: Adolescent; Adult; Age of Onset; Animals; Autoimmune Diseases; Benzhydryl Compounds; Cataplexy; Chil | 2012 |
[Effects of methylphenidate on anxiety].
Topics: Adolescent; Adult; Age Factors; Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Attention | 2012 |
[Behavioral and pharmacological studies of juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder].
Topics: Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2003 |
Experimental investigations on dopamine transmission can provide clues on the mechanism of the therapeutic effect of amphetamine and methylphenidate in ADHD.
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamin | 2004 |
Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M | 2005 |
The role of age, genotype, sex, and route of acute and chronic administration of methylphenidate: a review of its locomotor effects.
Topics: Age Factors; Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Child; Child | 2006 |
ADHD and the dopamine transporter: are there reasons to pay attention?
Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Base Sequence; Brain; Child; Disease | 2006 |
New perspectives from microdialysis studies in freely-moving, spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD.
Topics: Amphetamine; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Dise | 2008 |
Neuropharmacological basis of stimulant drug action in attention deficit disorder with hyperactivity: a review and synthesis.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Brain Chemistry; Central Nervous | 1984 |
Developmental and pharmacological aspects of attention deficit disorder (ADD).
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Brain Chemistry; Disease Models, Anim | 1983 |
Stimulant effects in attention deficit hyperactivity disorder: theoretical and empirical issues.
Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulant | 2001 |
The hyperkinetic child syndrome and brain monoamines: pharmacology and therapeutic implications.
Topics: Animals; Arousal; Attention; Brain; Child; Dextroamphetamine; Disease Models, Animal; Dopamine; Huma | 1978 |
On stereotypy and catalepsy: studies on the effect of amphetamines and neuroleptics in rats.
Topics: Amphetamine; Animals; Basal Ganglia; Caffeine; Catalepsy; Cocaine; Compulsive Behavior; Corpus Stria | 1972 |
161 other studies available for methylphenidate and Disease Models, Animal
| Article | Year |
|---|---|
Physical exercise and catecholamine reuptake inhibitors affect orienting behavior and social interaction in a rat model of attention-deficit/hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Catecholamines; Central Nervous System Stimu | 2021 |
Haloperidol and methylphenidate alter motor behavior and responses to conditioned fear of Carioca Low-conditioned Freezing rats.
Topics: Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Conditioning, Psy | 2021 |
Methylphenidate Restores Behavioral and Neuroplasticity Impairments in the Prenatal Nicotine Exposure Mouse Model of ADHD: Evidence for Involvement of AMPA Receptor Subunit Composition and Synaptic Spine Morphology in the Hippocampus.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Female; Hippocampus; | 2022 |
Former Training Relieves the Later Development of Behavioral Inflexibility in an Animal Model Overexpressing the Dopamine Transporter.
Topics: Animals; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Maze Learnin | 2022 |
Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Diet, Ket | 2023 |
Effects of adolescent methylphenidate administration on methamphetamine conditioned place preference in an animal model of attention-deficit/hyperactivity disorder: Examination of potential sex differences.
Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulant | 2023 |
Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Body Weight; Central Nervo | 2020 |
Effect of catalpol on behavior and neurodevelopment in an ADHD rat model.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Sti | 2019 |
Repeated restraint stress potentiates methylphenidate and modafinil-induced behavioral sensitization in rats.
Topics: Adaptation, Psychological; Animals; Behavior, Animal; Central Nervous System Stimulants; Disease Mod | 2020 |
Metabolomics study of the prefrontal cortex in a rat model of attention deficit hyperactivity disorder reveals the association between cholesterol metabolism disorder and hyperactive behavior.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Biomarkers; Central Nervou | 2020 |
Short term methylphenidate treatment does not increase myocardial injury in the ischemic rat heart.
Topics: Animals; Central Nervous System Stimulants; Disease Models, Animal; Drug Administration Schedule; Fe | 2020 |
Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopam | 2020 |
Frontal Cortical Monoamine Release, Attention, and Working Memory in a Perinatal Nicotine Exposure Mouse Model Following Kappa Opioid Receptor Antagonism.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Biogenic Monoamines; Disease Models, Animal; | 2021 |
Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy | 2021 |
Methylphenidate exerts neuroprotective effects through the AMPK signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; D | 2021 |
Acute intranasal dopamine application counteracts the reversal learning deficit of spontaneously hypertensive rats in an attentional set-shifting task.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine; Methylphen | 2021 |
Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; | 2017 |
The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD.
