methylphenidate has been researched along with Childhood Tic Disorders in 43 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylphenidate is an effective short-term treatment for oppositional behavior in children with comorbid ADHD and chronic multiple tic disorder." | 2.73 | Methylphenidate in children with oppositional defiant disorder and both comorbid chronic multiple tic disorder and ADHD. ( Gadow, KD; Nolan, EE; Schneider, J; Sprafkin, J; Sverd, J, 2008) |
| "Methylphenidate appears to be a safe and effective treatment for attention-deficit hyperactivity disorder in the majority of children with comorbid tic disorder." | 2.68 | Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. ( Ezor, SN; Gadow, KD; Nolan, EE; Sprafkin, J; Sverd, J, 1995) |
| "Dextroamphetamine tended to produce more compulsive behaviors, which were also more likely to resemble clinical obsessive-compulsive disorder (OCD), than did methylphenidate." | 2.67 | Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability? ( Amass, J; Borcherding, BG; Elia, J; Keysor, CS; Rapoport, JL, 1990) |
| " In one study, tics limited further dosage increases of methylphenidate." | 2.58 | Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders. ( Osland, ST; Pringsheim, T; Steeves, TD, 2018) |
| " For patients with pre-existing tic disorders, the usual recommended dosing of stimulants should be used because supratherapeutic doses of this class of medications, specifically dextroamphetamine, have shown to exacerbate tic disorders." | 2.53 | Attention Deficit Hyperactive Disorder and Occurrence of Tic Disorders in Children and Adolescents-What is the Verdict. ( Cooke, T; So, TY, 2016) |
| "Desipramine and placebo were similar on "all-cause treatment discontinuation" (RD -0." | 2.50 | Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents. ( Castells, X; Ehimare, UP; Otasowie, J; Smith, CH, 2014) |
| " While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs." | 2.49 | Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013) |
| "Approximately half of children with Tourette's syndrome experience comorbid attention-deficit/hyperactivity disorder (ADHD)." | 2.45 | Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. ( Bloch, MH; Landeros-Weisenberger, A; Leckman, JF; Panza, KE, 2009) |
| "The concomitant use of MPHs and SSRIs showed generally safe profiles in adolescent ADHD patients with depression." | 1.91 | Safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: ( Alhambra, DP; Kim, C; Kim, SJ; Lee, DY; Lee, J; Lee, S; Lee, YH; Park, J; Park, RW; Shin, Y; Tan, EH; Yang, SJ, 2023) |
| "Clonidine was associated with markedly higher clinical efficacy vs." | 1.91 | Efficacy of clonidine in the treatment of children with tic disorder co-morbid with attention deficit hyperactivity disorder. ( Hu, B; Huang, XH; Wang, GL; Yuan, Y; Zeng, KD; Zhang, W, 2023) |
| "Childhood narcolepsy is associated with various emotional, behavioural and cognitive dysfunctions as well as with psychiatric and neurodevelopmental disorders: anxiety, depression, attention deficit hyperactivity disorder and psychosis." | 1.48 | Childhood narcolepsy and autism spectrum disorders: four case reports. ( Dudova, I; Hrdlicka, M; Mohaplova, M; Nevsimalova, S; Prihodova, I, 2018) |
| " Personal or family tic history, medication selection, or dosage was not related to onset of T/D." | 1.29 | Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder. ( Adesman, AR; Goldstein, IJ; Lipkin, PH, 1994) |
| "The clinical diagnosis in 19 cases was minimal brain dysfunction (MBD), and in one case, Gilles de la Tourette syndrome." | 1.26 | Tics following methylphenidate administration. A report of 20 cases. ( Bemporad, JR; Denckla, MB; MacKay, MC, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (23.26) | 18.7374 |
