methylphenidate has been researched along with Chronic Disease in 27 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Fatigue and Sarcoidosis-Treatment with Methylphenidate study is a randomised, controlled, parallel-arm and feasibility trial of methylphenidate for the treatment of sarcoidosis-associated fatigue." | 9.24 | Feasibility study of a randomised controlled trial to investigate the treatment of sarcoidosis-associated fatigue with methylphenidate (FaST-MP): a study protocol. ( Atkins, C; Clark, AB; Fordham, R; Jones, AP; Stockl, A; Wilson, AM, 2017) |
| "In the absence of definitive evidence of effectiveness, trials of low-dose methylphenidate in medically ill adults with depression, fatigue, or apathy, with monitoring for response and adverse effects, are appropriate." | 8.85 | Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults. ( Hardy, SE, 2009) |
| " Larger studies with higher doses combined with individual dosage and longer follow-up periods are warranted." | 6.75 | Sustained release methylphenidate for the treatment of ADHD in amphetamine abusers: a pilot study. ( Beck, O; Franck, J; Jayaram-Lindström, N; Konstenius, M, 2010) |
| "The Fatigue and Sarcoidosis-Treatment with Methylphenidate study is a randomised, controlled, parallel-arm and feasibility trial of methylphenidate for the treatment of sarcoidosis-associated fatigue." | 5.24 | Feasibility study of a randomised controlled trial to investigate the treatment of sarcoidosis-associated fatigue with methylphenidate (FaST-MP): a study protocol. ( Atkins, C; Clark, AB; Fordham, R; Jones, AP; Stockl, A; Wilson, AM, 2017) |
| " We included studies investigating pemoline and modafinil in participants with multiple sclerosis (MS)-associated fatigue and methylphenidate in patients suffering from advanced cancer and fatigue in meta-analysis." | 4.91 | Pharmacological treatments for fatigue associated with palliative care. ( Cuhls, H; Minton, O; Mücke, M; Peuckmann-Post, V; Radbruch, L; Stone, P, 2015) |
| "In the absence of definitive evidence of effectiveness, trials of low-dose methylphenidate in medically ill adults with depression, fatigue, or apathy, with monitoring for response and adverse effects, are appropriate." | 4.85 | Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults. ( Hardy, SE, 2009) |
| " Larger studies with higher doses combined with individual dosage and longer follow-up periods are warranted." | 2.75 | Sustained release methylphenidate for the treatment of ADHD in amphetamine abusers: a pilot study. ( Beck, O; Franck, J; Jayaram-Lindström, N; Konstenius, M, 2010) |
| "Methylphenidate was tapered and discontinued during weeks 9 and 10." | 2.71 | Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trial. ( Kim, MD; Kumar, A; Lavretsky, H; Reynolds, CF, 2003) |
| " The medication trials were double-blind, placebo-controlled, dose-response studies." | 2.66 | Treatment of chronic closed head injury with psychostimulant drugs: a controlled case study and an appropriate evaluation procedure. ( Evans, RW; Gualtieri, CT; Patterson, D, 1987) |
| "Fatigue is a common symptom experienced by people with cancer and other long-term, non-malignant conditions." | 2.61 | The holistic management of fatigue within palliative care. ( Dean, A, 2019) |
| " Personal or family tic history, medication selection, or dosage was not related to onset of T/D." | 1.29 | Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder. ( Adesman, AR; Goldstein, IJ; Lipkin, PH, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.93) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dean, A | 1 |
| Atkins, C | 1 |