Topics: Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 2017 |
Methylphenidate and Atomoxetine-Responsive Prefrontal Cortical Genetic Overlaps in "Impulsive" SHR/NCrl and Wistar Rats.
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Choice Behavior; | 2017 |
Topiramate via NMDA, AMPA/kainate, GABA
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Disease Models, Anima | 2017 |
Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder.
Topics: Animals; Ankyrins; Bipolar Disorder; Disease Models, Animal; GABAergic Neurons; Lithium; Methylpheni | 2017 |
Impact of developmental exposure to methylphenidate on rat brain's immune privilege and behavior: Control versus ADHD model.
Topics: Animals; Anxiety; Attention; Attention Deficit Disorder with Hyperactivity; Blood-Brain Barrier; Bra | 2018 |
Unraveling Individual Differences In The HIV-1 Transgenic Rat: Therapeutic Efficacy Of Methylphenidate.
Topics: Animals; Behavior, Animal; Biological Variation, Population; Central Nervous System Stimulants; Cogn | 2018 |
Methylphenidate regulation of osteoclasts in a dose- and sex-dependent manner adversely affects skeletal mechanical integrity.
Topics: Animals; Bone Resorption; Cells, Cultured; Central Nervous System Stimulants; Disease Models, Animal | 2018 |
Chronic Methylphenidate Alters Tonic and Phasic Glutamate Signaling in the Frontal Cortex of a Freely-Moving Rat Model of ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M | 2019 |
Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models.
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Biomarkers; Disea | 2018 |
Methylphenidate Attenuates the Cognitive and Mood Alterations Observed in Mbnl2 Knockout Mice and Reduces Microglia Overexpression.
Topics: Affect; Animals; Brain; Central Nervous System Stimulants; Cognition; Cognitive Dysfunction; Depress | 2019 |
Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Body Weight; Centr | 2019 |
Serotonin transporter inhibition and 5-HT
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Classical; Disease Models, Animal; Dopamine; Dopam | 2019 |
Acute and chronic methylphenidate administration in intact and VTA-specific and nonspecific lesioned rats.
Topics: Adrenergic Agents; Animals; Behavior, Animal; Central Nervous System Stimulants; Disease Models, Ani | 2019 |
Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.
Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Corpus Striatu | 2019 |
Methylphenidate administration promotes sociability and reduces aggression in a mouse model of callousness.
Topics: Aggression; Animals; Attention; Conduct Disorder; Disease Models, Animal; Dopamine Uptake Inhibitors | 2019 |
Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug | 2020 |
The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Disease Models, Animal; Dose-Response Re | 2013 |
Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M | 2013 |
A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism.
Topics: Aminopyridines; Animals; Atomoxetine Hydrochloride; Disease Models, Animal; Impulsive Behavior; Indo | 2013 |
Methylphenidate and venlafaxine attenuate locomotion in spontaneously hypertensive rats, an animal model of attention-deficit/hyperactivity disorder, through α2-adrenoceptor activation.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Attentio | 2013 |
Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Choice Behavior; Disease Models, A | 2014 |
Transgenerational transmission of hyperactivity in a mouse model of ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M | 2014 |
Aberrant CaMKII activity in the medial prefrontal cortex is associated with cognitive dysfunction in ADHD model rats.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; CA1 Region, Hippocampal; Calcium- | 2014 |
Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cofilin 1 | 2015 |
Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison with drugs used in ADHD.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy | 2014 |
Methylphenidate treatment causes oxidative stress and alters energetic metabolism in an animal model of attention-deficit hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Di | 2014 |
Pay attention to impulsivity: modelling low attentive and high impulsive subtypes of adult ADHD in the 5-choice continuous performance task (5C-CPT) in female rats.
Topics: Analysis of Variance; Animals; Atomoxetine Hydrochloride; Attention; Attention Deficit Disorder with | 2014 |
Prefrontal cortical and striatal transcriptional responses to the reinforcing effect of repeated methylphenidate treatment in the spontaneously hypertensive rat, animal model of attention-deficit/hyperactivity disorder (ADHD).
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Sti | 2014 |
Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.