| 1990's | 14 (32.56) | 18.2507 |
| 2000's | 9 (20.93) | 29.6817 |
| 2010's | 6 (13.95) | 24.3611 |
| 2020's | 4 (9.30) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, C | 1 |
| Lee, DY | 1 |
| Park, J | 1 |
| Yang, SJ | 1 |
| Tan, EH | 1 |
| Alhambra, DP | 1 |
| Lee, YH | 1 |
| Lee, S | 1 |
| Kim, SJ | 1 |
| Lee, J | 1 |
| Park, RW | 1 |
| Shin, Y | 1 |
| Zeng, KD | 1 |
| Wang, GL | 1 |
| Yuan, Y | 1 |
| Zhang, W | 1 |
| Huang, XH | 1 |
| Hu, B | 1 |
| Yang, C | 1 |
| Cheng, X | 1 |
| Zhang, Q | 1 |
| Yu, D | 1 |
| Li, J | 1 |
| Zhang, L | 1 |
| Naguy, A | 1 |
| Allami, S | 1 |
| Abuzeid, MY | 1 |
| Alamiri, B | 1 |
| Osland, ST | 1 |
| Steeves, TD | 1 |
| Pringsheim, T | 1 |
| Prihodova, I | 1 |
| Dudova, I | 1 |
| Mohaplova, M | 1 |
| Hrdlicka, M | 1 |
| Nevsimalova, S | 1 |
| Otasowie, J | 1 |
| Castells, X | 1 |
| Ehimare, UP | 1 |
| Smith, CH | 1 |
| Cooke, T | 1 |
| So, TY | 1 |
| Bloch, MH | 1 |
| Panza, KE | 1 |
| Landeros-Weisenberger, A | 1 |
| Leckman, JF | 1 |
| Gadow, KD | 12 |
| Nolan, EE | 11 |
| Cortese, S | 1 |
| Holtmann, M | 1 |
| Banaschewski, T | 2 |
| Buitelaar, J | 2 |
| Coghill, D | 2 |
| Danckaerts, M | 2 |
| Dittmann, RW | 1 |
| Graham, J | 1 |
| Taylor, E | 2 |
| Sergeant, J | 2 |
| Kociancic, T | 1 |
| Reed, MD | 1 |
| Findling, RL | 1 |
| Döpfner, M | 1 |
| Asherson, P | 1 |
| Rothenberger, A | 2 |
| Sonuga-Barke, E | 1 |
| Steinhausen, HC | 1 |
| Zuddas, A | 1 |
| Sverd, J | 9 |
| Sprafkin, J | 7 |
| Schneider, J | 2 |
| Gualtieri, CT | 3 |
| Evans, RW | 1 |
| Klein, RG | 1 |
| Ezor, SN | 2 |
| Wilens, TE | 2 |
| Spencer, T | 1 |
| Biederman, J | 2 |
| Wozniak, J | 1 |
| Connor, D | 1 |
| Lipkin, PH | 1 |
| Goldstein, IJ | 1 |
| Adesman, AR | 1 |
| Grossman, S | 1 |
| Castellanos, FX | 1 |
| Law, SF | 1 |
| Schachar, RJ | 1 |
| Moll, GH | 1 |
| Heinrich, H | 1 |
| Schwartz, J | 1 |
| Eggers, C | 1 |
| Margolin, DI | 1 |
| Denckla, MB | 1 |
| Bemporad, JR | 1 |
| MacKay, MC | 1 |
| Borcherding, BG | 1 |
| Keysor, CS | 1 |
| Rapoport, JL | 1 |
| Elia, J | 1 |
| Amass, J | 1 |
| Stevenson, RD | 1 |
| Wolraich, ML | 1 |
| Chandler, ML | 1 |
| Barnhill, JL | 1 |
| Patterson, DR | 2 |
| Erenberg, G | 1 |
| Cruse, RP | 1 |
| Rothner, AD | 1 |
| Caine, ED | 1 |
| McBride, MC | 1 |
| Chiverton, P | 1 |
| Bamford, KA | 1 |
| Rediess, S | 1 |
| Shiao, J | 1 |
| Casat, CD | 1 |
| Wilson, DC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323] | 80 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Methylphenidate Treatment of ADHD in Children With Tourette Syndrome[NCT00441649] | 71 participants | Interventional | 2000-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for methylphenidate and Childhood Tic Disorders
| Article | Year |
|---|---|
Interventions for tic disorders: An updated overview of systematic reviews and meta analyses.
Topics: Antipsychotic Agents; Aripiprazole; Child; Cost-Benefit Analysis; Exercise; Guanfacine; Humans; Meta | 2020 |
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervou | 2018 |
Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central | 2014 |
Attention Deficit Hyperactive Disorder and Occurrence of Tic Disorders in Children and Adolescents-What is the Verdict.
Topics: Adolescent; Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Child; Comorbi | 2016 |
Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders.
Topics: Adrenergic alpha-Agonists; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; | 2009 |
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure | 2013 |
Evaluation of risks associated with short- and long-term psychostimulant therapy for treatment of ADHD in children.
Topics: Appetite; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; D | 2004 |
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate.