| Fordham, R | 1 |
| Clark, AB | 1 |
| Stockl, A | 1 |
| Jones, AP | 1 |
| Wilson, AM | 1 |
| Konova, AB | 1 |
| Moeller, SJ | 1 |
| Tomasi, D | 1 |
| Goldstein, RZ | 1 |
| Mücke, M | 1 |
| Cuhls, H | 1 |
| Peuckmann-Post, V | 1 |
| Minton, O | 1 |
| Stone, P | 1 |
| Radbruch, L | 1 |
| Hardy, SE | 1 |
| Konstenius, M | 1 |
| Jayaram-Lindström, N | 1 |
| Beck, O | 1 |
| Franck, J | 1 |
| FRANKL, VE | 1 |
| GEORGE, RB | 1 |
| LEE, CH | 1 |
| Lavretsky, H | 1 |
| Kim, MD | 1 |
| Kumar, A | 1 |
| Reynolds, CF | 1 |
| Miller, AR | 1 |
| Lalonde, CE | 1 |
| McGrail, KM | 1 |
| Truter, I | 1 |
| Tennant, FS | 1 |
| Szymanski, S | 1 |
| Lieberman, JA | 1 |
| Alvir, JM | 1 |
| Mayerhoff, D | 1 |
| Loebel, A | 1 |
| Geisler, S | 1 |
| Chakos, M | 1 |
| Koreen, A | 1 |
| Jody, D | 1 |
| Kane, J | 1 |
| Johnson, CJ | 1 |
| Auger, WR | 1 |
| Fedullo, PF | 1 |
| Dimsdale, JE | 1 |
| Lipkin, PH | 1 |
| Goldstein, IJ | 1 |
| Adesman, AR | 1 |
| O'Neill, WM | 1 |
| Frye, CB | 1 |
| Gadow, KD | 1 |
| Sverd, J | 1 |
| Sprafkin, J | 1 |
| Nolan, EE | 1 |
| Grossman, S | 1 |
| Kruithof, H | 1 |
| Fluit, M | 1 |
| Bridgeford, D | 1 |
| Arciniegas, DB | 1 |
| Batkis, M | 1 |
| Sandberg, E | 1 |
| Beresford, TP | 1 |
| LeGrand, SB | 1 |
| Kajiki, A | 1 |
| Tsuda, T | 1 |
| Yamazaki, H | 1 |
| Kido, M | 1 |
| Barkley, RA | 1 |
| Murphy, JV | 1 |
| Little, KY | 1 |
| Gay, TL | 1 |
| Vore, M | 1 |
| Evans, RW | 1 |
| Gualtieri, CT | 1 |
| Patterson, D | 1 |
| St Jean, A | 1 |
| Sterlin, C | 1 |
| Noe, W | 1 |
| Ban, TA | 1 |
| Rappaport, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility Study of Adjunctive Bright Light Therapy (BLT) for Amelioration of Fatigue in Chinese Cancer Patients Admitted to a Palliative Care Unit[NCT04525924] | 42 participants (Anticipated) | Interventional | 2020-08-01 | Recruiting | |||
| Fatigue in Sarcoidosis - A Feasibility Study Investigating the Treatment of Fatigue in Stable Sarcoidosis Patients Using Methylphenidate[NCT02643732] | 30 participants (Anticipated) | Interventional | 2016-11-30 | Recruiting | |||
| Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417] | Phase 2 | 120 participants (Anticipated) | Interventional | 2022-05-01 | Not yet recruiting | ||
| A Randomized Trial Administering Estradiol Patch vs. Placebo Patch as add-on to Antipsychotics in Female Patients Above the Age of 38 With Schizophrenia, Schizoaffective or Schizophreniform Disorder[NCT04093518] | Phase 3 | 100 participants (Anticipated) | Interventional | 2019-12-02 | Recruiting | ||
| Methylphenidate Treatment of ADHD in Children With Tourette Syndrome[NCT00441649] | 71 participants | Interventional | 2000-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for methylphenidate and Chronic Disease
| Article | Year |
|---|---|
The holistic management of fatigue within palliative care.
Topics: Central Nervous System Stimulants; Chronic Disease; Cognitive Behavioral Therapy; Complementary Ther | 2019 |
Pharmacological treatments for fatigue associated with palliative care.
Topics: Adult; Amantadine; Benzhydryl Compounds; Carnitine; Central Nervous System Stimulants; Chronic Disea | 2015 |
Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Depressio | 2009 |
Treating attention-deficit hyperactivity disorder: medication and behavior management training.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Chronic Disease; | 1991 |
7 trials available for methylphenidate and Chronic Disease
| Article | Year |
|---|---|
Feasibility study of a randomised controlled trial to investigate the treatment of sarcoidosis-associated fatigue with methylphenidate (FaST-MP): a study protocol.