Topics: Acclimatization; Altitude; Altitude Sickness; Animals; Cell Hypoxia; Disease Models, Animal; Dose-Re | 2014 |
Individual and combined effects of physical exercise and methylphenidate on orienting behavior and social interaction in spontaneously hypertensive rats.
Topics: Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 2014 |
The spontaneously hypertensive rat/Izm (SHR/Izm) shows attention deficit/hyperactivity disorder-like behaviors but without impulsive behavior: therapeutic implications of low-dose methylphenidate.
Topics: Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 2014 |
Individual differences in novelty-seeking behavior in spontaneously hypertensive rats: Enhanced sensitivity to the reinforcing effect of methylphenidate in the high novelty-preferring subpopulation.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Condition | 2015 |
Methylphenidate and desipramine combined treatment improves PTSD symptomatology in a rat model.
Topics: Animals; Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Desipramine; Disease M | 2014 |
Effects of methylphenidate on the behavior of male 5xFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anxiety; Behavior, Animal; Central Nervo | 2015 |
Acoustic noise improves motor learning in spontaneously hypertensive rats, a rat model of attention deficit hyperactivity disorder.
Topics: Acoustic Stimulation; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 2015 |
Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats.
Topics: Animals; Brain; Central Nervous System Stimulants; Cocaine; Dietary Sucrose; Disease Models, Animal; | 2014 |
Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2015 |
Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder.
Topics: Age Factors; Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Central N | 2015 |
Methamphetamine-sensitized rats show augmented dopamine release to methylphenidate stimulation: a positron emission tomography using [18F]fallypride.
Topics: Animals; Benzamides; Biomarkers; Central Nervous System Stimulants; Corpus Striatum; Disease Models, | 2015 |
ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine; Dopamine P | 2016 |
Striatal and extrastriatal dopamine release in the common marmoset brain measured by positron emission tomography and [(18)F]fallypride.
Topics: Animals; Benzamides; Brain; Callithrix; Central Nervous System Stimulants; Cerebellum; Corpus Striat | 2015 |
Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Biological Transport; Central Nervous System | 2015 |
Effects of methylphenidate and atomoxetine on impulsivity and motor activity in preadolescent rats prenatally-treated with alcohol.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Central Nervous System Depressants | 2015 |
Neonatal handling causes impulsive behavior and decreased pharmacological response to methylphenidate in male adult wistar rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Biogenic Monoamines; Body Weight; Cent | 2016 |
Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD.
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Di | 2016 |
Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism.
Topics: Animals; Atomoxetine Hydrochloride; Autistic Disorder; Behavior, Animal; Dendritic Spines; Disease M | 2016 |
Perseveration by NK1R-/- ('knockout') mice is blunted by doses of methylphenidate that affect neither other aspects of their cognitive performance nor the behaviour of wild-type mice in the 5-Choice Continuous Performance Test.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Sti | 2016 |
Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions: functional imaging of methylphenidate treatment in a novel rodent model.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain; Disease | 2017 |
The neuroprotective effect of lithium against high dose methylphenidate: Possible role of BDNF.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Cytokines; Disease Mo | 2016 |
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Central Nervous System Stimulants; Di | 2016 |
Preventative treatment in an animal model of ADHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cocaine; | 2016 |
Effects of methylphenidate on the impairment of spontaneous alternation behavior in mice intermittently deprived of REM sleep.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Hippocampus; Male; M | 2016 |
Neuroprotective effects of various doses of topiramate against methylphenidate-induced oxidative stress and inflammation in isolated rat amygdala: the possible role of CREB/BDNF signaling pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; CREB-Binding Protein; | 2016 |
Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4).
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Benzylamines; Central Nervous Sys | 2017 |
Disrupted Glutamatergic Transmission in Prefrontal Cortex Contributes to Behavioral Abnormality in an Animal Model of ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M | 2017 |
Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat.
Topics: Acetamides; Acetylcholine; Amphetamine; Animals; Behavior, Animal; Cognition; Disease Models, Animal | 2008 |
Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury.
Topics: Animals; Brain Injuries; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; | 2009 |
Early postnatal exposure to methylphenidate alters stress reactivity and increases hippocampal ectopic granule cells in adult rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Beha | 2009 |
Adolescent and adult male spontaneous hyperactive rats (SHR) respond differently to acute and chronic methylphenidate (Ritalin).
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain; Brain Chemis | 2009 |
Development of 5-HT transporter density and long-term effects of methylphenidate in an animal model of ADHD.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Carrier Proteins; Central Nervo | 2009 |
Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology.