Topics: Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimu | 2006 |
The role of methylphenidate in psychiatry.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Child; Cost-Benefit Analysis; Fema | 1995 |
Stimulants and tic disorders: from dogma to data.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clinical Trials as | 1999 |
[Transcranial magnetic stimulation in child and adolescent psychiatry: excitability of the motor system in tic disorders and/or attention deficit hyperactivity disorders].
Topics: Adolescent; Adolescent Psychiatry; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy | 2001 |
[Psychotropic drug therapy in children].
Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; | 1977 |
The stimulants.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 1992 |
Stimulant medication therapy in the treatment of children with attention deficit hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Dopamine; Growth; Humans; M | 1989 |
13 trials available for methylphenidate and Childhood Tic Disorders
| Article | Year |
|---|---|
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD.
Topics: Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2011 |
Immediate-release methylphenidate for ADHD in children with comorbid chronic multiple tic disorder.
Topics: Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2007 |
Methylphenidate in children with oppositional defiant disorder and both comorbid chronic multiple tic disorder and ADHD.
Topics: Age Factors; Aggression; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Diso | 2008 |
Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Comorbidity; Dose-Response Relationship, Drug; | 1995 |
Observations and ratings of tics in school settings.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; Female; Huma | 1994 |
Children with ADHD and tic disorder and their classmates: behavioral normalization with methylphenidate.
Topics: Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 1997 |
Stimulant medication withdrawal during long-term therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 1999 |
Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Chronic Dis | 1999 |
Do typical clinical doses of methylphenidate cause tics in children treated for attention-deficit hyperactivity disorder?
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Double-Blin | 1999 |
Treatment of ADHD in children with tics: a randomized controlled trial.
Topics: Adolescent; Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Central Nervou | 2002 |
Anxiety and depression symptoms and response to methylphenidate in children with attention-deficit hyperactivity disorder and tic disorder.
Topics: Adolescent; Analysis of Variance; Anxiety; Attention Deficit Disorder with Hyperactivity; Central Ne | 2002 |
Methylphenidate in hyperactive boys with comorbid tic disorder: II. Short-term behavioral effects in school settings.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Comorbidity; Dose-Re | 1992 |
Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability?
Topics: Attention Deficit Disorder with Hyperactivity; Child; Compulsive Behavior; Dextroamphetamine; Double | 1990 |
16 other studies available for methylphenidate and Childhood Tic Disorders
| Article | Year |
|---|---|
Safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression:
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cohort | 2023 |
Efficacy of clonidine in the treatment of children with tic disorder co-morbid with attention deficit hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clonidine; | 2023 |
Successful Ziprasidone Treatment for Resistant Attention-Deficit/Hyperactivity Disorder and Provisional Motor Tic Disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Comorbidity; Humans; Methylphenidate; Piperazines; Th | 2022 |
Childhood narcolepsy and autism spectrum disorders: four case reports.
Topics: Age of Onset; Antidepressive Agents; Anxiety Disorders; Asperger Syndrome; Attention Deficit Disorde | 2018 |
European clinical guidelines for hyperkinetic disorder -- first upgrade.
Topics: Alleles; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Ch | 2004 |
Carbamazepine-induced tics.
Topics: Carbamazepine; Child; Dextroamphetamine; Humans; Male; Methylphenidate; Tic Disorders | 1984 |
Combined pharmacotherapy: an emerging trend in pediatric psychopharmacology.
Topics: Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Child Psychiatry; | 1995 |
Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Chronic Disease; | 1994 |
Letter: Methylphenidate-induced tics.
Topics: Humans; Hyperkinesis; Methylphenidate; Tic Disorders | 1976 |
Tics following methylphenidate administration. A report of 20 cases.
Topics: Acute Disease; Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Female | 1976 |
Methylphenidate in hyperactive boys with comorbid tic disorder. I. Clinic evaluations.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior; Child; Humans; Male; Methylphen | 1992 |
Tryptophan antagonism of stimulant-induced tics.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Drug Therapy, Combination; Humans; Male; Methy | 1989 |
Gilles de la Tourette's syndrome: effects of stimulant drugs.
Topics: Central Nervous System Stimulants; Child; Dextroamphetamine; Humans; Methylphenidate; Pemoline; Tic | 1985 |
Neuroleptic-induced tics in two hyperactive children.
Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Halop | 1986 |
Tourette's syndrome in Monroe County school children.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior; Child; Child, Preschool; Clonid | 1988 |
Tics with combined thioridazine-methylphenidate therapy: case report.
Topics: Child; Drug Therapy, Combination; Haloperidol; Humans; Male; Methylphenidate; Receptors, Dopamine; T | 1986 |