Topics: Central Nervous System Stimulants; Chronic Disease; Double-Blind Method; England; Fatigue; Feasibili | 2017 |
Sustained release methylphenidate for the treatment of ADHD in amphetamine abusers: a pilot study.
Topics: Adult; Amphetamine-Related Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2010 |
Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trial.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Central Nervous System Stimulants | 2003 |
The cognitive and psychomotor effects of opioid drugs in cancer pain management.
Topics: Adult; Amphetamines; Analgesics, Opioid; Buprenorphine; Central Nervous System Stimulants; Chronic D | 1994 |
Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Chronic Dis | 1999 |
Treatment of chronic closed head injury with psychostimulant drugs: a controlled case study and an appropriate evaluation procedure.
Topics: Adult; Attention; Chronic Disease; Clinical Trials as Topic; Cognition Disorders; Craniocerebral Tra | 1987 |
Clinical studies with propericiazine (R.P. 8909).
Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin | 1967 |
16 other studies available for methylphenidate and Chronic Disease
| Article | Year |
|---|---|
Effects of chronic and acute stimulants on brain functional connectivity hubs.
Topics: Brain; Brain Mapping; Central Nervous System Stimulants; Chronic Disease; Cocaine; Cocaine-Related D | 2015 |
[On a new principle in the treatment of chronic sleep disorders: paradoxal medication].
Topics: Chronic Disease; Health Services; Methylphenidate; Sleep; Sleep Wake Disorders | 1960 |
A STIMULANT SUPPLEMENT FOR THE CHRONICALLY ILL: THREE-MONTH STUDY IN A TUBERCULOSIS WARD.
Topics: Chronic Disease; Geriatrics; Humans; Methylphenidate; Methyltestosterone; Tuberculosis; Tuberculosis | 1965 |
Children's persistence with methylphenidate therapy: a population-based study.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; British Columbia; Central Nervous | 2004 |
Methylphenidate: prescribing patterns in a South African primary care patient population.
Topics: Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Chemistry, Pharmaceutical; C | 2005 |
The California registration system for habitues to schedule II drugs.
Topics: Barbiturates; California; Chronic Disease; Humans; Methylphenidate; Pain; Registries; Substance-Rela | 1981 |
Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients.
Topics: Adolescent; Adult; Age of Onset; Antipsychotic Agents; Chronic Disease; Female; Follow-Up Studies; H | 1995 |
Methylphenidate in the 'hard to wean' patient.
Topics: Aged; Chronic Disease; Critical Care; Depressive Disorder; Female; Humans; Male; Methylphenidate; Pa | 1995 |
Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Chronic Disease; | 1994 |
Methylphenidate for depression in the elderly, medically ill patient.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Central Nervous System Stimulants; Chronic Disease; | 1997 |
[Physician-assisted suicide of a patient suffering from a psycho- organic disorder].
Topics: Aged; Central Nervous System Stimulants; Chronic Disease; Dementia, Vascular; Ethics, Medical; Human | 1999 |
Methylphenidate treatment of neuropsychiatric symptoms of central and extrapontine myelinolysis.
Topics: Alcoholism; Central Nervous System Stimulants; Chronic Disease; Corpus Striatum; Humans; Magnetic Re | 2000 |
Cancer fatigue--more data, less information?
Topics: Anemia; Central Nervous System Stimulants; Chronic Disease; Cytokines; Depression; Exercise; Fatigue | 2002 |
[Two cases of chronic respiratory failure in intravenous methylphenidate (Ritalin) abusers].
Topics: Adult; Chronic Disease; Humans; Lung Diseases, Obstructive; Male; Methylphenidate; Middle Aged; Resp | 1992 |
Predictors of response to high dose antipsychotics in chronic schizophrenics.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Dose-Response Relationship, Drug; Female; Hallucinatio | 1989 |
Attention to competing voice messages by nonacute schizophrenic patients. Effects of message load, drugs, dosage levels and patient background.
Topics: Acute Disease; Adult; Attention; Auditory Perception; Chlorpromazine; Chronic Disease; Dextroampheta | 1968 |