Topics: Aging; Animals; Behavior, Animal; Cell Enlargement; Cells, Cultured; Central Nervous System Stimulan | 2009 |
Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Attention Deficit Dis | 2009 |
DRL performance of spontaneously hypertensive rats: dissociation of timing and inhibition of responses.
Topics: Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Cent | 2009 |
Prefrontal cortex Homer expression in an animal model of attention-deficit/hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Blotting, Western; Carrier Proteins; Central | 2009 |
Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate.
Topics: Action Potentials; Animals; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Diseas | 2009 |
Prepuberal subchronic methylphenidate and atomoxetine induce different long-term effects on adult behaviour and forebrain dopamine, norepinephrine and serotonin in Naples high-excitability rats.
Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Atomoxetine Hydrochloride; Attention; Attention Defici | 2010 |
Mice lacking p35 display hyperactivity and paradoxical response to psychostimulants.
Topics: Animals; Central Nervous System Stimulants; Corpus Striatum; Cyclin-Dependent Kinase 5; Dextroamphet | 2010 |
The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Binding Sites; Brain; Central Nervous System | 2010 |
Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD).
Topics: Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Blood Pressure; Caffei | 2010 |
Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35.
Topics: Animals; Atrophy; Attention Deficit Disorder with Hyperactivity; Brain; Disease Models, Animal; Dopa | 2010 |
Methylphenidate and atomoxetine enhance prefrontal function through α2-adrenergic and dopamine D1 receptors.
Topics: Adrenergic Uptake Inhibitors; Animals; Appetitive Behavior; Atomoxetine Hydrochloride; Attention Def | 2010 |
Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Central Nervous System Stimulants; | 2011 |
Noise benefit in prepulse inhibition of the acoustic startle reflex.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; | 2011 |
Methylphenidate self-administration and conditioned place preference in an animal model of attention-deficit hyperactivity disorder: the spontaneously hypertensive rat.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Sti | 2011 |
Magnesium sulfate and sodium valproate block methylphenidate-induced hyperlocomotion, an animal model of mania.
Topics: Animals; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Central Nervous System Stimulants; Dis | 2011 |
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice.
Topics: Adaptor Proteins, Signal Transducing; Amphetamine; Animals; Attention Deficit Disorder with Hyperact | 2011 |
Methylphenidate and fluphenazine, but not amphetamine, differentially affect impulsive choice in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats.
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2011 |
Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats.
Topics: Aging; Animals; Animals, Newborn; Central Nervous System Stimulants; Disease Models, Animal; Female; | 2011 |
Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Body Weight; Central Nervous System Stimulants; | 2012 |
Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain-Derived Neurotrophic Factor; Central N | 2011 |
Strain differences in self-administration of methylphenidate and sucrose pellets in a rat model of attention-deficit hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Sti | 2011 |
Methylphenidate treatment in the spontaneously hypertensive rat: influence on methylphenidate self-administration and reinstatement in comparison with Wistar rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Sti | 2012 |
Behavioral and neuromorphological characterization of a novel Tuba1 mutant mouse.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Attention; Behavior, Animal; Bromode | 2012 |
Effects of methylphenidate on attentional set-shifting in a genetic model of attention-deficit/hyperactivity disorder.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants | 2012 |
Differential behavioral responses of the spontaneously hypertensive rat to methylphenidate and methamphetamine: lack of a rewarding effect of repeated methylphenidate treatment.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Sti | 2012 |
In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson disease using 11C-methylphenidate PET.
Topics: Animals; Carbon Radioisotopes; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; | 2012 |
The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development.
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Diencephalon; Dis | 2012 |
Isolation rearing as a preclinical model of attention/deficit-hyperactivity disorder.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Attention Deficit Disorder with Hypera | 2012 |
Distinct age-dependent effects of methylphenidate on developing and adult prefrontal neurons.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2012 |
Prenatal nicotine exposure mouse model showing hyperactivity, reduced cingulate cortex volume, reduced dopamine turnover, and responsiveness to oral methylphenidate treatment.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine; Female; Gy | 2012 |
A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M | 2012 |
Physical exercise and catecholamine reuptake inhibitors affect orienting behavior and social interaction in a rat model of attention-deficit/hyperactivity disorder.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention; Attention Deficit Disor | 2012 |
Social isolation induces deficit of latent learning performance in mice: a putative animal model of attention deficit/hyperactivity disorder.
Topics: Aggression; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Caffeine; Central Ner | 2013 |
Intra-orbitofrontal cortex injection of haloperidol removes the beneficial effect of methylphenidate on reversal learning of spontaneously hypertensive rats in an attentional set-shifting task.
Topics: Animals; Attention; Attention Deficit and Disruptive Behavior Disorders; Disease Models, Animal; Dop | 2013 |
Impaired cliff avoidance reaction in dopamine transporter knockout mice.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Behavior, Animal; Diseas | 2013 |
Subchronic methylphenidate administration has no effect on locomotion, emotional behavior, or water maze learning in prepubertal mice.
Topics: Affect; Animals; Attention Deficit Disorder with Hyperactivity; Body Weight; Central Nervous System | 2002 |
Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, but not raclopride in mice selectively bred for hyperactive wheel-running behavior.
Topics: Animals; Animals, Outbred Strains; Apomorphine; Benzazepines; Breeding; Disease Models, Animal; Dopa | 2003 |
A longitudinal study of short- and long-term activity levels in male and female spontaneously hypertensive, Wistar-Kyoto, and Sprague-Dawley rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Central Nervous System Stimul | 2003 |
What are the long-term effects of methylphenidate treatment?
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Cognition Disorders; Disease Models, | 2003 |
Methylphenidate-induced plasticity: what should we be looking for?
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Di | 2003 |
The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder.
Topics: Amphetamine; Animals; Animals, Outbred Strains; Attention Deficit Disorder with Hyperactivity; Behav | 2004 |
Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy | 2005 |
An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Carbidopa; Cell Count; Differential Threshold; Dise | 2005 |
Behavioural and pharmacological magnetic resonance imaging assessment of the effects of methylphenidate in a potential new rat model of attention deficit hyperactivity disorder.
Topics: Analysis of Variance; Animals; Animals, Newborn; Attention Deficit and Disruptive Behavior Disorders | 2005 |
Hyperactivity, impaired learning on a vigilance task, and a differential response to methylphenidate in the TRbetaPV knock-in mouse.
Topics: Alleles; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Central Nervous System S | 2005 |
Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment.
Topics: Action Potentials; Animals; Animals, Newborn; Apomorphine; Attention Deficit Disorder with Hyperacti | 2006 |
Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervo | 2006 |
Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervo | 2006 |
Transgenic mice expressing a human mutant beta1 thyroid receptor are hyperactive, impulsive, and inattentive.
Topics: Age Factors; Analysis of Variance; Animals; Attention; Attention Deficit Disorder with Hyperactivity | 2006 |
Preadolescent methylphenidate versus cocaine treatment differ in the expression of cocaine-induced locomotor sensitization during adolescence and adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cocaine; Cocaine-Rel | 2006 |
Dopamine transporter density and behavioral response to methylphenidate in a hyperlocomotor rat model.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Bromodeoxyuridine; Disease | 2006 |
A novel method for oral stimulant administration in the neonate rat and similar species.
Topics: Administration, Oral; Animals; Animals, Newborn; Animals, Suckling; Attention Deficit Disorder with | 2007 |
Dimensional analysis of ADHD subtypes in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy | 2007 |
Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains.
Topics: Adolescent; Age Factors; Aging; Animals; Behavior, Animal; Central Nervous System; Central Nervous S | 2006 |
Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Benzhydryl Compounds; Cent | 2007 |
Parallel loss of hippocampal LTD and cognitive flexibility in a genetic model of hyperdopaminergia.
Topics: Animals; Brain Diseases, Metabolic; Cognition Disorders; Disease Models, Animal; Dopamine; Dopamine | 2007 |
Methylphenidate reduces impulsive behaviour in juvenile Wistar rats, but not in adult Wistar, SHR and WKY rats.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervo | 2007 |
Methylphenidate treatment recovers stress-induced elevated dendritic spine densities in the rodent dorsal anterior cingulate cortex.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants | 2007 |
Early stress and chronic methylphenidate cross-sensitize dopaminergic responses in the adolescent medial prefrontal cortex and nucleus accumbens.
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine; Dop | 2007 |
Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice.
Topics: Amphetamine; Animals; Behavior, Animal; Biogenic Monoamines; Cell Count; Central Nervous System Stim | 2008 |
Chronic methylphenidate treatment during adolescence increases anxiety-related behaviors and ethanol drinking in adult spontaneously hypertensive rats.
Topics: Age Factors; Aging; Alcohol Drinking; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cent | 2008 |
Behavioural characterisation of rats exposed neonatally to bisphenol-A: responses to a novel environment and to methylphenidate challenge in a putative model of attention-deficit hyperactivity disorder.
Topics: Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Benzhydr | 2008 |
Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder.
Topics: Animals; Association Learning; Attention; Attention Deficit Disorder with Hyperactivity; Central Ner | 2008 |
Haloperidol-induced hyperactivity in neonatal rats: effect of lithium and stimulants.
Topics: Animals; Animals, Newborn; Dextroamphetamine; Disease Models, Animal; Female; Haloperidol; Humans; H | 1982 |
Behavioral and pharmacological studies on the validation of a new animal model for attention deficit hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, Animal; Ma | 1996 |
Differences between electrically-, ritalin- and D-amphetamine-stimulated release of [3H]dopamine from brain slices suggest impaired vesicular storage of dopamine in an animal model of Attention-Deficit Hyperactivity Disorder.
Topics: Animals; Brain; Brain Mapping; Central Nervous System Stimulants; Culture Techniques; Dextroamphetam | 1998 |
How stimulant drugs may calm hyperactivity.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain; Carrier Proteins; C | 1999 |
Non-selective attention in a rat model of hyperactivity and attention deficit: subchronic methylphenydate and nitric oxide synthesis inhibitor treatment.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine | 2000 |
"Model" behavior.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Carrier Proteins; Central Nervous System Sti | 2000 |
Methylphenidate affects striatal dopamine differently in an animal model for attention-deficit/hyperactivity disorder--the spontaneously hypertensive rat.
Topics: Acetylcholine; Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopam | 2000 |
Drugs used in the treatment of attention-deficit/hyperactivity disorder affect postsynaptic firing rate and oscillation without preferential dopamine autoreceptor action.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Autoreceptors; Catecholamines; Central Nervo | 2001 |
Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.
Topics: Animals; Anti-Anxiety Agents; Arousal; Attention Deficit Disorder with Hyperactivity; Avoidance Lear | 2002 |
Behavioural and pharmacological relevance of stroke-prone spontaneously hypertensive rats as an animal model of a developmental disorder.
Topics: Animals; Arousal; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2002 |
Anoxic myoclonus in the rat.
Topics: Acetazolamide; Amphetamines; Anesthetics; Animals; Brain; Carbon Dioxide; Disease Models, Animal; El | 1979 |
Methylphenidate in 6-hydroxydopamine-treated developing rat pups. Effects on activity and maze performance.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain Chemist | 1978 |
A dog model for human psychopathology.
Topics: Animals; Anxiety; Arrhythmias, Cardiac; Behavior, Animal; Brain; Conditioning, Psychological; Diseas | 1979 |
Characteristics of unlimited access to self-administered stimulant infusions in dogs.
Topics: Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Dogs; Humans; Infusions, Parent | 1976 |
Actions of dopaminergic agonists on motor function.
Topics: Amantadine; Animals; Apomorphine; Behavior; Dextroamphetamine; Disease Models, Animal; Dopamine Anta | 1975 |
The spontaneously hypertensive rat (SHR) as an animal model of childhood hyperactivity (ADHD): changed reactivity to reinforcers and to psychomotor stimulants.
Topics: Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 1992 |
Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamines; Animals; Apomorphine; Brai | 1992 |
The spontaneously hypertensive rat as an animal model of attention-deficit hyperactivity disorder: effects of methylphenidate on exploratory behavior.
Topics: Animals; Arousal; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dose-Respon | 1990 |
Effects of methylphenidate on whirler mice: an animal model for hyperkinesis.
Topics: Administration, Oral; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 1985 |
Prenatal methylazoxymethanol treatment potentiates d-amphetamine- and methylphenidate-induced motor activity in male and female rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Azo Compounds; Dextroamphetamine; Disease Mo | 1988 |
Lead-induced behavioral dysfunction: an animal model of hyperactivity.
Topics: Amphetamine; Animals; Chloral Hydrate; Dextroamphetamine; Disease Models, Animal; Female; Humans; Hy | 1974 |